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Protein

SEC23-interacting protein

Gene

SEC23IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P).3 Publications

Caution

Although belonging to the PA-PL1 family, does not seem to have any phospholipase activity.Curated

GO - Molecular functioni

  • metal ion binding Source: InterPro
  • phospholipase activity Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Chemistry databases

SwissLipidsiSLP:000001071

Names & Taxonomyi

Protein namesi
Recommended name:
SEC23-interacting protein
Alternative name(s):
p125
Gene namesi
Name:SEC23IP
ORF Names:MSTP053
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107651.12
HGNCiHGNC:17018 SEC23IP
MIMi617852 gene
neXtProtiNX_Q9Y6Y8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11196
OpenTargetsiENSG00000107651
PharmGKBiPA134964657

Polymorphism and mutation databases

BioMutaiSEC23IP
DMDMi55584014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975541 – 1000SEC23-interacting proteinAdd BLAST1000

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei737PhosphoserineBy similarity1
Modified residuei926PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6Y8
PaxDbiQ9Y6Y8
PeptideAtlasiQ9Y6Y8
PRIDEiQ9Y6Y8
ProteomicsDBi86828
86829 [Q9Y6Y8-2]

PTM databases

iPTMnetiQ9Y6Y8
PhosphoSitePlusiQ9Y6Y8

Expressioni

Tissue specificityi

Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000107651 Expressed in 218 organ(s), highest expression level in stomach
CleanExiHS_SEC23IP
ExpressionAtlasiQ9Y6Y8 baseline and differential
GenevisibleiQ9Y6Y8 HS

Organism-specific databases

HPAiHPA038403
HPA043305

Interactioni

Subunit structurei

Interacts with SEC23A.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116365, 59 interactors
IntActiQ9Y6Y8, 22 interactors
STRINGi9606.ENSP00000358071

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Y8
SMRiQ9Y6Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini644 – 707SAMAdd BLAST64
Domaini779 – 989DDHDPROSITE-ProRule annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 367Interaction with SEC23A1 PublicationAdd BLAST367

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 259Pro-richAdd BLAST118

Sequence similaritiesi

Belongs to the PA-PLA1 family.Curated

Phylogenomic databases

eggNOGiKOG2308 Eukaryota
ENOG410YDSX LUCA
GeneTreeiENSGT00530000063155
HOGENOMiHOG000007725
HOVERGENiHBG057256
InParanoidiQ9Y6Y8
OMAiSCDLDVE
OrthoDBiEOG091G02T5
PhylomeDBiQ9Y6Y8
TreeFamiTF314133

Family and domain databases

CDDicd09584 SAM_sec23ip, 1 hit
InterProiView protein in InterPro
IPR004177 DDHD_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037603 SEC23IP_SAM
PfamiView protein in Pfam
PF02862 DDHD, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM01127 DDHD, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51043 DDHD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERKPNGGS GGASTSSSGT NLLFSSSATE FSFNVPFIPV TQASASPASL
60 70 80 90 100
LLPGEDSTDV GEEDSFLGQT SIHTSAPQTF SYFSQVSSSS DPFGNIGQSP
110 120 130 140 150
LTTAATSVGQ SGFPKPLTAL PFTTGSQDVS NAFSPSISKA QPGAPPSSLM
160 170 180 190 200
GINSYLPSQP SSLPPSYFGN QPQGIPQPGY NPYRHTPGSS RANPYIAPPQ
210 220 230 240 250
LQQCQTPGPP AHPPPSGPPV QMYQMPPGSL PPVPSSVQSP AQQQVPARPG
260 270 280 290 300
APSVQVPSPF LLQNQYEPVQ PHWFYCKEVE YKQLWMPFSV FDSLNLEEIY
310 320 330 340 350
NSVQPDPESV VLGTDGGRYD VYLYDRIRKA AYWEEEPAEV RRCTWFYKGD
360 370 380 390 400
TDSRFIPYTE EFSEKLEAEY KKAVTTNQWH RRLEFPSGET IVMHNPKVIV
410 420 430 440 450
QFQPSSVPDE WGTTQDGQTR PRVVKRGIDD NLDEIPDGEM PQVDHLVFVV
460 470 480 490 500
HGIGPVCDLR FRSIIECVDD FRVVSLKLLR THFKKSLDDG KVSRVEFLPV
510 520 530 540 550
HWHSSLGGDA TGVDRNIKKI TLPSIGRFRH FTNETLLDIL FYNSPTYCQT
560 570 580 590 600
IVEKVGMEIN HLHALFMSRN PDFKGGVSVA GHSLGSLILF DILSNQKDLN
610 620 630 640 650
LSKCPGPLAV ANGVVKQLHF QEKQMPEEPK LTLDESYDLV VENKEVLTLQ
660 670 680 690 700
ETLEALSLSE YFSTFEKEKI DMESLLMCTV DDLKEMGIPL GPRKKIANFV
710 720 730 740 750
EHKAAKLKKA ASEKKAVAAT STKGQEQSAQ KTKDMASLPS ESNEPKRKLP
760 770 780 790 800
VGACVSSVCV NYESFEVGAG QVSVAYNSLD FEPEIFFALG SPIAMFLTIR
810 820 830 840 850
GVDRIDENYS LPTCKGFFNI YHPLDPVAYR LEPMIVPDLD LKAVLIPHHK
860 870 880 890 900
GRKRLHLELK ESLSRMGSDL KQGFISSLKS AWQTLNEFAR AHTSSTQLQE
910 920 930 940 950
ELEKVANQIK EEEEKQVVEA EKVVESPDFS KDEDYLGKVG MLNGGRRIDY
960 970 980 990 1000
VLQEKPIESF NEYLFALQSH LCYWESEDTA LLLLKEIYRT MNISPEQPQH
Length:1,000
Mass (Da):111,076
Last modified:November 1, 1999 - v1
Checksum:iDC71C274179F2CE9
GO
Isoform 2 (identifier: Q9Y6Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     920-924: AEKVV → GKFDI
     925-1000: Missing.

