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Protein

Formimidoyltransferase-cyclodeaminase

Gene

FTCD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).By similarity
Binds and promotes bundling of vimentin filaments originating from the Golgi.By similarity

Catalytic activityi

5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.
5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3.

Cofactori

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (transferase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoyltransferase-cyclodeaminase (FTCD)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (transferase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82For formimidoyltransferase activityBy similarity1
Active sitei412For cyclodeaminase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Multifunctional enzyme, Transferase
Biological processHistidine metabolism
LigandFolate-binding, Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.1.2.5 1306
4.3.1.4 1306
UniPathwayiUPA00193
UPA00379; UER00555

Names & Taxonomyi

Protein namesi
Recommended name:
Formimidoyltransferase-cyclodeaminase
Alternative name(s):
Formiminotransferase-cyclodeaminase
Short name:
FTCD
p60
Including the following 2 domains:
Glutamate formimidoyltransferase (EC:2.1.2.5)
Alternative name(s):
Glutamate formiminotransferase
Glutamate formyltransferase
Formimidoyltetrahydrofolate cyclodeaminase (EC:4.3.1.4)
Alternative name(s):
Formiminotetrahydrofolate cyclodeaminase
Gene namesi
Name:FTCD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002855761 – 541Formimidoyltransferase-cyclodeaminaseAdd BLAST541

Proteomic databases

PaxDbiQ9YH58
PRIDEiQ9YH58

Interactioni

Subunit structurei

Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009880

Structurei

3D structure databases

ProteinModelPortaliQ9YH58
SMRiQ9YH58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 181Formiminotransferase N-subdomainBy similarityAdd BLAST181
Regioni163 – 172Folate bindingSequence analysis10
Regioni182 – 326Formiminotransferase C-subdomainBy similarityAdd BLAST145
Regioni327 – 334LinkerBy similarity8
Regioni335 – 541Cyclodeaminase/cyclohydrolaseBy similarityAdd BLAST207

Sequence similaritiesi

In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.Curated
In the N-terminal section; belongs to the formiminotransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IERX Eukaryota
COG3404 LUCA
COG3643 LUCA
HOGENOMiHOG000006949
HOVERGENiHBG000168
InParanoidiQ9YH58
KOiK13990
PhylomeDBiQ9YH58

Family and domain databases

Gene3Di1.20.120.680, 1 hit
3.30.70.670, 1 hit
3.30.990.10, 1 hit
InterProiView protein in InterPro
IPR007044 Cyclodeamin/CycHdrlase
IPR013802 Formiminotransferase_C
IPR037070 Formiminotransferase_C_sf
IPR004227 Formiminotransferase_cat
IPR012886 Formiminotransferase_N
IPR037064 Formiminotransferase_N_sf
IPR022384 FormiminoTrfase_cat_dom_sf
IPR036178 Formintransfe-cycloase-like_sf
PfamiView protein in Pfam
PF02971 FTCD, 1 hit
PF04961 FTCD_C, 1 hit
PF07837 FTCD_N, 1 hit
SMARTiView protein in SMART
SM01221 FTCD, 1 hit
SM01222 FTCD_N, 1 hit
SUPFAMiSSF101262 SSF101262, 1 hit
SSF55116 SSF55116, 2 hits
TIGRFAMsiTIGR02024 FtcD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YH58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLVECVPN FSEGCNKEVI EALGRAISQT PGCTLLDVDA GASTNRTVYT
60 70 80 90 100
FVGTPEAVVE GALSAARMAW ELIDMSRHKG EHPRMGALDV CPFVPVMNIS
110 120 130 140 150
MEECVICAHV FGQRLSEELG VPVYLYGEAA RQESRRTLPA IRAGEYEALP
160 170 180 190 200
KKLEKPEWVP DFGPPAFVPQ WGATVTGART FLIAYNINLL CTKELAHRIA
210 220 230 240 250
LNIREQGRGA DQPGSLKKVQ GIGWYLEEEN IAQVSTNLLD FETTPLHAVY
260 270 280 290 300
EEVCYNAEAL KLPVVGSQLV GLVPKKAMLD AAEFYIKKEK LFILEEEHKI
310 320 330 340 350
KLVVSRLGLD SLSPFNPRER IIEYLVQAGQ EDKGLVTKPL GAFVRAVGGR
360 370 380 390 400
SAAPGGGSVA ATAASLGAAL GCMVGLMSYG KRQFEQLDSI MRNVIPPLHQ
410 420 430 440 450
AMDELVAMVD ADSRAFSSYM EAMKLPKSTP EERERRVVAM QQGLKTAVEV
460 470 480 490 500
PCTLAVKVNN LWSSLKMLAH HGNLACKSDL QVGAKMLEAA VFGAYFNVMI
510 520 530 540
NLKDITDEKF KTETSQMVTR LLEEAKQGSA LVLALLEKRE A
Length:541
Mass (Da):59,154
Last modified:May 1, 1999 - v1
Checksum:iA37BEF9654D46470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224473 mRNA Translation: CAA11966.1
RefSeqiNP_990234.1, NM_204903.1
UniGeneiGga.2513

Genome annotation databases

GeneIDi395726
KEGGigga:395726

Similar proteinsi

Entry informationi

Entry nameiFTCD_CHICK
AccessioniPrimary (citable) accession number: Q9YH58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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