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Protein

Stress-associated endoplasmic reticulum protein 1

Gene

SERP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-associated endoplasmic reticulum protein 1
Alternative name(s):
Ribosome-attached membrane protein 4
Gene namesi
Name:SERP1
Synonyms:RAMP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000120742.10
HGNCiHGNC:10759 SERP1
MIMi617674 gene
neXtProtiNX_Q9Y6X1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 66ExtracellularSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27230
OpenTargetsiENSG00000120742
PharmGKBiPA162402942

Polymorphism and mutation databases

BioMutaiSERP1
DMDMi74721555

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747941 – 66Stress-associated endoplasmic reticulum protein 1Add BLAST66

Proteomic databases

PaxDbiQ9Y6X1
PeptideAtlasiQ9Y6X1
PRIDEiQ9Y6X1
ProteomicsDBi86809
TopDownProteomicsiQ9Y6X1

PTM databases

iPTMnetiQ9Y6X1
PhosphoSitePlusiQ9Y6X1

Expressioni

Gene expression databases

BgeeiENSG00000120742 Expressed in 233 organ(s), highest expression level in parotid gland
CleanExiHS_SERP1
ExpressionAtlasiQ9Y6X1 baseline and differential
GenevisibleiQ9Y6X1 HS

Organism-specific databases

HPAiHPA038970

Interactioni

Subunit structurei

Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM79Q9BSE23EBI-10329948,EBI-8649725

Protein-protein interaction databases

BioGridi118079, 14 interactors
IntActiQ9Y6X1, 35 interactors
STRINGi9606.ENSP00000239944

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3491 Eukaryota
ENOG411221U LUCA
GeneTreeiENSGT00390000012245
HOVERGENiHBG058555
InParanoidiQ9Y6X1
OMAiTSQWLIG
PhylomeDBiQ9Y6X1
TreeFamiTF313229

Family and domain databases

InterProiView protein in InterPro
IPR010580 ER_stress-assoc
PANTHERiPTHR15601 PTHR15601, 1 hit
PfamiView protein in Pfam
PF06624 RAMP4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y6X1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV
60
CGSAIFQIIQ SIRMGM
Length:66
Mass (Da):7,374
Last modified:November 1, 1999 - v1
Checksum:iDC15C0143AAE0D91
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUH5C9JUH5_HUMAN
Stress-associated endoplasmic retic...
SERP1
78Annotation score:
C9JSB0C9JSB0_HUMAN
Stress-associated endoplasmic retic...
SERP1
55Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022427 mRNA Translation: BAA81895.1
AF136975 mRNA Translation: AAG49436.1
AL136807 mRNA Translation: CAB66741.1
CR533472 mRNA Translation: CAG38503.1
CH471052 Genomic DNA Translation: EAW78834.1
CH471052 Genomic DNA Translation: EAW78835.1
CH471052 Genomic DNA Translation: EAW78836.1
BC108314 mRNA Translation: AAI08315.1
BC112364 mRNA Translation: AAI12365.1
BC112365 mRNA Translation: AAI12366.1
CCDSiCCDS3150.1
RefSeqiNP_055260.1, NM_014445.3
XP_011511000.1, XM_011512698.2
UniGeneiHs.518326
Hs.713956

Genome annotation databases

EnsembliENST00000239944; ENSP00000239944; ENSG00000120742
ENST00000479209; ENSP00000420076; ENSG00000120742
GeneIDi27230
KEGGihsa:27230
UCSCiuc003exy.4 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022427 mRNA Translation: BAA81895.1
AF136975 mRNA Translation: AAG49436.1
AL136807 mRNA Translation: CAB66741.1
CR533472 mRNA Translation: CAG38503.1
CH471052 Genomic DNA Translation: EAW78834.1
CH471052 Genomic DNA Translation: EAW78835.1
CH471052 Genomic DNA Translation: EAW78836.1
BC108314 mRNA Translation: AAI08315.1
BC112364 mRNA Translation: AAI12365.1
BC112365 mRNA Translation: AAI12366.1
CCDSiCCDS3150.1
RefSeqiNP_055260.1, NM_014445.3
XP_011511000.1, XM_011512698.2
UniGeneiHs.518326
Hs.713956

3D structure databases

ProteinModelPortaliQ9Y6X1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118079, 14 interactors
IntActiQ9Y6X1, 35 interactors
STRINGi9606.ENSP00000239944

PTM databases

iPTMnetiQ9Y6X1
PhosphoSitePlusiQ9Y6X1

Polymorphism and mutation databases

BioMutaiSERP1
DMDMi74721555

Proteomic databases

PaxDbiQ9Y6X1
PeptideAtlasiQ9Y6X1
PRIDEiQ9Y6X1
ProteomicsDBi86809
TopDownProteomicsiQ9Y6X1

Protocols and materials databases

DNASUi27230
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239944; ENSP00000239944; ENSG00000120742
ENST00000479209; ENSP00000420076; ENSG00000120742
GeneIDi27230
KEGGihsa:27230
UCSCiuc003exy.4 human

Organism-specific databases

CTDi27230
DisGeNETi27230
EuPathDBiHostDB:ENSG00000120742.10
GeneCardsiSERP1
HGNCiHGNC:10759 SERP1
HPAiHPA038970
MIMi617674 gene
neXtProtiNX_Q9Y6X1
OpenTargetsiENSG00000120742
PharmGKBiPA162402942
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3491 Eukaryota
ENOG411221U LUCA
GeneTreeiENSGT00390000012245
HOVERGENiHBG058555
InParanoidiQ9Y6X1
OMAiTSQWLIG
PhylomeDBiQ9Y6X1
TreeFamiTF313229

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSERP1 human
GeneWikiiSERP1
GenomeRNAii27230
PROiPR:Q9Y6X1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120742 Expressed in 233 organ(s), highest expression level in parotid gland
CleanExiHS_SERP1
ExpressionAtlasiQ9Y6X1 baseline and differential
GenevisibleiQ9Y6X1 HS

Family and domain databases

InterProiView protein in InterPro
IPR010580 ER_stress-assoc
PANTHERiPTHR15601 PTHR15601, 1 hit
PfamiView protein in Pfam
PF06624 RAMP4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSERP1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6X1
Secondary accession number(s): D3DNI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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