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Protein

Influenza virus NS1A-binding protein

Gene

IVNS1ABP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).By similarity3 Publications
(Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.2 Publications

GO - Biological processi

  • negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  • negative regulation of protein ubiquitination Source: UniProtKB
  • response to virus Source: UniProtKB
  • RNA splicing Source: UniProtKB
  • transcription by RNA polymerase III Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Influenza virus NS1A-binding protein
Short name:
NS1-BP
Short name:
NS1-binding protein1 Publication
Alternative name(s):
Aryl hydrocarbon receptor-associated protein 31 Publication
Kelch-like protein 391 Publication
Gene namesi
Name:IVNS1ABPImported
Synonyms:ARA3, FLARA3, KIAA0850, KLHL391 Publication, NS1, NS1BP
ORF Names:HSPC068
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116679.15
HGNCiHGNC:16951 IVNS1ABP
MIMi609209 gene
neXtProtiNX_Q9Y6Y0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi198V → M: Significant inhibition of interaction with AHR; partial decrease of AHR signaling induced by IVNS1ABP. 1 Publication1
Mutagenesisi288E → K: Significant inhibition of interaction with AHR; partial decrease of AHR signaling induced by IVNS1ABP. 1 Publication1

Organism-specific databases

DisGeNETi10625
OpenTargetsiENSG00000116679
PharmGKBiPA134875300

Polymorphism and mutation databases

BioMutaiIVNS1ABP
DMDMi146325015

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850771 – 642Influenza virus NS1A-binding proteinAdd BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6Y0
MaxQBiQ9Y6Y0
PaxDbiQ9Y6Y0
PeptideAtlasiQ9Y6Y0
PRIDEiQ9Y6Y0
ProteomicsDBi86824

PTM databases

iPTMnetiQ9Y6Y0
PhosphoSitePlusiQ9Y6Y0

Expressioni

Gene expression databases

BgeeiENSG00000116679 Expressed in 236 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_IVNS1ABP
ExpressionAtlasiQ9Y6Y0 baseline and differential
GenevisibleiQ9Y6Y0 HS

Organism-specific databases

HPAiHPA003405

Interactioni

Subunit structurei

Homodimer; through the BTB domain (By similarity). Interacts with AHR/Aryl hydrocarbon receptor (PubMed:16582008). Interacts with HNRNPK (PubMed:23825951). Interacts (via kelch repeats) with KLHL20 (via kelch repeats); this interaction blocks the assembly of Cul3-KLHL20 complex (PubMed:25619834).By similarity3 Publications
(Microbial infection) Interacts with influenza A virus non-structural protein 1/NS (PubMed:9696811).1 Publication

Protein-protein interaction databases

BioGridi115869, 89 interactors
IntActiQ9Y6Y0, 22 interactors
STRINGi9606.ENSP00000356468

Structurei

Secondary structure

1642
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6Y0
SMRiQ9Y6Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 99BTBPROSITE-ProRule annotationAdd BLAST68
Domaini134 – 233BACKAdd BLAST100
Repeati369 – 415Kelch 1Add BLAST47
Repeati416 – 463Kelch 2Add BLAST48
Repeati465 – 512Kelch 3Add BLAST48
Repeati513 – 559Kelch 4Add BLAST47
Repeati560 – 606Kelch 5Add BLAST47
Repeati608 – 642Kelch 6Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 368Sufficient for AHR interaction and signalingAdd BLAST205

Domaini

When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.1 Publication

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOVERGENiHBG082407
InParanoidiQ9Y6Y0
KOiK15046
OMAiPESNEWS
OrthoDBiEOG091G024F
PhylomeDBiQ9Y6Y0
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029849 NS1BP
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24411:SF7 PTHR24411:SF7, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y6Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL
60 70 80 90 100
ACCSPYLFEI FNSDSDPHGI SHVKFDDLNP EAVEVLLNYA YTAQLKADKE
110 120 130 140 150
LVKDVYSAAK KLKMDRVKQV CGDYLLSRMD VTSCISYRNF ASCMGDSRLL
160 170 180 190 200
NKVDAYIQEH LLQISEEEEF LKLPRLKLEV MLEDNVCLPS NGKLYTKVIN
210 220 230 240 250
WVQRSIWENG DSLEELMEEV QTLYYSADHK LLDGNLLDGQ AEVFGSDDDH
260 270 280 290 300
IQFVQKKPPR ENGHKQISSS STGCLSSPNA TVQSPKHEWK IVASEKTSNN
310 320 330 340 350
TYLCLAVLDG IFCVIFLHGR NSPQSSPTST PKLSKSLSFE MQQDELIEKP
360 370 380 390 400
MSPMQYARSG LGTAEMNGKL IAAGGYNREE CLRTVECYNP HTDHWSFLAP
410 420 430 440 450
MRTPRARFQM AVLMGQLYVV GGSNGHSDDL SCGEMYDSNI DDWIPVPELR
460 470 480 490 500
TNRCNAGVCA LNGKLYIVGG SDPYGQKGLK NCDVFDPVTK LWTSCAPLNI
510 520 530 540 550
RRHQSAVCEL GGYLYIIGGA ESWNCLNTVE RYNPENNTWT LIAPMNVARR
560 570 580 590 600
GAGVAVLNGK LFVCGGFDGS HAISCVEMYD PTRNEWKMMG NMTSPRSNAG
610 620 630 640
IATVGNTIYA VGGFDGNEFL NTVEVYNLES NEWSPYTKIF QF
Length:642
Mass (Da):71,729
Last modified:May 1, 2007 - v3
Checksum:i456E30DC4E351CCD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R674X6R674_HUMAN
Influenza virus NS1A-binding protei...
IVNS1ABP
135Annotation score:
H0Y5Y2H0Y5Y2_HUMAN
Influenza virus NS1A-binding protei...
IVNS1ABP
117Annotation score:

