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Entry version 95 (07 Oct 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Protein dopey

Gene

dop1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum (By similarity). During the vegetative phase, contributes to the highly polarized hyphal growth. Required for the reproductive cycle. Involved in conidiophore initiation and differentiation. May have a role in controlling the balance between vegetative proliferation and developmental morphogenesis.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein dopey
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dop1
ORF Names:AN2094
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1695I → R: Inactivated function at 42 degrees Celsius. Altered cellular morphology and cell pattern formation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001909751 – 1858Protein dopeyAdd BLAST1858

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00008766

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1838 – 1854TransactivationAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dopey family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3613, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001197_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y7B3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVLLCFQ

Database of Orthologous Groups

More...
OrthoDBi
29961at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR040314, DOP1
IPR007249, Dopey_N

The PANTHER Classification System

More...
PANTHERi
PTHR14042, PTHR14042, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04118, Dopey_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y7B3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLDPSSFPR SNSPASSDSS LTRSRLRGKE GSLKKDKNYR RYASSVERAL
60 70 80 90 100
SLFDNTLQEW ADYISFLSRL LKALQTHPPD QPVVPHKVLV AKRLSQSMNP
110 120 130 140 150
SLPSGVHQKA LEVYTYIFNL IKPEGLSHDL PLYYPGIAPT LTFASLTVRP
160 170 180 190 200
LFLSLVETYV CDLEPWAIRP ALKAIILSLL PGLEEETSDD FDSTLRLLNT
210 220 230 240 250
LREIASRMDT QRPGAETNSS GQYFWQCFFL ASITSPSRRL GILAYLNRYL
260 270 280 290 300
PKLGVTDRRP SRHEEVDATA MPLEMQVAVD SVILPEPGLL IRCFATGLTD
310 320 330 340 350
EQVLVQRNFL DLLVTHLPLS SPILQTRITK DDLQRLIVAA AGVVSRRDMS
360 370 380 390 400
LNRRLWAWLL GPDPVGDRAS FEARPSISST ASKTAAESEE LSQSQYFSRF
410 420 430 440 450
GLQPLASGLL QLLKRDTELP SEKAKPFRIT LSLMDRWEVG GHVVPAVFLP
460 470 480 490 500
FMRSVKAYKL AAPKAHFDEV FRSATSFFDG VESGMIFSEL LNLIDWDAKS
510 520 530 540 550
LANDAPRILD NLNLAHFILD HFNVREEDMV LNHAPLLTLA ALIKMSELSS
560 570 580 590 600
EATTSVAHDQ LQAVSNGLSK VVTLLTGLLI DRAFLRKSDS KNSVNEPSML
610 620 630 640 650
LDRPGSAILR QIHQFYDRSR NSLDLQPPPF PPTDLADLII KNVYEQAISA
660 670 680 690 700
VNACNDAKSI PERLNLLIVV LKKLPRSRIL RDKRLYVAIG KHIQASTVEL
710 720 730 740 750
STASFSHLSS MSTTITSLYC IHKLGYYITY EEVSDLIPPL VRQLWQFLSP
760 770 780 790 800
LSPKFHVEAV RCLWNLHSVS WSDHLVESTI TSLMFTPPAP GSYQLSSEEE
810 820 830 840 850
AGRYFILWNH SHHGTYELPP KNLQDSAQSQ ASYHSSMLER PLFTVLDLLS
860 870 880 890 900
QGSTQPAQVV QLWLQDLPSV AKVFRIIISK LEGVLHRGNQ LGTFEGNTVV
910 920 930 940 950
SPDDYAECNY LFETIHNVLG ALNHNGWVSL LTQTMAHNSR RHDASASEDN
960 970 980 990 1000
AEAPSLHSVV FQASLKIVSG YKSGTATANA EEVKLQQISL LVMRQLLLGP
1010 1020 1030 1040 1050
GVEELVESGI DSLLVDRLYS MLDEGGDIAI QAALIDTLLA VLKARFSQAY
1060 1070 1080 1090 1100
LPPPPTKPKH QRGGSREKLT SPSLLSFTSD KPEKSSVLLP SPEPPQRLLD
1110 1120 1130 1140 1150
CLLKGLSSPR SRAIIDKWIM LLCEILPIYS TCIFQILLTL VDCLGREIRQ
1160 1170 1180 1190 1200
SYTNLQSAFE KTEGWPKDRP EQTTISLLTG FETCIAAAHE RLLMEEVNAP
1210 1220 1230 1240 1250
AAKSPDQTHG FFGNMVSGVF ASDSNHPRSA AMNNRLTVLL SFQDAVRLCF
1260 1270 1280 1290 1300
SIWSWGAAER SSLPQDTESI ASFQYTSLRM RNRSRRILEH LFTAEALECL
1310 1320 1330 1340 1350
ETMVDMWIKS DRDTSPLIFN LLHTLDGSRP KIAIPAIFNA IYTRTNPAAL
1360 1370 1380 1390 1400
DPSRKSTMTT ALTETELAGF LVTYARSLDD DVLDEIWIDC TTFLRDVLSN
1410 1420 1430 1440 1450
PFPHRQILPR LVEFAAILGV KLENTNFGED RRMRKELGDV ILRLLTAIFT
1460 1470 1480 1490 1500
SKPMGFTQEQ GLLGRASLDY DSSSIQRIGP DDMLSILVAS MPAFSMTLGD
1510 1520 1530 1540 1550
MDRITTAVSN ISTNIIGPFI RARLFPNNLN TSFMALMQHI SKIPQVAKVW
1560 1570 1580 1590 1600
KKDVADAFND PRFFGSQLDL VKGGWMTLLR QWALVDKDRL SEIMTRLTPP
1610 1620 1630 1640 1650
ATAGIMFGVG ASAARLDADR KAQLNLRRIS LLVLSTAEDY FIAEMPALLQ
1660 1670 1680 1690 1700
KLEDLLGATA SSSPSSATRA EIFMVLRALI LKSTTTTLSP FWPLINSELQ
1710 1720 1730 1740 1750
EAISAISSGN QQELYNPYSL LQACKLLDTL LVLAPDDFQL LEWLYVTDTV
1760 1770 1780 1790 1800
DAIYPPEQFE PTALADEVSH NLGVRWSTSS DPTRESTNLH HGVRYPGLAA
1810 1820 1830 1840 1850
DWIRETAKDE IVDRVLRPFF DQLSIHAFES TYSISNPNLE ACRDDLLADL

