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Protein

Peroxiredoxin TSA1-A

Gene

TSA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.1 Publication

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.By similarity

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48Cysteine sulfenic acid (-SOH) intermediateBy similarity1
Binding sitei124SubstrateBy similarity1

GO - Molecular functioni

  • high molecular weight kininogen binding Source: CGD
  • thioredoxin peroxidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Protein family/group databases

MoonDBiQ9Y7F0 Curated
MoonProtiQ9Y7F0
PeroxiBasei4472 Cal2CysPrx01

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxiredoxin TSA1-A (EC:1.11.1.15)
Alternative name(s):
Thiol-specific antioxidant protein
Thioredoxin peroxidase
Gene namesi
Name:TSA11 Publication
Synonyms:TSA1A1 Publication
Ordered Locus Names:CAALFM_C306180CA
ORF Names:CaO19.7417
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000174369 TSA1
CAL0000189947 TSA1B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Results in delayed hyphal development and enhanced sensitivity to cell wall-perturbing agents, yet does not impair virulence in vivo.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001350941 – 196Peroxiredoxin TSA1-AAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48Interchain (with C-169); in linked formBy similarity
Disulfide bondi169Interchain (with C-48); in linked formBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9Y7F0

Expressioni

Inductioni

Induced by oxidative stress.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked, upon oxidation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1225363, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9Y7F0
SMRiQ9Y7F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 161ThioredoxinPROSITE-ProRule annotationAdd BLAST159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 47Substrate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

InParanoidiQ9Y7F0
KOiK03386
OrthoDBiEOG092C53IH

Family and domain databases

InterProiView protein in InterPro
IPR000866 AhpC/TSA
IPR024706 Peroxiredoxin_AhpC-typ
IPR019479 Peroxiredoxin_C
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF10417 1-cysPrx_C, 1 hit
PF00578 AhpC-TSA, 1 hit
PIRSFiPIRSF000239 AHPC, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y7F0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVVQQPAP SFKKTAVVDG VFEEVTLEQY KGKWVLLAFI PLAFTFVCPS
60 70 80 90 100
EIIAYSEAVK KFAEKDAQVL FASTDSEYTW LAWTNVARKD GGIGKVDFPV
110 120 130 140 150
LADTNHSLSR DYGVLIEEEG VALRGIFLID PKGVLRQITI NDLPVGRSVE
160 170 180 190
ESLRLLEAFQ FTEKYGEVCP ANWHPGDETI KPSPEASKEY FNKVNK
Length:196
Mass (Da):21,860
Last modified:November 1, 1999 - v1
Checksum:i0BD7B6B4715DCDBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149421 mRNA Translation: AAD34017.1
CP017625 Genomic DNA Translation: AOW28625.1
RefSeqiXP_019330878.1, XM_019475333.1
XP_716082.1, XM_710989.1

Genome annotation databases

EnsemblFungiiAOW28625; AOW28625; CAALFM_C306180CA
AOW28640; AOW28640; CAALFM_C306330WA
GeneIDi30515214
3642269
KEGGical:CAALFM_C306180CA
cal:CAALFM_C306330WA

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149421 mRNA Translation: AAD34017.1
CP017625 Genomic DNA Translation: AOW28625.1
RefSeqiXP_019330878.1, XM_019475333.1
XP_716082.1, XM_710989.1

3D structure databases

ProteinModelPortaliQ9Y7F0
SMRiQ9Y7F0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1225363, 1 interactor

Protein family/group databases

MoonDBiQ9Y7F0 Curated
MoonProtiQ9Y7F0
PeroxiBasei4472 Cal2CysPrx01

Proteomic databases

PRIDEiQ9Y7F0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAOW28625; AOW28625; CAALFM_C306180CA
AOW28640; AOW28640; CAALFM_C306330WA
GeneIDi30515214
3642269
KEGGical:CAALFM_C306180CA
cal:CAALFM_C306330WA

Organism-specific databases

CGDiCAL0000174369 TSA1
CAL0000189947 TSA1B

Phylogenomic databases

InParanoidiQ9Y7F0
KOiK03386
OrthoDBiEOG092C53IH

Family and domain databases

InterProiView protein in InterPro
IPR000866 AhpC/TSA
IPR024706 Peroxiredoxin_AhpC-typ
IPR019479 Peroxiredoxin_C
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF10417 1-cysPrx_C, 1 hit
PF00578 AhpC-TSA, 1 hit
PIRSFiPIRSF000239 AHPC, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSA1_CANAL
AccessioniPrimary (citable) accession number: Q9Y7F0
Secondary accession number(s): A0A1D8PKI8, Q5A2Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Candida albicans
    Candida albicans: entries and gene names
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Main funding by: National Institutes of Health

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