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Protein

Unconventional myosin-XVI

Gene

MYO16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi497 – 504ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • actin filament binding Source: HGNC
  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro

GO - Biological processi

  • cerebellum development Source: HGNC
  • negative regulation of cell proliferation Source: HGNC
  • negative regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVI
Alternative name(s):
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
Unconventional myosin-16
Gene namesi
Name:MYO16Imported
Synonyms:KIAA0865Imported, MYO16BImported, NYAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000041515.15
HGNCiHGNC:29822 MYO16
MIMi615479 gene
neXtProtiNX_Q9Y6X6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23026
OpenTargetsiENSG00000041515
PharmGKBiPA162396437

Polymorphism and mutation databases

BioMutaiMYO16
DMDMi152112422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891361 – 1858Unconventional myosin-XVIAdd BLAST1858

Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6X6
PaxDbiQ9Y6X6
PeptideAtlasiQ9Y6X6
PRIDEiQ9Y6X6
ProteomicsDBi86817
86818 [Q9Y6X6-2]
86819 [Q9Y6X6-3]
86820 [Q9Y6X6-4]

PTM databases

iPTMnetiQ9Y6X6
PhosphoSitePlusiQ9Y6X6

Expressioni

Gene expression databases

BgeeiENSG00000041515
CleanExiHS_MYO16
ExpressionAtlasiQ9Y6X6 baseline and differential
GenevisibleiQ9Y6X6 HS

Organism-specific databases

HPAiHPA040110
HPA058769
HPA071948

Interactioni

Subunit structurei

Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive manner. Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity). Interacts with KIRREL3 (PubMed:25902260).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: HGNC

Protein-protein interaction databases

BioGridi116666, 7 interactors
ELMiQ9Y6X6
IntActiQ9Y6X6, 7 interactors
MINTiQ9Y6X6
STRINGi9606.ENSP00000349145

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X6
SMRiQ9Y6X6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 88ANK 1Sequence analysisAdd BLAST30
Repeati92 – 121ANK 2Sequence analysisAdd BLAST30
Repeati125 – 154ANK 3Sequence analysisAdd BLAST30
Repeati158 – 189ANK 4Sequence analysisAdd BLAST32
Repeati191 – 217ANK 5Sequence analysisAdd BLAST27
Repeati221 – 250ANK 6Sequence analysisAdd BLAST30
Repeati254 – 283ANK 7Sequence analysisAdd BLAST30
Domaini401 – 1145Myosin motorPROSITE-ProRule annotationAdd BLAST745
Domaini1147 – 1176IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1111 – 1377Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1389 – 1671Pro-richSequence analysisAdd BLAST283

Sequence similaritiesi

In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated
In the C-terminal section; belongs to the NYAP family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIRW Eukaryota
COG5022 LUCA
GeneTreeiENSGT00920000149012
HOVERGENiHBG108163
InParanoidiQ9Y6X6
KOiK17481
PhylomeDBiQ9Y6X6
TreeFamiTF332267

