Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity protein phosphatase 10

Gene

DUSP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation2 Publications
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei408Phosphocysteine intermediate2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
3.1.3.48 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SABIO-RKiQ9Y6W6
SignaLinkiQ9Y6W6
SIGNORiQ9Y6W6

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 10 (EC:3.1.3.162 Publications, EC:3.1.3.482 Publications)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 5
Short name:
MAP kinase phosphatase 5
Short name:
MKP-5
Gene namesi
Name:DUSP10
Synonyms:MKP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143507.17
HGNCiHGNC:3065 DUSP10
MIMi608867 gene
neXtProtiNX_Q9Y6W6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi180 – 181FM → DD: Reduced enzyme activity with MAPK14. 1 Publication2
Mutagenesisi203 – 204RR → AA: Strongly reduced affinity for MAPK14. Almost abolishes enzyme activity with MAPK14. 1 Publication2

Organism-specific databases

DisGeNETi11221
OpenTargetsiENSG00000143507
PharmGKBiPA27520

Chemistry databases

ChEMBLiCHEMBL2396511

Polymorphism and mutation databases

BioMutaiDUSP10
DMDMi20138090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948131 – 482Dual specificity protein phosphatase 10Add BLAST482

Proteomic databases

EPDiQ9Y6W6
PaxDbiQ9Y6W6
PeptideAtlasiQ9Y6W6
PRIDEiQ9Y6W6
ProteomicsDBi86803
86804 [Q9Y6W6-2]

PTM databases

DEPODiQ9Y6W6
iPTMnetiQ9Y6W6
PhosphoSitePlusiQ9Y6W6

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiENSG00000143507 Expressed in 212 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_DUSP10
ExpressionAtlasiQ9Y6W6 baseline and differential
GenevisibleiQ9Y6W6 HS

Organism-specific databases

HPAiHPA016758

Interactioni

Subunit structurei

Monomer. Interacts with MAPK14.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPK9P459843EBI-3443946,EBI-713568

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116389, 23 interactors
ELMiQ9Y6W6
IntActiQ9Y6W6, 14 interactors
MINTiQ9Y6W6
STRINGi9606.ENSP00000355866

Chemistry databases

BindingDBiQ9Y6W6

Structurei

Secondary structure

1482
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6W6
SMRiQ9Y6W6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6W6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 285RhodanesePROSITE-ProRule annotationAdd BLAST118
Domaini384 – 453Tyrosine-protein phosphataseAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 215Interaction with MAP kinasesAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000069871
HOVERGENiHBG102158
InParanoidiQ9Y6W6
KOiK20216
OMAiMTKCSKS
OrthoDBiEOG091G0V6S
PhylomeDBiQ9Y6W6
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSANPGSN SHPPVIATTV
60 70 80 90 100
VSLKAANLTY MPSSSGSARS LNCGCSSASC CTVATYDKDN QAQTQAIAAG
110 120 130 140 150
TTTTAIGTST TCPANQMVNN NENTGSLSPS SGVGSPVSGT PKQLASIKII
160 170 180 190 200
YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF MEYNKSHIQG AVHINCADKI
210 220 230 240 250
SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT NEPSRVMPSQ
260 270 280 290 300
PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA
310 320 330 340 350
SAASSLLPQP IPTTPDIENA ELTPILPFLF LGNEQDAQDL DTMQRLNIGY
360 370 380 390 400
VINVTTHLPL YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC
410 420 430 440 450
GKGLLIHCQA GVSRSATIVI AYLMKHTRMT MTDAYKFVKG KRPIISPNLN
460 470 480
FMGQLLEFEE DLNNGVTPRI LTPKLMGVET VV
Length:482
Mass (Da):52,642
Last modified:November 1, 1999 - v1
Checksum:iA8CB74ABF9498CD4
GO
Isoform 2 (identifier: Q9Y6W6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.

