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UniProtKB - Q9Y7I4 (ALG3_SCHPO)
Protein
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Gene
alg3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.
By similarityCatalytic activityi
- α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl β-D-mannosyl phosphate = α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+EC:2.4.1.258
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
GO - Biological processi
- dolichol-linked oligosaccharide biosynthetic process Source: PomBase
- protein glycosylation Source: GO_Central
- protein N-linked glycosylation Source: PomBase
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.4.1.258, 5613 |
Reactomei | R-SPO-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT58, Glycosyltransferase Family 58 |
Names & Taxonomyi
Protein namesi | Recommended name: Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC:2.4.1.258)Alternative name(s): Asparagine-linked glycosylation protein 3 Dol-P-Man-dependent alpha(1-3)-mannosyltransferase Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase |
Gene namesi | Name:alg3 ORF Names:SPAC7D4.06c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC7D4.06c, alg3 |
VEuPathDBi | FungiDB:SPAC7D4.06c |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- integral component of endoplasmic reticulum membrane Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 261 – 281 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 313 – 333 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 349 – 369 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327764 | 1 – 406 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseAdd BLAST | 406 |
Proteomic databases
PaxDbi | Q9Y7I4 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 279218, 1 interactor |
STRINGi | 4896.SPAC7D4.06c.1 |
Structurei
3D structure databases
AlphaFoldDBi | Q9Y7I4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 58 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_035382_3_0_1 |
InParanoidi | Q9Y7I4 |
OMAi | PERYGIH |
PhylomeDBi | Q9Y7I4 |
Family and domain databases
InterProi | View protein in InterPro IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y7I4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSVETRNSF NPFRVLFDLG SYGWLHPSRL LLLEIPFVFA IISKVPYTEI
60 70 80 90 100
DWIAYMEQVN SFLLGERDYK SLVGCTGPLV YPGGHVFLYT LLYYLTDGGT
110 120 130 140 150
NIVRAQYIFA FVYWITTAIV GYLFKIVRAP FYIYVLLILS KRLHSIFILR
160 170 180 190 200
LFNDGFNSLF SSLFILSSCK KKWVRASILL SVACSVKMSS LLYVPAYLVL
210 220 230 240 250
LLQILGPKKT WMHIFVIIIV QILFSIPFLA YFWSYWTQAF DFGRAFDYKW
260 270 280 290 300
TVNWRFIPRS IFESTSFSTS ILFLHVALLV AFTCKHWNKL SRATPFAMVN
310 320 330 340 350
SMLTLKPLPK LQLATPNFIF TALATSNLIG ILCARSLHYQ FYAWFAWYSP
360 370 380 390 400
YLCYQASFPA PIVIGLWMLQ EYAWNVFPST KLSSLIAVCV PLITILKLYT
SDYRKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16723.2 |
PIRi | T39084 |
RefSeqi | NP_593853.1, NM_001019282.2 |
Genome annotation databases
EnsemblFungii | SPAC7D4.06c.1; SPAC7D4.06c.1:pep; SPAC7D4.06c |
GeneIDi | 2542768 |
KEGGi | spo:SPAC7D4.06c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16723.2 |
PIRi | T39084 |
RefSeqi | NP_593853.1, NM_001019282.2 |
3D structure databases
AlphaFoldDBi | Q9Y7I4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 279218, 1 interactor |
STRINGi | 4896.SPAC7D4.06c.1 |
Protein family/group databases
CAZyi | GT58, Glycosyltransferase Family 58 |
Proteomic databases
PaxDbi | Q9Y7I4 |
Genome annotation databases
EnsemblFungii | SPAC7D4.06c.1; SPAC7D4.06c.1:pep; SPAC7D4.06c |
GeneIDi | 2542768 |
KEGGi | spo:SPAC7D4.06c |
Organism-specific databases
PomBasei | SPAC7D4.06c, alg3 |
VEuPathDBi | FungiDB:SPAC7D4.06c |
Phylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_035382_3_0_1 |
InParanoidi | Q9Y7I4 |
OMAi | PERYGIH |
PhylomeDBi | Q9Y7I4 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
BRENDAi | 2.4.1.258, 5613 |
Reactomei | R-SPO-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
Miscellaneous databases
PROi | PR:Q9Y7I4 |
Family and domain databases
InterProi | View protein in InterPro IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG3_SCHPO | |
Accessioni | Q9Y7I4Primary (citable) accession number: Q9Y7I4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families