Note: No experimental confirmation available.
Show »
Length:924
Mass (Da):102,187
Checksum:i06D7CC3BC6A408D9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4C4H7C4C4_HUMAN
SEC23-interacting protein
SEC23IP
153Annotation score:
H7C0V8H7C0V8_HUMAN
SEC23-interacting protein
SEC23IP
194Annotation score:
A0A0C4DH82A0A0C4DH82_HUMAN
SEC23-interacting protein
SEC23IP
486Annotation score:

Sequence cautioni

The sequence AAP35401 differs from that shown. Reason: Frameshift at position 471.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti590F → L in AAO15299 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019806644K → E2 PublicationsCorresponds to variant dbSNP:rs2475298Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011831920 – 924AEKVV → GKFDI in isoform 2. 1 Publication5
Alternative sequenceiVSP_011832925 – 1000Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019435 mRNA Translation: BAA77392.1
AF116723 mRNA Translation: AAO15299.1
CH471066 Genomic DNA Translation: EAW49372.1
CH471066 Genomic DNA Translation: EAW49373.1
BC063800 mRNA Translation: AAH63800.1
BT006755 mRNA Translation: AAP35401.1 Frameshift.
CCDSiCCDS7618.1 [Q9Y6Y8-1]
RefSeqiNP_009121.1, NM_007190.3 [Q9Y6Y8-1]
UniGeneiHs.435004

Genome annotation databases

EnsembliENST00000369075; ENSP00000358071; ENSG00000107651 [Q9Y6Y8-1]
GeneIDi11196
KEGGihsa:11196
UCSCiuc001leu.3 human [Q9Y6Y8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019435 mRNA Translation: BAA77392.1
AF116723 mRNA Translation: AAO15299.1
CH471066 Genomic DNA Translation: EAW49372.1
CH471066 Genomic DNA Translation: EAW49373.1
BC063800 mRNA Translation: AAH63800.1
BT006755 mRNA Translation: AAP35401.1 Frameshift.
CCDSiCCDS7618.1 [Q9Y6Y8-1]
RefSeqiNP_009121.1, NM_007190.3 [Q9Y6Y8-1]
UniGeneiHs.435004

3D structure databases

ProteinModelPortaliQ9Y6Y8
SMRiQ9Y6Y8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116365, 59 interactors
IntActiQ9Y6Y8, 22 interactors
STRINGi9606.ENSP00000358071

Chemistry databases

SwissLipidsiSLP:000001071

PTM databases

iPTMnetiQ9Y6Y8
PhosphoSitePlusiQ9Y6Y8

Polymorphism and mutation databases

BioMutaiSEC23IP
DMDMi55584014

Proteomic databases

EPDiQ9Y6Y8
PaxDbiQ9Y6Y8
PeptideAtlasiQ9Y6Y8
PRIDEiQ9Y6Y8
ProteomicsDBi86828
86829 [Q9Y6Y8-2]

Protocols and materials databases

DNASUi11196
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369075; ENSP00000358071; ENSG00000107651 [Q9Y6Y8-1]
GeneIDi11196
KEGGihsa:11196
UCSCiuc001leu.3 human [Q9Y6Y8-1]

Organism-specific databases

CTDi11196
DisGeNETi11196
EuPathDBiHostDB:ENSG00000107651.12
GeneCardsiSEC23IP
HGNCiHGNC:17018 SEC23IP
HPAiHPA038403
HPA043305
MIMi617852 gene
neXtProtiNX_Q9Y6Y8
OpenTargetsiENSG00000107651
PharmGKBiPA134964657
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2308 Eukaryota
ENOG410YDSX LUCA
GeneTreeiENSGT00530000063155
HOGENOMiHOG000007725
HOVERGENiHBG057256
InParanoidiQ9Y6Y8
OMAiSCDLDVE
OrthoDBiEOG091G02T5
PhylomeDBiQ9Y6Y8
TreeFamiTF314133

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRSiSEC23IP human
GeneWikiiSEC23IP
GenomeRNAii11196
PROiPR:Q9Y6Y8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107651 Expressed in 218 organ(s), highest expression level in stomach
CleanExiHS_SEC23IP
ExpressionAtlasiQ9Y6Y8 baseline and differential
GenevisibleiQ9Y6Y8 HS

Family and domain databases

CDDicd09584 SAM_sec23ip, 1 hit
InterProiView protein in InterPro
IPR004177 DDHD_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037603 SEC23IP_SAM
PfamiView protein in Pfam
PF02862 DDHD, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM01127 DDHD, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51043 DDHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS23IP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y8
Secondary accession number(s): D3DRD2, Q8IXH5, Q9BUK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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