UniProtKB - Q9Y6Y9 (LY96_HUMAN)
Lymphocyte antigen 96
LY96
Functioni
GO - Molecular functioni
- coreceptor activity Source: ProtInc
- lipopolysaccharide binding Source: InterPro
- lipopolysaccharide immune receptor activity Source: UniProtKB
- Toll-like receptor 4 binding Source: InterPro
GO - Biological processi
- apoptotic signaling pathway Source: Reactome
- cell surface receptor signaling pathway Source: ProtInc
- cellular defense response Source: ProtInc
- cellular response to lipopolysaccharide Source: GO_Central
- detection of lipopolysaccharide Source: UniProtKB
- I-kappaB kinase/NF-kappaB signaling Source: Reactome
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- MyD88-dependent toll-like receptor signaling pathway Source: Reactome
- MyD88-independent toll-like receptor signaling pathway Source: Reactome
- necroptotic process Source: Reactome
- negative regulation of MyD88-independent toll-like receptor signaling pathway Source: Reactome
- positive regulation of lipopolysaccharide-mediated signaling pathway Source: GO_Central
- positive regulation of tumor necrosis factor production Source: UniProtKB
- response to lipopolysaccharide Source: MGI
- toll-like receptor 4 signaling pathway Source: UniProtKB
- toll-like receptor signaling pathway Source: Reactome
- TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6Y9 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166166, MyD88-independent TLR4 cascade R-HSA-2562578, TRIF-mediated programmed cell death R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
SIGNORi | Q9Y6Y9 |
Names & Taxonomyi
Protein namesi | Recommended name: Lymphocyte antigen 96Short name: Ly-96 Alternative name(s): ESOP-11 Publication Protein MD-21 Publication |
Gene namesi | Name:LY96 Synonyms:ESOP1, MD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17156, LY96 |
MIMi | 605243, gene |
neXtProti | NX_Q9Y6Y9 |
VEuPathDBi | HostDB:ENSG00000154589.6 |
Subcellular locationi
Extracellular region or secreted
- extracellular space 1 Publication2 Publications
- Secreted 1 Publication
Note: Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).2 Publications
Endosome
- endosome membrane Source: Reactome
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Plasma Membrane
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- lipopolysaccharide receptor complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 95 | C → Y: Abolishes LPS-response. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23643 |
OpenTargetsi | ENSG00000154589 |
PharmGKBi | PA134924906 |
Miscellaneous databases
Pharosi | Q9Y6Y9, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2375202 |
DrugBanki | DB02767, (R)-3-hydroxytetradecanoic acid DB03017, Lauric acid DB00295, Morphine DB08231, Myristic acid |
GuidetoPHARMACOLOGYi | 2890 |
Genetic variation databases
BioMutai | LY96 |
DMDMi | 296434574 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000018619 | 19 – 160 | Lymphocyte antigen 96Add BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 51 | Combined sources2 Publications | ||
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 37 ↔ 148 | Combined sources2 Publications | ||
Disulfide bondi | 95 ↔ 105 | Combined sources2 Publications | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9Y6Y9 |
MassIVEi | Q9Y6Y9 |
PaxDbi | Q9Y6Y9 |
PeptideAtlasi | Q9Y6Y9 |
PRIDEi | Q9Y6Y9 |
ProteomicsDBi | 16624 86830 [Q9Y6Y9-1] |
PTM databases
GlyGeni | Q9Y6Y9, 2 sites |
iPTMneti | Q9Y6Y9 |
PhosphoSitePlusi | Q9Y6Y9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154589, Expressed in monocyte and 211 other tissues |
Genevisiblei | Q9Y6Y9, HS |
Organism-specific databases
HPAi | ENSG00000154589, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.
5 PublicationsBinary interactionsi
Hide detailsQ9Y6Y9
GO - Molecular functioni
- Toll-like receptor 4 binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 117170, 8 interactors |
DIPi | DIP-38571N |
IntActi | Q9Y6Y9, 8 interactors |
STRINGi | 9606.ENSP00000284818 |
Chemistry databases
BindingDBi | Q9Y6Y9 |
Miscellaneous databases
RNActi | Q9Y6Y9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y6Y9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y6Y9 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 123 | Interaction with lipopolysaccharideCombined sources2 Publications | 5 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SD7W, Eukaryota |
GeneTreei | ENSGT00390000000742 |
HOGENOMi | CLU_141711_0_0_1 |
InParanoidi | Q9Y6Y9 |
OMAi | EVICRGY |
OrthoDBi | 1320082at2759 |
PhylomeDBi | Q9Y6Y9 |
TreeFami | TF335876 |
Family and domain databases
InterProi | View protein in InterPro IPR014756, Ig_E-set IPR039217, LY96 IPR003172, ML_dom |
PANTHERi | PTHR15218, PTHR15218, 1 hit |
