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Entry version 136 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Rho1 guanine nucleotide exchange factor 1

Gene

rgf1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Septation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho1 guanine nucleotide exchange factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rgf1
ORF Names:SPCC645.07
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC645.07

Schizosaccharomyces pombe database

More...
PomBasei
SPCC645.07, rgf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809701 – 1334Rho1 guanine nucleotide exchange factor 1Add BLAST1334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei381Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y7U6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y7U6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y7U6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y7U6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276139, 21 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC645.07.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y7U6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini621 – 808DHPROSITE-ProRule annotationAdd BLAST188
Domaini843 – 973PHPROSITE-ProRule annotationAdd BLAST131
Domaini995 – 1293CNHPROSITE-ProRule annotationAdd BLAST299

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi898 – 905Poly-Leu8

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4305, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001251_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y7U6

KEGG Orthology (KO)

More...
KOi
K19842

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFDGGRK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y7U6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180, CNH_dom
IPR035899, DBL_dom_sf
IPR000591, DEP_dom
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR041675, PH_5
IPR001849, PH_domain
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF00610, DEP, 1 hit
PF15405, PH_5, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036, CNH, 1 hit
SM00049, DEP, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219, CNH, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y7U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYRHPNALG VNESSRAYEE IFGAPRKREP ARTVSTPAFM EPAPVSKKPL
60 70 80 90 100
PPPTRRLPRK PLPFRSTSLQ PPSSQPPAPP THQREASPVK NIEHSESFPS
110 120 130 140 150
VFGTSNNHQI VPLTLKDGND FGALYASLNT TPHFPQVSNH APNNSNSPSL
160 170 180 190 200
TWHTSSGDDS NQNPFFVRRQ SQSSTSPVSD SVDENLLSAV SSVTESVETN
210 220 230 240 250
LHLDQNYPYG SPVRSSKNPF LSSNSRLPTD DSSHTVGSHS FTSGTHPPIV
260 270 280 290 300
SSNSAFTLPN AVTPAAQAPL IRSVSEYPAN VSPPAQSLQL PKSTSNPADL
310 320 330 340 350
HLSIASASSH KNIFSGLDVF SNVFHGPSTT LRDREHDMRN RSFDHSTLAH
360 370 380 390 400
YEAVKQQRLG VEPTARSFTL SSYKSRASGN SLINDRSSTT TPTFVNSEAS
410 420 430 440 450
SPVHKNKRRR RIYAALLSRV ASELLDRLQL GDITKDGLIY SNAFTGDHAV
460 470 480 490 500
TVLMGIIHTS DRNLALLVGR SLDAQKFIHD VTYDHRLRDS HREIYQLQGT
510 520 530 540 550
GYRPFLRAND NASINNKNHH KELEDNESGT RISPSTLGDT SFPNGIFTLL
560 570 580 590 600
THCYSPTCAK DHPCYSISCP RRLEQQHRLF AKMRANTEQS SSLAFDDKEQ
610 620 630 640 650
KLWIHSVPQE IAYSVSDRER KRQEVICEVI YTERDFVKDL EYLRDYWIKP
660 670 680 690 700
LWASSCIPER KKEKFIRTVF LNALEVQAVN SKLAEALTKR QNYKPIVDNI
710 720 730 740 750
ADIFLEHVPK FEPFIRYGAG QLYGKYEFEK EKSSNPAFAK FVSDVERLKE
760 770 780 790 800
SRKLELNGYL TKPTTRLARY PLLLEAVLKY TDEGNPDKQD IPKVINIVRG
810 820 830 840 850
FLSRLNVESG KAENKFNLFH LNQQLVFKPG EHYDLHLLDA NRQLIFKGPL
860 870 880 890 900
KKRSAGSTSS ESASDVTLFL FDHALLIVKP KTINKRELLK VFQRPIPLLL
910 920 930 940 950
LQLFLVDDNG LRIPYSSKQQ LAAVSKAANG KPPSRFYPFS LQLLGRRGYE
960 970 980 990 1000
ITLYATTEVS RDKWLEHIDN QQTLLQHRNQ WFESVTICSN FFVGDNKVNA
1010 1020 1030 1040 1050
IGVYDSGRRL LYGTDTGVYV SLRKANSPLQ FKPVRALNIP NISQLEVIEE
1060 1070 1080 1090 1100
YSLLLLLSDK VLYSYPLEMI DADTTQAPKK ARKVSGHTTF FRVGICLGKV
1110 1120 1130 1140 1150
LVCAVKSSVL SATIKVFEPV TNYSKTRNMP SLKKFLTVNQ DPLRIVKELY
1160 1170 1180 1190 1200
IPTESTSVHF LKNKLCVGCT RGFEVVSLDN LETQSLLDPA DTSLEFVEKK
1210 1220 1230 1240 1250
ENVKPIAIYR MNGGEFLLCY SQFAFYVNRD GWRSRPTWFV VWEGSPQNFA
1260 1270 1280 1290 1300
LSYPYILAFE PTFIEIRHVE TSELIHVISG RNIRLLADGR GKLGDGGEIF
1310 1320 1330
YACDQRGENC ETSVVCSLRL TSAAAHAKEQ HVDK
Length:1,334
Mass (Da):150,114
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i637BAF224817FF66
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB39903.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T41524

NCBI Reference Sequences

More...
RefSeqi
NP_588116.1, NM_001023106.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC645.07.1; SPCC645.07.1:pep; SPCC645.07

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC645.07

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB39903.1
PIRiT41524
RefSeqiNP_588116.1, NM_001023106.2

3D structure databases

SMRiQ9Y7U6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276139, 21 interactors
STRINGi4896.SPCC645.07.1

PTM databases

iPTMnetiQ9Y7U6

Proteomic databases

MaxQBiQ9Y7U6
PaxDbiQ9Y7U6
PRIDEiQ9Y7U6

Genome annotation databases

EnsemblFungiiSPCC645.07.1; SPCC645.07.1:pep; SPCC645.07
GeneIDi2539580
KEGGispo:SPCC645.07

Organism-specific databases

EuPathDBiFungiDB:SPCC645.07
PomBaseiSPCC645.07, rgf1

Phylogenomic databases

eggNOGiKOG4305, Eukaryota
HOGENOMiCLU_001251_2_1_1
InParanoidiQ9Y7U6
KOiK19842
OMAiPFDGGRK
PhylomeDBiQ9Y7U6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9Y7U6

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001180, CNH_dom
IPR035899, DBL_dom_sf
IPR000591, DEP_dom
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR041675, PH_5
IPR001849, PH_domain
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF00610, DEP, 1 hit
PF15405, PH_5, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SM00049, DEP, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGF1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y7U6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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