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Protein

Voltage-gated potassium channel

Gene

APE_0955

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyciAPER272557:GJD6-695-MONOMER

Protein family/group databases

TCDBi1.A.1.17.1 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel
Alternative name(s):
KvAP
Gene namesi
Ordered Locus Names:APE_0955
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicAdd BLAST38
Transmembranei39 – 63Helical; Name=Segment S1Add BLAST25
Topological domaini64 – 67ExtracellularSequence analysis4
Transmembranei68 – 92Helical; Name=Segment S2Add BLAST25
Topological domaini93 – 96Cytoplasmic4
Intramembranei97 – 105Helical; Name=Segment S3A9
Topological domaini106 – 108ExtracellularSequence analysis3
Transmembranei109 – 125Helical; Voltage-sensor; Name=Segment S3BAdd BLAST17
Topological domaini126 – 128Cytoplasmic3
Transmembranei129 – 145Helical; Voltage-sensor; Name=Segment S4Add BLAST17
Topological domaini146 – 159CytoplasmicAdd BLAST14
Transmembranei160 – 184Helical; Name=Segment S5Add BLAST25
Topological domaini185 – 195ExtracellularSequence analysisAdd BLAST11
Intramembranei196 – 208Pore-formingSequence analysisAdd BLAST13
Topological domaini209 – 221ExtracellularSequence analysisAdd BLAST13
Transmembranei222 – 253Helical; Name=Segment S6Add BLAST32
Topological domaini254 – 295CytoplasmicAdd BLAST42

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540971 – 295Voltage-gated potassium channelAdd BLAST295

Proteomic databases

PRIDEiQ9YDF8

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15692219,EBI-15692219

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29648N
STRINGi272557.APE_0955

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9YDF8
SMRiQ9YDF8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YDF8

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi209 – 214Selectivity filter6

Domaini

Contains a central ion-conduction pore surrounded by four voltage sensors which form the voltage-sensor paddles that move in response to membrane voltage changes through the fluid membrane interior, each voltage-sensor carrying their four positive charges across the membrane. It is thought that the S4 arginine residues move through the membrane's electric field to open the pore.

Sequence similaritiesi

Belongs to the potassium channel family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01964 Archaea
COG1226 LUCA
KOiK10716
OMAiIRENWAY
OrthoDBiPOG093Z0B4R

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YDF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVERWVFPG CSVMARFRRG LSDLGGRVRN IGDVMEHPLV ELGVSYAALL
60 70 80 90 100
SVIVVVVEYT MQLSGEYLVR LYLVDLILVI ILWADYAYRA YKSGDPAGYV
110 120 130 140 150
KKTLYEIPAL VPAGLLALIE GHLAGLGLFR LVRLLRFLRI LLIISRGSKF
160 170 180 190 200
LSAIADAADK IRFYHLFGAV MLTVLYGAFA IYIVEYPDPN SSIKSVFDAL
210 220 230 240 250
WWAVVTATTV GYGDVVPATP IGKVIGIAVM LTGISALTLL IGTVSNMFQK
260 270 280 290
ILVGEPEPSC SPAKLAEMVS SMSEEEFEEF VRTLKNLRRL ENSMK
Length:295
Mass (Da):32,535
Last modified:November 1, 1999 - v1
Checksum:i1EC8CE1E39E24D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA79939.1
PIRiC72692

Genome annotation databases

EnsemblBacteriaiBAA79939; BAA79939; APE_0955
KEGGiape:APE_0955

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA79939.1
PIRiC72692

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ORQX-ray3.20C31-253[»]
1ORSX-ray1.90C33-161[»]
2A0LX-ray3.90A/B20-259[»]
2KYHNMR-A18-160[»]
ProteinModelPortaliQ9YDF8
SMRiQ9YDF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29648N
STRINGi272557.APE_0955

Protein family/group databases

TCDBi1.A.1.17.1 the voltage-gated ion channel (vic) superfamily

Proteomic databases

PRIDEiQ9YDF8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79939; BAA79939; APE_0955
KEGGiape:APE_0955

Phylogenomic databases

eggNOGiarCOG01964 Archaea
COG1226 LUCA
KOiK10716
OMAiIRENWAY
OrthoDBiPOG093Z0B4R

Enzyme and pathway databases

BioCyciAPER272557:GJD6-695-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ9YDF8

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKVAP_AERPE
AccessioniPrimary (citable) accession number: Q9YDF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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