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UniProtKB - Q9Y757 (CP52L_DEBHN)
Protein
Cytochrome P450 52A12
Gene
CYP52A12
Organism
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Status
Functioni
Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 467 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 52A12 (EC:1.14.14.-)Alternative name(s): Alkane hydroxylase 1 Alkane-inducible p450alk 1 DH-ALK2 |
Gene namesi | Name:CYP52A12 Synonyms:ALK1 |
Organismi | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) |
Taxonomic identifieri | 4959 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces |
Subcellular locationi
Other locations
- Membrane Curated
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052030 | 1 – 519 | Cytochrome P450 52A12Add BLAST | 519 |
Expressioni
Inductioni
By N-alkanes.
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002974, Cyt_P450_E_CYP52 IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01239, EP450IICYP52 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y757-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFDVDTVHNF FTSWYGILLA VLIGYHVFDY IRIQIVMKKL GCVSPPVESD
60 70 80 90 100
GFFGFKLLYT SLKHKKEGTL VNFIKERFET VGKDTFSFRI AGTPVISTKN
110 120 130 140 150
PENIKALLAT QFSDFALGTR HAQFKPLLGD GIFTLDGSGW KHSRAMLRPQ
160 170 180 190 200
FAREQVAHVK SLEPHIQMLA KHVRRAKGGA FDVQSLFFRL TVDSATEFLF
210 220 230 240 250
GESVESLQDE SIGMAKDAVD FDGKAGFAEA FNTAQVYLSI RSLAQKAYFL
260 270 280 290 300
VNNKEFRSSN EKVHKFADYY VQKALNSSPE ELEKHSQDGY IFLYELVKQT
310 320 330 340 350
RDPHVLRDQL LNILLAGRDT TAGLLSFTFY ELARNPQVWS KLKEEIYEKF
360 370 380 390 400
GKGDDARLED ITFESLKKCE YLKALLNEVL RLYPSVPQNF RVAQKDTSLP
410 420 430 440 450
RGGGPNRDQP IFIAKGQTVT YTVYAMHRDE QFYGKDSEVF RPERWFEPET
460 470 480 490 500
RKLGWAFLPF NGGPRICLGQ QFALTEASYV IARLAQLFPN LASHDDEYPP
510
RKASHLTMCH QSEVKISLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF103948 Genomic DNA Translation: AAD22536.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF103948 Genomic DNA Translation: AAD22536.2 |
3D structure databases
SMRi | Q9Y757 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002974, Cyt_P450_E_CYP52 IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01239, EP450IICYP52 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP52L_DEBHN | |
Accessioni | Q9Y757Primary (citable) accession number: Q9Y757 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 2, 2020 | |
This is version 78 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |