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Entry version 134 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Rho1 guanine nucleotide exchange factor 3

Gene

rgf3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3-glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: PomBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Septation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho1 guanine nucleotide exchange factor 3
Alternative name(s):
Lethal at division protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rgf3
Synonyms:lad1
ORF Names:SPCC645.06c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC645.06c

Schizosaccharomyces pombe database

More...
PomBasei
SPCC645.06c, rgf3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809721 – 1275Rho1 guanine nucleotide exchange factor 3Add BLAST1275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei293Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y7U5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y7U5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y7U5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y7U5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276000, 20 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC645.06c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y7U5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini465 – 657DHPROSITE-ProRule annotationAdd BLAST193
Domaini692 – 855PHPROSITE-ProRule annotationAdd BLAST164
Domaini930 – 1239CNHPROSITE-ProRule annotationAdd BLAST310

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi178 – 262Ser-richAdd BLAST85

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4305, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001083_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y7U5

Identification of Orthologs from Complete Genome Data

More...
OMAi
YFEWFNE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y7U5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180, CNH_dom
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR041675, PH_5
IPR001849, PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF15405, PH_5, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036, CNH, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219, CNH, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y7U5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSNELFHR SSKDHGGKSR ICLDSSEDTY PPHSSSPPSF QKRLSFSDFS
60 70 80 90 100
TTRLFSPPFL SKRSNNSPHR FSYSPPQHPA SINSRRVASY TVQSSPSRTT
110 120 130 140 150
YRQLPNEPQN SAAYTTYSSF PNALFDDFSP NNPLDTDPFL TSPGNKQNTV
160 170 180 190 200
DSFRPLPETP VSPGGSLVHP LPRPPLPSSV SSHSSPYSTT SSTSLYSLYN
210 220 230 240 250
DISLSCSPEP YLPLSPTRSP ARTPSPIRLY SSDALRPQSP LSPSVEYLTP
260 270 280 290 300
PNPYSLKSDI SSTRQLPKIP VQDYASGKIS SPLITRTHRR AQSETLFSSC
310 320 330 340 350
REPWLVGKLY KWCKEEVFTA LGGLVHEGVS RREVAQVMAT LFTIHIASME
360 370 380 390 400
FLIAEIIAKN ILGDWINYGL VEVINLEKLQ IAFTSNEPPS GSGVLPFLTN
410 420 430 440 450
GGCYSYICRS RSCPSKYQCY SCRCARNSSL EFTSLPGQSS DTWSIFWNIS
460 470 480 490 500
SLNSLPSSLS KREIARQNNI HELICKESDY VADLNTLAEL FRDGIVQQQD
510 520 530 540 550
AIVPSNRVAD FIQSVFGNVE SIRQLHSRLF LPQLIMRERL QGPVVSIIGD
560 570 580 590 600
ILLEWIHAAK SSYINYAKQF PLADETYKLE CQRNTYFARW LAACRSDPRC
610 620 630 640 650
RRLDFQHFLQ RPTQRLQRYT LELDTILKHT EQSSWDFQLI TQAVKELRAT
660 670 680 690 700
CEECDAVIAT VLEANRIRDL SYQLLFKNHE SVNLELRDPE REFFFEGIVQ
710 720 730 740 750
RRSDSRLDWL DIHLFLLDNY LIMAKARKDK RTNASRYVVS KRPIPLDLLV
760 770 780 790 800
LSPKMDDFQL KSNTNKFLGS LAGNLPQESL TTKSKRKSKV NLELMFDATA
810 820 830 840 850
EKNNENSMNS AVFEKSQLYP FTIRHLGAYT ASYTLYVESL QLRKLWVEKI
860 870 880 890 900
NVAKKRHSQK INIKNPFALK VVSDVAFQYP PSDLVNGNEP LNSFNEITLV
910 920 930 940 950
EGSSIDRALN EVAWKHPIVS EELLPEPIAY GDISCIAQFN DYEGHVSVLI
960 970 980 990 1000
ATSTGIFLGA FGDSSDIRDW KKISSQRRVT QLGVVEEFDI LLELRDKTLY
1010 1020 1030 1040 1050
AHKLSRIIEM GLIESKIAVV IGTPHAVSFF KIGKLSEGAS VKRERTLVFY
1060 1070 1080 1090 1100
KEGLGNTTTI ICCEPVIGLG HNYQKTYAFK RKDVTSFRTL DDFHVTANCH
1110 1120 1130 1140 1150
SIDCFKYSIA LCHNKGIDVL RLDPKLAVGF PSPSVLNDTL FRNRINNSKP
1160 1170 1180 1190 1200
LGVFRIHDPS LFACCYQFGA VFVNGEGSMV NKECWFDWIG KPNSVTSCHG
1210 1220 1230 1240 1250
YLIAFNDEFV EIWNTRTRKL NQIIQGNDIK YYPSNSDWLA NGKYIMFGMV
1260 1270
HPQYHDRHLI LALNKAKTNS FIIED
Length:1,275
Mass (Da):144,431
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5B6CFA7780FD2FF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB39902.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T41523

NCBI Reference Sequences

More...
RefSeqi
NP_588115.1, NM_001023105.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC645.06c.1; SPCC645.06c.1:pep; SPCC645.06c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC645.06c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB39902.1
PIRiT41523
RefSeqiNP_588115.1, NM_001023105.2

3D structure databases

SMRiQ9Y7U5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276000, 20 interactors
STRINGi4896.SPCC645.06c.1

PTM databases

iPTMnetiQ9Y7U5

Proteomic databases

MaxQBiQ9Y7U5
PaxDbiQ9Y7U5
PRIDEiQ9Y7U5

Genome annotation databases

EnsemblFungiiSPCC645.06c.1; SPCC645.06c.1:pep; SPCC645.06c
GeneIDi2539437
KEGGispo:SPCC645.06c

Organism-specific databases

EuPathDBiFungiDB:SPCC645.06c
PomBaseiSPCC645.06c, rgf3

Phylogenomic databases

eggNOGiKOG4305, Eukaryota
HOGENOMiCLU_001083_1_0_1
InParanoidiQ9Y7U5
OMAiYFEWFNE
PhylomeDBiQ9Y7U5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9Y7U5

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR001180, CNH_dom
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR041675, PH_5
IPR001849, PH_domain
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF15405, PH_5, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGF3_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y7U5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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