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UniProtKB - Q9Y6Y1 (CMTA1_HUMAN)

Entry version 170 (25 May 2022)
Sequence version 4 (16 May 2006)
Previous versions | rss
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Protein

Calmodulin-binding transcription activator 1

Gene

CAMTA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator.

1 Publication

Miscellaneous

A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi63 – 188CG-1PROSITE-ProRule annotationAdd BLAST126

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y6Y1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y6Y1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y6Y1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMTA1Imported
Synonyms:KIAA0833Imported
ORF Names:MSTP023Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18806, CAMTA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611501, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y6Y1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000171735

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebellar ataxia, non-progressive, with mental retardation (CANPMR)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurodevelopmental disorder characterized by mildly delayed psychomotor development, early onset of cerebellar ataxia, and intellectual disability later in childhood and adult life. Other features may include neonatal hypotonia, dysarthria, and dysmetria. Brain imaging in some patients shows cerebellar atrophy. Dysmorphic facial features are variable.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		23261

MalaCards human disease database

More...MalaCardsi		CAMTA1
MIMi614756, phenotype

Open Targets

More...OpenTargetsi		ENSG00000171735

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		157791, Epithelioid hemangioendothelioma
314647, Non-progressive cerebellar ataxia with intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38688

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y6Y1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAMTA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		97046872

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358201 – 1673Calmodulin-binding transcription activator 1Add BLAST1673

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y6Y1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y6Y1

PeptideAtlas

More...PeptideAtlasi		Q9Y6Y1

PRoteomics IDEntifications database

More...PRIDEi		Q9Y6Y1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86825 [Q9Y6Y1-1]
86826 [Q9Y6Y1-2]
86827 [Q9Y6Y1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y6Y1, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y6Y1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y6Y1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Detected at low levels at interphase and in resting cells. Up-regulated during S phase and mitosis. Levels decrease at the end of mitosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171735, Expressed in caudate nucleus and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y6Y1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y6Y1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171735, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with calmodulin.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116863, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y6Y1, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306522

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y6Y1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y6Y1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y6Y1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y6Y1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini875 – 953IPT/TIGCombined sourcesAdd BLAST79
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1064 – 1093ANK 1Add BLAST30
Repeati1109 – 1129ANK 2Add BLAST21
Repeati1143 – 1172ANK 3Add BLAST30
Domaini1547 – 1576IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1577 – 1599IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini1600 – 1622IQ 3PROSITE-ProRule annotationAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni283 – 375DisorderedSequence analysisAdd BLAST93
Regioni990 – 1021DisorderedSequence analysisAdd BLAST32
Regioni1215 – 1246DisorderedSequence analysisAdd BLAST32
Regioni1264 – 1317DisorderedSequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi112 – 119Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi305 – 331Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi337 – 370Polar residuesSequence analysisAdd BLAST34
Compositional biasi991 – 1021Polar residuesSequence analysisAdd BLAST31
Compositional biasi1222 – 1236Polar residuesSequence analysisAdd BLAST15
Compositional biasi1269 – 1288Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0520, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003170_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y6Y1

Identification of Orthologs from Complete Genome Data

More...OMAi		CSPQQGG

Database of Orthologous Groups

More...OrthoDBi		315169at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y6Y1

TreeFam database of animal gene trees

More...TreeFami		TF323452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR039033, Camta1
IPR005559, CG-1_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR23335:SF11, PTHR23335:SF11, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03859, CG-1, 1 hit
PF00612, IQ, 1 hit
PF01833, TIG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01076, CG-1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS51437, CG_1, 1 hit
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK 
        60         70         80         90        100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT 
       110        120        130        140        150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG 
       160        170        180        190        200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN 
       210        220        230        240        250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS 
       260        270        280        290        300
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH 
       310        320        330        340        350
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE 
       360        370        380        390        400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF 
       410        420        430        440        450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS 
       460        470        480        490        500
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG 
       510        520        530        540        550
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS 
       560        570        580        590        600
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS 
       610        620        630        640        650
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE 
       660        670        680        690        700
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG 
       710        720        730        740        750
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP 
       760        770        780        790        800
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS 
       810        820        830        840        850
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE 
       860        870        880        890        900
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN 
       910        920        930        940        950
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF 
       960        970        980        990       1000
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK 
      1010       1020       1030       1040       1050
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC 
      1060       1070       1080       1090       1100
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE 
      1110       1120       1130       1140       1150
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI 
      1160       1170       1180       1190       1200
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE 
      1210       1220       1230       1240       1250
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP 
      1260       1270       1280       1290       1300
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL 
      1310       1320       1330       1340       1350
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP 
      1360       1370       1380       1390       1400
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL 
      1410       1420       1430       1440       1450
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL 
      1460       1470       1480       1490       1500
PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS 
      1510       1520       1530       1540       1550
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA 
      1560       1570       1580       1590       1600
AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI 
      1610       1620       1630       1640       1650
QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC 
      1660       1670 
RHSPLVDHRL YKRSERIEKG QGT
Length:1,673
Mass (Da):183,672
Last modified:May 16, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i008AA6A906374C00
GO
Isoform 2 (identifier: Q9Y6Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1458-1471: Missing.
     1653-1673: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Show »
Length:1,659
Mass (Da):182,257
Checksum:iE03DDA09EEB25873
GO
Isoform 3 (identifier: Q9Y6Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-80: EI → RS
     81-1673: Missing.