Family and domain databases

CDDicd00204 ANK, 2 hits
cd14878 MYSc_Myo16, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000048 IQ_motif_EF-hand-BS
IPR001609 Myosin_head_motor_dom
IPR036042 MYSc_Myo16
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9Y6X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIDQCLLES LPLGQRQRLV KRMRCEQIKA YYEREKAFQK QEGFLKRLKH
60 70 80 90 100
AKNPKVHFNL TDMLQDAIIH HNDKEVLRLL KEGADPHTLV SSGGSLLHLC
110 120 130 140 150
ARYDNAFIAE ILIDRGVNVN HQDEDFWTPM HIACACDNPD IVLLLVLAGA
160 170 180 190 200
NVLLQDVNGN IPLDYAVEGT ESSSILLTYL DENGVDLTSL RQMKLQRPMS
210 220 230 240 250
MLTDVKHFLS SGGNVNEKND EGVTLLHMAC ASGYKEVVSL ILEHGGDLNI
260 270 280 290 300
VDDQYWTPLH LAAKYGQTNL VKLLLMHQAN PHLVNCNEEK ASDIAASEFI
310 320 330 340 350
EEMLLKAEIA WEEKMKEPLS ASTLAQEEPY EEIIHDLPVL SSKLSPLVLP
360 370 380 390 400
IAKQDSLLEK DIMFKDATKG LCKQQSQDSI PENPMMSGST KPEQVKLMPP
410 420 430 440 450
APNDDLATLS ELNDGSLLYE IQKRFGNNQI YTFIGDILLL VNPYKELPIY
460 470 480 490 500
SSMVSQLYFS SSGKLCSSLP PHLFSCVERA FHQLFREQRP QCFILSGERG
510 520 530 540 550
SGKSEASKQI IRHLTCRAGA SRATLDSRFK HVVCILEAFG HAKTTLNDLS
560 570 580 590 600
SCFIKYFELQ FCERKQQLTG ARIYTYLLEK SRLVSQPLGQ SNFLIFYLLM
610 620 630 640 650
DGLSAEEKYG LHLNNLCAHR YLNQTIQDDA STGERSLNRE KLAVLKRALN
660 670 680 690 700
VVGFSSLEVE NLFVILAAIL HLGDIRFTAL NEGNSAFVSD LQLLEQVAGM
710 720 730 740 750
LQVSTDELAS ALTTDIQYFK GDMIIRRHTI QIAEFFRDLL AKSLYSRLFS
760 770 780 790 800
FLVNTMNSCL HSQDEQKSMQ TLDIGILDIF GFEEFQKNEF EQLCVNMTNE
810 820 830 840 850
KMHHYINEVL FLHEQVECVQ EGVTMETAYS PGNQNGVLDF FFQKPSGFLT
860 870 880 890 900
LLDEESQMIW SVESNFPKKL QSLLESSNTN AVYSPMKDGN GNVALKDHGT
910 920 930 940 950
AFTIMHYAGR VMYDVVGAIE KNKDSLSQNL LFVMKTSENV VINHLFQSKL
960 970 980 990 1000
SQTGSLVSAY PSFKFRGHKS ALLSKKMTAS SIIGENKNYL ELSKLLKKKG
1010 1020 1030 1040 1050
TSTFLQRLER GDPVTIASQL RKSLMDIIGK LQKCTPHFIH CIRPNNSKLP
1060 1070 1080 1090 1100
DTFDNFYVSA QLQYIGVLEM VKIFRYGYPV RLSFSDFLSR YKPLADTFLR
1110 1120 1130 1140 1150
EKKEQSAAER CRLVLQQCKL QGWQMGVRKV FLKYWHADQL NDLCLQLQRK
1160 1170 1180 1190 1200
IITCQKVIRG FLARQHLLQR ISIRQQEVTS INSFLQNTED MGLKTYDALV
1210 1220 1230 1240 1250
IQNASDIARE NDRLRSEMNA PYHKEKLEVR NMQEEGSKRT DDKSGPRHFH
1260 1270 1280 1290 1300
PSSMSVCAAV DGLGQCLVGP SIWSPSLHSV FSMDDSSSLP SPRKQPPPKP
1310 1320 1330 1340 1350
KRDPNTRLSA SYEAVSACLS AAREAANEAL ARPRPHSDDY STMKKIPPRK
1360 1370 1380 1390 1400
PKRSPNTKLS GSYEEISGSR PGDARPAGAP GAAARVLTPG TPQCALPPAA
1410 1420 1430 1440 1450
PPGDEDDSEP VYIEMLGHAA RPDSPDPGES VYEEMKCCLP DDGGPGAGSF
1460 1470 1480 1490 1500
LLHGASPPLL HRAPEDEAAG PPGDACDIPP PFPNLLPHRP PLLVFPPTPV
1510 1520 1530 1540 1550
TCSPASDESP LTPLEVKKLP VLETNLKYPV QPEGSSPLSP QYSKSQKGDG
1560 1570 1580 1590 1600
DRPASPGLAL FNGSGRASPP STPPPPPPPP GPPPAPYRPC AHLAFPPEPA
1610 1620 1630 1640 1650
PVNAGKAGPS AEAPKVHPKP NSAPVAGPCS SFPKIPYSPV KATRADARKA
1660 1670 1680 1690 1700
GSSASPPAPY SPPSSRPLSS PLDELASLFN SGRSVLRKSA AGRKIREAEG
1710 1720 1730 1740 1750
FETNMNISSR DDPSTSEITS ETQDRNANNH GIQLSNSLSS AITAENGNSI
1760 1770 1780 1790 1800
SNGLPEEDGY SRLSISGTGT STFQRHRDSH TTQVIHQLRL SENESVALQE
1810 1820 1830 1840 1850
LLDWRRKLCE EGQDWQQILH HAEPRVPPPP PCKKPSLLKK PEGASCNRLP

