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UniProtKB - Q9Y818 (UBC15_SCHPO)
Protein
Ubiquitin-conjugating enzyme E2 15
Gene
ubc15
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalyzes the covalent attachment of ubiquitin to other proteins. Has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors.
PROSITE-ProRule annotation1 PublicationCatalytic activityi
- S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation EC:2.3.2.23
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 90 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ubiquitin conjugating enzyme activity Source: PomBase
GO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein polyubiquitination Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-conjugating enzyme E2 15 (EC:2.3.2.23)Alternative name(s): E2 ubiquitin-conjugating enzyme 15 Ubiquitin carrier protein 15 Ubiquitin-protein ligase 15 |
Gene namesi | Name:ubc15 ORF Names:SPBC1105.09 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC1105.09, ubc15 |
VEuPathDBi | FungiDB:SPBC1105.09 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082589 | 1 – 167 | Ubiquitin-conjugating enzyme E2 15Add BLAST | 167 |
Proteomic databases
MaxQBi | Q9Y818 |
PaxDbi | Q9Y818 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 276539, 32 interactors |
STRINGi | 4896.SPBC1105.09.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y818 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 165 | UBC corePROSITE-ProRule annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0425, Eukaryota |
HOGENOMi | CLU_030988_10_1_1 |
InParanoidi | Q9Y818 |
OMAi | ACVRKSQ |
PhylomeDBi | Q9Y818 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y818-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSSASEQLL RKQLKEIQKN PPQGFSVGLV DDKSIFEWEV MIIGPEDTLY
60 70 80 90 100
EGGFFHATLS FPQDYPLMPP KMKFTTEIWH PNVHPNGEVC ISILHPPGDD
110 120 130 140 150
KYGYEDAGER WLPVHSPETI LISVISMLSS PNDESPANID AAKEFRENPQ
160
EFKKRVRRLV RRSIEMI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB50972.1 |
PIRi | T39286 |
RefSeqi | NP_596465.1, NM_001022384.2 |
Genome annotation databases
EnsemblFungii | SPBC1105.09.1; SPBC1105.09.1:pep; SPBC1105.09 |
GeneIDi | 2539995 |
KEGGi | spo:SPBC1105.09 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB50972.1 |
PIRi | T39286 |
RefSeqi | NP_596465.1, NM_001022384.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5KNL | X-ray | 2.50 | C/F | 1-167 | [»] | |
SMRi | Q9Y818 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 276539, 32 interactors |
STRINGi | 4896.SPBC1105.09.1 |
Proteomic databases
MaxQBi | Q9Y818 |
PaxDbi | Q9Y818 |
Genome annotation databases
EnsemblFungii | SPBC1105.09.1; SPBC1105.09.1:pep; SPBC1105.09 |
GeneIDi | 2539995 |
KEGGi | spo:SPBC1105.09 |
Organism-specific databases
PomBasei | SPBC1105.09, ubc15 |
VEuPathDBi | FungiDB:SPBC1105.09 |
Phylogenomic databases
eggNOGi | KOG0425, Eukaryota |
HOGENOMi | CLU_030988_10_1_1 |
InParanoidi | Q9Y818 |
OMAi | ACVRKSQ |
PhylomeDBi | Q9Y818 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-SPO-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
PROi | PR:Q9Y818 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBC15_SCHPO | |
Accessioni | Q9Y818Primary (citable) accession number: Q9Y818 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | September 29, 2021 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families