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UniProtKB - Q9YBY6 (LYSJ_AERPE)
Protein
Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase
Gene
lysJ
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Functioni
Involved in both the arginine and lysine biosynthetic pathways.
UniRule annotationCatalytic activityi
- 2-oxoglutarate + [amino-group carrier protein]-C-terminal-γ-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamateUniRule annotationEC:2.6.1.118UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation
: L-lysine biosynthesis via AAA pathway Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route).UniRule annotation This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.
Pathwayi: L-arginine biosynthesis
This protein is involved in the pathway L-arginine biosynthesis, which is part of Amino-acid biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 127 | Pyridoxal phosphate; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 130 | SubstrateUniRule annotation | 1 | |
Binding sitei | 268 | SubstrateUniRule annotation | 1 | |
Binding sitei | 269 | Pyridoxal phosphateUniRule annotation | 1 |
GO - Molecular functioni
- pyridoxal phosphate binding Source: InterPro
- transaminase activity Source: UniProtKB-UniRule
GO - Biological processi
- arginine biosynthetic process via ornithine Source: UniProtKB-UniRule
- lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniRule
Keywordsi
Molecular function | Aminotransferase, Transferase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis, Lysine biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00033;UER00038 UPA00068 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lysJUniRule annotation Ordered Locus Names:APE_1464 |
Organismi | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) |
Taxonomic identifieri | 272557 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000112818 | 1 – 388 | Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminaseAdd BLAST | 388 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 240 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 272557.APE_1464 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 101 | Pyridoxal phosphate bindingUniRule annotation | 2 | |
Regioni | 211 – 214 | Pyridoxal phosphate bindingUniRule annotation | 4 |
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00914, Archaea |
OMAi | HSAWDLC |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_02084, LysJ_aminotrans_3, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR037537, LysJ IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9YBY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVVLKFVRF YGYRGLRIVK GSMQYVWDDS GRKYLDCHAG HGAAFLGHSN
60 70 80 90 100
PAIVEAVVRQ ARELVAASSS FSTPSLEEAL TEFSRIAPPW AEEIVFLNTG
110 120 130 140 150
TEAVEAALKA AWLATGKRGI VALKNSFHGR TLASLSVTWN PRYRRGVPVL
160 170 180 190 200
DTRFLSPSTD PGEVEKLVPE DTAAIIVEPI QGEGGLTKIY AELAKALREA
210 220 230 240 250
ADRVGALLIF DEIQTGFGRT GRVWAHESLG VEPDIMTAGK SIAGGLPASA
260 270 280 290 300
VLSREGVLAT LASGRHGSTH AANPLSMAAV AAASRFLREE GVPDKARAAG
310 320 330 340 350
ALLEGLLRDR IEGLRLVRGV RGEGLMLGVE LRLDPGPVLR CLQESERVLA
360 370 380
LRSGATVVRL LPPYSISRED AEMVVYGLER CICGGSGC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA80462.1 |
PIRi | H72625 |
Genome annotation databases
EnsemblBacteriai | BAA80462; BAA80462; APE_1464 |
KEGGi | ape:APE_1464 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA80462.1 |
PIRi | H72625 |
3D structure databases
SMRi | Q9YBY6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272557.APE_1464 |
Genome annotation databases
EnsemblBacteriai | BAA80462; BAA80462; APE_1464 |
KEGGi | ape:APE_1464 |
Phylogenomic databases
eggNOGi | arCOG00914, Archaea |
OMAi | HSAWDLC |
Enzyme and pathway databases
UniPathwayi | UPA00033;UER00038 UPA00068 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_02084, LysJ_aminotrans_3, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR037537, LysJ IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LYSJ_AERPE | |
Accessioni | Q9YBY6Primary (citable) accession number: Q9YBY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | September 29, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families