Show »
Length:80
Mass (Da):9,173
Checksum:i4745CB6B383AB10A
GO
Isoform 4 (identifier: Q9Y6Y1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: EIAAYLITFEKHEEWLTTSPKTR → ALTTHLFMGAAKKRDPQSWSHEG
     102-1673: Missing.

Show »
Length:101
Mass (Da):11,480
Checksum:iDF1CD8DF69AAE9E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJK7H0YJK7_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
637Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJR7H0YJR7_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGL0A0A0C4DGL0_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V297G3V297_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJY7H0YJY7_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJG5H0YJG5_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJV1H0YJV1_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39006 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA74856 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence EAW71580 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0478241177N → K1 PublicationCorresponds to variant dbSNP:rs41278952EnsemblClinVar.1
Natural variantiVAR_0478251218N → T1 PublicationCorresponds to variant dbSNP:rs41278954EnsemblClinVar.1
Natural variantiVAR_0478261336T → I1 PublicationCorresponds to variant dbSNP:rs137974312EnsemblClinVar.1
Natural variantiVAR_0850431473S → T Found in patients with late onset progressive myoclonus epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776553769Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04635879 – 101EIAAY…SPKTR → ALTTHLFMGAAKKRDPQSWS HEG in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_04384279 – 80EI → RS in isoform 3. 2 Publications2
Alternative sequenceiVSP_04384381 – 1673Missing in isoform 3. 2 PublicationsAdd BLAST1593
Alternative sequenceiVSP_046359102 – 1673Missing in isoform 4. 1 PublicationAdd BLAST1572
Alternative sequenceiVSP_0359361458 – 1471Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0359371653 – 1673SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020640 mRNA Translation: BAA74856.3 Different initiation.
AY037153 mRNA Translation: AAK67633.1
AL359881 Genomic DNA No translation available.
AL365194 Genomic DNA No translation available.
AL590128 Genomic DNA No translation available.
AL596210 Genomic DNA No translation available.
Z97635 Genomic DNA No translation available.
Z98052 Genomic DNA No translation available.
Z98884 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71580.1 Sequence problems.
BC116457 mRNA Translation: AAI16458.1
BC151835 mRNA Translation: AAI51836.1
CD103791 mRNA No translation available.
AF111804 mRNA Translation: AAL39006.1 Different initiation.
AY349360 mRNA Translation: AAQ56724.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30576.1 [Q9Y6Y1-1]
CCDS55574.1 [Q9Y6Y1-3]
CCDS55575.1 [Q9Y6Y1-4]

NCBI Reference Sequences

More...RefSeqi		NP_001182492.1, NM_001195563.1 [Q9Y6Y1-3]
NP_001229630.1, NM_001242701.1 [Q9Y6Y1-4]
NP_056030.1, NM_015215.3 [Q9Y6Y1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303635.12; ENSP00000306522.6; ENSG00000171735.19
ENST00000473578.5; ENSP00000451388.1; ENSG00000171735.19 [Q9Y6Y1-3]
ENST00000557126.5; ENSP00000451510.1; ENSG00000171735.19 [Q9Y6Y1-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23261

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000303635.12; ENSP00000306522.6; NM_015215.4; NP_056030.1

