LY96

Functionⁱ

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).5 Publications

GO - Molecular functionⁱ

coreceptor activity
Source: ProtInc
Traceable author statementⁱ
- 10359581
lipopolysaccharide receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19252480

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway Source: Reactome
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10359581
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 10359581
detection of lipopolysaccharide
Source: UniProtKB
Inferred from direct assayⁱ
- 19252480
I-kappaB kinase/NF-kappaB signaling Source: Reactome
inflammatory response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
MyD88-dependent toll-like receptor signaling pathway Source: Reactome
MyD88-independent toll-like receptor signaling pathway Source: Reactome
necroptotic process Source: Reactome
negative regulation of MyD88-independent toll-like receptor signaling pathway Source: Reactome
positive regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
positive regulation of tumor necrosis factor production Source: UniProtKB
response to lipopolysaccharide
Source: MGI
Inferred from direct assayⁱ
- 12594207
toll-like receptor 4 signaling pathway Source: UniProtKB
toll-like receptor signaling pathway Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity, Inflammatory response, Innate immunity

Biological process

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-140534 Ligand-dependent caspase activation R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-2562578 TRIF-mediated programmed cell death R-HSA-5602498 MyD88 deficiency (TLR2/4) R-HSA-5603041 IRAK4 deficiency (TLR2/4) R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SIGNORⁱ	Q9Y6Y9

Reactomeⁱ

R-HSA-1236974 ER-Phagosome pathway
R-HSA-140534 Ligand-dependent caspase activation
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-2562578 TRIF-mediated programmed cell death
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

SIGNORⁱ

Q9Y6Y9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lymphocyte antigen 96 Short name: Ly-96 Alternative name(s): ESOP-11 Publication Protein MD-21 Publication
Gene namesⁱ	Name:LY96 Synonyms:ESOP1, MD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154589.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17156 LY96
MIMⁱ	605243 gene
neXtProtⁱ	NX_Q9Y6Y9

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	95	C → Y: Abolishes LPS-response. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23643
Open Targets More...OpenTargetsⁱ	ENSG00000154589
PharmGKBⁱ	PA134924906

Chemistry databases

ChEMBLⁱ	CHEMBL2375202
Drug and drug target database More...DrugBankⁱ	DB02767 3-Hydroxy-Myristic Acid DB03017 Lauric Acid DB08231 MYRISTIC ACID
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2890

Polymorphism and mutation databases

BioMutaⁱ	LY96
DMDMⁱ	296434574

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000018619	19 – 160	Lymphocyte antigen 96Add BLAST		142

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	25 ↔ 51	Combined sources2 Publications
Glycosylationⁱ	26	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	37 ↔ 148	Combined sources2 Publications
Disulfide bondⁱ	95 ↔ 105	Combined sources2 Publications
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1

Post-translational modificationⁱ

N-glycosylated; high-mannose.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9Y6Y9
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6Y9
PRIDEⁱ	Q9Y6Y9
ProteomicsDBⁱ	86830

PTM databases

iPTMnetⁱ	Q9Y6Y9
PhosphoSitePlusⁱ	Q9Y6Y9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000154589
CleanExⁱ	HS_LY96
Genevisibleⁱ	Q9Y6Y9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053060

HPAⁱ

HPA053060

Interactionⁱ

Subunit structureⁱ

Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DERP2	P49278	2	EBI-1539247,EBI-15745025	From Dermatophagoides pteronyssinus.
TLR4	O00206	5	EBI-1539247,EBI-528701
TLR4	O00206-1	5	EBI-1539247,EBI-15745059

Show more details

Protein-protein interaction databases

BioGridⁱ	117170, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-38571N
IntActⁱ	Q9Y6Y9, 8 interactors
STRINGⁱ	9606.ENSP00000284818

Chemistry databases

BindingDBⁱ

Q9Y6Y9

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 26	Combined sources	5
Beta strandⁱ	28 – 36	Combined sources	9
Beta strandⁱ	38 – 40	Combined sources	3
Beta strandⁱ	45 – 50	Combined sources	6
Beta strandⁱ	57 – 65	Combined sources	9
Beta strandⁱ	75 – 82	Combined sources	8
Beta strandⁱ	90 – 93	Combined sources	4
Beta strandⁱ	97 – 101	Combined sources	5
Helixⁱ	103 – 106	Combined sources	4
Beta strandⁱ	113 – 121	Combined sources	9
Beta strandⁱ	129 – 139	Combined sources	11
Turnⁱ	140 – 143	Combined sources	4
Beta strandⁱ	144 – 155	Combined sources	12

