UniProtKB - Q9YFU8 (CDC62_AERPE)
Protein
ORC1-type DNA replication protein 2
Gene
orc2
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Functioni
Involved in regulation of DNA replication (By similarity). Binds DNA.UniRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 213 | ATPUniRule annotation1 Publication | 1 | |
Binding sitei | 225 | ATPUniRule annotation1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 60 – 65 | ATPUniRule annotation1 Publication | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- DNA replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ORC1-type DNA replication protein 2UniRule annotationAlternative name(s): ORC2 |
Gene namesi | Name:orc2 Ordered Locus Names:APE_0152.1 |
Organismi | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) |
Taxonomic identifieri | 272557 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000421876 | 1 – 410 | ORC1-type DNA replication protein 2Add BLAST | 410 |
Proteomic databases
PRIDEi | Q9YFU8 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9YFU8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9YFU8 |
Family & Domainsi
Domaini
Contains an N-terminal AAA+ ATPase domain and a C-terminal winged-helix (WH) domain.1 Publication
Sequence similaritiesi
Belongs to the CDC6/cdc18 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00467, Archaea |
OMAi | YLFYENE |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_01407, ORC1_type_DNA_replic_protein, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR015163, Cdc6_C IPR014277, Orc1/Cdc6_arc IPR027417, P-loop_NTPase IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF13401, AAA_22, 1 hit PF09079, Cdc6_C, 1 hit |
SMARTi | View protein in SMART SM01074, Cdc6_C, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02928, TIGR02928, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9YFU8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRHGLFKDR RVFDENYIPP ELRVRRGEAE ALARIYLNRL LSGAGLSDVN
60 70 80 90 100
MIYGSIGRVG IGKTTLAKFT VKRVSEAAAK EGLTVKQAYV NAFNAPNLYT
110 120 130 140 150
ILSLIVRQTG YPIQVRGAPA LDILKALVDN LYVENHYLLV ILDEFQSMLS
160 170 180 190 200
SPRIAAEDLY TLLRVHEEIP SRDGVNRIGF LLVASDVRAL SYMREKIPQV
210 220 230 240 250
ESQIGFKLHL PAYKSRELYT ILEQRAELGL RDTVWEPRHL ELISDVYGED
260 270 280 290 300
KGGDGSARRA IVALKMACEM AEAMGRDSLS EDLVRKAVSE NEAASIQTHE
310 320 330 340 350
LEALSIHELI ILRLIAEATL GGMEWINAGL LRQRYEDASL TMYNVKPRGY
360 370 380 390 400
TQYHIYLKHL TSLGLVDAKP SGRGMRGRTT LFRLAPHLPA DRLIEVVDNI
410
IQAKMASGYE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA79063.2 |
PIRi | E72770 |
Genome annotation databases
EnsemblBacteriai | BAA79063; BAA79063; APE_0152.1 |
KEGGi | ape:APE_0152.1 |
PATRICi | fig|272557.25.peg.106 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA79063.2 |
PIRi | E72770 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1W5S | X-ray | 2.40 | A/B | 2-410 | [»] | |
1W5T | X-ray | 2.40 | A/B/C | 2-410 | [»] | |
SMRi | Q9YFU8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 272557.APE_0152.1 |
Proteomic databases
PRIDEi | Q9YFU8 |
Genome annotation databases
EnsemblBacteriai | BAA79063; BAA79063; APE_0152.1 |
KEGGi | ape:APE_0152.1 |
PATRICi | fig|272557.25.peg.106 |
Phylogenomic databases
eggNOGi | arCOG00467, Archaea |
OMAi | YLFYENE |
Miscellaneous databases
EvolutionaryTracei | Q9YFU8 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_01407, ORC1_type_DNA_replic_protein, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR015163, Cdc6_C IPR014277, Orc1/Cdc6_arc IPR027417, P-loop_NTPase IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF13401, AAA_22, 1 hit PF09079, Cdc6_C, 1 hit |
SMARTi | View protein in SMART SM01074, Cdc6_C, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02928, TIGR02928, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC62_AERPE | |
Accessioni | Q9YFU8Primary (citable) accession number: Q9YFU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2013 |
Last sequence update: | November 14, 2006 | |
Last modified: | April 7, 2021 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families