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Entry version 154 (13 Feb 2019)
Sequence version 4 (16 May 2006)
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Protein

Calmodulin-binding transcription activator 1

Gene

CAMTA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator. May act as a tumor suppressor.2 Publications

Miscellaneous

A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi63 – 188CG-1PROSITE-ProRule annotationAdd BLAST126

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMTA1
Synonyms:KIAA0833
ORF Names:MSTP023
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171735.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18806 CAMTA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611501 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6Y1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebellar ataxia, non-progressive, with mental retardation (CANPMR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodevelopmental disorder characterized by mildly delayed psychomotor development, early onset of cerebellar ataxia, and intellectual disability later in childhood and adult life. Other features may include neonatal hypotonia, dysarthria, and dysmetria. Brain imaging in some patients shows cerebellar atrophy. Dysmorphic facial features are variable.
See also OMIM:614756

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
23261

MalaCards human disease database

More...
MalaCardsi
CAMTA1
MIMi614756 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000171735

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
157791 Epithelioid hemangioendothelioma
314647 Non-progressive cerebellar ataxia with intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38688

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAMTA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97046872

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358201 – 1673Calmodulin-binding transcription activator 1Add BLAST1673

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6Y1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6Y1

PeptideAtlas

More...
PeptideAtlasi
Q9Y6Y1

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6Y1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86825
86826 [Q9Y6Y1-2]
86827 [Q9Y6Y1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6Y1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6Y1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Detected at low levels at interphase and in resting cells. Up-regulated during S phase and mitosis. Levels decrease at the end of mitosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171735 Expressed in 218 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6Y1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6Y1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036342
HPA036343

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with calmodulin.Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116863, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y6Y1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306522

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y6Y1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y6Y1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y6Y1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini873 – 953IPT/TIGAdd BLAST81
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1064 – 1093ANK 1Add BLAST30
Repeati1109 – 1129ANK 2Add BLAST21
Repeati1143 – 1172ANK 3Add BLAST30
Domaini1547 – 1576IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1577 – 1599IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini1600 – 1622IQ 3PROSITE-ProRule annotationAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi112 – 119Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi499 – 502Poly-Gly4
Compositional biasi1038 – 1041Poly-Val4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0520 Eukaryota
ENOG410XS5M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111813

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080107

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6Y1

KEGG Orthology (KO)

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KOi
K21596

Identification of Orthologs from Complete Genome Data

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OMAi
CSSEHYL

Database of Orthologous Groups

More...
OrthoDBi
315169at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6Y1

TreeFam database of animal gene trees

More...
TreeFami
TF323452

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039033 Camta1
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR23335:SF11 PTHR23335:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03859 CG-1, 1 hit
PF00612 IQ, 1 hit
PF01833 TIG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01076 CG-1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK
60 70 80 90 100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT
110 120 130 140 150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG
160 170 180 190 200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN
210 220 230 240 250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS
260 270 280 290 300
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH
310 320 330 340 350
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE
360 370 380 390 400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF
410 420 430 440 450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS
460 470 480 490 500
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG
510 520 530 540 550
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS
560 570 580 590 600
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS
610 620 630 640 650
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE
660 670 680 690 700
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG
710 720 730 740 750
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP
760 770 780 790 800
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS
810 820 830 840 850
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE
860 870 880 890 900
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN
910 920 930 940 950
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF
960 970 980 990 1000
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK
1010 1020 1030 1040 1050
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC
1060 1070 1080 1090 1100
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE
1110 1120 1130 1140 1150
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI
1160 1170 1180 1190 1200
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE
1210 1220 1230 1240 1250
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP
1260 1270 1280 1290 1300
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL
1310 1320 1330 1340 1350
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP
1360 1370 1380 1390 1400
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL
1410 1420 1430 1440 1450
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL
1460 1470 1480 1490 1500
PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS
1510 1520 1530 1540 1550
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA
1560 1570 1580 1590 1600
AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI
1610 1620 1630 1640 1650
QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC
1660 1670
RHSPLVDHRL YKRSERIEKG QGT
Length:1,673
Mass (Da):183,672
Last modified:May 16, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i008AA6A906374C00
GO
Isoform 2 (identifier: Q9Y6Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1458-1471: Missing.
     1653-1673: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Show »
Length:1,659
Mass (Da):182,257
Checksum:iE03DDA09EEB25873
GO
Isoform 3 (identifier: Q9Y6Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-80: EI → RS
     81-1673: Missing.

