UniProtKB - Q9YGP3 (GLHA_ICTPU)
Protein
Glycoprotein hormones alpha chain
Gene
cga
Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Functioni
Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Involved in gametogenesis and steroidogenesis.By similarity
GO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
- protein heterodimerization activity Source: AgBase
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of steroid biosynthetic process Source: UniProtKB
- regulation of signaling receptor activity Source: UniProtKB
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chainAlternative name(s): GTH-alpha Gonadotropin alpha chain |
Gene namesi | Name:cga |
Organismi | Ictalurus punctatus (Channel catfish) (Silurus punctatus) |
Taxonomic identifieri | 7998 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Siluriformes › Ictaluridae › Ictalurus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
- follicle-stimulating hormone complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000011667 | 25 – 116 | Glycoprotein hormones alpha chainAdd BLAST | 92 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 56 | By similarity | ||
Disulfide bondi | 35 ↔ 85 | By similarity | ||
Disulfide bondi | 53 ↔ 106 | By similarity | ||
Disulfide bondi | 57 ↔ 108 | By similarity | ||
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 84 ↔ 111 | By similarity | ||
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Heterodimer. Glycoprotein hormones are heterodimers composed of a common alpha chain described here and a unique beta chain which confers their biological specificity to the different hormones.
By similarityGO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
- protein heterodimerization activity Source: AgBase
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalPhylogenomic databases
KOi | K08522 |
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone |
PANTHERi | PTHR11509 PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236 Hormone_6, 1 hit |
PRINTSi | PR00274 GLYCOHORMONE |
SMARTi | View protein in SMART SM00067 GHA, 1 hit |
SUPFAMi | SSF57501 SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9YGP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILILKYTGA TIILLSVLIE IGQLFPNNDF GCEECKLKEN NIFSKPGAPV
60 70 80 90 100
YQCMGCCFSR AYPTPLRSEK TMLVPKNITS EATCCVAKEV KRVIVNDVKL
110
MNHTDCHCST CYYHKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF112190 mRNA Translation: AAD18004.1 |
RefSeqi | NP_001187007.1, NM_001200078.1 |
Genome annotation databases
GeneIDi | 100304479 |
KEGGi | ipu:100304479 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF112190 mRNA Translation: AAD18004.1 |
RefSeqi | NP_001187007.1, NM_001200078.1 |
3D structure databases
SMRi | Q9YGP3 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 100304479 |
KEGGi | ipu:100304479 |
Organism-specific databases
CTDi | 1081 |
Phylogenomic databases
KOi | K08522 |
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone |
PANTHERi | PTHR11509 PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236 Hormone_6, 1 hit |
PRINTSi | PR00274 GLYCOHORMONE |
SMARTi | View protein in SMART SM00067 GHA, 1 hit |
SUPFAMi | SSF57501 SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA_ICTPU | |
Accessioni | Q9YGP3Primary (citable) accession number: Q9YGP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 8, 2019 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families