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UniProtKB - Q9Y6W6 (DUS10_HUMAN)
Protein
Dual specificity protein phosphatase 10
Gene
DUSP10
Organism
Homo sapiens (Human)
Status
Functioni
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
3 PublicationsCatalytic activityi
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphatePROSITE-ProRule annotation2 PublicationsEC:3.1.3.48PROSITE-ProRule annotation2 Publications
- EC:3.1.3.162 Publications
- EC:3.1.3.162 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 408 | Phosphocysteine intermediatePROSITE-ProRule annotation2 Publications | 1 |
GO - Molecular functioni
- JUN kinase binding Source: BHF-UCL
- MAP kinase phosphatase activity Source: UniProtKB
- MAP kinase tyrosine/serine/threonine phosphatase activity Source: GO_Central
- mitogen-activated protein kinase p38 binding Source: BHF-UCL
- phosphatase activity Source: UniProtKB
- phosphoprotein phosphatase activity Source: GO_Central
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
- protein tyrosine/threonine phosphatase activity Source: BHF-UCL
- protein tyrosine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- dephosphorylation Source: UniProtKB
- negative regulation of cell migration Source: BHF-UCL
- negative regulation of epithelial cell migration Source: BHF-UCL
- negative regulation of epithelial cell proliferation Source: BHF-UCL
- negative regulation of epithelium regeneration Source: BHF-UCL
- negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- negative regulation of JNK cascade Source: BHF-UCL
- negative regulation of JUN kinase activity Source: BHF-UCL
- negative regulation of MAPK cascade Source: GO_Central
- negative regulation of oligodendrocyte differentiation Source: Ensembl
- negative regulation of p38MAPK cascade Source: BHF-UCL
- negative regulation of protein kinase activity by regulation of protein phosphorylation Source: Ensembl
- negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
- oligodendrocyte differentiation Source: Ensembl
- peptidyl-threonine dephosphorylation Source: BHF-UCL
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: BHF-UCL
- positive regulation of regulatory T cell differentiation Source: BHF-UCL
- regulation of adaptive immune response Source: Ensembl
- regulation of brown fat cell differentiation Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 3.1.3.48, 2681 |
PathwayCommonsi | Q9Y6W6 |
Reactomei | R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-9652817, Signaling by MAPK mutants |
SABIO-RKi | Q9Y6W6 |
SignaLinki | Q9Y6W6 |
SIGNORi | Q9Y6W6 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DUSP10 Synonyms:MKP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3065, DUSP10 |
MIMi | 608867, gene |
neXtProti | NX_Q9Y6W6 |
VEuPathDBi | HostDB:ENSG00000143507 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 180 – 181 | FM → DD: Reduced enzyme activity with MAPK14. 1 Publication | 2 | |
Mutagenesisi | 203 – 204 | RR → AA: Strongly reduced affinity for MAPK14. Almost abolishes enzyme activity with MAPK14. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 11221 |
OpenTargetsi | ENSG00000143507 |
PharmGKBi | PA27520 |
Miscellaneous databases
Pharosi | Q9Y6W6, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2396511 |
Genetic variation databases
BioMutai | DUSP10 |
DMDMi | 20138090 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094813 | 1 – 482 | Dual specificity protein phosphatase 10Add BLAST | 482 |
Proteomic databases
MassIVEi | Q9Y6W6 |
PaxDbi | Q9Y6W6 |
PeptideAtlasi | Q9Y6W6 |
PRIDEi | Q9Y6W6 |
ProteomicsDBi | 86803 [Q9Y6W6-1] 86804 [Q9Y6W6-2] |
PTM databases
DEPODi | DUSP10 |
iPTMneti | Q9Y6W6 |
PhosphoSitePlusi | Q9Y6W6 |
Expressioni
Tissue specificityi
Expressed in keratinocytes (at protein level) (PubMed:29043977). Detected in brain (PubMed:16806267).2 Publications
Gene expression databases
Bgeei | ENSG00000143507, Expressed in liver and 227 other tissues |
ExpressionAtlasi | Q9Y6W6, baseline and differential |
Genevisiblei | Q9Y6W6, HS |
Organism-specific databases
HPAi | ENSG00000143507, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Monomer.
