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Protein

Iroquois-class homeodomain protein IRX-4

Gene

IRX4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (Vmhc1) and suppressing the expression of the atrial myosin heavy chain-1 (Amhc1) in the ventricles. May play a critical role in establishing chamber-specific gene expression in the developing heart.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi142 – 203Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-4
Alternative name(s):
Iroquois homeobox protein 4
Gene namesi
Name:IRX4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491591 – 485Iroquois-class homeodomain protein IRX-4Add BLAST485

Proteomic databases

PRIDEiQ9YGS0

Expressioni

Tissue specificityi

Ventricles of the heart, developing feather buds, retina, hindbrain.

Developmental stagei

All stages of heart development.

Gene expression databases

ExpressionAtlasiQ9YGS0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ9YGS0
SMRiQ9YGS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 229Poly-Glu9
Compositional biasi298 – 301Poly-Ala4
Compositional biasi302 – 307Poly-Glu6
Compositional biasi381 – 384Poly-Ala4

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00750000117365
HOVERGENiHBG006180
InParanoidiQ9YGS0
PhylomeDBiQ9YGS0

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9YGS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYPQFGYPY SSAPQFLMST NSLTPCCESG GRTLPESGPA APAQTPVYCP
60 70 80 90 100
VYESRLLATA RHELNSAAAL GVYGGPYGGP QGYGNYVTYG TEAPAFYSLN
110 120 130 140 150
TLEAKDGGGS AHAGISPAAA YYPYEHSLSQ YQYDRYGAMD GGTRRKNATR
160 170 180 190 200
ETTSTLKAWL QEHRKNPYPT KGEKIMLAII TKMTLTQVST WFANARRRLK
210 220 230 240 250
KENKMTWPPR NKCSDEKRPY EEEEEEEEEC SQEDAMKSEK AEEPTGKEEK
260 270 280 290 300
ELELSDLEDL DAAESESSEC EMRRPFPHPH PHPLPGGGPP PRAAEPPAAA
310 320 330 340 350
AEEEEEEAAE RARGCLKPAA EECEAALLGA RPRGCEAKLC FPQGQPLLEA
360 370 380 390 400
KPRIWSLAHT ATSLNQAEYP SCMLKRSGGS AAAAVSAPVS VMDRHQDSPV
410 420 430 440 450
TNLRNWVDGV FHDPLFRHST LNQALSNTTV SWATTKGAIL ETGALGRSVG
460 470 480
NGANVLKGQL ANLAHQDSSK EFLAFPKAGS KMFCS
Length:485
Mass (Da):52,774
Last modified:May 1, 1999 - v1
Checksum:i81F5A72F9B30C208
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1NQQ7F1NQQ7_CHICK
Iroquois-class homeodomain protein ...
IRX4
485Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091504 mRNA Translation: AAD16100.1
RefSeqiNP_001001744.1, NM_001001744.1
XP_015137809.1, XM_015282323.1
XP_015137810.1, XM_015282324.1
UniGeneiGga.416

Genome annotation databases

EnsembliENSGALT00000036981; ENSGALP00000036193; ENSGALG00000022896
GeneIDi373974
KEGGigga:373974

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091504 mRNA Translation: AAD16100.1
RefSeqiNP_001001744.1, NM_001001744.1
XP_015137809.1, XM_015282323.1
XP_015137810.1, XM_015282324.1
UniGeneiGga.416

3D structure databases

ProteinModelPortaliQ9YGS0
SMRiQ9YGS0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9YGS0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000036981; ENSGALP00000036193; ENSGALG00000022896
GeneIDi373974
KEGGigga:373974

Organism-specific databases

CTDi50805

Phylogenomic databases

GeneTreeiENSGT00750000117365
HOVERGENiHBG006180
InParanoidiQ9YGS0
PhylomeDBiQ9YGS0

Miscellaneous databases

PROiPR:Q9YGS0

Gene expression databases

ExpressionAtlasiQ9YGS0 baseline and differential

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX4_CHICK
AccessioniPrimary (citable) accession number: Q9YGS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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