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Entry version 117 (12 Aug 2020)
Sequence version 1 (01 May 1999)
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Protein

Alpha-tectorin

Gene

TECTA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-tectorin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TECTA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004173925 – 2058Alpha-tectorinAdd BLAST2034
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000417402059 – 2120Removed in mature formSequence analysisAdd BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi822N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi834N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi907N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1041N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1537N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1684 ↔ 1742By similarity
Disulfide bondi1708 ↔ 1751By similarity
Glycosylationi1723N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1739N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1753 ↔ 1785By similarity
Glycosylationi1761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1773 ↔ 1865By similarity
Disulfide bondi1804 ↔ 1824By similarity
Glycosylationi1818N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1831N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1847N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1887N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1906N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1947 ↔ 2007PROSITE-ProRule annotation
Disulfide bondi1968 ↔ 2023By similarity
Disulfide bondi2012 ↔ 2019By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2058GPI-anchor amidated asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

At least 3 products of tectorin seem to exist: HMM, MMM and LMM. They may be generated by active processing or the result of proteolysis occurring between intrachain disulfide bonds.
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9YH85

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the inner ear.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Apically located within the epithelium of the developing basilar papilla at days E5.5 to E8. As development proceeds, expression becomes restricted to the basal layer. In the utricle, alpha-tectorin is first expressed at E4.5.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000040065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9YH85

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 252NIDOPROSITE-ProRule annotationAdd BLAST155
Domaini260 – 312VWFCAdd BLAST53
Domaini318 – 520VWFD 1PROSITE-ProRule annotationAdd BLAST203
Domaini578 – 620TIL 1Add BLAST43
Domaini691 – 908VWFD 2PROSITE-ProRule annotationAdd BLAST218
Domaini963 – 1013TIL 2Add BLAST51
Domaini1067 – 1289VWFD 3PROSITE-ProRule annotationAdd BLAST223
Domaini1345 – 1398TIL 3Add BLAST54
Domaini1459 – 1674VWFD 4PROSITE-ProRule annotationAdd BLAST216
Domaini1772 – 2026ZPPROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2091 – 2094Poly-Ser4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Zona pellucida domain may enable to form filaments.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216, Eukaryota
KOG4291, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9YH85

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9YH85

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003886, NIDO_dom
IPR036084, Ser_inhib-like_sf
IPR033026, TECTA
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR001507, ZP_dom
IPR017977, ZP_dom_CS