UCSC genome browser

More...UCSCi		uc001aoh.4, human [Q9Y6Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020640 mRNA Translation: BAA74856.3 Different initiation.
AY037153 mRNA Translation: AAK67633.1
AL359881 Genomic DNA No translation available.
AL365194 Genomic DNA No translation available.
AL590128 Genomic DNA No translation available.
AL596210 Genomic DNA No translation available.
Z97635 Genomic DNA No translation available.
Z98052 Genomic DNA No translation available.
Z98884 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71580.1 Sequence problems.
BC116457 mRNA Translation: AAI16458.1
BC151835 mRNA Translation: AAI51836.1
CD103791 mRNA No translation available.
AF111804 mRNA Translation: AAL39006.1 Different initiation.
AY349360 mRNA Translation: AAQ56724.1
CCDSiCCDS30576.1 [Q9Y6Y1-1]
CCDS55574.1 [Q9Y6Y1-3]
CCDS55575.1 [Q9Y6Y1-4]
RefSeqiNP_001182492.1, NM_001195563.1 [Q9Y6Y1-3]
NP_001229630.1, NM_001242701.1 [Q9Y6Y1-4]
NP_056030.1, NM_015215.3 [Q9Y6Y1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]
AlphaFoldDBiQ9Y6Y1
SMRiQ9Y6Y1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116863, 8 interactors
IntActiQ9Y6Y1, 5 interactors
STRINGi9606.ENSP00000306522

PTM databases

GlyGeniQ9Y6Y1, 1 site
iPTMnetiQ9Y6Y1
PhosphoSitePlusiQ9Y6Y1

Genetic variation databases

BioMutaiCAMTA1
DMDMi97046872

Proteomic databases

MassIVEiQ9Y6Y1
PaxDbiQ9Y6Y1
PeptideAtlasiQ9Y6Y1
PRIDEiQ9Y6Y1
ProteomicsDBi86825 [Q9Y6Y1-1]
86826 [Q9Y6Y1-2]
86827 [Q9Y6Y1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49059, 69 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		23261

Genome annotation databases

EnsembliENST00000303635.12; ENSP00000306522.6; ENSG00000171735.19
ENST00000473578.5; ENSP00000451388.1; ENSG00000171735.19 [Q9Y6Y1-3]
ENST00000557126.5; ENSP00000451510.1; ENSG00000171735.19 [Q9Y6Y1-4]
GeneIDi23261
KEGGihsa:23261
MANE-SelectiENST00000303635.12; ENSP00000306522.6; NM_015215.4; NP_056030.1
UCSCiuc001aoh.4, human [Q9Y6Y1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23261
DisGeNETi23261

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAMTA1
HGNCiHGNC:18806, CAMTA1
HPAiENSG00000171735, Low tissue specificity
MalaCardsiCAMTA1
MIMi611501, gene
614756, phenotype
neXtProtiNX_Q9Y6Y1
OpenTargetsiENSG00000171735
Orphaneti157791, Epithelioid hemangioendothelioma
314647, Non-progressive cerebellar ataxia with intellectual disability
PharmGKBiPA38688
VEuPathDBiHostDB:ENSG00000171735

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0520, Eukaryota
GeneTreeiENSGT00940000155203
HOGENOMiCLU_003170_1_0_1
InParanoidiQ9Y6Y1
OMAiCSPQQGG
OrthoDBi315169at2759
PhylomeDBiQ9Y6Y1
TreeFamiTF323452

Enzyme and pathway databases

PathwayCommonsiQ9Y6Y1
SignaLinkiQ9Y6Y1
SIGNORiQ9Y6Y1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23261, 7 hits in 1099 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAMTA1, human
EvolutionaryTraceiQ9Y6Y1

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CAMTA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23261
PharosiQ9Y6Y1, Tbio

Protein Ontology

More...PROi		PR:Q9Y6Y1
RNActiQ9Y6Y1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171735, Expressed in caudate nucleus and 233 other tissues
ExpressionAtlasiQ9Y6Y1, baseline and differential
GenevisibleiQ9Y6Y1, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR039033, Camta1
IPR005559, CG-1_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase
PANTHERiPTHR23335:SF11, PTHR23335:SF11, 1 hit
PfamiView protein in Pfam
PF03859, CG-1, 1 hit
PF00612, IQ, 1 hit
PF01833, TIG, 1 hit
SMARTiView protein in SMART
SM01076, CG-1, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS51437, CG_1, 1 hit
PS50096, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6Y1
Secondary accession number(s): A7MBM4
, G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 25, 2022
This is version 170 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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