Interacts with MAPK14.
3 PublicationsBinary interactionsi
Q9Y6W6
GO - Molecular functioni
- JUN kinase binding Source: BHF-UCL
- mitogen-activated protein kinase p38 binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 116389, 68 interactors |
ELMi | Q9Y6W6 |
IntActi | Q9Y6W6, 31 interactors |
MINTi | Q9Y6W6 |
STRINGi | 9606.ENSP00000355866 |
Chemistry databases
BindingDBi | Q9Y6W6 |
Miscellaneous databases
RNActi | Q9Y6W6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y6W6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y6W6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 285 | RhodanesePROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 321 – 464 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 199 – 215 | Interaction with MAP kinasesAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1716, Eukaryota |
GeneTreei | ENSGT00940000157671 |
HOGENOMi | CLU_027074_0_1_1 |
InParanoidi | Q9Y6W6 |
OMAi | QRMNIGY |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q9Y6W6 |
TreeFami | TF105122 |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR008343, MKP IPR029021, Prot-tyrosine_phosphatase-like IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR016130, Tyr_Pase_AS IPR000387, Tyr_Pase_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit PF00581, Rhodanese, 1 hit |
PRINTSi | PR01764, MAPKPHPHTASE |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit SM00450, RHOD, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y6W6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSANPGSN SHPPVIATTV
60 70 80 90 100
VSLKAANLTY MPSSSGSARS LNCGCSSASC CTVATYDKDN QAQTQAIAAG
110 120 130 140 150
TTTTAIGTST TCPANQMVNN NENTGSLSPS SGVGSPVSGT PKQLASIKII
160 170 180 190 200
YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF MEYNKSHIQG AVHINCADKI
210 220 230 240 250
SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT NEPSRVMPSQ
260 270 280 290 300
PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA
310 320 330 340 350
SAASSLLPQP IPTTPDIENA ELTPILPFLF LGNEQDAQDL DTMQRLNIGY
360 370 380 390 400
VINVTTHLPL YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC
410 420 430 440 450
GKGLLIHCQA GVSRSATIVI AYLMKHTRMT MTDAYKFVKG KRPIISPNLN
460 470 480
FMGQLLEFEE DLNNGVTPRI LTPKLMGVET VV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J2F5 | A0A0B4J2F5_HUMAN | Dual-specificity protein phosphatas... | DUSP10 | 66 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036549 | 1 – 342 | Missing in isoform 2. 2 PublicationsAdd BLAST | 342 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB026436 mRNA Translation: BAA81668.1 AF179212 mRNA Translation: AAD51857.1 AK022513 mRNA Translation: BAB14070.1 AL590966 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93283.1 CH471100 Genomic DNA Translation: EAW93285.1 CH471100 Genomic DNA Translation: EAW93286.1 CH471100 Genomic DNA Translation: EAW93287.1 BC020608 mRNA Translation: AAH20608.1 BC031405 mRNA Translation: AAH31405.1 BC063826 mRNA Translation: AAH63826.1 |
CCDSi | CCDS1528.1 [Q9Y6W6-1] |
RefSeqi | NP_009138.1, NM_007207.5 [Q9Y6W6-1] |
Genome annotation databases
Ensembli | ENST00000366899; ENSP00000355866; ENSG00000143507 |
GeneIDi | 11221 |
KEGGi | hsa:11221 |
MANE-Selecti | ENST00000366899.4; ENSP00000355866.3; NM_007207.6; NP_009138.1 |
