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UniProtKB - Q9YGY0 (AXIN1_XENLA)
Protein
Axin-1
Gene
axin1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
By similarityGO - Molecular functioni
- beta-catenin binding Source: InterPro
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- negative regulation of canonical Wnt signaling pathway Source: InterPro
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Axin-1Alternative name(s): Axis inhibition protein 1 Short name: xAxin |
Gene namesi | Name:axin1 Synonyms:axin, axn |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-17339457, axin1.L |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Membrane By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- beta-catenin destruction complex Source: InterPro
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220892 | 1 – 842 | Axin-1Add BLAST | 842 |
Post-translational modificationi
ADP-ribosylated by tankyrase tnks and tnks2. Poly-ADP-ribosylated protein is recognized by rnf146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.By similarity
Ubiquitinated by rnf146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway.By similarity
Keywords - PTMi
ADP-ribosylation, Phosphoprotein, Ubl conjugationExpressioni
Developmental stagei
Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.1 Publication
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with hwa; leading to promote the tankyrase-mediated degradation of axin1 (By similarity).
By similarityBinary interactionsi
Q9YGY0
With | #Exp. | IntAct |
---|---|---|
apc [P70039] | 2 | EBI-1037449,EBI-8069633 |
wdr26.L [A0A0H5BJW1] | 3 | EBI-1037449,EBI-11786127 |
CTNNB1 [P35222] from Homo sapiens. | 2 | EBI-1037449,EBI-491549 |
GO - Molecular functioni
- beta-catenin binding Source: InterPro
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 99432, 1 interactor |
DIPi | DIP-36387N |
ELMi | Q9YGY0 |
IntActi | Q9YGY0, 3 interactors |
MINTi | Q9YGY0 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9YGY0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9YGY0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 88 – 211 | RGSPROSITE-ProRule annotationAdd BLAST | 124 | |
Domaini | 760 – 842 | DIXPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 75 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 218 – 242 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 277 – 297 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 316 – 344 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 348 – 433 | Interaction with GSK3BBy similarityAdd BLAST | 86 | |
Regioni | 414 – 451 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 434 – 508 | Interaction with beta-cateninAdd BLAST | 75 | |
Regioni | 482 – 532 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 543 – 562 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 615 – 637 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 656 – 675 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 729 – 754 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 61 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 218 – 235 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 316 – 339 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 510 – 531 | Polar residuesSequence analysisAdd BLAST | 22 |
Phylogenomic databases
OrthoDBi | 1481971at2759 |
Family and domain databases
CDDi | cd11582, Axin_TNKS_binding, 1 hit |
DisProti | DP00954 |
Gene3Di | 1.10.167.10, 1 hit 1.10.196.10, 2 hits 2.40.240.130, 1 hit |
IDEALi | IID50017 |
InterProi | View protein in InterPro IPR043581, Axin-like IPR029797, AXIN1 IPR014936, Axin_b-cat-bd IPR032101, Axin_TNKS-bd IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 IPR044926, RGS_subdomain_2 IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 1 hit PTHR46102:SF3, PTHR46102:SF3, 1 hit |
Pfami | View protein in Pfam PF16646, AXIN1_TNKS_BD, 1 hit PF08833, Axin_b-cat_bind, 1 hit PF00778, DIX, 1 hit PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9YGY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVKGKGFPL DLGGSFTEDA PRPPVPGEEG ELITTDQRPF SHTYYSLKND
60 70 80 90 100
GIKNETSTAT PRRPDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIH
110 120 130 140 150
LFRTFLQQEN CADLLDFWFA CSGFRKLEPN DSKVEKRLKL AKAIYKKYVL
160 170 180 190 200
DSNGIVSRQI KPATKSFIKD CVLRQQIDPA MFDQAQMEIQ SMMEDNTYPV
210 220 230 240 250
FLKSDIYLEY TTIGGESPKN YSDQSSGSGT GKGPSGYLPT LNEDEEWRCD
260 270 280 290 300
QGGEHERERE CIPSSLFSQK LALDSSSHCA GSNRRLSDGR EFRPGTWREP
310 320 330 340 350
VNPYYVNTGY AGAPVTSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK
360 370 380 390 400
HYRREMQESA NANGRGPLPH IPRTYHMPKD IHVDPEKFAA ELISRLEGVL
410 420 430 440 450
RDREAEQKLE ERLKRVRAEE EGDDGDVSSG PSVISHKLPS GPPMHHFNSR
460 470 480 490 500
YSETGCVGMQ IRDAHEENPE SILDEHVQRV MKTPGCQSPG TGRHSPKSRS
510 520 530 540 550
PDGHLSKTLP GSLGTMQTGH GKHSSKSTAK VDSGNLHHHK HVYHHVHHHG
560 570 580 590 600
GVKPKEQIDG ESTQRVQTNF PWNVESHNYA TKSRNYAESM GMAPNPMDSL
610 620 630 640 650
AYSGKVSMLS KRNAKKADLG KSESASHEMP VVPEDSERHQ KILQWIMEGE
660 670 680 690 700
KEIIRHKKSN HSSSSAKKQP PTELARPLSI ERPGAVHPWV SAQLRNVVQP
710 720 730 740 750
SHPFIQDPTM PPNPAPNPLT QLVSKPGARL EEEEKKAAKM PQKQRLKPQK
760 770 780 790 800
KNVSAPSQPC DNIVVAYYFC GEPIPYRTMV KGRVVTLGQF KELLTKKGNY
810 820 830 840
RYYFKKVSDE FDCGVVFEEV REDDMILPIY EEKIIGQVEK ID
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097313 mRNA Translation: AAC71036.1 |
RefSeqi | NP_001081874.1, NM_001088405.1 |
Genome annotation databases
GeneIDi | 398097 |
KEGGi | xla:398097 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097313 mRNA Translation: AAC71036.1 |
RefSeqi | NP_001081874.1, NM_001088405.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QZ7 | X-ray | 2.20 | B | 435-504 | [»] | |
SMRi | Q9YGY0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 99432, 1 interactor |
DIPi | DIP-36387N |
ELMi | Q9YGY0 |
IntActi | Q9YGY0, 3 interactors |
MINTi | Q9YGY0 |
Genome annotation databases
GeneIDi | 398097 |
KEGGi | xla:398097 |
Organism-specific databases
CTDi | 398097 |
Xenbasei | XB-GENE-17339457, axin1.L |
Phylogenomic databases
OrthoDBi | 1481971at2759 |
Miscellaneous databases
EvolutionaryTracei | Q9YGY0 |
PROi | PR:Q9YGY0 |
Family and domain databases
CDDi | cd11582, Axin_TNKS_binding, 1 hit |
DisProti | DP00954 |
Gene3Di | 1.10.167.10, 1 hit 1.10.196.10, 2 hits 2.40.240.130, 1 hit |
IDEALi | IID50017 |
InterProi | View protein in InterPro IPR043581, Axin-like IPR029797, AXIN1 IPR014936, Axin_b-cat-bd IPR032101, Axin_TNKS-bd IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 IPR044926, RGS_subdomain_2 IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 1 hit PTHR46102:SF3, PTHR46102:SF3, 1 hit |
Pfami | View protein in Pfam PF16646, AXIN1_TNKS_BD, 1 hit PF08833, Axin_b-cat_bind, 1 hit PF00778, DIX, 1 hit PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AXIN1_XENLA | |
Accessioni | Q9YGY0Primary (citable) accession number: Q9YGY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references