UniProtKB - Q9Y7B5 (ACS2_KLULA)
Protein
Acetyl-coenzyme A synthetase 2
Gene
ACS2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Functioni
Catalytic activityi
- EC:6.2.1.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 326 | Coenzyme ABy similarity | 1 | |
Binding sitei | 517 | ATPBy similarity | 1 | |
Binding sitei | 532 | ATPBy similarity | 1 | |
Binding sitei | 540 | Coenzyme A; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 543 | ATPBy similarity | 1 | |
Binding sitei | 613 | Coenzyme ABy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 402 – 404 | ATPBy similarity | 3 | |
Nucleotide bindingi | 426 – 431 | ATPBy similarity | 6 |
GO - Molecular functioni
- acetate-CoA ligase activity Source: UniProtKB-EC
- acid-ammonia (or amide) ligase activity Source: EnsemblFungi
- AMP binding Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- acetyl-CoA biosynthetic process from acetate Source: InterPro
- histone acetylation Source: EnsemblFungi
Keywordsi
Molecular function | Ligase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Acetyl-coenzyme A synthetase 2 (EC:6.2.1.1)Alternative name(s): Acetate--CoA ligase 2 Acyl-activating enzyme 2 |
Gene namesi | Name:ACS2 Ordered Locus Names:KLLA0D17336g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208415 | 1 – 684 | Acetyl-coenzyme A synthetase 2Add BLAST | 684 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 207 – 210 | Coenzyme A bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
HOGENOMi | CLU_000022_3_6_1 |
InParanoidi | Q9Y7B5 |
OMAi | AIKASWP |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR011904, Ac_CoA_lig IPR032387, ACAS_N IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR02188, Ac_CoA_lig_AcsA, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y7B5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDKLHKVV HEAHDVEARH APEHFYNSQP GKSYCTDEEH YREMYTQSIE
60 70 80 90 100
DPAGFFGPLA KEYLDWDRPF TQVQSGSLEH GDIAWFLNGE LNASYNCVDR
110 120 130 140 150
HAFANPDKPA LIYEADDESE NKVITFGELL RQVSEVAGVL QSWGVKKGDT
160 170 180 190 200
VAVYLPMIPA AVVAMLAVAR LGAIHSVIFA GFSAGSLKER VVDAGCKVVI
210 220 230 240 250
TCDEGKRGGK TVHTKKIVDE GLAGVDSVSK ILVFQRTGTQ GIPMKPARDF
260 270 280 290 300
WWHEECVKQR GYLPPVPVNS EDPLFLLYTS GSTGSPKGVV HSTAGYLLGS
310 320 330 340 350
ALTTRFVFDI HPEDVLFTAG DVGWITGHTY ALYGPLTLGT ATIIFESTPA
360 370 380 390 400
YPDYGRYWRI IERHRATHFY VAPTALRLIK RVGEEEIAKY DTSSLRVLGS
410 420 430 440 450
VGEPISPDLW EWYHEKVGKN NCVICDTMWQ TESGSHLIAP LAGAVPTKPG
460 470 480 490 500
SATVPFFGIN ACIIDPVSGE ELKGNDVEGV LAVKSPWPSM ARSVWNNHAR
510 520 530 540 550
YFETYLKPYP GYYFTGDGAG RDHDGYYWIR GRVDDVVNVS GHRLSTAEIE
560 570 580 590 600
AALAEHEGVS EAAVVGITDE LTGQAVIAFV SLKDGYLSEN AVEGDSTHIS
610 620 630 640 650
PDNLRRELIL QVRGEIGPFA APKTVVVVND LPKTRSGKIM RRVLRKVASK
660 670 680
EADQLGDLST LANADVVPSI ISAVENQFFS QQKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 491 | A → D in AAD30108 (PubMed:12489122).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF134491 Genomic DNA Translation: AAD30108.1 CR382124 Genomic DNA Translation: CAH00923.1 |
RefSeqi | XP_453827.1, XM_453827.1 |
Genome annotation databases
EnsemblFungii | CAH00923; CAH00923; KLLA0_D17336g |
GeneIDi | 2893299 |
KEGGi | kla:KLLA0_D17336g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF134491 Genomic DNA Translation: AAD30108.1 CR382124 Genomic DNA Translation: CAH00923.1 |
RefSeqi | XP_453827.1, XM_453827.1 |
3D structure databases
SMRi | Q9Y7B5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 28985.XP_453827.1 |
Genome annotation databases
EnsemblFungii | CAH00923; CAH00923; KLLA0_D17336g |
GeneIDi | 2893299 |
KEGGi | kla:KLLA0_D17336g |
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
HOGENOMi | CLU_000022_3_6_1 |
InParanoidi | Q9Y7B5 |
OMAi | AIKASWP |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR011904, Ac_CoA_lig IPR032387, ACAS_N IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR02188, Ac_CoA_lig_AcsA, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACS2_KLULA | |
Accessioni | Q9Y7B5Primary (citable) accession number: Q9Y7B5 Secondary accession number(s): Q6CQG2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | September 27, 2004 | |
Last modified: | February 10, 2021 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families