UCSCi | uc001hmy.3, human [Q9Y6W6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB026436 mRNA Translation: BAA81668.1 AF179212 mRNA Translation: AAD51857.1 AK022513 mRNA Translation: BAB14070.1 AL590966 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93283.1 CH471100 Genomic DNA Translation: EAW93285.1 CH471100 Genomic DNA Translation: EAW93286.1 CH471100 Genomic DNA Translation: EAW93287.1 BC020608 mRNA Translation: AAH20608.1 BC031405 mRNA Translation: AAH31405.1 BC063826 mRNA Translation: AAH63826.1 |
CCDSi | CCDS1528.1 [Q9Y6W6-1] |
RefSeqi | NP_009138.1, NM_007207.5 [Q9Y6W6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZZW | X-ray | 1.60 | A/B | 320-467 | [»] | |
2OUC | X-ray | 2.20 | A/B | 148-287 | [»] | |
2OUD | X-ray | 2.80 | A | 315-482 | [»] | |
3TG1 | X-ray | 2.71 | B | 139-288 | [»] | |
6MC1 | X-ray | 2.70 | A/B/C/D/E/F | 320-467 | [»] | |
SMRi | Q9Y6W6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116389, 68 interactors |
ELMi | Q9Y6W6 |
IntActi | Q9Y6W6, 31 interactors |
MINTi | Q9Y6W6 |
STRINGi | 9606.ENSP00000355866 |
Chemistry databases
BindingDBi | Q9Y6W6 |
ChEMBLi | CHEMBL2396511 |
PTM databases
DEPODi | DUSP10 |
iPTMneti | Q9Y6W6 |
PhosphoSitePlusi | Q9Y6W6 |
Genetic variation databases
BioMutai | DUSP10 |
DMDMi | 20138090 |
Proteomic databases
MassIVEi | Q9Y6W6 |
PaxDbi | Q9Y6W6 |
PeptideAtlasi | Q9Y6W6 |
PRIDEi | Q9Y6W6 |
ProteomicsDBi | 86803 [Q9Y6W6-1] 86804 [Q9Y6W6-2] |
Protocols and materials databases
Antibodypediai | 20739, 361 antibodies from 36 providers |
DNASUi | 11221 |
Genome annotation databases
Ensembli | ENST00000366899; ENSP00000355866; ENSG00000143507 |
GeneIDi | 11221 |
KEGGi | hsa:11221 |
MANE-Selecti | ENST00000366899.4; ENSP00000355866.3; NM_007207.6; NP_009138.1 |
UCSCi | uc001hmy.3, human [Q9Y6W6-1] |
Organism-specific databases
CTDi | 11221 |
DisGeNETi | 11221 |
GeneCardsi | DUSP10 |
HGNCi | HGNC:3065, DUSP10 |
HPAi | ENSG00000143507, Tissue enhanced (liver) |
MIMi | 608867, gene |
neXtProti | NX_Q9Y6W6 |
OpenTargetsi | ENSG00000143507 |
PharmGKBi | PA27520 |
VEuPathDBi | HostDB:ENSG00000143507 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1716, Eukaryota |
GeneTreei | ENSGT00940000157671 |
HOGENOMi | CLU_027074_0_1_1 |
InParanoidi | Q9Y6W6 |
OMAi | QRMNIGY |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q9Y6W6 |
TreeFami | TF105122 |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 3.1.3.48, 2681 |
PathwayCommonsi | Q9Y6W6 |
Reactomei | R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-9652817, Signaling by MAPK mutants |
SABIO-RKi | Q9Y6W6 |
SignaLinki | Q9Y6W6 |
SIGNORi | Q9Y6W6 |
Miscellaneous databases
BioGRID-ORCSi | 11221, 21 hits in 1054 CRISPR screens |
EvolutionaryTracei | Q9Y6W6 |
GeneWikii | DUSP10 |
GenomeRNAii | 11221 |
Pharosi | Q9Y6W6, Tbio |
PROi | PR:Q9Y6W6 |
RNActi | Q9Y6W6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143507, Expressed in liver and 227 other tissues |
ExpressionAtlasi | Q9Y6W6, baseline and differential |
Genevisiblei | Q9Y6W6, HS |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR008343, MKP IPR029021, Prot-tyrosine_phosphatase-like IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR016130, Tyr_Pase_AS IPR000387, Tyr_Pase_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit PF00581, Rhodanese, 1 hit |
PRINTSi | PR01764, MAPKPHPHTASE |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit SM00450, RHOD, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DUS10_HUMAN | |
Accessioni | Q9Y6W6Primary (citable) accession number: Q9Y6W6 Secondary accession number(s): D3DTB4, Q6GSI4, Q9H9Z5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families