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Protein

Orotate phosphoribosyltransferase

Gene

pyrE

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei965-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1005-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1025-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei125OrotateUniRule annotation1
Binding sitei153OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyrimidine biosynthesis
LigandMagnesium

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00119

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRTUniRule annotation
Short name:
OPRTaseUniRule annotation
Gene namesi
Name:pyrEUniRule annotation
Ordered Locus Names:APE_2349.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001107761 – 186Orotate phosphoribosyltransferaseAdd BLAST186

Proteomic databases

PRIDEiQ9Y9D8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_2349.1

Structurei

Secondary structure

1186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y9D8
SMRiQ9Y9D8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y9D8

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 1295-phosphoribose 1-diphosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00029 Archaea
COG0461 LUCA
HOGENOMiHOG000037976
KOiK00762
OrthoDBiPOG093Z0DC2

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y9D8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHEELAEVL AKVLKKRGAV LRGDFVLSSG RRSSVYIDMR RLLGDESSYS
60 70 80 90 100
VALDLLLEVG GQDLARSSAV IGVATGGLPW AAMLALRLSK PLGYVRPERK
110 120 130 140 150
GHGTLSQVEG DPPKGRVVVV DDVATTGTSI AKSIEVLRSN GYTVGTALVL
160 170 180
VDRGEGAGEL LARMGVRLVS VATLKTILEK LGWGGE
Length:186
Mass (Da):19,638
Last modified:July 10, 2007 - v2
Checksum:iA05A8636B3A22B91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81362.2
PIRiB72463

Genome annotation databases

EnsemblBacteriaiBAA81362; BAA81362; APE_2349.1
KEGGiape:APE_2349.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81362.2
PIRiB72463

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YZKX-ray1.80A/B/C/D10-186[»]
ProteinModelPortaliQ9Y9D8
SMRiQ9Y9D8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_2349.1

Proteomic databases

PRIDEiQ9Y9D8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA81362; BAA81362; APE_2349.1
KEGGiape:APE_2349.1

Phylogenomic databases

eggNOGiarCOG00029 Archaea
COG0461 LUCA
HOGENOMiHOG000037976
KOiK00762
OrthoDBiPOG093Z0DC2

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00119

Miscellaneous databases

EvolutionaryTraceiQ9Y9D8

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRE_AERPE
AccessioniPrimary (citable) accession number: Q9Y9D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 10, 2007
Last modified: October 10, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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