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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

set1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.3 Publications

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].1 Publication

GO - Molecular functioni

  • histone methyltransferase activity (H3-K4 specific) Source: PomBase
  • RNA binding Source: PomBase

GO - Biological processi

  • heterochromatin assembly involved in chromatin silencing Source: PomBase
  • histone H3-K4 methylation Source: PomBase

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component set1
Lysine N-methyltransferase 2
SET domain-containing protein 1
Set1 complex component set1
Short name:
Set1C component set1
Spset1
Gene namesi
Name:set1Imported
Synonyms:kmt2
ORF Names:SPCC306.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC306.04c
PomBaseiSPCC306.04c set1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860851 – 920Histone-lysine N-methyltransferase, H3 lysine-4 specificAdd BLAST920

Proteomic databases

MaxQBiQ9Y7R4
PaxDbiQ9Y7R4
PRIDEiQ9Y7R4

PTM databases

iPTMnetiQ9Y7R4

Interactioni

Subunit structurei

Component of the Set1 complex composed of ash2, sdc1, set1, shg1, spp1, swd1, swd2 and swd3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
lid2Q9HDV42EBI-2106005,EBI-2105919

Protein-protein interaction databases

BioGridi275345, 361 interactors
ELMiQ9Y7R4
IntActiQ9Y7R4, 1 interactor
STRINGi4896.SPCC306.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7R4
SMRiQ9Y7R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 179RRMPROSITE-ProRule annotationAdd BLAST86
Domaini781 – 898SETPROSITE-ProRule annotationAdd BLAST118
Domaini904 – 920Post-SETPROSITE-ProRule annotationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi469 – 474Poly-ArgSequence analysis6

Domaini

A construct containing set1 C-terminal fragment of 692-920 is able to form H3K4me.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ9Y7R4
KOiK11422
OMAiPSCTAKI
OrthoDBiEOG092C3T9B
PhylomeDBiQ9Y7R4

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PANTHERiPTHR22884:SF462 PTHR22884:SF462, 2 hits
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 2 hits
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y7R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV
60 70 80 90 100
VRDPRLKNPI YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN
110 120 130 140 150
ISPLVTSEQL RYHFKSFGEV FDLDLKLNPY TGTSLGLCCI SFDKRSSISV
160 170 180 190 200
AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG SLCEEAFKKA LNAVEKQFQE
210 220 230 240 250
ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL SNGDLQHSKV
260 270 280 290 300
QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVPPDRVY YTDIKHHFRK
310 320 330 340 350
FLYEKIYMNK DGFYITFNNY REASNCYRAL DRTYVQNCRI KLKFHDIPSR
360 370 380 390 400
TKEDGKKSAV RRVVLPPEEA YAEATSVVLR DLEAALLRDV KSKIIGPAIF
410 420 430 440 450
KYLHSMPKPS VKEELQENLL VSSTSVPDVP LKIESTVGKL PSLPKFKKRV
460 470 480 490 500
DSSKMNLSAG SKTKSKLQRR RRRRHEARPL HYQLNQMYNS SASEAESDQE
510 520 530 540 550
LLLSSGDERV ERGKIGSIKS VKSDEATPVF SDTSDENDKF HRFRTKSKIS
560 570 580 590 600
KKKYEKMEVD YTSSSETESD ASILSPSAAI PKSGSAIKDE LISPKKEIDE
610 620 630 640 650
VLALAPKWRI NEFDETGSVY YGALPYNYPE DDVLLDLDGL QYLVKNDEDY
660 670 680 690 700
SYLQEALKDE PLMDINDPNF WAYERKSCKF KNGDVKYGDT AILPEPKGYF
710 720 730 740 750
RSNTSGSAKS EGYYIIPTTE KSLYLPLRNR STIDTISHST SRITSRMNRV
760 770 780 790 800
NNRRLAAGVE KSQLPAEADL LRFNALKARK KQLHFGPSRI HTLGLFAMEN
810 820 830 840 850
IDKNDMVIEY IGEIIRQRVA DNREKNYVRE GIGDSYLFRI DEDVIVDATK
860 870 880 890 900
KGNIARFINH SCAPNCIARI IRVEGKRKIV IYADRDIMHG EELTYDYKFP
910 920
EEADKIPCLC GAPTCRGYLN
Length:920
Mass (Da):105,038
Last modified:November 1, 1999 - v1
Checksum:iC4AD7E6C3ECFF8BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB41652.1
PIRiT41282
RefSeqiNP_587812.1, NM_001022805.2

Genome annotation databases

EnsemblFungiiSPCC306.04c.1; SPCC306.04c.1:pep; SPCC306.04c
GeneIDi2538762
KEGGispo:SPCC306.04c

Similar proteinsi

Entry informationi

Entry nameiSET1_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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