3D structure databases

ProteinModelPortalⁱ	Q9Y6Y9
SMRⁱ	Q9Y6Y9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y6Y9

EvolutionaryTraceⁱ

Q9Y6Y9

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	119 – 123	Interaction with lipopolysaccharideCombined sources2 Publications		5

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4Q5 Eukaryota ENOG411154R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000742
HOGENOMⁱ	HOG000001152
HOVERGENⁱ	HBG032514
InParanoidⁱ	Q9Y6Y9
KEGG Orthology (KO) More...KOⁱ	K05400
OMAⁱ	YIPRRDI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T85
PhylomeDBⁱ	Q9Y6Y9
TreeFamⁱ	TF335876

Family and domain databases

InterProⁱ	View protein in InterPro IPR014756 Ig_E-set IPR039217 LY96 IPR003172 ML_dom
PANTHERⁱ	PTHR15218 PTHR15218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02221 E1_DerP2_DerF2, 1 hit
SMARTⁱ	View protein in SMART SM00737 ML, 1 hit
SUPFAMⁱ	SSF81296 SSF81296, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9Y6Y9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCDKM QYPISINVNP 
        60         70         80         90        100
CIELKRSKGL LHIFYIPRRD LKQLYFNLYI TVNTMNLPKR KEVICRGSDD 
       110        120        130        140        150
DYSFCRALKG ETVNTTISFS FKGIKFSKGK YKCVVEAISG SPEEMLFCLE 
       160
FVILHQPNSN

Length:160

Mass (Da):18,546

Last modified:May 18, 2010 - v2

Checksum:ⁱ0F92AFF583637C6B

GO

Isoform 2 (identifier: Q9Y6Y9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
38-68: DKMQYPISINVNPCIELKRSKGLLHIFYIPR → G

« Hide

        10         20         30         40         50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCGRD LKQLYFNLYI 
        60         70         80         90        100
TVNTMNLPKR KEVICRGSDD DYSFCRALKG ETVNTTISFS FKGIKFSKGK 
       110        120        130
YKCVVEAISG SPEEMLFCLE FVILHQPNSN

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:130

Mass (Da):14,933

Checksum:ⁱ7D92D168412B21C7

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050030	56	R → G5 PublicationsCorresponds to variant dbSNP:rs6472812Ensembl.		1
Natural variantⁱVAR_024532	157	P → S. Corresponds to variant dbSNP:rs11466004Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055045	38 – 68	DKMQY…FYIPR → G in isoform 2. CuratedAdd BLAST		31

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018549 mRNA Translation: BAA78717.1 AF168121 mRNA Translation: AAF89635.1 AB446498 mRNA Translation: BAG55275.1 AC022868 Genomic DNA No translation available. AC087672 Genomic DNA No translation available. BC020690 mRNA Translation: AAH20690.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56540.1 [Q9Y6Y9-2] CCDS6216.1 [Q9Y6Y9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182726.1, NM_001195797.1 [Q9Y6Y9-2] NP_056179.3, NM_015364.4
UniGeneⁱ	Hs.726603

Genome annotation databases

Ensemblⁱ	ENST00000284818; ENSP00000284818; ENSG00000154589 [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589 [Q9Y6Y9-2]
GeneIDⁱ	23643
KEGGⁱ	hsa:23643
UCSC genome browser More...UCSCⁱ	uc003yad.4 human [Q9Y6Y9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9Y6Y9	LY96 isoform 1		PANTR		160
Lymphocyte antigen 96 precursor		PANPA		160
UPI000156181E		HUMAN		144
Lymphocyte antigen 96		MACMU		160
Lymphocyte antigen 96 precursor		MACNE		160
+20
Q9Y6Y9-2	Lymphocyte antigen 96 precursor		MACMU		130
Lymphocyte antigen 96 precursor		MACFA		130
Lymphocyte antigen 96 precursor		MACNE		130
LY96 isoform 2		PANTR		130
Lymphocyte antigen 96 precursor		PANPA		130
+9

Protein	Similar proteins		Species	Score	Length
Q9Y6Y9	Lymphocyte antigen 96		NOMLE		160
Lymphocyte antigen 96		CERAT		160
Lymphocyte antigen 96		CHLSB		160
Lymphocyte antigen 96		COLAP		160
LY96 isoform 1		PANTR		160
+101
Q9Y6Y9-2	Lymphocyte antigen 96 precursor		MACMU		130
Lymphocyte antigen 96 precursor		MACFA		130
Lymphocyte antigen 96 precursor		MACNE		130
LY96 isoform 2		PANTR		130
Lymphocyte antigen 96 precursor		PANPA		130
+28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018549 mRNA Translation: BAA78717.1 AF168121 mRNA Translation: AAF89635.1 AB446498 mRNA Translation: BAG55275.1 AC022868 Genomic DNA No translation available. AC087672 Genomic DNA No translation available. BC020690 mRNA Translation: AAH20690.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56540.1 [Q9Y6Y9-2] CCDS6216.1 [Q9Y6Y9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182726.1, NM_001195797.1 [Q9Y6Y9-2] NP_056179.3, NM_015364.4
UniGeneⁱ	Hs.726603

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1T2Z	model	-	A	19-160	[»]
	2E56	X-ray	2.00	A	17-160	[»]
	2E59	X-ray	2.21	A	17-160	[»]
	2Z65	X-ray	2.70	C/D	19-158	[»]
	3FXI	X-ray	3.10	C/D	19-160	[»]
	3ULA	X-ray	3.60	B/D	19-158	[»]
	4G8A	X-ray	2.40	C/D	17-160	[»]
ProteinModelPortalⁱ	Q9Y6Y9
SMRⁱ	Q9Y6Y9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117170, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-38571N
IntActⁱ	Q9Y6Y9, 8 interactors
STRINGⁱ	9606.ENSP00000284818

Chemistry databases

BindingDBⁱ	Q9Y6Y9
ChEMBLⁱ	CHEMBL2375202
Drug and drug target database More...DrugBankⁱ	DB02767 3-Hydroxy-Myristic Acid DB03017 Lauric Acid DB08231 MYRISTIC ACID
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2890

PTM databases

iPTMnetⁱ	Q9Y6Y9
PhosphoSitePlusⁱ	Q9Y6Y9

Polymorphism and mutation databases

BioMutaⁱ	LY96
DMDMⁱ	296434574

Proteomic databases

PaxDbⁱ	Q9Y6Y9
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6Y9
PRIDEⁱ	Q9Y6Y9
ProteomicsDBⁱ	86830

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000284818; ENSP00000284818; ENSG00000154589 [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589 [Q9Y6Y9-2]
GeneIDⁱ	23643
KEGGⁱ	hsa:23643
UCSC genome browser More...UCSCⁱ	uc003yad.4 human [Q9Y6Y9-1]

Organism-specific databases

CTDⁱ	23643
DisGeNET More...DisGeNETⁱ	23643
EuPathDBⁱ	HostDB:ENSG00000154589.6
GeneCardsⁱ	LY96
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17156 LY96
Human Protein Atlas More...HPAⁱ	HPA053060
MIMⁱ	605243 gene
neXtProtⁱ	NX_Q9Y6Y9
Open Targets More...OpenTargetsⁱ	ENSG00000154589
PharmGKBⁱ	PA134924906
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4Q5 Eukaryota ENOG411154R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000742
HOGENOMⁱ	HOG000001152
HOVERGENⁱ	HBG032514
InParanoidⁱ	Q9Y6Y9
KEGG Orthology (KO) More...KOⁱ	K05400
OMAⁱ	YIPRRDI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T85
PhylomeDBⁱ	Q9Y6Y9
TreeFamⁱ	TF335876

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-140534 Ligand-dependent caspase activation R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-2562578 TRIF-mediated programmed cell death R-HSA-5602498 MyD88 deficiency (TLR2/4) R-HSA-5603041 IRAK4 deficiency (TLR2/4) R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SIGNORⁱ	Q9Y6Y9

Reactomeⁱ

R-HSA-1236974 ER-Phagosome pathway
R-HSA-140534 Ligand-dependent caspase activation
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-2562578 TRIF-mediated programmed cell death
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

SIGNORⁱ

Q9Y6Y9

Miscellaneous databases

ChiTaRSⁱ	LY96 human
EvolutionaryTraceⁱ	Q9Y6Y9
GeneWikiⁱ	Lymphocyte_antigen_96
GenomeRNAiⁱ	23643
Protein Ontology More...PROⁱ	PR:Q9Y6Y9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154589
CleanExⁱ	HS_LY96
Genevisibleⁱ	Q9Y6Y9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR014756 Ig_E-set IPR039217 LY96 IPR003172 ML_dom
PANTHERⁱ	PTHR15218 PTHR15218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02221 E1_DerP2_DerF2, 1 hit
SMARTⁱ	View protein in SMART SM00737 ML, 1 hit
SUPFAMⁱ	SSF81296 SSF81296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LY96_HUMAN
Accessionⁱ	Q9Y6Y9Primary (citable) accession number: Q9Y6Y9 Secondary accession number(s): B3Y6A5, E5RJJ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	May 18, 2010
	Last modified:	July 18, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y6Y9 (LY96_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Lymphocyte antigen 96

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endosome

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