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UniProtKB - Q9Y8B8 (PRX5_PENCI)
Protein
Peroxiredoxin Pen c 3
Gene
N/A
Organism
Penicillium citrinum
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
By similarityMiscellaneous
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys Prx, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.By similarity
Catalytic activityi
- EC:1.11.1.24By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 60 | Cysteine sulfenic acid (-SOH) intermediateBy similarity | 1 |
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- thioredoxin peroxidase activity Source: UniProtKB
GO - Biological processi
- cell redox homeostasis Source: UniProtKB
- cellular response to oxidative stress Source: UniProtKB
- hydrogen peroxide catabolic process Source: UniProtKB
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxiredoxin Pen c 3Curated (EC:1.11.1.24By similarity)Short name: PrxCurated Alternative name(s): Peroxisomal membrane protein1 PublicationImported Thioredoxin peroxidaseCurated Short name: TPxCurated Thioredoxin-dependent peroxiredoxinCurated Allergen: Pen c 31 Publication |
Organismi | Penicillium citrinumImported |
Taxonomic identifieri | 5077 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Penicillium |
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Binds to IgE in 46% of 28 Penicillium-sensitized asthmatic patients from Taipei area.1 Publication
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3405, Pen c 3.0101 523, Pen c 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000446340 | 1 – 167 | Peroxiredoxin Pen c 3Add BLAST | 167 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 | Interchain (with C-60); in linked formBy similarity | ||
Disulfide bondi | 60 | Interchain (with C-30); in linked formBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homodimer; disulfide-linked, upon oxidation.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 167 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 165 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerFamily and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y8B8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLKAGDSFP EGVTFSYIPW AEDASEITSC GIPINYNASK EFANKKVVLF
60 70 80 90 100
ALPGAFTPVC SANHVPEYIQ KLPELRAKGV DQVAVLAYND AYVMSAWGKA
110 120 130 140 150
NGVTGDDILF LSDPEAKFSK SIGWADEEGR TYRYVLVIDN GKIIYAAKEA
160
AKNSLELSRA DHVLKQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144753 mRNA Translation: AAD42074.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144753 mRNA Translation: AAD42074.1 |
3D structure databases
SMRi | Q9Y8B8 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 3405, Pen c 3.0101 523, Pen c 3 |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRX5_PENCI | |
Accessioni | Q9Y8B8Primary (citable) accession number: Q9Y8B8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 13, 2019 |
Last sequence update: | November 1, 1999 | |
Last modified: | September 29, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families