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Entry version 125 (02 Jun 2021)
Sequence version 2 (01 May 2000)
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Protein
Submitted name:

Zinc finger transcription factor gli2

Gene

gli2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger transcription factor gli2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gli2aImported
Synonyms:gli2Imported, you-tooImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990706-8, gli2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini440 – 467C2H2-typeInterPro annotationAdd BLAST28
Domaini468 – 497C2H2-typeInterPro annotationAdd BLAST30
Domaini498 – 528C2H2-typeInterPro annotationAdd BLAST31
Domaini529 – 559C2H2-typeInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni321 – 387DisorderedSequence analysisAdd BLAST67
Regioni542 – 684DisorderedSequence analysisAdd BLAST143
Regioni769 – 843DisorderedSequence analysisAdd BLAST75
Regioni1249 – 1304DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi27 – 42Polar residuesSequence analysisAdd BLAST16
Compositional biasi321 – 358Polar residuesSequence analysisAdd BLAST38
Compositional biasi542 – 570Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi577 – 593Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi614 – 651Polar residuesSequence analysisAdd BLAST38
Compositional biasi669 – 683Polar residuesSequence analysisAdd BLAST15
Compositional biasi1263 – 1304Polar residuesSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAQDHSM

Database of Orthologous Groups

More...
OrthoDBi
56870at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9YGS4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043359, GLI-like
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR45718, PTHR45718, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9YGS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METTSPTSTE KKELKPSVLD GSSFTDLPKK PSPTTASRAP HLFSTFHTPI
60 70 80 90 100
PIDMRHHEGR YHYEPHPLHP MHGPHGLAGS PVISDISLIR LSPHAAATGE
110 120 130 140 150
SPFNPPHPYV NPHMEHYLRS VHSSPTLSMI SAARGLSPAE LTHEHLKERS
160 170 180 190 200
LFGLPPPPPG ANPSEYYHLI ASHRSPYGDL LMQTGAAAAH LPDYMSPVDM
210 220 230 240 250
SRFPSPRLTP RVSRKRALSI SPVSDASIDL QTMIRTSPNS LVAYINNSRS
260 270 280 290 300
SSAASSSYGH LSVGAISPSF TFPHPITPVA YHQLLSQQRG LNAFGHTPPL
310 320 330 340 350
LQPSPALSSR QQTLVAAAAL NNTTSSSTSS STADTSTESS QNAGGDPAVS
360 370 380 390 400
STVNPMIFKR SKVKTEAEGP HPISPGSQDH LELREELDKD ECKQEPEAVY
410 420 430 440 450
ETNCHWEGCA KEYDTQDQLV HHISNDHIHG EKKEFVCRWV ECSREQKPFK
460 470 480 490 500
AQYMLVVHMR RHTGEKPHKC TFEGCSKAYS RLENLKTHLR SHTGEKPYVC
510 520 530 540 550
EHEGCNKAFS NASDRAKHQN RTHSNEKPYV CKIPGCTKRY TDPSSLRKHV
560 570 580 590 600
KTVHGPEAHV TKKQRGDAPP KPHPPKGNGE NEAHTKHVRG RTDGSGEANS
610 620 630 640 650
TTRGVEDCQH VKTIKTENTV MYQSSPGGQS SCSSEPSPLG SATNNDSGVE
660 670 680 690 700
MAMHSGGSLG DLSALDDTPV VDSTGSPGTS AGVGLQLRKN RAGLLQLEHI
710 720 730 740 750
KKEKLKTVRD SCSWANAPPQ VRNTKLPPIP SIDSLLDAPN MGTQMSVPPT
760 770 780 790 800
QHLGDLSSYE MTMLNQLHER RDSSTSTMSS AYISRRSSGI SPCYSSRRSS
810 820 830 840 850
EASQFGVRNN NVSSADSYDP ISTDLSRRSS EASQCGGTGG LPSLLNLTPA
860 870 880 890 900
QHYSLKAKYA AATGGAPPTP LPNMDRMSLK TRMAMYNDSQ DSSAHLHHAQ
910 920 930 940 950
GVVNSRRCSD TGYGAPGMMP HEVPANLPRR ASDPVRRTTL DPLSLPRVQR
960 970 980 990 1000
FNSISNMNLS RLPAYDRRAF NMQNNTWSDG SLHRHPFSQR PPSISENILM
1010 1020 1030 1040 1050
ENMATDGGDQ QGDDLVLPDD MVQYLRSQNG NSNHDSGISV NGGHALEFHG
1060 1070 1080 1090 1100
NMTSQQQQFY GQRRMGMAGI NGSHVEPVPE QIADPQGMNK NNMPVQWNEV
1110 1120 1130 1140 1150
SSGSADAVSR VPKQQQQQLR GNLTVVQQKQ NFGSYQGFGS NQQIVPMSQN
1160 1170 1180 1190 1200
LASLQQAYPQ RNIQRMNTVQ QFRQSISNPC QNIGEQVNRQ DLSYNSNQRL
1210 1220 1230 1240 1250
ICNSMGPPNG RMVQNQELQN YRSNLMHMNN INQQNYVPLT QTAFQNAGRG
1260 1270 1280 1290 1300
LIQPRPPSEP KPLNRQHSGS GMVQPNGCSL SNVNSSEASP KRPGEVGQHS
1310 1320 1330 1340 1350
NGNGTMYYSG EIHMLDNGID YGSPMSPCTN QAPVASVSTM ASPGVNQVTS
1360 1370 1380 1390 1400
TVDSTQSLDH TQIDFDAMLD DGDHSSLMSG TLSPGLLQSI SQNSSRLTTP
1410 1420 1430
RNSVTLASVP AGIGNMAIGD MSSMLTALAE ESKFLNMMA
Length:1,439
Mass (Da):156,791
Last modified:May 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC52934C05FDFA3FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF085746 mRNA Translation: AAD18135.2

NCBI Reference Sequences

More...
RefSeqi
NP_571042.1, NM_130967.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:30154

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085746 mRNA Translation: AAD18135.2
RefSeqiNP_571042.1, NM_130967.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi30154
KEGGidre:30154

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30154
ZFINiZDB-GENE-990706-8, gli2a

Phylogenomic databases

OMAiGAQDHSM
OrthoDBi56870at2759
PhylomeDBiQ9YGS4

Family and domain databases

InterProiView protein in InterPro
IPR043359, GLI-like
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR45718, PTHR45718, 2 hits
PfamiView protein in Pfam
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9YGS4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9YGS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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