FNESTMAN
Length:1,858
Mass (Da):207,245
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9ED4B7D8CB1373E4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134206 mRNA Translation: AAD28280.1
AACD01000032 Genomic DNA Translation: EAA64926.1
BN001307 Genomic DNA Translation: CBF86166.1

NCBI Reference Sequences

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RefSeqi
XP_659698.1, XM_654606.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF86166; CBF86166; ANIA_02094
EAA64926; EAA64926; AN2094.2

Database of genes from NCBI RefSeq genomes

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GeneIDi
2874634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN2094.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134206 mRNA Translation: AAD28280.1
AACD01000032 Genomic DNA Translation: EAA64926.1
BN001307 Genomic DNA Translation: CBF86166.1
RefSeqiXP_659698.1, XM_654606.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi162425.CADANIAP00008766

Genome annotation databases

EnsemblFungiiCBF86166; CBF86166; ANIA_02094
EAA64926; EAA64926; AN2094.2
GeneIDi2874634
KEGGiani:AN2094.2

Phylogenomic databases

eggNOGiKOG3613, Eukaryota
HOGENOMiCLU_001197_1_0_1
InParanoidiQ9Y7B3
OMAiTVLLCFQ
OrthoDBi29961at2759

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR040314, DOP1
IPR007249, Dopey_N
PANTHERiPTHR14042, PTHR14042, 1 hit
PfamiView protein in Pfam
PF04118, Dopey_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOP1_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y7B3
Secondary accession number(s): C8VLX2, Q5BBI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1999
Last modified: October 7, 2020
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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