UniProtKB - Q9YES4 (PSB1_AERPE)
Proteasome subunit beta 1
psmB1
Functioni
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
UniRule annotationCatalytic activityi
- Cleavage of peptide bonds with very broad specificity.UniRule annotation EC:3.4.25.1
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 7 | NucleophileUniRule annotation | 1 |
GO - Molecular functioni
- threonine-type endopeptidase activity Source: UniProtKB-UniRule
GO - Biological processi
- proteasomal protein catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Protein family/group databases
MEROPSi | T01.002 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit beta 1UniRule annotation (EC:3.4.25.1UniRule annotation)Alternative name(s): 20S proteasome beta subunit 1UniRule annotation Proteasome core protein PsmB 1UniRule annotation |
Gene namesi | Name:psmB1UniRule annotation Ordered Locus Names:APE_0507.1 |
Organismi | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) |
Taxonomic identifieri | 272557 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
- proteasome core complex, beta-subunit complex Source: UniProtKB-UniRule
Keywords - Cellular componenti
Cytoplasm, ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000397276 | 1 – 6 | Removed in mature form; by autocatalysisUniRule annotation | 6 | |
ChainiPRO_0000397277 | 7 – 203 | Proteasome subunit beta 1Add BLAST | 197 |
Keywords - PTMi
Autocatalytic cleavage, ZymogenInteractioni
Subunit structurei
The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
UniRule annotationProtein-protein interaction databases
STRINGi | 272557.APE_0507.1 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG00970, Archaea |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
HAMAPi | MF_02113_A, Proteasome_B_A, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR019983, Pept_T1A_Psome_bsu_arc IPR000243, Pept_T1A_subB IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
TIGRFAMsi | TIGR03634, arc_protsome_B, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSFAGATALG IRVEDGVVLA ADKRMSYGGF ILSRNFKKIF VINDRIGIAF
60 70 80 90 100
AGLYGDMGGL VRIVEGQMRL ASLETGKPAT VRNVAKFLSS LLYSYKFFPF
110 120 130 140 150
NVEAIVGGID PGGEPKLYVL DPLGSIIEED YVAAGTGATT AFGLLEHVYK
160 170 180 190 200
RGMSLEEAKK AAVEALRASM ARDAGTGDGI DVLVLPVSGK PSLETIKFRL
VEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA79472.2 |
PIRi | D72747 |
Genome annotation databases
EnsemblBacteriai | BAA79472; BAA79472; APE_0507.1 |
KEGGi | ape:APE_0507.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA79472.2 |
PIRi | D72747 |
3D structure databases
AlphaFoldDBi | Q9YES4 |
SMRi | Q9YES4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272557.APE_0507.1 |
Protein family/group databases
MEROPSi | T01.002 |
Genome annotation databases
EnsemblBacteriai | BAA79472; BAA79472; APE_0507.1 |
KEGGi | ape:APE_0507.1 |
Phylogenomic databases
eggNOGi | arCOG00970, Archaea |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
HAMAPi | MF_02113_A, Proteasome_B_A, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR019983, Pept_T1A_Psome_bsu_arc IPR000243, Pept_T1A_subB IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
TIGRFAMsi | TIGR03634, arc_protsome_B, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PSB1_AERPE | |
Accessioni | Q9YES4Primary (citable) accession number: Q9YES4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | November 14, 2006 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families