The PANTHER Classification System

More...
PANTHERi
PTHR46160:SF3, PTHR46160:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742, C8, 3 hits
PF06119, NIDO, 1 hit
PF01826, TIL, 3 hits
PF12714, TILa, 1 hit
PF00094, VWD, 4 hits
PF00100, Zona_pellucida, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 3 hits
SM00539, NIDO, 1 hit
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits
SM00241, ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567, SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51220, NIDO, 1 hit
PS51233, VWFD, 4 hits
PS00682, ZP_1, 1 hit
PS51034, ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YH85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTRSLLSAW AALLVVTVRH RAHAMASLYP FWPNDTKTPK VDDGSSSEIK
60 70 80 90 100
LSVPFIFFRS PYRTVYVNNN GVISFNSLVS QFTPEAFPLA DGRAFVAPFC
110 120 130 140 150
GDVANGIRGE IYYRESTNPE LLGESSKDIR KYFKDMASFS ASWVFIVTWE
160 170 180 190 200
EVQFYGGSST TPVNTFQAVL ITDGVSSFAI FNYQEISWTT GTASGGDPLT
210 220 230 240 250
GLGGVMAQAG FNGGNISNFF SIPGSRTPDI VNIEQTTNVN IPGRWAFKID
260 270 280 290 300
GREIDPANLS LRGQFLHQGE IFWENSNCST KCRCLDFNNE IFCQEMLAPF
310 320 330 340 350
ETVEPKIKFF QCVPVETACV VFGDPHYHTF DGFLFHFQGS CSYLLARQCW
360 370 380 390 400
PGSQLPYFNV EAKNERGGSS VSWAEDIFVE VYRHKIVLPK GGFGKAKVDD
410 420 430 440 450
LVVSLGAIKV YQSGLSTALE TDFGLLVTYD GQHYASVSVP GTYINGTCGL
460 470 480 490 500
CGNYNKDPED DALRSDGRLA SSVPELGESW RVPHPERKCS PGCVENCSVC
510 520 530 540 550
DASRILYSPI CGFSQECGAW SVLVATAFVH SCVYDLCSAR RTHRLCQAIQ
560 570 580 590 600
VTLRCCQGLG IRWENGVPDG MRGGLAVPGH SHYSGCASGC PATCSDLTAP
610 620 630 640 650
LRCTAPCPEG CECDDGHVLS ARPLHSLCRS GCVVDGRSRC REVFWATADC
660 670 680 690 700
TAECQCEDGG EAKCFNTSCP EGEVCTIEDG YRGCYPKREG LCSVGQNQVL
710 720 730 740 750
RTFDGVTFPY PLEHSYTLLK TCMEKPDFIE VDISQKKPDT LPMAGRVVRI
760 770 780 790 800
QVVGQEVKVG GASLSEVKVN GYDVDLPYFH PSGHLEIYRT DNGTVTESEG
810 820 830 840 850
LLSIGYYDSG LLEIRLSTAY FNCTGGLCGF FNGNDSDEFC TPKAKCTDNL
860 870 880 890 900
ELFLESWTTF DEICNGECGD LLKACNNDSE LLKTYRSRSN CAIINDPTNS
910 920 930 940 950
SFLECHNVSI VSAYYRTCLF RLCQSGGNQS ELCSAVARYA SACKNSEVDV
960 970 980 990 1000
GQWRSHSFCP LACPENSHFE ECMSCVETCE TLATGCCMDT CTEGCQCDEG
1010 1020 1030 1040 1050
FALRSPCVPR GECGCNFEGH ELATNQTFWM DISCHLLCYC NGSDNSVYCE
1060 1070 1080 1090 1100
NVLQDDEYYC HVRTDASCIV SGYGHYLTFD GFSFDFQSSC ALVLCTTIHG
1110 1120 1130 1140 1150
ACERSDTFPT FTVTVTAKNE DRDTSLACVV KQVEVEVFNY YIVIHRAYKY
1160 1170 1180 1190 1200
TVMINNERLY LPLKLGQGKV NIFAFGFHIV VETDFGLKVV YDWKTFLSVT
1210 1220 1230 1240 1250
IPRSFQNLTY GLCGRYNGNP DDDLVAAGGT PRFGVTDFVQ SWAKRDTFCR
1260 1270 1280 1290 1300
VGSGDRCPAC GKVEGFWKPQ QLCSLIPSQS GVFAKCHSKI NPSYFYKNCL
1310 1320 1330 1340 1350
FDTVVDGGAM ARRVADWLQN YASTCQTQGI AIIGWRNFTS CSVSCPPNSH
1360 1370 1380 1390 1400
YESCVSLCQP RCAAIRLKSD CGHYCVEGCQ CDPGYVLNGK SCILPQNCGC
1410 1420 1430 1440 1450
YSDGKYYEPK QLFWNGDCTR RCARFRRNLI QCDPRHCKSD EECASRNGVR
1460 1470 1480 1490 1500
GCFSTRSSFC LAAGGGVFRT FDGAFLRFPA NCAFVLSTIC QRLADFSFQL
1510 1520 1530 1540 1550
IINFDKWSSP NLTIISVYIY INEEQILISD RSTVKVNGSL VSIPFVTGLS
1560 1570 1580 1590 1600
TKIYSQEGFL VIDSGPDIHI RYNGFNVIKI TIGDRLQNKV CGLCGNFNGD
1610 1620 1630 1640 1650
PADDYATLRG KPVVSSVVLA QSWKTNGMQK SCNELQYSQY AASCDNVQIQ
1660 1670 1680 1690 1700
KLQSDSYCLK LTDMKGFFQP CYGLLDPLPF YESCFLDGCY NRKQVQLCGS
1710 1720 1730 1740 1750
LAAYGEACRT FGILGTEWIE KENCSGVVED PCAGADCPNR TCELDDGGEL
1760 1770 1780 1790 1800
CGCIEPPPYG NTTHDIIDAE VTCKAAQMEV SISKCKLFQL GFEREGVRVN
1810 1820 1830 1840 1850
DRHCPGIEGE DFISFQINNT KGNCGNLVQS NSTHIVYKNT VWIESANNTG
1860 1870 1880 1890 1900
NIITRDRTIN VEVFCAYELD IKISLDSVVR PMLSVINLTV PTQEGSFTTK
1910 1920 1930 1940 1950
MALYKNSSYK HPYRQGEVVL TTRDVLYVGV FVVGADSNHL ILMLNKCYAT
1960 1970 1980 1990 2000
PSRDSNDKLR YFIIEGGCQN LKDNTIGIEE NGVSLTCRFH VTVFKFIGDY
2010 2020 2030 2040 2050
DEVHLHCAVS LCDSEKYSCK INCPQHRRSA SAFAQEAHEQ ILSVGPIRRK
2060 2070 2080 2090 2100
RSDWCEDNGG CEQICTSQAD GPLCSCVTGT LQGDGKSCMA SSSSADIRAQ
2110 2120
ASLLVAAQLW LWAALHDPTS
Length:2,120
Mass (Da):233,965
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE93F69EA18B51A4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1114 – 1115Missing AA sequence (PubMed:9079715).Curated2
Sequence conflicti1123Missing AA sequence (PubMed:9079715).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ012287 mRNA Translation: CAA09979.1

Protein sequence database of the Protein Information Resource

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PIRi
T30243

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012287 mRNA Translation: CAA09979.1
PIRiT30243

3D structure databases

SMRiQ9YH85
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040065

Proteomic databases

PRIDEiQ9YH85

Phylogenomic databases

eggNOGiKOG1216, Eukaryota
KOG4291, Eukaryota
InParanoidiQ9YH85
PhylomeDBiQ9YH85

Family and domain databases

InterProiView protein in InterPro
IPR003886, NIDO_dom
IPR036084, Ser_inhib-like_sf
IPR033026, TECTA
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR001507, ZP_dom
IPR017977, ZP_dom_CS
PANTHERiPTHR46160:SF3, PTHR46160:SF3, 1 hit
PfamiView protein in Pfam
PF08742, C8, 3 hits
PF06119, NIDO, 1 hit
PF01826, TIL, 3 hits
PF12714, TILa, 1 hit
PF00094, VWD, 4 hits
PF00100, Zona_pellucida, 1 hit
SMARTiView protein in SMART
SM00832, C8, 3 hits
SM00539, NIDO, 1 hit
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits
SM00241, ZP, 1 hit
SUPFAMiSSF57567, SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51220, NIDO, 1 hit
PS51233, VWFD, 4 hits
PS00682, ZP_1, 1 hit
PS51034, ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTECTA_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9YH85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1999
Last modified: August 12, 2020
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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