UniProtKB - Q9YA72 (KHSE_AERPE)
Protein
Homoserine kinase
Gene
thrB
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Functioni
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation
Catalytic activityi
- EC:2.7.1.39UniRule annotation
: L-threonine biosynthesis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Aspartokinase (lysC)
- no protein annotated in this organism
- Homoserine dehydrogenase (hom)
- Homoserine kinase (thrB)
- Threonine synthase (thrC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 92 – 102 | ATPUniRule annotationAdd BLAST | 11 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- homoserine kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- threonine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Amino-acid biosynthesis, Threonine biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00050;UER00064 |
Names & Taxonomyi
Protein namesi | Recommended name: Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)Short name: HKUniRule annotation Short name: HSKUniRule annotation |
Gene namesi | Name:thrBUniRule annotation Ordered Locus Names:APE_2067.1 |
Organismi | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) |
Taxonomic identifieri | 272557 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156638 | 1 – 313 | Homoserine kinaseAdd BLAST | 313 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG01027, Archaea |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.30.70.890, 1 hit |
HAMAPi | MF_00384, Homoser_kinase, 1 hit |
InterProi | View protein in InterPro IPR013750, GHMP_kinase_C_dom IPR036554, GHMP_kinase_C_sf IPR006204, GHMP_kinase_N_dom IPR006203, GHMP_knse_ATP-bd_CS IPR000870, Homoserine_kinase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
Pfami | View protein in Pfam PF08544, GHMP_kinases_C, 1 hit PF00288, GHMP_kinases_N, 1 hit |
PIRSFi | PIRSF000676, Homoser_kin, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55060, SSF55060, 1 hit |
TIGRFAMsi | TIGR00191, thrB, 1 hit |
PROSITEi | View protein in PROSITE PS00627, GHMP_KINASES_ATP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9YA72-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACSRARARA YSSAANLGPG FDALAVALDA YYDEVEVRVC SGGNSVYVDE
60 70 80 90 100
VEGKFSSGVL QGPNTAAEAV RGLLNMEGVE AEVGIRVYKG VPPGRGLGSS
110 120 130 140 150
GASAAAAVAA VSHALALEVP VDRLVFYAGL GERAAAGQPH FDNAAASILG
160 170 180 190 200
GLAVVASDAA GKLRVFRVPF KAWFAVVTPM NPVPQGKTGV MRKVLPENVS
210 220 230 240 250
FRDAVRNFSR AAGIVAAAVN GDLKSMGALM MSDEIVEPRR RSYVPCYTQV
260 270 280 290 300
RKAALQAGAL GFSLSGAGPS MIALAPSSEA AREIAAAMEE SCICCDNPMT
310
VAAEPAPGAS VVG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA81077.2 |
PIRi | E72511 |
Genome annotation databases
EnsemblBacteriai | BAA81077; BAA81077; APE_2067.1 |
KEGGi | ape:APE_2067.1 |
PATRICi | fig|272557.25.peg.1373 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000002 Genomic DNA Translation: BAA81077.2 |
PIRi | E72511 |
3D structure databases
SMRi | Q9YA72 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272557.APE_2067.1 |
Genome annotation databases
EnsemblBacteriai | BAA81077; BAA81077; APE_2067.1 |
KEGGi | ape:APE_2067.1 |
PATRICi | fig|272557.25.peg.1373 |
Phylogenomic databases
eggNOGi | arCOG01027, Archaea |
Enzyme and pathway databases
UniPathwayi | UPA00050;UER00064 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.30.70.890, 1 hit |
HAMAPi | MF_00384, Homoser_kinase, 1 hit |
InterProi | View protein in InterPro IPR013750, GHMP_kinase_C_dom IPR036554, GHMP_kinase_C_sf IPR006204, GHMP_kinase_N_dom IPR006203, GHMP_knse_ATP-bd_CS IPR000870, Homoserine_kinase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
Pfami | View protein in Pfam PF08544, GHMP_kinases_C, 1 hit PF00288, GHMP_kinases_N, 1 hit |
PIRSFi | PIRSF000676, Homoser_kin, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55060, SSF55060, 1 hit |
TIGRFAMsi | TIGR00191, thrB, 1 hit |
PROSITEi | View protein in PROSITE PS00627, GHMP_KINASES_ATP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KHSE_AERPE | |
Accessioni | Q9YA72Primary (citable) accession number: Q9YA72 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | July 10, 2007 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families