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UniProtKB - Q9YGY0 (AXIN1_XENLA)

Entry version 138 (23 Feb 2022)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Axin-1

Gene

axin1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Short name:
xAxin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:axin1
Synonyms:axin, axn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-17339457, axin1.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002208921 – 842Axin-1Add BLAST842

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated by tankyrase tnks and tnks2. Poly-ADP-ribosylated protein is recognized by rnf146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.By similarity
Ubiquitinated by rnf146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with hwa; leading to promote the tankyrase-mediated degradation of axin1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		99432, 1 interactor

Database of interacting proteins

More...DIPi		DIP-36387N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9YGY0

Protein interaction database and analysis system

More...IntActi		Q9YGY0, 3 interactors

Molecular INTeraction database

More...MINTi		Q9YGY0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1842
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9YGY0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9YGY0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 211RGSPROSITE-ProRule annotationAdd BLAST124
Domaini760 – 842DIXPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni218 – 242DisorderedSequence analysisAdd BLAST25
Regioni277 – 297DisorderedSequence analysisAdd BLAST21
Regioni316 – 344DisorderedSequence analysisAdd BLAST29
Regioni348 – 433Interaction with GSK3BBy similarityAdd BLAST86
Regioni414 – 451DisorderedSequence analysisAdd BLAST38
Regioni434 – 508Interaction with beta-cateninAdd BLAST75
Regioni482 – 532DisorderedSequence analysisAdd BLAST51
Regioni543 – 562DisorderedSequence analysisAdd BLAST20
Regioni615 – 637DisorderedSequence analysisAdd BLAST23
Regioni656 – 675DisorderedSequence analysisAdd BLAST20
Regioni729 – 754DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 61Polar residuesSequence analysisAdd BLAST26
Compositional biasi218 – 235Polar residuesSequence analysisAdd BLAST18
Compositional biasi316 – 339Polar residuesSequence analysisAdd BLAST24
Compositional biasi510 – 531Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		1481971at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd11582, Axin_TNKS_binding, 1 hit

Database of protein disorder

More...DisProti		DP00954

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.167.10, 1 hit
1.10.196.10, 2 hits
2.40.240.130, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50017

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043581, Axin-like
IPR029797, AXIN1
IPR014936, Axin_b-cat-bd
IPR032101, Axin_TNKS-bd
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR044926, RGS_subdomain_2
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR46102, PTHR46102, 1 hit
PTHR46102:SF3, PTHR46102:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16646, AXIN1_TNKS_BD, 1 hit
PF08833, Axin_b-cat_bind, 1 hit
PF00778, DIX, 1 hit
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00021, DAX, 1 hit
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9YGY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVKGKGFPL DLGGSFTEDA PRPPVPGEEG ELITTDQRPF SHTYYSLKND 
        60         70         80         90        100
GIKNETSTAT PRRPDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIH 
       110        120        130        140        150
LFRTFLQQEN CADLLDFWFA CSGFRKLEPN DSKVEKRLKL AKAIYKKYVL 
       160        170        180        190        200
DSNGIVSRQI KPATKSFIKD CVLRQQIDPA MFDQAQMEIQ SMMEDNTYPV 
       210        220        230        240        250
FLKSDIYLEY TTIGGESPKN YSDQSSGSGT GKGPSGYLPT LNEDEEWRCD 
       260        270        280        290        300
QGGEHERERE CIPSSLFSQK LALDSSSHCA GSNRRLSDGR EFRPGTWREP 
       310        320        330        340        350
VNPYYVNTGY AGAPVTSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK 
       360        370        380        390        400
HYRREMQESA NANGRGPLPH IPRTYHMPKD IHVDPEKFAA ELISRLEGVL 
       410        420        430        440        450
RDREAEQKLE ERLKRVRAEE EGDDGDVSSG PSVISHKLPS GPPMHHFNSR 
       460        470        480        490        500
YSETGCVGMQ IRDAHEENPE SILDEHVQRV MKTPGCQSPG TGRHSPKSRS 
       510        520        530        540        550
PDGHLSKTLP GSLGTMQTGH GKHSSKSTAK VDSGNLHHHK HVYHHVHHHG 
       560        570        580        590        600
GVKPKEQIDG ESTQRVQTNF PWNVESHNYA TKSRNYAESM GMAPNPMDSL 
       610        620        630        640        650
AYSGKVSMLS KRNAKKADLG KSESASHEMP VVPEDSERHQ KILQWIMEGE 
       660        670        680        690        700
KEIIRHKKSN HSSSSAKKQP PTELARPLSI ERPGAVHPWV SAQLRNVVQP 
       710        720        730        740        750
SHPFIQDPTM PPNPAPNPLT QLVSKPGARL EEEEKKAAKM PQKQRLKPQK 
       760        770        780        790        800
KNVSAPSQPC DNIVVAYYFC GEPIPYRTMV KGRVVTLGQF KELLTKKGNY 
       810        820        830        840 
RYYFKKVSDE FDCGVVFEEV REDDMILPIY EEKIIGQVEK ID
Length:842
Mass (Da):94,460
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDA152734C97191E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF097313 mRNA Translation: AAC71036.1

NCBI Reference Sequences

More...RefSeqi		NP_001081874.1, NM_001088405.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		398097

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:398097

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097313 mRNA Translation: AAC71036.1
RefSeqiNP_001081874.1, NM_001088405.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZ7X-ray2.20B435-504[»]
SMRiQ9YGY0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi99432, 1 interactor
DIPiDIP-36387N
ELMiQ9YGY0
IntActiQ9YGY0, 3 interactors
MINTiQ9YGY0

Genome annotation databases

GeneIDi398097
KEGGixla:398097

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		398097
XenbaseiXB-GENE-17339457, axin1.L

Phylogenomic databases

OrthoDBi1481971at2759

Miscellaneous databases

EvolutionaryTraceiQ9YGY0

Protein Ontology

More...PROi		PR:Q9YGY0

Family and domain databases

CDDicd11582, Axin_TNKS_binding, 1 hit
DisProtiDP00954
Gene3Di1.10.167.10, 1 hit
1.10.196.10, 2 hits
2.40.240.130, 1 hit
IDEALiIID50017
InterProiView protein in InterPro
IPR043581, Axin-like
IPR029797, AXIN1
IPR014936, Axin_b-cat-bd
IPR032101, Axin_TNKS-bd
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR044926, RGS_subdomain_2
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR46102, PTHR46102, 1 hit
PTHR46102:SF3, PTHR46102:SF3, 1 hit
PfamiView protein in Pfam
PF16646, AXIN1_TNKS_BD, 1 hit
PF08833, Axin_b-cat_bind, 1 hit
PF00778, DIX, 1 hit
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00021, DAX, 1 hit
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAXIN1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9YGY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: February 23, 2022
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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