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UniProtKB - Q9Y7W4 (BUR1_CANAL)
Protein
Serine/threonine-protein kinase BUR1
Gene
CRK1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).
Required for pseudohyphal growth and virulence in mice.
By similarity1 PublicationCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 73 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 179 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 50 – 58 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: GO_Central
GO - Biological processi
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CRK1 Synonyms:BUR1 Ordered Locus Names:CAALFM_C204930CA ORF Names:CaO19.11006, CaO19.3523/3524 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000191033, CRK1 |
VEuPathDBi | FungiDB:C2_04930C_A |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- mediator complex Source: GO_Central
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085679 | 1 – 745 | Serine/threonine-protein kinase BUR1Add BLAST | 745 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 1226444, 3 interactors |
IntActi | Q9Y7W4, 2 interactors |
MINTi | Q9Y7W4 |
STRINGi | 237561.Q9Y7W4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 349 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 306 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 380 – 701 | DisorderedSequence analysisAdd BLAST | 322 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 380 – 404 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 429 – 477 | Basic and acidic residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 504 – 538 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 583 – 598 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 599 – 635 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 641 – 670 | Polar residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0600, Eukaryota |
HOGENOMi | CLU_000288_181_21_1 |
InParanoidi | Q9Y7W4 |
OrthoDBi | 925637at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y7W4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVIAGHHVP RSNDQRQYDT PSVPINIAPD SEGHIHEMSR LKDYEVIEKL
60 70 80 90 100
GQGTFGVVQK AKSKKDGSLV AIKQLINHSA KEGFPITAMR EITILKQLNH
110 120 130 140 150
KNILTIQDMI FEEPKMSNRT DIITMRGSFY TVTPYMSSDL VGLLENPKIK
160 170 180 190 200
LELGQIKCIM QQLLKGIQYV HNQKFLHRDI KAANILIGQD GVLKIADFGL
210 220 230 240 250
ARIYHGNVPR LGMGPGGGEK AYTGLVVTRW YRPPEILLGE RKYTTAVDLW
260 270 280 290 300
GIGCVFAELF TGKPILVGKS DSHQAQIVFE LVGSPLTWTD AAKLPNKNEY
310 320 330 340 350
SCGLACKRSL EAKFASIMPT EAIDLLSGLL TLDPFKRLNA LDALNHKFFS
360 370 380 390 400
TDPLPLLPTQ MPKFEESHEI DKERFKKLKD KEQAVSELKP PTEIRYDNHS
410 420 430 440 450
ESRYNADHST FGGGVGGKET SFSSGKSDYI DHYEPRARRD HYEPRIRNDN
460 470 480 490 500
KDSNDVRGEF ESATRQEQRR RDIQNRLDAG GMDTYIPKTT TAKLREHSGT
510 520 530 540 550
ESLSKKYDNY QPINVSRGSK SPSPSKLSSI SQSKADLISK PSAPKVASRE
560 570 580 590 600
SSLERKQVSN GIRTTTDVEP PRARARRPTD MFGRPLTSNS TQAQPTRNKS
610 620 630 640 650
VERPKDLEKP TNGVTEDRNK KPVLEEKKEV VKPNLAIPKI KKSSSLVSLS
660 670 680 690 700
SRSSTTPVIS NPSKVTKRAA SSVTPPVLPK KPKISKTSSE SEVSDLEEDS
710 720 730 740
DFTGENATVF ERFMALEQLQ KSPVYKRIIN EKMRFEKLSG GHKSM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 249 – 250 | LW → QR in AAD25159 (PubMed:11073971).Curated | 2 | |
Sequence conflicti | 414 | G → GG in AAD25159 (PubMed:11073971).Curated | 1 | |
Sequence conflicti | 492 | A → G in AAD25159 (PubMed:11073971).Curated | 1 | |
Sequence conflicti | 505 | K → Q in AAD25159 (PubMed:11073971).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U92261 Genomic DNA Translation: AAD25159.1 CP017624 Genomic DNA Translation: AOW27512.1 |
RefSeqi | XP_714883.2, XM_709790.2 |
Genome annotation databases
GeneIDi | 3643414 |
KEGGi | cal:CAALFM_C204930CA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U92261 Genomic DNA Translation: AAD25159.1 CP017624 Genomic DNA Translation: AOW27512.1 |
RefSeqi | XP_714883.2, XM_709790.2 |
3D structure databases
AlphaFoldDBi | Q9Y7W4 |
SMRi | Q9Y7W4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 1226444, 3 interactors |
IntActi | Q9Y7W4, 2 interactors |
MINTi | Q9Y7W4 |
STRINGi | 237561.Q9Y7W4 |
Genome annotation databases
GeneIDi | 3643414 |
KEGGi | cal:CAALFM_C204930CA |
Organism-specific databases
CGDi | CAL0000191033, CRK1 |
VEuPathDBi | FungiDB:C2_04930C_A |
Phylogenomic databases
eggNOGi | KOG0600, Eukaryota |
HOGENOMi | CLU_000288_181_21_1 |
InParanoidi | Q9Y7W4 |
OrthoDBi | 925637at2759 |
Miscellaneous databases
PHI-basei | PHI:172 |
PROi | PR:Q9Y7W4 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BUR1_CANAL | |
Accessioni | Q9Y7W4Primary (citable) accession number: Q9Y7W4 Secondary accession number(s): A0A1D8PH82 Q59ZR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | May 10, 2017 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - SIMILARITY comments
Index of protein domains and families