Note: No experimental confirmation available.
Show »
Length:80
Mass (Da):9,173
Checksum:i4745CB6B383AB10A
GO
Isoform 4 (identifier: Q9Y6Y1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: EIAAYLITFEKHEEWLTTSPKTR → ALTTHLFMGAAKKRDPQSWSHEG
     102-1673: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,480
Checksum:iDF1CD8DF69AAE9E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJK7H0YJK7_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
637Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGL0A0A0C4DGL0_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJR7H0YJR7_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJG5H0YJG5_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V297G3V297_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJV1H0YJV1_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJY7H0YJY7_HUMAN
Calmodulin-binding transcription ac...
CAMTA1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39006 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA74856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW71580 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0478241177N → K1 PublicationCorresponds to variant dbSNP:rs41278952EnsemblClinVar.1
Natural variantiVAR_0478251218N → T1 PublicationCorresponds to variant dbSNP:rs41278954Ensembl.1
Natural variantiVAR_0478261336T → I1 PublicationCorresponds to variant dbSNP:rs137974312Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04635879 – 101EIAAY…SPKTR → ALTTHLFMGAAKKRDPQSWS HEG in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_04384279 – 80EI → RS in isoform 3. 2 Publications2
Alternative sequenceiVSP_04384381 – 1673Missing in isoform 3. 2 PublicationsAdd BLAST1593
Alternative sequenceiVSP_046359102 – 1673Missing in isoform 4. 1 PublicationAdd BLAST1572
Alternative sequenceiVSP_0359361458 – 1471Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0359371653 – 1673SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020640 mRNA Translation: BAA74856.3 Different initiation.
AY037153 mRNA Translation: AAK67633.1
AL359881 Genomic DNA No translation available.
AL365194 Genomic DNA No translation available.
AL590128 Genomic DNA No translation available.
AL596210 Genomic DNA No translation available.
Z97635 Genomic DNA No translation available.
Z98052 Genomic DNA No translation available.
Z98884 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71580.1 Sequence problems.
BC116457 mRNA Translation: AAI16458.1
BC151835 mRNA Translation: AAI51836.1
CD103791 mRNA No translation available.
AF111804 mRNA Translation: AAL39006.1 Different initiation.
AY349360 mRNA Translation: AAQ56724.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30576.1 [Q9Y6Y1-1]
CCDS55574.1 [Q9Y6Y1-3]
CCDS55575.1 [Q9Y6Y1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001182492.1, NM_001195563.1 [Q9Y6Y1-3]
NP_001229630.1, NM_001242701.1 [Q9Y6Y1-4]
NP_056030.1, NM_015215.3 [Q9Y6Y1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.397705
Hs.671020

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303635; ENSP00000306522; ENSG00000171735 [Q9Y6Y1-1]
ENST00000473578; ENSP00000451388; ENSG00000171735 [Q9Y6Y1-3]
ENST00000557126; ENSP00000451510; ENSG00000171735 [Q9Y6Y1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23261

UCSC genome browser

More...
UCSCi
uc001aoh.4 human [Q9Y6Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020640 mRNA Translation: BAA74856.3 Different initiation.
AY037153 mRNA Translation: AAK67633.1
AL359881 Genomic DNA No translation available.
AL365194 Genomic DNA No translation available.
AL590128 Genomic DNA No translation available.
AL596210 Genomic DNA No translation available.
Z97635 Genomic DNA No translation available.
Z98052 Genomic DNA No translation available.
Z98884 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71580.1 Sequence problems.
BC116457 mRNA Translation: AAI16458.1
BC151835 mRNA Translation: AAI51836.1
CD103791 mRNA No translation available.
AF111804 mRNA Translation: AAL39006.1 Different initiation.
AY349360 mRNA Translation: AAQ56724.1
CCDSiCCDS30576.1 [Q9Y6Y1-1]
CCDS55574.1 [Q9Y6Y1-3]
CCDS55575.1 [Q9Y6Y1-4]
RefSeqiNP_001182492.1, NM_001195563.1 [Q9Y6Y1-3]
NP_001229630.1, NM_001242701.1 [Q9Y6Y1-4]
NP_056030.1, NM_015215.3 [Q9Y6Y1-1]
UniGeneiHs.397705
Hs.671020

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]
ProteinModelPortaliQ9Y6Y1
SMRiQ9Y6Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116863, 4 interactors
IntActiQ9Y6Y1, 1 interactor
STRINGi9606.ENSP00000306522

PTM databases

iPTMnetiQ9Y6Y1
PhosphoSitePlusiQ9Y6Y1

Polymorphism and mutation databases

BioMutaiCAMTA1
DMDMi97046872

Proteomic databases

jPOSTiQ9Y6Y1
PaxDbiQ9Y6Y1
PeptideAtlasiQ9Y6Y1
PRIDEiQ9Y6Y1
ProteomicsDBi86825
86826 [Q9Y6Y1-2]
86827 [Q9Y6Y1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303635; ENSP00000306522; ENSG00000171735 [Q9Y6Y1-1]
ENST00000473578; ENSP00000451388; ENSG00000171735 [Q9Y6Y1-3]
ENST00000557126; ENSP00000451510; ENSG00000171735 [Q9Y6Y1-4]
GeneIDi23261
KEGGihsa:23261
UCSCiuc001aoh.4 human [Q9Y6Y1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23261
DisGeNETi23261
EuPathDBiHostDB:ENSG00000171735.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAMTA1
HGNCiHGNC:18806 CAMTA1
HPAiHPA036342
HPA036343
MalaCardsiCAMTA1
MIMi611501 gene
614756 phenotype
neXtProtiNX_Q9Y6Y1
OpenTargetsiENSG00000171735
Orphaneti157791 Epithelioid hemangioendothelioma
314647 Non-progressive cerebellar ataxia with intellectual disability
PharmGKBiPA38688

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00940000155203
HOGENOMiHOG000111813
HOVERGENiHBG080107
InParanoidiQ9Y6Y1
KOiK21596
OMAiCSSEHYL
OrthoDBi315169at2759
PhylomeDBiQ9Y6Y1
TreeFamiTF323452

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAMTA1 human
EvolutionaryTraceiQ9Y6Y1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CAMTA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23261

Protein Ontology

More...
PROi
PR:Q9Y6Y1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171735 Expressed in 218 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9Y6Y1 baseline and differential
GenevisibleiQ9Y6Y1 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039033 Camta1
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PANTHERiPTHR23335:SF11 PTHR23335:SF11, 1 hit
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF00612 IQ, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6Y1
Secondary accession number(s): A7MBM4
, G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 13, 2019
This is version 154 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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