UniProtKB - Q9Y6W5 (WASF2_HUMAN)

BLAST

>sp|Q9Y6W5|WASF2_HUMAN Wiskott-Aldrich syndrome protein family member 2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3
MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD
FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL
SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE
YSDSEDDSSEFDEDDWSD

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History
Entry version 170 (07 Nov 2018)
Sequence version 3 (01 Feb 2005)
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Protein

Wiskott-Aldrich syndrome protein family member 2

Gene

WASF2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.2 Publications

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- 10970852
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18560548
protein kinase A binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25097019
SH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19798448

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: ProtInc
Traceable author statementⁱ
- 9732292
actin filament-based movement Source: Ensembl
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9732292
ameboidal-type cell migration Source: Ensembl
angiogenesis Source: Ensembl
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
lamellipodium assembly Source: Ensembl
lamellipodium morphogenesis Source: Ensembl
megakaryocyte development Source: Ensembl
negative regulation of stress fiber assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21107423
positive regulation of lamellipodium assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18560548
- 21107423
postsynaptic actin cytoskeleton organization Source: Ensembl
Rac protein signal transduction Source: Ensembl
vascular endothelial growth factor receptor signaling pathway Source: Reactome
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding
Biological process	Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
SignaLinkⁱ	Q9Y6W5
SIGNORⁱ	Q9Y6W5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Wiskott-Aldrich syndrome protein family member 2 Short name: WASP family protein member 2 Alternative name(s): Protein WAVE-2 Verprolin homology domain-containing protein 2
Gene namesⁱ	Name:WASF2Imported Synonyms:WAVE2Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158195.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12733 WASF2
MIMⁱ	605875 gene
neXtProtⁱ	NX_Q9Y6W5

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	40	L → D: Decreased interaction with WAVE complex; when associated with D-51. 1 Publication	1
Mutagenesisⁱ	50	I → D: Decreased interaction with WAVE complex; when associated with D-54. 1 Publication	1
Mutagenesisⁱ	51	F → D: Decreased interaction with WAVE complex; when associated with D-40. 1 Publication	1
Mutagenesisⁱ	54	L → D: Decreased interaction with WAVE complex; when associated with D-50. 1 Publication	1
Mutagenesisⁱ	124	Y → D: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia. 1 Publication	1
Mutagenesisⁱ	150	Y → D: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia. 1 Publication	1
Mutagenesisⁱ	160 – 161	WK → ED: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia. 1 Publication	2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10163
Open Targets More...OpenTargetsⁱ	ENSG00000158195
PharmGKBⁱ	PA37344

Polymorphism and mutation databases

BioMutaⁱ	WASF2
DMDMⁱ	59800456

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000188994	1 – 498	Wiskott-Aldrich syndrome protein family member 2Add BLAST		498

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	474	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y6W5
PaxDbⁱ	Q9Y6W5
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6W5
PRIDEⁱ	Q9Y6W5
ProteomicsDBⁱ	86801 86802 [Q9Y6W5-2]

PTM databases

iPTMnetⁱ	Q9Y6W5
PhosphoSitePlusⁱ	Q9Y6W5

Miscellaneous databases

PMAP-CutDBⁱ	Q9Y6W5

PMAP-CutDBⁱ

Q9Y6W5

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000158195 Expressed in 239 organ(s), highest expression level in female reproductive system
CleanExⁱ	HS_WASF2
Genevisibleⁱ	Q9Y6W5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022632 HPA045288

HPAⁱ

CAB022632
HPA045288

Interactionⁱ

Subunit structureⁱ

Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406). Directly interacts with BRK1. Interacts with FNBP1L (via the SH3 domain) (PubMed:19798448).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BAIAP2	Q9UQB8-4	5	EBI-4290615,EBI-6174091
SORBS3	O60504-2	3	EBI-4290615,EBI-1222956
ZDHHC17	Q8IUH5	2	EBI-4290615,EBI-524753

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- 10970852
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
protein kinase A binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25097019
SH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19798448

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115465, 39 interactors
CORUMⁱ	Q9Y6W5
Database of interacting proteins More...DIPⁱ	DIP-41817N
ELMⁱ	Q9Y6W5
IntActⁱ	Q9Y6W5, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y6W5
STRINGⁱ	9606.ENSP00000396211

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	436 – 446	Combined sources		11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y6W5
SMRⁱ	Q9Y6W5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y6W5

EvolutionaryTraceⁱ

Q9Y6W5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	436 – 453	WH2PROSITE-ProRule annotationAdd BLAST		18

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	268 – 271	Poly-Pro	4
Compositional biasⁱ	318 – 328	Poly-ProAdd BLAST	11
Compositional biasⁱ	333 – 338	Poly-Pro	6
Compositional biasⁱ	347 – 350	Poly-Pro	4
Compositional biasⁱ	364 – 371	Poly-Pro	8
Compositional biasⁱ	379 – 382	Poly-Pro	4
Compositional biasⁱ	391 – 406	Poly-ProAdd BLAST	16

Domainⁱ

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.2 Publications

Sequence similaritiesⁱ

Belongs to the SCAR/WAVE family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1830 Eukaryota ENOG410Y6V4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110593
HOGENOMⁱ	HOG000021456
HOVERGENⁱ	HBG058482
InParanoidⁱ	Q9Y6W5
KEGG Orthology (KO) More...KOⁱ	K05748
OMAⁱ	PADSNQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08O1
PhylomeDBⁱ	Q9Y6W5
TreeFamⁱ	TF315031

Family and domain databases

InterProⁱ	View protein in InterPro IPR028288 SCAR/WAVE_fam IPR003124 WH2_dom
PANTHERⁱ	PTHR12902 PTHR12902, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02205 WH2, 1 hit
SMARTⁱ	View protein in SMART SM00246 WH2, 1 hit
PROSITEⁱ	View protein in PROSITE PS51082 WH2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Y6W5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLVTRNIEP RHLCRQTLPS VRSELECVTN ITLANVIRQL GSLSKYAEDI 
        60         70         80         90        100
FGELFTQANT FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF 
       110        120        130        140        150
RSSTIQDQKL FDRNSLPVPV LETYNTCDTP PPLNNLTPYR DDGKEALKFY 
       160        170        180        190        200
TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK 
       210        220        230        240        250
EEWEKMKMGQ EFVESKEKLG TSGYPPTLVY QNGSIGCVEN VDASSYPPPP 
       260        270        280        290        300
QSDSASSPSP SFSEDNLPPP PAEFSYPVDN QRGSGLAGPK RSSVVSPSHP 
       310        320        330        340        350
PPAPPLGSPP GPKPGFAPPP APPPPPPPMI GIPPPPPPVG FGSPGTPPPP 
       360        370        380        390        400
SPPSFPPHPD FAAPPPPPPP PAADYPTLPP PPLSQPTGGA PPPPPPPPPP 
       410        420        430        440        450
GPPPPPFTGA DGQPAIPPPL SDTTKPKSSL PAVSDARSDL LSAIRQGFQL 
       460        470        480        490 
RRVEEQREQE KRDVVGNDVA TILSRRIAVE YSDSEDDSSE FDEDDWSD

Length:498

Mass (Da):54,284

Last modified:February 1, 2005 - v3

Checksum:ⁱC737CE963016DE94

Isoform 2 (identifier: Q9Y6W5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
275-281: SYPVDNQ → RFSAAQG
282-498: Missing.

« Hide

        10         20         30         40         50
MPLVTRNIEP RHLCRQTLPS VRSELECVTN ITLANVIRQL GSLSKYAEDI 
        60         70         80         90        100
FGELFTQANT FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF 
       110        120        130        140        150
RSSTIQDQKL FDRNSLPVPV LETYNTCDTP PPLNNLTPYR DDGKEALKFY 
       160        170        180        190        200
TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK 
       210        220        230        240        250
EEWEKMKMGQ EFVESKEKLG TSGYPPTLVY QNGSIGCVEN VDASSYPPPP 
       260        270        280 
QSDSASSPSP SFSEDNLPPP PAEFRFSAAQ G

Note: No experimental confirmation available.

Show »

Length:281

Mass (Da):31,979

Checksum:ⁱC5E79110854FAF56

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042514	275 – 281	SYPVDNQ → RFSAAQG in isoform 2. 1 Publication		7
Alternative sequenceⁱVSP_042515	282 – 498	Missing in isoform 2. 1 PublicationAdd BLAST		217

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB026542 mRNA Translation: BAA81795.1 AK303011 mRNA Translation: BAG64142.1 AL096774 Genomic DNA Translation: CAC18518.1 AL663122 Genomic DNA No translation available. BX293535 Genomic DNA No translation available. BC040943 mRNA Translation: AAH40943.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS304.1 [Q9Y6W5-1] CCDS55582.1 [Q9Y6W5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001188333.1, NM_001201404.2 [Q9Y6W5-2] NP_008921.1, NM_006990.4 [Q9Y6W5-1]
UniGeneⁱ	Hs.469244 Hs.512079

Genome annotation databases

Ensemblⁱ	ENST00000536657; ENSP00000439883; ENSG00000158195 [Q9Y6W5-2] ENST00000618852; ENSP00000483313; ENSG00000158195 [Q9Y6W5-1]
GeneIDⁱ	10163
KEGGⁱ	hsa:10163
UCSC genome browser More...UCSCⁱ	uc057dvq.1 human [Q9Y6W5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6W5	WAS protein family member 2		PANTR		498	UniRef100_Q9Y6W5
cDNA FLJ55445, highly similar to Wiskott-Aldrich syndrome protein family member 2		HUMAN		335
Q9Y6W5-2	WAS protein family member 2		PANTR		281	UniRef100_A0A2I3S2N9
Uncharacterized protein		MACMU		281
WASF2 isoform 2		PONAB		281
Uncharacterized protein		PANPA		281
WAS protein family member 2		GORGO		281
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2		BOVIN		493	UniRef90_Q9Y6W5
WAS protein family member 2		PANTR		498
cDNA FLJ55445, highly similar to Wiskott-Aldrich syndrome protein family member 2		HUMAN		335
Uncharacterized protein		SHEEP		504
WAS protein family member 2		MACNE		499
+42
Q9Y6W5-2	Uncharacterized protein		PONAB		325	UniRef90_H2N8D0
Uncharacterized protein		AOTNA		281
wiskott-Aldrich syndrome protein family member 2 isoform X2		LIPVE		281
WAS protein family member 2		PANTR		281
Uncharacterized protein		MACMU		281
+28

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2		BOVIN		493	UniRef50_Q9Y6W5
Wiskott-Aldrich syndrome protein family member 2		MOUSE		497
WAS protein family member 2		PANTR		498
cDNA FLJ55445, highly similar to Wiskott-Aldrich syndrome protein family member 2		HUMAN		335
Uncharacterized protein		SHEEP		504
+199
Q9Y6W5-2	Uncharacterized protein		PONAB		325	UniRef50_H2N8D0
Uncharacterized protein		FELCA		281
Uncharacterized protein		CALJA		281
wiskott-Aldrich syndrome protein family member 2 isoform X2		LIPVE		281
wiskott-Aldrich syndrome protein family member 2		ERIEU		281
+38

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB026542 mRNA Translation: BAA81795.1 AK303011 mRNA Translation: BAG64142.1 AL096774 Genomic DNA Translation: CAC18518.1 AL663122 Genomic DNA No translation available. BX293535 Genomic DNA No translation available. BC040943 mRNA Translation: AAH40943.1
CCDSⁱ	CCDS304.1 [Q9Y6W5-1] CCDS55582.1 [Q9Y6W5-2]
RefSeqⁱ	NP_001188333.1, NM_001201404.2 [Q9Y6W5-2] NP_008921.1, NM_006990.4 [Q9Y6W5-1]
UniGeneⁱ	Hs.469244 Hs.512079

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2A40	X-ray	1.80	C/F	433-464	[»]
ProteinModelPortalⁱ	Q9Y6W5
SMRⁱ	Q9Y6W5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115465, 39 interactors
CORUMⁱ	Q9Y6W5
DIPⁱ	DIP-41817N
ELMⁱ	Q9Y6W5
IntActⁱ	Q9Y6W5, 18 interactors
MINTⁱ	Q9Y6W5
STRINGⁱ	9606.ENSP00000396211

PTM databases

iPTMnetⁱ	Q9Y6W5
PhosphoSitePlusⁱ	Q9Y6W5

Polymorphism and mutation databases

BioMutaⁱ	WASF2
DMDMⁱ	59800456

Proteomic databases

EPDⁱ	Q9Y6W5
PaxDbⁱ	Q9Y6W5
PeptideAtlasⁱ	Q9Y6W5
PRIDEⁱ	Q9Y6W5
ProteomicsDBⁱ	86801 86802 [Q9Y6W5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000536657; ENSP00000439883; ENSG00000158195 [Q9Y6W5-2] ENST00000618852; ENSP00000483313; ENSG00000158195 [Q9Y6W5-1]
GeneIDⁱ	10163
KEGGⁱ	hsa:10163
UCSCⁱ	uc057dvq.1 human [Q9Y6W5-1]

Organism-specific databases

CTDⁱ	10163
DisGeNETⁱ	10163
EuPathDBⁱ	HostDB:ENSG00000158195.10
GeneCardsⁱ	WASF2
HGNCⁱ	HGNC:12733 WASF2
HPAⁱ	CAB022632 HPA045288
MIMⁱ	605875 gene
neXtProtⁱ	NX_Q9Y6W5
OpenTargetsⁱ	ENSG00000158195
PharmGKBⁱ	PA37344
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1830 Eukaryota ENOG410Y6V4 LUCA
GeneTreeⁱ	ENSGT00730000110593
HOGENOMⁱ	HOG000021456
HOVERGENⁱ	HBG058482
InParanoidⁱ	Q9Y6W5
KOⁱ	K05748
OMAⁱ	PADSNQR
OrthoDBⁱ	EOG091G08O1
PhylomeDBⁱ	Q9Y6W5
TreeFamⁱ	TF315031

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
SignaLinkⁱ	Q9Y6W5
SIGNORⁱ	Q9Y6W5

Miscellaneous databases

ChiTaRSⁱ	WASF2 human
EvolutionaryTraceⁱ	Q9Y6W5
GeneWikiⁱ	WASF2
GenomeRNAiⁱ	10163
PMAP-CutDBⁱ	Q9Y6W5
Protein Ontology More...PROⁱ	PR:Q9Y6W5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158195 Expressed in 239 organ(s), highest expression level in female reproductive system
CleanExⁱ	HS_WASF2
Genevisibleⁱ	Q9Y6W5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028288 SCAR/WAVE_fam IPR003124 WH2_dom
PANTHERⁱ	PTHR12902 PTHR12902, 1 hit
Pfamⁱ	View protein in Pfam PF02205 WH2, 1 hit
SMARTⁱ	View protein in SMART SM00246 WH2, 1 hit
PROSITEⁱ	View protein in PROSITE PS51082 WH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WASF2_HUMAN
Accessionⁱ	Q9Y6W5Primary (citable) accession number: Q9Y6W5 Secondary accession number(s): B4DZN0, O60794, Q9UDY7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	February 1, 2005
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y6W5 (WASF2_HUMAN)

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Wiskott-Aldrich syndrome protein family member 2

WASF2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Endosome

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