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Entry version 50 (05 Jun 2019)
Sequence version 1 (01 Nov 1999)
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Protein
Submitted name:

Glucan synthase

Gene

FKS

Organism
Paracoccidioides brasiliensis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glucan synthaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParacoccidioides brasiliensisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri121759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei479 – 503HelicalSequence analysisAdd BLAST25
Transmembranei524 – 546HelicalSequence analysisAdd BLAST23
Transmembranei566 – 585HelicalSequence analysisAdd BLAST20
Transmembranei592 – 614HelicalSequence analysisAdd BLAST23
Transmembranei653 – 675HelicalSequence analysisAdd BLAST23
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Transmembranei1332 – 1351HelicalSequence analysisAdd BLAST20
Transmembranei1475 – 1495HelicalSequence analysisAdd BLAST21
Transmembranei1501 – 1519HelicalSequence analysisAdd BLAST19
Transmembranei1590 – 1612HelicalSequence analysisAdd BLAST23
Transmembranei1632 – 1656HelicalSequence analysisAdd BLAST25
Transmembranei1668 – 1692HelicalSequence analysisAdd BLAST25
Transmembranei1698 – 1717HelicalSequence analysisAdd BLAST20
Transmembranei1825 – 1849HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini333 – 445FKS1_dom1InterPro annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 67DisorderedSequence analysisAdd BLAST67
Regioni81 – 106DisorderedSequence analysisAdd BLAST26
Regioni134 – 155DisorderedSequence analysisAdd BLAST22
Regioni284 – 311DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1009 – 1029Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 61PolarSequence analysisAdd BLAST31
Compositional biasi92 – 106PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0916 Eukaryota
ENOG410XQ8V LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y8B3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAHPQGGRN GYDDGYGHNP QADAYYQDGY YDQNDYSQHD GYYDNRGNGD
60 70 80 90 100
NSYQPQDGYY DNNHQGYEDE YYNDQYYDQG AAGYQYGPQQ GRRRGHDSEE
110 120 130 140 150
DSETFSDFTM RSETARAADM DYYGRGDERY NSYNDSQMGG RGYRPPSSQI
160 170 180 190 200
SYSVNRSSGA STPVYGYDYG NALPAGQRTR EPYPAWTSDS QIPLSKEEIE
210 220 230 240 250
DIFLDLVNKF GSQRDSMRNM YDHFMTLLDS RASRMTPNQA LLSLHADYIG
260 270 280 290 300
GDNANYRRWY FAAHLDLDDA VGFANMNLGK ASRKTRKARK AAKKAAGGGP
310 320 330 340 350
QNEEQTLADL EGDNSLEAAE YRWKTRMNRM SQHERARQIA LYLLCWGEAN
360 370 380 390 400
QVRFMPEALC FIFKCADDFY HSPECQNRVE PVQEFTYLNE IITPLYQYCR
410 420 430 440 450
DQGYEIFDGK YVRRERDHNK IIGYDDINQL FWYPEGIERI VMNDKSRIVD
460 470 480 490 500
IPPAERYQKL KDVNWKKVFF KTYKETRSWF HMMVNFNRVW VIHVGAFWFY
510 520 530 540 550
TAFNSPTLYT RNYKQRENTQ PTAAARWTAS GLGGAVATFI MIFATICEWA
560 570 580 590 600
YVPRAWTGAQ HLTKRLIFLI GIFIINVGPA VYVFGVNQDN KIAHILGIVS
610 620 630 640 650
FFFNLLTFFM FSIMPLGGLF GSYLTKNSRK YVASQTFTAS YPRLHGNDMW
660 670 680 690 700
MSYGLWVCVF GAKLAESYFF LTLSFRDPIR ILSQMRISKC AGDALFGASR
710 720 730 740 750
DVLCKQQPKI LLGLMFFTDL SLFFLDTYMW YIILNAIFSV ARSFYLGVSI
760 770 780 790 800
WTPWRNIFSR LPKRIYSKVL ATTDMEIKYK PKVLISQVWN AIVISMYREH
810 820 830 840 850
LLAIDHVQKL LYHQVPSEQE GKRTLRAPTF FVSQEDHSFK TEFFPTQSEA
860 870 880 890 900
ERRISFFAQS LSTPIPEPVP VDNMPTFTVL IPHYSEKILL SLREIIREDE
910 920 930 940 950
PYSRVTLLEY LKQLHPHEWD CFVKDTKILA DETSQFNGEE KNEKDAAKSK
960 970 980 990 1000
IDDLPFYCIG FKSAAPEYTL RTRIWASLRS QTLYRTISGF MNYSRAIKLL
1010 1020 1030 1040 1050
YRVENPEVVQ MFGANSEKLE RELERMARRK FRIVVSMQRY AKFNKEEREN
1060 1070 1080 1090 1100
TEFLLRAYPD LQISYLDEEP PANEGEEPRL YSALIDGHSE IMENGLRRPK
1110 1120 1130 1140 1150
FRVQLSGNPI LGDGKSDNQN HAIIFYRGEY IQLIDANQDN YLEECLKIRS
1160 1170 1180 1190 1200
VLAEFEEMNT DNVSPYVPGL PPSKTNPVAI LGAREYIFSE NIGMLGDVAA
1210 1220 1230 1240 1250
GKEQTFGTLF ARTLAQIGGK LHYGHPDFLN GVFMTTRGGV SKAQKGLHLN
1260 1270 1280 1290 1300
EDIYAGMNAL LRGGRIKHCE YYQCGKGRDL GFGSVLNFTT KIGTGMGEQM
1310 1320 1330 1340 1350
LSREYYYLGT QLPLDRFLSF YYAHPGFHIN NLFIMLSVQM FMICLINLGA
1360 1370 1380 1390 1400
LKHETIPCIV KKGVPITDPI LPTGCADTIP IQEWVQRCTA SICIVFLLSF
1410 1420 1430 1440 1450
LPLVVQELTE RGSWRAITRL AKHFGSLSPF FEVFVCQIYA NSLHNNLSFG
1460 1470 1480 1490 1500
GARYIGTGRG FATARIPFGV LYSRFAGPSI YFGSRLLMML LFGTLTVWTG
1510 1520 1530 1540 1550
WLLYFWASLL ALCISPFLFN PHQFAWNDFF IDYRDYLRWL SRGNSRSHAS
1560 1570 1580 1590 1600
SWIAFCGLSR TRITGYKRKV LGSPSEKLSG DAPRAQFTNI FFSEIVGPLV
1610 1620 1630 1640 1650
LVVVTLIPYL FINAQTGVKE DEAKPTNSII RLAIIAFAPI AVNAGLLAVL
1660 1670 1680 1690 1700
FAMACCMGPV LSMCCKKFGS VLAAIAHGVA VVMLMAFFEV MFFLEGWVFV
1710 1720 1730 1740 1750
KALLGMIAVI ATQRFIYKLI ISLALTREFR QDTSNIAWWT GKWYNMGWHS
1760 1770 1780 1790 1800
MSQPGREFLC KITELGMFSA DFILGHVLLF FMLPPLCIPY VDKGHSVMLF
1810 1820 1830 1840 1850
WLRPSRQIRP PIYSMKQSKL RKRGVIRFAI LYFVMLVIFL ALIVGPIVAS
1860 1870 1880 1890 1900
RFLSPLPSIP MNLLQPTGLN NNDTTSELTG LALRGVTDQR RPVSRGCEVV
1910 1920
LVWGKTIREW GIGGLIEGWV SRKTNV
Length:1,926
Mass (Da):220,576
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB098950FD2253D5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF148715 Genomic DNA Translation: AAD37783.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148715 Genomic DNA Translation: AAD37783.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0916 Eukaryota
ENOG410XQ8V LUCA

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9Y8B3_PARBR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y8B3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: June 5, 2019
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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