Calmodulin-binding transcription activator 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SBInferred from sequence modelⁱ
  • 19274049
• sequence-specific DNA binding Source: GO_Central
• transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• neuromuscular process controlling balance Source: Ensembl
• positive regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23853098
• positive regulation of protein dephosphorylation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23853098
• positive regulation of transcription by RNA polymerase II Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseaseⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK 
        60         70         80         90        100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT 
       110        120        130        140        150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG 
       160        170        180        190        200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN 
       210        220        230        240        250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS 
       260        270        280        290        300
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH 
       310        320        330        340        350
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE 
       360        370        380        390        400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF 
       410        420        430        440        450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS 
       460        470        480        490        500
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG 
       510        520        530        540        550
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS 
       560        570        580        590        600
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS 
       610        620        630        640        650
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE 
       660        670        680        690        700
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG 
       710        720        730        740        750
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP 
       760        770        780        790        800
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS 
       810        820        830        840        850
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE 
       860        870        880        890        900
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN 
       910        920        930        940        950
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF 
       960        970        980        990       1000
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK 
      1010       1020       1030       1040       1050
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC 
      1060       1070       1080       1090       1100
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE 
      1110       1120       1130       1140       1150
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI 
      1160       1170       1180       1190       1200
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE 
      1210       1220       1230       1240       1250
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP 
      1260       1270       1280       1290       1300
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL 
      1310       1320       1330       1340       1350
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP 
      1360       1370       1380       1390       1400
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL 
      1410       1420       1430       1440       1450
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL 
      1460       1470       1480       1490       1500
PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS 
      1510       1520       1530       1540       1550
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA 
      1560       1570       1580       1590       1600
AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI 
      1610       1620       1630       1640       1650
QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC 
      1660       1670 
RHSPLVDHRL YKRSERIEKG QGT                              

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK 
        60         70         80         90        100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT 
       110        120        130        140        150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG 
       160        170        180        190        200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN 
       210        220        230        240        250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS 
       260        270        280        290        300
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH 
       310        320        330        340        350
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE 
       360        370        380        390        400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF 
       410        420        430        440        450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS 
       460        470        480        490        500
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG 
       510        520        530        540        550
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS 
       560        570        580        590        600
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS 
       610        620        630        640        650
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE 
       660        670        680        690        700
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG 
       710        720        730        740        750
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP 
       760        770        780        790        800
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS 
       810        820        830        840        850
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE 
       860        870        880        890        900
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN 
       910        920        930        940        950
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF 
       960        970        980        990       1000
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK 
      1010       1020       1030       1040       1050
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC 
      1060       1070       1080       1090       1100
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE 
      1110       1120       1130       1140       1150
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI 
      1160       1170       1180       1190       1200
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE 
      1210       1220       1230       1240       1250
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP 
      1260       1270       1280       1290       1300
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL 
      1310       1320       1330       1340       1350
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP 
      1360       1370       1380       1390       1400
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL 
      1410       1420       1430       1440       1450
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL 
      1460       1470       1480       1490       1500
PSAAQIRLSP VGSPVSEIAF EKPNLPSAAD WSEFLSASTS EKVENEFAQL 
      1510       1520       1530       1540       1550
TLSDHEQREL YEAARLVQTA FRKYKGRPLR EQQEVAAAVI QRCYRKYKQY 
      1560       1570       1580       1590       1600
ALYKKMTQAA ILIQSKFRSY YEQKKFQQSR RAAVLIQKYY RSYKKCGKRR 
      1610       1620       1630       1640       1650
QARRTAVIVQ QKLRSSLLTK KQDQAARKIM RFLRRCRHRV KELKKAKELE 

DIQQHPLAM                                              

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK 
        60         70         80
IFLPKKLLEC LPKCSSLPKE RHRWNTNERS                       

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK 
        60         70         80         90        100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEAL TTHLFMGAAK KRDPQSWSHE 

G                                                      

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families