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Entry version 171 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

SEC23-interacting protein

Gene

SEC23IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P).

3 Publications

Caution

Although belonging to the PA-PL1 family, does not seem to have any phospholipase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y6Y8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005, COPII-mediated vesicle transport

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001071

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SEC23-interacting protein
Alternative name(s):
p125
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC23IP
ORF Names:MSTP053
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17018, SEC23IP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617852, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6Y8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000107651.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11196

Open Targets

More...
OpenTargetsi
ENSG00000107651

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134964657

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6Y8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC23IP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55584014

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975541 – 1000SEC23-interacting proteinAdd BLAST1000

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei737PhosphoserineBy similarity1
Modified residuei926PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6Y8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6Y8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y6Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6Y8

PeptideAtlas

More...
PeptideAtlasi
Q9Y6Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6Y8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86828 [Q9Y6Y8-1]
86829 [Q9Y6Y8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9Y6Y8, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6Y8

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9Y6Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107651, Expressed in stomach and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6Y8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6Y8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000107651, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SEC23A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116365, 120 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y6Y8

Protein interaction database and analysis system

More...
IntActi
Q9Y6Y8, 34 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358071

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y6Y8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6Y8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini644 – 707SAMAdd BLAST64
Domaini779 – 989DDHDPROSITE-ProRule annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 367Interaction with SEC23A1 PublicationAdd BLAST367
Regioni133 – 252DisorderedSequence analysisAdd BLAST120
Regioni716 – 748DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi133 – 202Polar residuesSequence analysisAdd BLAST70
Compositional biasi203 – 234Pro residuesSequence analysisAdd BLAST32
Compositional biasi235 – 249Polar residuesSequence analysisAdd BLAST15
Compositional biasi718 – 739Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PA-PLA1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2308, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006932_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6Y8

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVKHKAV

Database of Orthologous Groups

More...
OrthoDBi
777968at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6Y8

TreeFam database of animal gene trees

More...
TreeFami
TF314133

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09584, SAM_sec23ip, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004177, DDHD_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR037603, SEC23IP_SAM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02862, DDHD, 1 hit
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01127, DDHD, 1 hit
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51043, DDHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERKPNGGS GGASTSSSGT NLLFSSSATE FSFNVPFIPV TQASASPASL
60 70 80 90 100
LLPGEDSTDV GEEDSFLGQT SIHTSAPQTF SYFSQVSSSS DPFGNIGQSP
110 120 130 140 150
LTTAATSVGQ SGFPKPLTAL PFTTGSQDVS NAFSPSISKA QPGAPPSSLM
160 170 180 190 200
GINSYLPSQP SSLPPSYFGN QPQGIPQPGY NPYRHTPGSS RANPYIAPPQ
210 220 230 240 250
LQQCQTPGPP AHPPPSGPPV QMYQMPPGSL PPVPSSVQSP AQQQVPARPG
260 270 280 290 300
APSVQVPSPF LLQNQYEPVQ PHWFYCKEVE YKQLWMPFSV FDSLNLEEIY
310 320 330 340 350
NSVQPDPESV VLGTDGGRYD VYLYDRIRKA AYWEEEPAEV RRCTWFYKGD
360 370 380 390 400
TDSRFIPYTE EFSEKLEAEY KKAVTTNQWH RRLEFPSGET IVMHNPKVIV
410 420 430 440 450
QFQPSSVPDE WGTTQDGQTR PRVVKRGIDD NLDEIPDGEM PQVDHLVFVV
460 470 480 490 500
HGIGPVCDLR FRSIIECVDD FRVVSLKLLR THFKKSLDDG KVSRVEFLPV
510 520 530 540 550
HWHSSLGGDA TGVDRNIKKI TLPSIGRFRH FTNETLLDIL FYNSPTYCQT
560 570 580 590 600
IVEKVGMEIN HLHALFMSRN PDFKGGVSVA GHSLGSLILF DILSNQKDLN
610 620 630 640 650
LSKCPGPLAV ANGVVKQLHF QEKQMPEEPK LTLDESYDLV VENKEVLTLQ
660 670 680 690 700
ETLEALSLSE YFSTFEKEKI DMESLLMCTV DDLKEMGIPL GPRKKIANFV
710 720 730 740 750
EHKAAKLKKA ASEKKAVAAT STKGQEQSAQ KTKDMASLPS ESNEPKRKLP
760 770 780 790 800
VGACVSSVCV NYESFEVGAG QVSVAYNSLD FEPEIFFALG SPIAMFLTIR
810 820 830 840 850
GVDRIDENYS LPTCKGFFNI YHPLDPVAYR LEPMIVPDLD LKAVLIPHHK
860 870 880 890 900
GRKRLHLELK ESLSRMGSDL KQGFISSLKS AWQTLNEFAR AHTSSTQLQE
910 920 930 940 950
ELEKVANQIK EEEEKQVVEA EKVVESPDFS KDEDYLGKVG MLNGGRRIDY
960 970 980 990 1000
VLQEKPIESF NEYLFALQSH LCYWESEDTA LLLLKEIYRT MNISPEQPQH
Length:1,000
Mass (Da):111,076
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC71C274179F2CE9
GO
Isoform 2 (identifier: Q9Y6Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     920-924: AEKVV → GKFDI
     925-1000: Missing.

Show »
Length:924
Mass (Da):102,187
Checksum:i06D7CC3BC6A408D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0V8H7C0V8_HUMAN
SEC23-interacting protein
SEC23IP
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4C4H7C4C4_HUMAN
SEC23-interacting protein
SEC23IP
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP35401 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti590F → L in AAO15299 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019806644K → E2 PublicationsCorresponds to variant dbSNP:rs2475298Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011831920 – 924AEKVV → GKFDI in isoform 2. 1 Publication5
Alternative sequenceiVSP_011832925 – 1000Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019435 mRNA Translation: BAA77392.1
AF116723 mRNA Translation: AAO15299.1
CH471066 Genomic DNA Translation: EAW49372.1
CH471066 Genomic DNA Translation: EAW49373.1
BC063800 mRNA Translation: AAH63800.1
BT006755 mRNA Translation: AAP35401.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7618.1 [Q9Y6Y8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_009121.1, NM_007190.3 [Q9Y6Y8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369075; ENSP00000358071; ENSG00000107651 [Q9Y6Y8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11196

UCSC genome browser

More...
UCSCi
uc001leu.3, human [Q9Y6Y8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019435 mRNA Translation: BAA77392.1
AF116723 mRNA Translation: AAO15299.1
CH471066 Genomic DNA Translation: EAW49372.1
CH471066 Genomic DNA Translation: EAW49373.1
BC063800 mRNA Translation: AAH63800.1
BT006755 mRNA Translation: AAP35401.1 Frameshift.
CCDSiCCDS7618.1 [Q9Y6Y8-1]
RefSeqiNP_009121.1, NM_007190.3 [Q9Y6Y8-1]

3D structure databases

SMRiQ9Y6Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116365, 120 interactors
CORUMiQ9Y6Y8
IntActiQ9Y6Y8, 34 interactors
STRINGi9606.ENSP00000358071

Chemistry databases

SwissLipidsiSLP:000001071

PTM databases

GlyGeniQ9Y6Y8, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ9Y6Y8
MetOSiteiQ9Y6Y8
PhosphoSitePlusiQ9Y6Y8

Genetic variation databases

BioMutaiSEC23IP
DMDMi55584014

Proteomic databases

EPDiQ9Y6Y8
jPOSTiQ9Y6Y8
MassIVEiQ9Y6Y8
PaxDbiQ9Y6Y8
PeptideAtlasiQ9Y6Y8
PRIDEiQ9Y6Y8
ProteomicsDBi86828 [Q9Y6Y8-1]
86829 [Q9Y6Y8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32172, 184 antibodies

The DNASU plasmid repository

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DNASUi
11196

Genome annotation databases

EnsembliENST00000369075; ENSP00000358071; ENSG00000107651 [Q9Y6Y8-1]
GeneIDi11196
KEGGihsa:11196
UCSCiuc001leu.3, human [Q9Y6Y8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11196
DisGeNETi11196

GeneCards: human genes, protein and diseases

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GeneCardsi
SEC23IP
HGNCiHGNC:17018, SEC23IP
HPAiENSG00000107651, Low tissue specificity
MIMi617852, gene
neXtProtiNX_Q9Y6Y8
OpenTargetsiENSG00000107651
PharmGKBiPA134964657
VEuPathDBiHostDB:ENSG00000107651.12

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2308, Eukaryota
GeneTreeiENSGT00940000156602
HOGENOMiCLU_006932_4_0_1
InParanoidiQ9Y6Y8
OMAiFVKHKAV
OrthoDBi777968at2759
PhylomeDBiQ9Y6Y8
TreeFamiTF314133

Enzyme and pathway databases

PathwayCommonsiQ9Y6Y8
ReactomeiR-HSA-204005, COPII-mediated vesicle transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11196, 32 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEC23IP, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEC23IP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11196
PharosiQ9Y6Y8, Tbio

Protein Ontology

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PROi
PR:Q9Y6Y8
RNActiQ9Y6Y8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107651, Expressed in stomach and 229 other tissues
ExpressionAtlasiQ9Y6Y8, baseline and differential
GenevisibleiQ9Y6Y8, HS

Family and domain databases

CDDicd09584, SAM_sec23ip, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR004177, DDHD_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR037603, SEC23IP_SAM
PfamiView protein in Pfam
PF02862, DDHD, 1 hit
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM01127, DDHD, 1 hit
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51043, DDHD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS23IP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6Y8
Secondary accession number(s): D3DRD2, Q8IXH5, Q9BUK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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