SMARTi | View protein in SMART SM00737, ML, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCDKM QYPISINVNP
60 70 80 90 100
CIELKRSKGL LHIFYIPRRD LKQLYFNLYI TVNTMNLPKR KEVICRGSDD
110 120 130 140 150
DYSFCRALKG ETVNTTISFS FKGIKFSKGK YKCVVEAISG SPEEMLFCLE
160
FVILHQPNSN
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050030 | 56 | R → G5 PublicationsCorresponds to variant dbSNP:rs6472812Ensembl. | 1 | |
Natural variantiVAR_024532 | 157 | P → S. Corresponds to variant dbSNP:rs11466004Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055045 | 38 – 68 | DKMQY…FYIPR → G in isoform 2. CuratedAdd BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018549 mRNA Translation: BAA78717.1 AF168121 mRNA Translation: AAF89635.1 AB446498 mRNA Translation: BAG55275.1 AC022868 Genomic DNA No translation available. AC087672 Genomic DNA No translation available. BC020690 mRNA Translation: AAH20690.1 |
CCDSi | CCDS56540.1 [Q9Y6Y9-2] CCDS6216.1 [Q9Y6Y9-1] |
RefSeqi | NP_001182726.1, NM_001195797.1 [Q9Y6Y9-2] NP_056179.3, NM_015364.4 [Q9Y6Y9-1] |
Genome annotation databases
Ensembli | ENST00000284818; ENSP00000284818; ENSG00000154589 [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589 [Q9Y6Y9-2] |
GeneIDi | 23643 |
KEGGi | hsa:23643 |
UCSCi | uc003yad.4, human [Q9Y6Y9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018549 mRNA Translation: BAA78717.1 AF168121 mRNA Translation: AAF89635.1 AB446498 mRNA Translation: BAG55275.1 AC022868 Genomic DNA No translation available. AC087672 Genomic DNA No translation available. BC020690 mRNA Translation: AAH20690.1 |
CCDSi | CCDS56540.1 [Q9Y6Y9-2] CCDS6216.1 [Q9Y6Y9-1] |
RefSeqi | NP_001182726.1, NM_001195797.1 [Q9Y6Y9-2] NP_056179.3, NM_015364.4 [Q9Y6Y9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T2Z | model | - | A | 19-160 | [»] | |
2E56 | X-ray | 2.00 | A | 17-160 | [»] | |
2E59 | X-ray | 2.21 | A | 17-160 | [»] | |
2Z65 | X-ray | 2.70 | C/D | 19-158 | [»] | |
3FXI | X-ray | 3.10 | C/D | 19-160 | [»] | |
3ULA | X-ray | 3.60 | B/D | 19-158 | [»] | |
4G8A | X-ray | 2.40 | C/D | 17-160 | [»] | |
SMRi | Q9Y6Y9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117170, 8 interactors |
DIPi | DIP-38571N |
IntActi | Q9Y6Y9, 8 interactors |
STRINGi | 9606.ENSP00000284818 |
Chemistry databases
BindingDBi | Q9Y6Y9 |
ChEMBLi | CHEMBL2375202 |
DrugBanki | DB02767, (R)-3-hydroxytetradecanoic acid DB03017, Lauric acid DB00295, Morphine DB08231, Myristic acid |
GuidetoPHARMACOLOGYi | 2890 |
PTM databases
GlyGeni | Q9Y6Y9, 2 sites |
iPTMneti | Q9Y6Y9 |
PhosphoSitePlusi | Q9Y6Y9 |
Genetic variation databases
BioMutai | LY96 |
DMDMi | 296434574 |
Proteomic databases
jPOSTi | Q9Y6Y9 |
MassIVEi | Q9Y6Y9 |
PaxDbi | Q9Y6Y9 |
PeptideAtlasi | Q9Y6Y9 |
PRIDEi | Q9Y6Y9 |
ProteomicsDBi | 16624 86830 [Q9Y6Y9-1] |
Protocols and materials databases
Antibodypediai | 12334, 475 antibodies |
Genome annotation databases
Ensembli | ENST00000284818; ENSP00000284818; ENSG00000154589 [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589 [Q9Y6Y9-2] |
GeneIDi | 23643 |
KEGGi | hsa:23643 |
UCSCi | uc003yad.4, human [Q9Y6Y9-1] |
Organism-specific databases
CTDi | 23643 |
DisGeNETi | 23643 |
GeneCardsi | LY96 |
HGNCi | HGNC:17156, LY96 |
HPAi | ENSG00000154589, Tissue enhanced (blood) |
MIMi | 605243, gene |
neXtProti | NX_Q9Y6Y9 |
OpenTargetsi | ENSG00000154589 |
PharmGKBi | PA134924906 |
VEuPathDBi | HostDB:ENSG00000154589.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SD7W, Eukaryota |
GeneTreei | ENSGT00390000000742 |
HOGENOMi | CLU_141711_0_0_1 |
InParanoidi | Q9Y6Y9 |
OMAi | EVICRGY |
OrthoDBi | 1320082at2759 |
PhylomeDBi | Q9Y6Y9 |
TreeFami | TF335876 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6Y9 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166166, MyD88-independent TLR4 cascade R-HSA-2562578, TRIF-mediated programmed cell death R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
SIGNORi | Q9Y6Y9 |
Miscellaneous databases
BioGRID-ORCSi | 23643, 8 hits in 924 CRISPR screens |
ChiTaRSi | LY96, human |
EvolutionaryTracei | Q9Y6Y9 |
GeneWikii | Lymphocyte_antigen_96 |
GenomeRNAii | 23643 |
Pharosi | Q9Y6Y9, Tchem |
PROi | PR:Q9Y6Y9 |
RNActi | Q9Y6Y9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154589, Expressed in monocyte and 211 other tissues |
Genevisiblei | Q9Y6Y9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR014756, Ig_E-set IPR039217, LY96 IPR003172, ML_dom |
PANTHERi | PTHR15218, PTHR15218, 1 hit |
SMARTi | View protein in SMART SM00737, ML, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LY96_HUMAN | |
Accessioni | Q9Y6Y9Primary (citable) accession number: Q9Y6Y9 Secondary accession number(s): B3Y6A5, E5RJJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references