UniProtKB - Q9Y6U7 (RN215_HUMAN)
Protein
RING finger protein 215
Gene
RNF215
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 325 – 366 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- Golgi to vacuole transport Source: GO_Central
- protein targeting to vacuole Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6U7 |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 215 |
Gene namesi | Name:RNF215 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000099999.14 |
HGNCi | HGNC:33434, RNF215 |
neXtProti | NX_Q9Y6U7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endosome
- endosome Source: GO_Central
Golgi apparatus
- Golgi transport complex Source: GO_Central
- trans-Golgi network Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 43 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 44 – 250 | ExtracellularSequence analysisAdd BLAST | 207 | |
Transmembranei | 251 – 271 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 272 – 377 | CytoplasmicSequence analysisAdd BLAST | 106 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA162401807 |
Miscellaneous databases
Pharosi | Q9Y6U7, Tdark |
Polymorphism and mutation databases
BioMutai | RNF215 |
DMDMi | 147732500 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287534 | 1 – 377 | RING finger protein 215Add BLAST | 377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9Y6U7 |
PaxDbi | Q9Y6U7 |
PeptideAtlasi | Q9Y6U7 |
PRIDEi | Q9Y6U7 |
ProteomicsDBi | 86792 |
PTM databases
GlyGeni | Q9Y6U7, 1 site |
iPTMneti | Q9Y6U7 |
PhosphoSitePlusi | Q9Y6U7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000099999, Expressed in stomach and 159 other tissues |
ExpressionAtlasi | Q9Y6U7, baseline and differential |
Genevisiblei | Q9Y6U7, HS |
Organism-specific databases
HPAi | ENSG00000099999, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128317, 2 interactors |
IntActi | Q9Y6U7, 1 interactor |
STRINGi | 9606.ENSP00000371800 |
Miscellaneous databases
RNActi | Q9Y6U7, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 325 – 366 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Transmembrane, Transmembrane helix, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0800, Eukaryota |
GeneTreei | ENSGT00940000159671 |
HOGENOMi | CLU_049329_0_0_1 |
InParanoidi | Q9Y6U7 |
OMAi | GAQAYPK |
OrthoDBi | 1487241at2759 |
PhylomeDBi | Q9Y6U7 |
TreeFami | TF317074 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q9Y6U7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPAARPALR SPPPPPPPPP SPLLLLLPLL PLWLGLAGPG AAADGSEPAA
60 70 80 90 100
GAGRGGARAV RVDVRLPRQD ALVLEGVRIG SEADPAPLLG GRLLLMDIVD
110 120 130 140 150
AEQEAPVEGW IAVAYVGKEQ AAQFHQENKG SGPQAYPKAL VQQMRRALFL
160 170 180 190 200
GASALLLLIL NHNVVRELDI SQLLLRPVIV LHYSSNVTKL LDALLQRTQA
210 220 230 240 250
TAEITSGESL SANIEWKLTL WTTCGLSKDG YGGWQDLVCL GGSRAQEQKP
260 270 280 290 300
LQQLWNAILL VAMLLCTGLV VQAQRQASRQ SQRELGGQVD LFKRRVVRRL
310 320 330 340 350
ASLKTRRCRL SRAAQGLPDP GAETCAVCLD YFCNKQWLRV LPCKHEFHRD
360 370
CVDPWLMLQQ TCPLCKFNVL GNRYSDD
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y2L4 | H0Y2L4_HUMAN | RING finger protein 215 | RNF215 | 343 | Annotation score: | ||
C9JDL7 | C9JDL7_HUMAN | RING finger protein 215 | RNF215 | 99 | Annotation score: | ||
H7C0R1 | H7C0R1_HUMAN | RING finger protein 215 | RNF215 | 34 | Annotation score: | ||
A0A0D9SFN2 | A0A0D9SFN2_HUMAN | RING finger protein 215 | RNF215 | 30 | Annotation score: | ||
A0A0D9SGK3 | A0A0D9SGK3_HUMAN | RING finger protein 215 | RNF215 | 58 | Annotation score: | ||
A0A0D9SF05 | A0A0D9SF05_HUMAN | RING finger protein 215 | RNF215 | 135 | Annotation score: |
Sequence cautioni
The sequence AAD43187 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032319 | 322 | A → T. Corresponds to variant dbSNP:rs5749088Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004997 Genomic DNA Translation: AAD43187.1 Sequence problems. |
CCDSi | CCDS33633.1 |
RefSeqi | NP_001017981.1, NM_001017981.1 |
Genome annotation databases
Ensembli | ENST00000382363; ENSP00000371800; ENSG00000099999 |
GeneIDi | 200312 |
KEGGi | hsa:200312 |
UCSCi | uc003ahp.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004997 Genomic DNA Translation: AAD43187.1 Sequence problems. |
CCDSi | CCDS33633.1 |
RefSeqi | NP_001017981.1, NM_001017981.1 |
3D structure databases
SMRi | Q9Y6U7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128317, 2 interactors |
IntActi | Q9Y6U7, 1 interactor |
STRINGi | 9606.ENSP00000371800 |
PTM databases
GlyGeni | Q9Y6U7, 1 site |
iPTMneti | Q9Y6U7 |
PhosphoSitePlusi | Q9Y6U7 |
Polymorphism and mutation databases
BioMutai | RNF215 |
DMDMi | 147732500 |
Proteomic databases
MassIVEi | Q9Y6U7 |
PaxDbi | Q9Y6U7 |
PeptideAtlasi | Q9Y6U7 |
PRIDEi | Q9Y6U7 |
ProteomicsDBi | 86792 |
Protocols and materials databases
Antibodypediai | 24705, 106 antibodies |
DNASUi | 200312 |
Genome annotation databases
Ensembli | ENST00000382363; ENSP00000371800; ENSG00000099999 |
GeneIDi | 200312 |
KEGGi | hsa:200312 |
UCSCi | uc003ahp.4, human |
Organism-specific databases
CTDi | 200312 |
EuPathDBi | HostDB:ENSG00000099999.14 |
GeneCardsi | RNF215 |
HGNCi | HGNC:33434, RNF215 |
HPAi | ENSG00000099999, Low tissue specificity |
neXtProti | NX_Q9Y6U7 |
PharmGKBi | PA162401807 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0800, Eukaryota |
GeneTreei | ENSGT00940000159671 |
HOGENOMi | CLU_049329_0_0_1 |
InParanoidi | Q9Y6U7 |
OMAi | GAQAYPK |
OrthoDBi | 1487241at2759 |
PhylomeDBi | Q9Y6U7 |
TreeFami | TF317074 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6U7 |
Miscellaneous databases
BioGRID-ORCSi | 200312, 2 hits in 844 CRISPR screens |
GenomeRNAii | 200312 |
Pharosi | Q9Y6U7, Tdark |
PROi | PR:Q9Y6U7 |
RNActi | Q9Y6U7, protein |
Gene expression databases
Bgeei | ENSG00000099999, Expressed in stomach and 159 other tissues |
ExpressionAtlasi | Q9Y6U7, baseline and differential |
Genevisiblei | Q9Y6U7, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RN215_HUMAN | |
Accessioni | Q9Y6U7Primary (citable) accession number: Q9Y6U7 Secondary accession number(s): A6NEL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations