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Protein

ATP-dependent permease MDL1, mitochondrial

Gene

mdl1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates export of peptides generated upon proteolysis of mitochondrial inner membrane proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi517 – 524ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1369007 Mitochondrial ABC transporters

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease MDL1, mitochondrial
Alternative name(s):
ABC transporter mdl1
Gene namesi
Name:mdl1
ORF Names:SPBC9B6.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC9B6.09c
PomBaseiSPBC9B6.09c mdl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei158 – 178HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei196 – 216HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei306 – 326HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei386 – 406HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei423 – 443HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 112MitochondrionSequence analysisAdd BLAST112
ChainiPRO_0000093470113 – 726ATP-dependent permease MDL1, mitochondrialAdd BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi668N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y7M7
PaxDbiQ9Y7M7
PRIDEiQ9Y7M7

Interactioni

Protein-protein interaction databases

BioGridi277798, 4 interactors
STRINGi4896.SPBC9B6.09c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7M7
SMRiQ9Y7M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 447ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST290
Domaini482 – 719ABC transporterPROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9Y7M7
KOiK02021
OMAiMLIDPIS
OrthoDBiEOG092C3H79
PhylomeDBiQ9Y7M7

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030260 ABCB10-like
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF392 PTHR24221:SF392, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y7M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPIRFGLSR VPFAHCYNKR VIFRANYLVP LTWLKNNVAY KSTNTLLLPT
60 70 80 90 100
PNAEYYSTSK LSSQVNVSLN SLSQKASSGS KIYPFKNSFP LPFSRSILPI
110 120 130 140 150
RSLAFLKLCV RHNSTVPSKD EQAQDISKIN TNGTLQTPNK KVNVFRLFTL
160 170 180 190 200
ARGQGWNFFI AGSLLLVSSG VTMSIPYIVG KILDAGSSGD SSVTHIMGIP
210 220 230 240 250
SGTFYIGLLG LFFLGSACNF GRIITLRLLS ERIVSRLRAR LFAKCMSLDG
260 270 280 290 300
AFFDFHKHGD LISRLTTDSS IVGKSLSMYL SDGLRSSVSA IAGIGMMLYV
310 320 330 340 350
SMRLTGYMSL IVPPIALGAF FYGEYVRKLS RTTQDALGDL TRVSEEKLAN
360 370 380 390 400
VRTTQAFLGE RQEVNRYNDY IRNLFVLAKR EAFASGIFFG STGFLGNATV
410 420 430 440 450
IAILALGGRM VAAGDITVGQ LSSFLLYTVY AGGSIVGLSG CFTDIMKGLG
460 470 480 490 500
AASRLFELLD AKPKIAPTVG IPVPVTVGKA ILSFRNVGFA YPTRPSASIF
510 520 530 540 550
DNLSFDIHPG TNVAIVAPSG GGKSTISQLL LRFYAPSSGK ILADGVDIST
560 570 580 590 600
YNVHQWRSHF GLVGQEPVLF SGTIGENIAY GKSNASQEEI EDAAKRANCS
610 620 630 640 650
FVLSFPEKWS TQVGTRGLQL SGGQKQRIAI ARALLRNPAF LILDEATSAL
660 670 680 690 700
DGEAEVMVDK TIQSLMHNRS MTTITIAHKL ATIRRADQII VVGDGKVLEQ
710 720
GSFERLSRPG TNFYKLMRWQ LGKVEP
Length:726
Mass (Da):79,020
Last modified:November 1, 1999 - v1
Checksum:i203473D0B9585BCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB42370.1
PIRiT40790
RefSeqiNP_595751.1, NM_001021651.2

Genome annotation databases

EnsemblFungiiSPBC9B6.09c.1; SPBC9B6.09c.1:pep; SPBC9B6.09c
GeneIDi2541285
KEGGispo:SPBC9B6.09c

Similar proteinsi

Entry informationi

Entry nameiMDL1_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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