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Protein

Lymphocyte antigen 96

Gene

LY96

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).5 Publications

GO - Molecular functioni

  • coreceptor activity Source: ProtInc
  • lipopolysaccharide receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-140534 Ligand-dependent caspase activation
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-2562578 TRIF-mediated programmed cell death
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SIGNORiQ9Y6Y9

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 96
Short name:
Ly-96
Alternative name(s):
ESOP-11 Publication
Protein MD-21 Publication
Gene namesi
Name:LY96
Synonyms:ESOP1, MD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000154589.6
HGNCiHGNC:17156 LY96
MIMi605243 gene
neXtProtiNX_Q9Y6Y9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi95C → Y: Abolishes LPS-response. 1 Publication1

Organism-specific databases

DisGeNETi23643
OpenTargetsiENSG00000154589
PharmGKBiPA134924906

Chemistry databases

ChEMBLiCHEMBL2375202
DrugBankiDB02767 3-Hydroxy-Myristic Acid
DB03017 Lauric Acid
DB08231 MYRISTIC ACID
GuidetoPHARMACOLOGYi2890

Polymorphism and mutation databases

BioMutaiLY96
DMDMi296434574

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001861919 – 160Lymphocyte antigen 96Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 51Combined sources2 Publications
Glycosylationi26N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi37 ↔ 148Combined sources2 Publications
Disulfide bondi95 ↔ 105Combined sources2 Publications
Glycosylationi114N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Post-translational modificationi

N-glycosylated; high-mannose.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y6Y9
PeptideAtlasiQ9Y6Y9
PRIDEiQ9Y6Y9
ProteomicsDBi86830

PTM databases

iPTMnetiQ9Y6Y9
PhosphoSitePlusiQ9Y6Y9

Expressioni

Gene expression databases

BgeeiENSG00000154589
CleanExiHS_LY96
GenevisibleiQ9Y6Y9 HS

Organism-specific databases

HPAiHPA053060

Interactioni

Subunit structurei

Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117170, 6 interactors
DIPiDIP-38571N
IntActiQ9Y6Y9, 8 interactors
STRINGi9606.ENSP00000284818

Chemistry databases

BindingDBiQ9Y6Y9

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 26Combined sources5
Beta strandi28 – 36Combined sources9
Beta strandi38 – 40Combined sources3
Beta strandi45 – 50Combined sources6
Beta strandi57 – 65Combined sources9
Beta strandi75 – 82Combined sources8
Beta strandi90 – 93Combined sources4
Beta strandi97 – 101Combined sources5
Helixi103 – 106Combined sources4
Beta strandi113 – 121Combined sources9
Beta strandi129 – 139Combined sources11
Turni140 – 143Combined sources4
Beta strandi144 – 155Combined sources12

3D structure databases

ProteinModelPortaliQ9Y6Y9
SMRiQ9Y6Y9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6Y9

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 123Interaction with lipopolysaccharideCombined sources2 Publications5

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4Q5 Eukaryota
ENOG411154R LUCA
GeneTreeiENSGT00390000000742
HOGENOMiHOG000001152
HOVERGENiHBG032514
InParanoidiQ9Y6Y9
KOiK05400
OMAiYIPRRDI
OrthoDBiEOG091G0T85
PhylomeDBiQ9Y6Y9
TreeFamiTF335876

Family and domain databases

InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR039217 LY96
IPR003172 ML_dom
PANTHERiPTHR15218 PTHR15218, 1 hit
PfamiView protein in Pfam
PF02221 E1_DerP2_DerF2, 1 hit
SMARTiView protein in SMART
SM00737 ML, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6Y9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCDKM QYPISINVNP
60 70 80 90 100
CIELKRSKGL LHIFYIPRRD LKQLYFNLYI TVNTMNLPKR KEVICRGSDD
110 120 130 140 150
DYSFCRALKG ETVNTTISFS FKGIKFSKGK YKCVVEAISG SPEEMLFCLE
160
FVILHQPNSN
Length:160
Mass (Da):18,546
Last modified:May 18, 2010 - v2
Checksum:i0F92AFF583637C6B
GO
Isoform 2 (identifier: Q9Y6Y9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-68: DKMQYPISINVNPCIELKRSKGLLHIFYIPR → G

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:130
Mass (Da):14,933
Checksum:i7D92D168412B21C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05003056R → G5 PublicationsCorresponds to variant dbSNP:rs6472812Ensembl.1
Natural variantiVAR_024532157P → S. Corresponds to variant dbSNP:rs11466004Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05504538 – 68DKMQY…FYIPR → G in isoform 2. CuratedAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018549 mRNA Translation: BAA78717.1
AF168121 mRNA Translation: AAF89635.1
AB446498 mRNA Translation: BAG55275.1
AC022868 Genomic DNA No translation available.
AC087672 Genomic DNA No translation available.
BC020690 mRNA Translation: AAH20690.1
CCDSiCCDS56540.1 [Q9Y6Y9-2]
CCDS6216.1 [Q9Y6Y9-1]
RefSeqiNP_001182726.1, NM_001195797.1 [Q9Y6Y9-2]
NP_056179.3, NM_015364.4
UniGeneiHs.726603

Genome annotation databases

EnsembliENST00000284818; ENSP00000284818; ENSG00000154589 [Q9Y6Y9-1]
ENST00000518893; ENSP00000430533; ENSG00000154589 [Q9Y6Y9-2]
GeneIDi23643
KEGGihsa:23643
UCSCiuc003yad.4 human [Q9Y6Y9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLY96_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y9
Secondary accession number(s): B3Y6A5, E5RJJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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