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UniProtKB - Q9Y6W5 (WASF2_HUMAN)

Entry version 191 (25 May 2022)
Sequence version 3 (01 Feb 2005)
Previous versions | rss
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Protein

Wiskott-Aldrich syndrome protein family member 2

Gene

WASF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y6W5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013404, RAC2 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
R-HSA-9664422, FCGR3A-mediated phagocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y6W5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y6W5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Wiskott-Aldrich syndrome protein family member 2
Short name:
WASP family protein member 2
Alternative name(s):
Protein WAVE-2
Verprolin homology domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WASF2Imported
Synonyms:WAVE2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12733, WASF2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605875, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y6W5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000158195

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40L → D: Decreased interaction with WAVE complex; when associated with D-51. 1 Publication1
Mutagenesisi50I → D: Decreased interaction with WAVE complex; when associated with D-54. 1 Publication1
Mutagenesisi51F → D: Decreased interaction with WAVE complex; when associated with D-40. 1 Publication1
Mutagenesisi54L → D: Decreased interaction with WAVE complex; when associated with D-50. 1 Publication1
Mutagenesisi124Y → D: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia. 1 Publication1
Mutagenesisi150Y → D: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia. 1 Publication1
Mutagenesisi160 – 161WK → ED: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		10163

Open Targets

More...OpenTargetsi		ENSG00000158195

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37344

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y6W5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WASF2

Domain mapping of disease mutations (DMDM)

More...DMDMi		59800456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001889941 – 498Wiskott-Aldrich syndrome protein family member 2Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei474PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y6W5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y6W5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y6W5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y6W5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y6W5

PeptideAtlas

More...PeptideAtlasi		Q9Y6W5

PRoteomics IDEntifications database

More...PRIDEi		Q9Y6W5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86801 [Q9Y6W5-1]
86802 [Q9Y6W5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y6W5, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y6W5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y6W5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000158195, Expressed in female reproductive system and 247 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y6W5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000158195, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds actin and the Arp2/3 complex.

Interacts with BAIAP2.

Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406). Directly interacts with BRK1.

Interacts with FNBP1L (via the SH3 domain) (PubMed:19798448).

7 Publications

(Microbial infection) Interacts with human cytomegalovirus protein UL135.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115465, 102 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y6W5

Database of interacting proteins

More...DIPi		DIP-41817N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9Y6W5

Protein interaction database and analysis system

More...IntActi		Q9Y6W5, 36 interactors

Molecular INTeraction database

More...MINTi		Q9Y6W5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483313

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y6W5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1498
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y6W5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y6W5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y6W5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini436 – 453WH2PROSITE-ProRule annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni173 – 203DisorderedSequence analysisAdd BLAST31
Regioni240 – 435DisorderedSequence analysisAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi184 – 203Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi240 – 262Polar residuesSequence analysisAdd BLAST23
Compositional biasi295 – 413Pro residuesSequence analysisAdd BLAST119

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCAR/WAVE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1830, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182962

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036022_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y6W5

Identification of Orthologs from Complete Genome Data

More...OMAi		WEKIKMG

Database of Orthologous Groups

More...OrthoDBi		1183697at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y6W5

TreeFam database of animal gene trees

More...TreeFami		TF315031

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028288, SCAR/WAVE_fam
IPR003124, WH2_dom

The PANTHER Classification System

More...PANTHERi		PTHR12902, PTHR12902, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02205, WH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00246, WH2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51082, WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y6W5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLVTRNIEP RHLCRQTLPS VRSELECVTN ITLANVIRQL GSLSKYAEDI 
        60         70         80         90        100
FGELFTQANT FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF 
       110        120        130        140        150
RSSTIQDQKL FDRNSLPVPV LETYNTCDTP PPLNNLTPYR DDGKEALKFY 
       160        170        180        190        200
TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK 
       210        220        230        240        250
EEWEKMKMGQ EFVESKEKLG TSGYPPTLVY QNGSIGCVEN VDASSYPPPP 
       260        270        280        290        300
QSDSASSPSP SFSEDNLPPP PAEFSYPVDN QRGSGLAGPK RSSVVSPSHP 
       310        320        330        340        350
PPAPPLGSPP GPKPGFAPPP APPPPPPPMI GIPPPPPPVG FGSPGTPPPP 
       360        370        380        390        400
SPPSFPPHPD FAAPPPPPPP PAADYPTLPP PPLSQPTGGA PPPPPPPPPP 
       410        420        430        440        450
GPPPPPFTGA DGQPAIPPPL SDTTKPKSSL PAVSDARSDL LSAIRQGFQL 
       460        470        480        490 
RRVEEQREQE KRDVVGNDVA TILSRRIAVE YSDSEDDSSE FDEDDWSD
Length:498
Mass (Da):54,284
Last modified:February 1, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC737CE963016DE94
GO
Isoform 2 (identifier: Q9Y6W5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-281: SYPVDNQ → RFSAAQG
     282-498: Missing.

Show »
Length:281
Mass (Da):31,979
Checksum:iC5E79110854FAF56
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042514275 – 281SYPVDNQ → RFSAAQG in isoform 2. 1 Publication7
Alternative sequenceiVSP_042515282 – 498Missing in isoform 2. 1 PublicationAdd BLAST217

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB026542 mRNA Translation: BAA81795.1
AK303011 mRNA Translation: BAG64142.1
AL096774 Genomic DNA Translation: CAC18518.1
AL663122 Genomic DNA No translation available.
BX293535 Genomic DNA No translation available.
BC040943 mRNA Translation: AAH40943.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS304.1 [Q9Y6W5-1]
CCDS55582.1 [Q9Y6W5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001188333.1, NM_001201404.2 [Q9Y6W5-2]
NP_008921.1, NM_006990.4 [Q9Y6W5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000536657.1; ENSP00000439883.1; ENSG00000158195.11 [Q9Y6W5-2]
ENST00000618852.5; ENSP00000483313.1; ENSG00000158195.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10163

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10163

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000618852.5; ENSP00000483313.1; NM_006990.5; NP_008921.1

UCSC genome browser

More...UCSCi		uc057dvq.1, human [Q9Y6W5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026542 mRNA Translation: BAA81795.1
AK303011 mRNA Translation: BAG64142.1
AL096774 Genomic DNA Translation: CAC18518.1
AL663122 Genomic DNA No translation available.
BX293535 Genomic DNA No translation available.
BC040943 mRNA Translation: AAH40943.1
CCDSiCCDS304.1 [Q9Y6W5-1]
CCDS55582.1 [Q9Y6W5-2]
RefSeqiNP_001188333.1, NM_001201404.2 [Q9Y6W5-2]
NP_008921.1, NM_006990.4 [Q9Y6W5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A40X-ray1.80C/F433-464[»]
AlphaFoldDBiQ9Y6W5
SMRiQ9Y6W5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115465, 102 interactors
CORUMiQ9Y6W5
DIPiDIP-41817N
ELMiQ9Y6W5
IntActiQ9Y6W5, 36 interactors
MINTiQ9Y6W5
STRINGi9606.ENSP00000483313

PTM databases

GlyGeniQ9Y6W5, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9Y6W5
PhosphoSitePlusiQ9Y6W5

Genetic variation databases

BioMutaiWASF2
DMDMi59800456

Proteomic databases

EPDiQ9Y6W5
jPOSTiQ9Y6W5
MassIVEiQ9Y6W5
MaxQBiQ9Y6W5
PaxDbiQ9Y6W5
PeptideAtlasiQ9Y6W5
PRIDEiQ9Y6W5
ProteomicsDBi86801 [Q9Y6W5-1]
86802 [Q9Y6W5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30784, 353 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		10163

Genome annotation databases

EnsembliENST00000536657.1; ENSP00000439883.1; ENSG00000158195.11 [Q9Y6W5-2]
ENST00000618852.5; ENSP00000483313.1; ENSG00000158195.11
GeneIDi10163
KEGGihsa:10163
MANE-SelectiENST00000618852.5; ENSP00000483313.1; NM_006990.5; NP_008921.1
UCSCiuc057dvq.1, human [Q9Y6W5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10163
DisGeNETi10163

GeneCards: human genes, protein and diseases

More...GeneCardsi		WASF2
HGNCiHGNC:12733, WASF2
HPAiENSG00000158195, Low tissue specificity
MIMi605875, gene
neXtProtiNX_Q9Y6W5
OpenTargetsiENSG00000158195
PharmGKBiPA37344
VEuPathDBiHostDB:ENSG00000158195

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1830, Eukaryota
GeneTreeiENSGT00950000182962
HOGENOMiCLU_036022_2_0_1
InParanoidiQ9Y6W5
OMAiWEKIKMG
OrthoDBi1183697at2759
PhylomeDBiQ9Y6W5
TreeFamiTF315031

Enzyme and pathway databases

PathwayCommonsiQ9Y6W5
ReactomeiR-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013404, RAC2 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
R-HSA-9664422, FCGR3A-mediated phagocytosis
SignaLinkiQ9Y6W5
SIGNORiQ9Y6W5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10163, 88 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WASF2, human
EvolutionaryTraceiQ9Y6W5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WASF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10163
PharosiQ9Y6W5, Tbio

Protein Ontology

More...PROi		PR:Q9Y6W5
RNActiQ9Y6W5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000158195, Expressed in female reproductive system and 247 other tissues
GenevisibleiQ9Y6W5, HS

Family and domain databases

InterProiView protein in InterPro
IPR028288, SCAR/WAVE_fam
IPR003124, WH2_dom
PANTHERiPTHR12902, PTHR12902, 1 hit
PfamiView protein in Pfam
PF02205, WH2, 1 hit
SMARTiView protein in SMART
SM00246, WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082, WH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWASF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6W5
Secondary accession number(s): B4DZN0, O60794, Q9UDY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: May 25, 2022
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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