SELWDTTI
Length:1,858
Mass (Da):206,129
Last modified:May 29, 2007 - v3
Checksum:iB2D821DD53BD109E
GO
Isoform 21 Publication (identifier: Q9Y6X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1091-1858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,090
Mass (Da):123,160
Checksum:i4245550D45B08F75
GO
Isoform 31 Publication (identifier: Q9Y6X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-940: TSENV → RGRCF
     941-1858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:940
Mass (Da):106,160
Checksum:i1F22125264CA3ABA
GO
Isoform 41 Publication (identifier: Q9Y6X6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.
     206-225: Missing.
     936-940: TSENV → RGRCF
     941-1858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:728
Mass (Da):82,275
Checksum:iA290192D126CE028
GO

Sequence cautioni

The sequence BAA74888 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC04608 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87143 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti555K → E in CAD39107 (PubMed:17974005).Curated1
Sequence conflicti953T → A in BAC87143 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050214181D → E. Corresponds to variant dbSNP:rs911973Ensembl.1
Natural variantiVAR_050215339V → I. Corresponds to variant dbSNP:rs405397Ensembl.1
Natural variantiVAR_032584385M → T1 PublicationCorresponds to variant dbSNP:rs16973313Ensembl.1
Natural variantiVAR_032585831P → A5 PublicationsCorresponds to variant dbSNP:rs3825491Ensembl.1
Natural variantiVAR_0647371168L → H Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0502161171I → M. Corresponds to variant dbSNP:rs157024Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524471 – 192Missing in isoform 4. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_052448206 – 225Missing in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_052449936 – 940TSENV → RGRCF in isoform 3 and isoform 4. 1 Publication5
Alternative sequenceiVSP_052450941 – 1858Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST918
Alternative sequenceiVSP_0524511091 – 1858Missing in isoform 2. 1 PublicationAdd BLAST768

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020672 mRNA Translation: BAA74888.2 Different initiation.
AK095691 mRNA Translation: BAC04608.1 Different initiation.
AB290159 mRNA Translation: BAG06713.1
AL136132
, AL157771, AL161431, AL353143, AL390918 Genomic DNA Translation: CAH70519.1
AL136132
, AL157771, AL353143, AL390918 Genomic DNA Translation: CAH70520.1
AL136132, AL353143, AL390918 Genomic DNA Translation: CAH70521.1
AL157771
, AL136132, AL161431, AL353143, AL390918 Genomic DNA Translation: CAI16366.1
AL157771
, AL136132, AL353143, AL390918 Genomic DNA Translation: CAI16367.1
AL161431
, AL136132, AL157771, AL353143, AL390918 Genomic DNA Translation: CAI15548.1
AL353143
, AL136132, AL157771, AL161431, AL390918 Genomic DNA Translation: CAH73221.1
AL353143
, AL136132, AL157771, AL390918 Genomic DNA Translation: CAH73222.1
AL353143, AL136132, AL390918 Genomic DNA Translation: CAH73223.1
AL390918
, AL136132, AL157771, AL161431, AL353143 Genomic DNA Translation: CAI15821.1
AL390918
, AL136132, AL157771, AL353143 Genomic DNA Translation: CAI15822.1
AL390918, AL136132, AL353143 Genomic DNA Translation: CAI15823.1
AK127806 mRNA Translation: BAC87143.1 Different initiation.
BC146791 mRNA Translation: AAI46792.1
AL834447 mRNA Translation: CAD39107.2
CCDSiCCDS32008.1 [Q9Y6X6-1]
RefSeqiNP_055826.1, NM_015011.1 [Q9Y6X6-1]
XP_011519364.1, XM_011521062.1 [Q9Y6X6-1]
UniGeneiHs.656587

Genome annotation databases

EnsembliENST00000251041; ENSP00000251041; ENSG00000041515 [Q9Y6X6-3]
ENST00000356711; ENSP00000349145; ENSG00000041515 [Q9Y6X6-1]
ENST00000357550; ENSP00000350160; ENSG00000041515 [Q9Y6X6-1]
ENST00000634397; ENSP00000489329; ENSG00000282848 [Q9Y6X6-1]
ENST00000634825; ENSP00000489279; ENSG00000282848 [Q9Y6X6-3]
ENST00000635050; ENSP00000488918; ENSG00000282848 [Q9Y6X6-1]
GeneIDi23026
KEGGihsa:23026
UCSCiuc001vqt.1 human [Q9Y6X6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYO16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6X6
Secondary accession number(s): A6H8Y0
, A8MTX3, Q5VYX4, Q5VYX5, Q5VYX6, Q6ZS13, Q8N3C2, Q8N948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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