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UniProtKB - Q9YD40 (Q9YD40_AERPE)
Protein
Succinate--CoA ligase [ADP-forming] subunit alpha
Gene
sucD
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Functioni
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
UniRule annotationCatalytic activityi
- EC:6.2.1.5UniRule annotation
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | Coenzyme AUniRule annotation | 1 | |
Binding sitei | 160 | Substrate; shared with subunit betaUniRule annotation | 1 | |
Active sitei | 249 | Tele-phosphohistidine intermediateUniRule annotation | 1 |
GO - Molecular functioni
- acetate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC
- nucleotide binding Source: UniProtKB-KW
- succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-UniRule
GO - Biological processi
- tricarboxylic acid cycle Source: UniProtKB-UniRule
Keywordsi
Molecular function | LigaseUniRule annotation |
Biological process | Tricarboxylic acid cycleUniRule annotation |
Ligand | Nucleotide-bindingUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00999 |
Names & Taxonomyi
Protein namesi | Recommended name: Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)Alternative name(s): Succinyl-CoA synthetase subunit alphaUniRule annotation Short name: SCS-alphaUniRule annotation |
Gene namesi | Name:sucDUniRule annotationImported Ordered Locus Names:APE_1072.1Imported |
Organismi | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)Imported |
Taxonomic identifieri | 272557 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › |
Proteomesi |
|
Interactioni
Subunit structurei
Heterotetramer of two alpha and two beta subunits.
UniRule annotationProtein-protein interaction databases
STRINGi | 272557.APE_1072.1 |
Structurei
3D structure databases
SMRi | Q9YD40 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9YD40 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 101 | CoA_bindingInterPro annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 20 | Coenzyme A bindingUniRule annotation | 4 | |
Regioni | 97 – 99 | Coenzyme A bindingUniRule annotation | 3 |
Sequence similaritiesi
Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG01339, Archaea |
OMAi | VIICITE |
Family and domain databases
Gene3Di | 3.40.50.261, 1 hit |
HAMAPi | MF_01988, Succ_CoA_alpha, 1 hit |
InterProi | View protein in InterPro IPR017440, Cit_synth/succinyl-CoA_lig_AS IPR033847, Citrt_syn/SCS-alpha_CS IPR003781, CoA-bd IPR005810, CoA_lig_alpha IPR005811, CoA_ligase IPR036291, NAD(P)-bd_dom_sf IPR016102, Succinyl-CoA_synth-like |
Pfami | View protein in Pfam PF02629, CoA_binding, 1 hit PF00549, Ligase_CoA, 1 hit |
PIRSFi | PIRSF001553, SucCS_alpha, 1 hit |
SMARTi | View protein in SMART SM00881, CoA_binding, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF52210, SSF52210, 1 hit |
TIGRFAMsi | TIGR01019, sucCoAalpha, 1 hit |
PROSITEi | View protein in PROSITE PS01216, SUCCINYL_COA_LIG_1, 1 hit PS00399, SUCCINYL_COA_LIG_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9YD40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVLVDSETR VLVQGITGRE GSFHAKAMLE YGTKVVAGVT PGKGGSEVHG
60 70 80 90 100
VPVYDSVKEA LAEHPEINTS IVFVPAPFAP DAVYEAVDAG IRLVVVITEG
110 120 130 140 150
IPVHDTMRFV NYARQKGATI IGPNCPGAIT PGQAKVGIMP GHIFKEGGVA
160 170 180 190 200
VVSRSGTLTY EISYMLTRQG IGQSTVIGIG GDPIVGLSFT EALKLFQEDP
210 220 230 240 250
QTEALVLIGE IGGDMEERAA EMIKKGEFTK PVIAYIAGRT APPEKRMGHA
260 270 280 290
GAIIMMGTGT YEGKVKALRE AGVEVAETPF EVPELVRKAL RR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA80057.2 |
PIRi | A72707 |
Genome annotation databases
EnsemblBacteriai | BAA80057; BAA80057; APE_1072.1 |
KEGGi | ape:APE_1072.1 |
PATRICi | fig|272557.25.peg.754 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA80057.2 |
PIRi | A72707 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YV2 | X-ray | 2.20 | A | 1-292 | [»] | |
SMRi | Q9YD40 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 272557.APE_1072.1 |
Genome annotation databases
EnsemblBacteriai | BAA80057; BAA80057; APE_1072.1 |
KEGGi | ape:APE_1072.1 |
PATRICi | fig|272557.25.peg.754 |
Phylogenomic databases
eggNOGi | arCOG01339, Archaea |
OMAi | VIICITE |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00999 |
Miscellaneous databases
EvolutionaryTracei | Q9YD40 |
Family and domain databases
Gene3Di | 3.40.50.261, 1 hit |
HAMAPi | MF_01988, Succ_CoA_alpha, 1 hit |
InterProi | View protein in InterPro IPR017440, Cit_synth/succinyl-CoA_lig_AS IPR033847, Citrt_syn/SCS-alpha_CS IPR003781, CoA-bd IPR005810, CoA_lig_alpha IPR005811, CoA_ligase IPR036291, NAD(P)-bd_dom_sf IPR016102, Succinyl-CoA_synth-like |
Pfami | View protein in Pfam PF02629, CoA_binding, 1 hit PF00549, Ligase_CoA, 1 hit |
PIRSFi | PIRSF001553, SucCS_alpha, 1 hit |
SMARTi | View protein in SMART SM00881, CoA_binding, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF52210, SSF52210, 1 hit |
TIGRFAMsi | TIGR01019, sucCoAalpha, 1 hit |
PROSITEi | View protein in PROSITE PS01216, SUCCINYL_COA_LIG_1, 1 hit PS00399, SUCCINYL_COA_LIG_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9YD40_AERPE | |
Accessioni | Q9YD40Primary (citable) accession number: Q9YD40 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1999 |
Last sequence update: | November 14, 2006 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |