Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

mRNA export factor mex67

Gene

mex67

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.PROSITE-ProRule annotation2 Publications

GO - Molecular functioni

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: PomBase
  • ribosomal large subunit export from nucleus Source: PomBase

Keywordsi

Biological processmRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor mex67
Gene namesi
Name:mex67
ORF Names:SPBC1921.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1921.03c
PomBaseiSPBC1921.03c mex67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi460 – 462VHG → AAA: No mRNA export from nucleus. 1 Publication3
Mutagenesisi478 – 479RT → AA: Reduced mRNA export from nucleus. 1 Publication2
Mutagenesisi492 – 493II → AA: Reduced mRNA export from nucleus. 1 Publication2
Mutagenesisi494 – 495ND → AA: Reduced mRNA export from nucleus. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205411 – 596mRNA export factor mex67Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128Phosphoserine1 Publication1
Modified residuei130Phosphoserine1 Publication1
Modified residuei133Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y8G3
PaxDbiQ9Y8G3
PRIDEiQ9Y8G3

PTM databases

iPTMnetiQ9Y8G3

Interactioni

Subunit structurei

Interacts with mlo3 and rae1.1 Publication

Protein-protein interaction databases

BioGridi277250, 72 interactors
STRINGi4896.SPBC1921.03c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y8G3
SMRiQ9Y8G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati215 – 236LRR 1Add BLAST22
Repeati241 – 262LRR 2Add BLAST22
Repeati263 – 282LRR 3Add BLAST20
Domaini283 – 338LRRCTAdd BLAST56
Domaini338 – 499NTF2PROSITE-ProRule annotationAdd BLAST162
Domaini543 – 596TAP-CPROSITE-ProRule annotationAdd BLAST54

Domaini

The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.By similarity
The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.
The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

InParanoidiQ9Y8G3
KOiK14284
OMAiSYFGTET
OrthoDBiEOG092C3PB8
PhylomeDBiQ9Y8G3

Family and domain databases

CDDicd14342 UBA_TAP-C, 1 hit
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR030217 NXF_fam
IPR005637 TAP_C_dom
IPR009060 UBA-like_sf
PANTHERiPTHR10662 PTHR10662, 1 hit
PfamiView protein in Pfam
PF03943 TAP_C, 1 hit
SMARTiView protein in SMART
SM00804 TAP_C, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 2 hits
PS50177 NTF2_DOMAIN, 1 hit
PS51281 TAP_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y8G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRKRERRN AVKENEMVID TPLEKRRTPG KPRATREPPI SVVITGHSKG
60 70 80 90 100
SEDDLISFVW RKVKVRLMNI SYSPASVTAV VKSQDFSRLN GLNGAAFAGD
110 120 130 140 150
HLAIRRVDGA SNVTQDYRKA KTKRSFRSVS APSLSALATQ AQRNVSKTLP
160 170 180 190 200
QSTNETIEKL RQFLQTRYQP ATKFLDLGNL QQDPLLKQMG ILAEASTKSK
210 220 230 240 250
MFPALMKVAS LNFPDVISVS LSDNNLQSVT AVTTLAQTWP KLLNLSLANN
260 270 280 290 300
RITSLSDLDP WSPKTKLPEL QELVLVGNPI VTTFANRAMD YQREMVSRFP
310 320 330 340 350
KLRLLDGNSI NSEIIASQST VPFPVYQSFF DKVETEQIVN SFLAAFFKGW
360 370 380 390 400
DENRSALVNQ LYSPNATFSI SLNASNVRTN FSQKTDTKKW GAYKMKSRNL
410 420 430 440 450
LYSQSQKESK SRLFNGHEEI SNAVKSLPAT AHDLSDRSQW VFDGWNLVLP
460 470 480 490 500
SVGAAIKIVV HGQFEEPQNK RLLRSFDRTL LILPGGSTGI LIINDLLVIR
510 520 530 540 550
SFAGSLGWLP GQSSVRTSNN AMSASASKPS DIVQPRPEQA MLDTRQQIVL
560 570 580 590
KIKAETGLND YYAHMCCEQN NWDYNSALAS FLELKSRNVI PAEAFS
Length:596
Mass (Da):66,535
Last modified:November 1, 1999 - v1
Checksum:iB84345BBC0DC3D83
GO

Sequence cautioni

The sequence BAA87120 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055036 Genomic DNA Translation: AAD43831.1
CU329671 Genomic DNA Translation: CAB58969.1
AB027816 Genomic DNA Translation: BAA87120.1 Different initiation.
PIRiT43683
RefSeqiNP_595996.1, NM_001021904.2

Genome annotation databases

EnsemblFungiiSPBC1921.03c.1; SPBC1921.03c.1:pep; SPBC1921.03c
GeneIDi2540727
KEGGispo:SPBC1921.03c

Similar proteinsi

Entry informationi

Entry nameiMEX67_SCHPO
AccessioniPrimary (citable) accession number: Q9Y8G3
Secondary accession number(s): Q9UU47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: February 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again