Sequence cautioni

The sequence AAF29040 differs from that shown. Reason: Frameshift at positions 100 and 102.Curated
The sequence BAA74873 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA10029 differs from that shown. Reason: Frameshift at position 612.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111K → E in CAA10029 (PubMed:9696811).Curated1
Sequence conflicti148R → H in CAA10029 (PubMed:9696811).Curated1
Sequence conflicti218E → G in AAH67739 (PubMed:15489334).Curated1
Sequence conflicti579Y → H in ABE03889 (PubMed:16582008).Curated1
Sequence conflicti579Y → H in ABE03890 (PubMed:16582008).Curated1
Sequence conflicti591N → H in CAA10029 (PubMed:9696811).Curated1
Sequence conflicti623V → A in CAA10029 (PubMed:9696811).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012449 mRNA Translation: CAA10029.1 Frameshift.
DQ443528 mRNA Translation: ABE03889.1
DQ443529 mRNA Translation: ABE03890.1
AF205218 mRNA Translation: AAG43485.1
AB020657 mRNA Translation: BAA74873.2 Different initiation.
AF161553 mRNA Translation: AAF29040.1 Frameshift.
AL078644 Genomic DNA No translation available.
AL356273 Genomic DNA No translation available.
AK292431 mRNA Translation: BAF85120.1
CH471067 Genomic DNA Translation: EAW91194.1
BC067739 mRNA Translation: AAH67739.1
CCDSiCCDS1368.1
RefSeqiNP_006460.2, NM_006469.4
UniGeneiHs.497183
Hs.662668

Genome annotation databases

EnsembliENST00000367498; ENSP00000356468; ENSG00000116679
GeneIDi10625
KEGGihsa:10625
UCSCiuc001grl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012449 mRNA Translation: CAA10029.1 Frameshift.
DQ443528 mRNA Translation: ABE03889.1
DQ443529 mRNA Translation: ABE03890.1
AF205218 mRNA Translation: AAG43485.1
AB020657 mRNA Translation: BAA74873.2 Different initiation.
AF161553 mRNA Translation: AAF29040.1 Frameshift.
AL078644 Genomic DNA No translation available.
AL356273 Genomic DNA No translation available.
AK292431 mRNA Translation: BAF85120.1
CH471067 Genomic DNA Translation: EAW91194.1
BC067739 mRNA Translation: AAH67739.1
CCDSiCCDS1368.1
RefSeqiNP_006460.2, NM_006469.4
UniGeneiHs.497183
Hs.662668

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YY8X-ray1.98A330-642[»]
ProteinModelPortaliQ9Y6Y0
SMRiQ9Y6Y0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115869, 89 interactors
IntActiQ9Y6Y0, 22 interactors
STRINGi9606.ENSP00000356468

PTM databases

iPTMnetiQ9Y6Y0
PhosphoSitePlusiQ9Y6Y0

Polymorphism and mutation databases

BioMutaiIVNS1ABP
DMDMi146325015

Proteomic databases

EPDiQ9Y6Y0
MaxQBiQ9Y6Y0
PaxDbiQ9Y6Y0
PeptideAtlasiQ9Y6Y0
PRIDEiQ9Y6Y0
ProteomicsDBi86824

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367498; ENSP00000356468; ENSG00000116679
GeneIDi10625
KEGGihsa:10625
UCSCiuc001grl.4 human

Organism-specific databases

CTDi10625
DisGeNETi10625
EuPathDBiHostDB:ENSG00000116679.15
GeneCardsiIVNS1ABP
HGNCiHGNC:16951 IVNS1ABP
HPAiHPA003405
MIMi609209 gene
neXtProtiNX_Q9Y6Y0
OpenTargetsiENSG00000116679
PharmGKBiPA134875300
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOVERGENiHBG082407
InParanoidiQ9Y6Y0
KOiK15046
OMAiPESNEWS
OrthoDBiEOG091G024F
PhylomeDBiQ9Y6Y0
TreeFamiTF329218

Miscellaneous databases

ChiTaRSiIVNS1ABP human
GeneWikiiIVNS1ABP
GenomeRNAii10625
PROiPR:Q9Y6Y0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116679 Expressed in 236 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_IVNS1ABP
ExpressionAtlasiQ9Y6Y0 baseline and differential
GenevisibleiQ9Y6Y0 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029849 NS1BP
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24411:SF7 PTHR24411:SF7, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNS1BP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y0
Secondary accession number(s): A8K8R6
, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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