Show »
Length:140
Mass (Da):16,110
Checksum:iCE151F365D042516
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2F5A0A0B4J2F5_HUMAN
Dual-specificity protein phosphatas...
DUSP10
66Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365491 – 342Missing in isoform 2. 2 PublicationsAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026436 mRNA Translation: BAA81668.1
AF179212 mRNA Translation: AAD51857.1
AK022513 mRNA Translation: BAB14070.1
AL590966 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93283.1
CH471100 Genomic DNA Translation: EAW93285.1
CH471100 Genomic DNA Translation: EAW93286.1
CH471100 Genomic DNA Translation: EAW93287.1
BC020608 mRNA Translation: AAH20608.1
BC031405 mRNA Translation: AAH31405.1
BC063826 mRNA Translation: AAH63826.1
CCDSiCCDS1528.1 [Q9Y6W6-1]
RefSeqiNP_009138.1, NM_007207.5 [Q9Y6W6-1]
UniGeneiHs.497822
Hs.732301

Genome annotation databases

EnsembliENST00000366899; ENSP00000355866; ENSG00000143507 [Q9Y6W6-1]
GeneIDi11221
KEGGihsa:11221
UCSCiuc001hmy.3 human [Q9Y6W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026436 mRNA Translation: BAA81668.1
AF179212 mRNA Translation: AAD51857.1
AK022513 mRNA Translation: BAB14070.1
AL590966 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93283.1
CH471100 Genomic DNA Translation: EAW93285.1
CH471100 Genomic DNA Translation: EAW93286.1
CH471100 Genomic DNA Translation: EAW93287.1
BC020608 mRNA Translation: AAH20608.1
BC031405 mRNA Translation: AAH31405.1
BC063826 mRNA Translation: AAH63826.1
CCDSiCCDS1528.1 [Q9Y6W6-1]
RefSeqiNP_009138.1, NM_007207.5 [Q9Y6W6-1]
UniGeneiHs.497822
Hs.732301

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZZWX-ray1.60A/B320-467[»]
2OUCX-ray2.20A/B148-287[»]
2OUDX-ray2.80A315-482[»]
3TG1X-ray2.71B139-288[»]
ProteinModelPortaliQ9Y6W6
SMRiQ9Y6W6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116389, 23 interactors
ELMiQ9Y6W6
IntActiQ9Y6W6, 14 interactors
MINTiQ9Y6W6
STRINGi9606.ENSP00000355866

Chemistry databases

BindingDBiQ9Y6W6
ChEMBLiCHEMBL2396511

PTM databases

DEPODiQ9Y6W6
iPTMnetiQ9Y6W6
PhosphoSitePlusiQ9Y6W6

Polymorphism and mutation databases

BioMutaiDUSP10
DMDMi20138090

Proteomic databases

EPDiQ9Y6W6
PaxDbiQ9Y6W6
PeptideAtlasiQ9Y6W6
PRIDEiQ9Y6W6
ProteomicsDBi86803
86804 [Q9Y6W6-2]

Protocols and materials databases

DNASUi11221
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366899; ENSP00000355866; ENSG00000143507 [Q9Y6W6-1]
GeneIDi11221
KEGGihsa:11221
UCSCiuc001hmy.3 human [Q9Y6W6-1]

Organism-specific databases

CTDi11221
DisGeNETi11221
EuPathDBiHostDB:ENSG00000143507.17
GeneCardsiDUSP10
HGNCiHGNC:3065 DUSP10
HPAiHPA016758
MIMi608867 gene
neXtProtiNX_Q9Y6W6
OpenTargetsiENSG00000143507
PharmGKBiPA27520
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000069871
HOVERGENiHBG102158
InParanoidiQ9Y6W6
KOiK20216
OMAiMTKCSKS
OrthoDBiEOG091G0V6S
PhylomeDBiQ9Y6W6
TreeFamiTF105122

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
3.1.3.48 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SABIO-RKiQ9Y6W6
SignaLinkiQ9Y6W6
SIGNORiQ9Y6W6

Miscellaneous databases

ChiTaRSiDUSP10 human
EvolutionaryTraceiQ9Y6W6
GeneWikiiDUSP10
GenomeRNAii11221
PROiPR:Q9Y6W6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143507 Expressed in 212 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_DUSP10
ExpressionAtlasiQ9Y6W6 baseline and differential
GenevisibleiQ9Y6W6 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6W6
Secondary accession number(s): D3DTB4, Q6GSI4, Q9H9Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again