Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adseverin

Gene

SCIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi538Calcium 1Combined sources1
Metal bindingi539Calcium 1Combined sources1
Metal bindingi562Calcium 1Combined sources1
Metal bindingi643Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi644Calcium 2Combined sources1
Metal bindingi666Calcium 2Combined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin capping, Actin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adseverin
Alternative name(s):
Scinderin
Gene namesi
Name:SCIN
Synonyms:KIAA1905
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006747.14
HGNCiHGNC:21695 SCIN
MIMi613416 gene
neXtProtiNX_Q9Y6U3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi310M → D: Increases calcium-independent actin-severing activity. 1 Publication1
Mutagenesisi314E → S: Increases calcium-independent actin-severing activity. 1 Publication1
Mutagenesisi455F → D: Loss of actin-binding. 1 Publication1

Organism-specific databases

DisGeNETi85477
OpenTargetsiENSG00000006747
PharmGKBiPA134981389

Polymorphism and mutation databases

BioMutaiSCIN
DMDMi57015325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187441 – 715AdseverinAdd BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphotyrosineBy similarity1
Modified residuei599PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6U3
PaxDbiQ9Y6U3
PeptideAtlasiQ9Y6U3
PRIDEiQ9Y6U3
ProteomicsDBi86789
86790 [Q9Y6U3-2]
86791 [Q9Y6U3-3]

PTM databases

CarbonylDBiQ9Y6U3
iPTMnetiQ9Y6U3
PhosphoSitePlusiQ9Y6U3

Expressioni

Tissue specificityi

Expressed in megakaryocytes.1 Publication

Gene expression databases

BgeeiENSG00000006747 Expressed in 173 organ(s), highest expression level in tibia
CleanExiHS_SCIN
ExpressionAtlasiQ9Y6U3 baseline and differential
GenevisibleiQ9Y6U3 HS

Organism-specific databases

HPAiHPA020518
HPA024264

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124552, 13 interactors
IntActiQ9Y6U3, 2 interactors
STRINGi9606.ENSP00000297029

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6U3
SMRiQ9Y6U3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6U3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 76Gelsolin-like 1Add BLAST50
Repeati148 – 188Gelsolin-like 2Add BLAST41
Repeati265 – 307Gelsolin-like 3Add BLAST43
Repeati398 – 451Gelsolin-like 4Add BLAST54
Repeati523 – 564Gelsolin-like 5Add BLAST42
Repeati626 – 668Gelsolin-like 6Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 363Actin-severingSequence analysisAdd BLAST363
Regioni112 – 119Polyphosphoinositide bindingBy similarity8
Regioni138 – 146Polyphosphoinositide bindingBy similarity9
Regioni364 – 715Ca(2+)-dependent actin bindingAdd BLAST352

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000233630
HOVERGENiHBG004183
InParanoidiQ9Y6U3
KOiK05768
OMAiLGKECTQ
OrthoDBiEOG091G05SC
PhylomeDBiQ9Y6U3
TreeFamiTF313468

Family and domain databases

Gene3Di3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR030012 Adseverin
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF78 PTHR11977:SF78, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 6 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits
SUPFAMiSSF82754 SSF82754, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH
60 70 80 90 100
TAKTSRGFTY HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ
110 120 130 140 150
GYESNDFVSY FKGGLKYKAG GVASGLNHVL TNDLTAKRLL HVKGRRVVRA
160 170 180 190 200
TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS SCNKYERLKA NQVATGIRYN
210 220 230 240 250
ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII ADISNRKMAK
260 270 280 290 300
LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD
310 320 330 340 350
ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK
360 370 380 390 400
DQSDGFGKVY VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI
410 420 430 440 450
WRVENNGRIQ VDQNSYGEFY GGDCYIILYT YPRGQIIYTW QGANATRDEL
460 470 480 490 500
TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV HLLSLFKDKP LIIYKNGTSK
510 520 530 540 550
KGGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDV FVLKLPQNSG
560 570 580 590 600
YIWVGKGASQ EEEKGAEYVA SVLKCKTLRI QEGEEPEEFW NSLGGKKDYQ
610 620 630 640 650
TSPLLETQAE DHPPRLYGCS NKTGRFVIEE IPGEFTQDDL AEDDVMLLDA
660 670 680 690 700
WEQIFIWIGK DANEVEKKES LKSAKMYLET DPSGRDKRTP IVIIKQGHEP
710
PTFTGWFLGW DSSKW
Length:715
Mass (Da):80,489
Last modified:January 4, 2005 - v4
Checksum:i20420C82DB2E2D24
GO
Isoform 2 (identifier: Q9Y6U3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-580: VDVDANSLNS...SVLKCKTLRI → RSSGIPLEGK...RFQESSPRMI
     581-715: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):65,357
Checksum:i4291B928419AB445
GO
Isoform 3 (identifier: Q9Y6U3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Show »
Length:468
Mass (Da):52,814
Checksum:iFB1BAE7D65C7E39F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JGB6C9JGB6_HUMAN
Adseverin
SCIN
160Annotation score:
E5RHX6E5RHX6_HUMAN
Adseverin
SCIN
108Annotation score:
E5RHN8E5RHN8_HUMAN
Adseverin
SCIN
91Annotation score:
F8WBX5F8WBX5_HUMAN
Adseverin
SCIN
102Annotation score:

Sequence cautioni

The sequence BAB67798 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48V → M in BAC11416 (PubMed:14702039).Curated1
Sequence conflicti476G → D in AAK60494 (Ref. 1) Curated1
Sequence conflicti546P → S in AAK60494 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05995661H → R1 PublicationCorresponds to variant dbSNP:rs2240572Ensembl.1
Natural variantiVAR_059957443A → P. Corresponds to variant dbSNP:rs35083013Ensembl.1
Natural variantiVAR_057470455F → L. Corresponds to variant dbSNP:rs17166250Ensembl.1
Natural variantiVAR_059958500K → R. Corresponds to variant dbSNP:rs35705332Ensembl.1
Natural variantiVAR_057471578L → F. Corresponds to variant dbSNP:rs1138957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0405481 – 247Missing in isoform 3. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_012427528 – 580VDVDA…KTLRI → RSSGIPLEGKKTTRPHHYWK PRLKTIHLGFTAALTKLEDL LLKRFQESSPRMI in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_012428581 – 715Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276507 mRNA Translation: AAK60494.1
AK027778 mRNA Translation: BAB55361.1
AK075123 mRNA Translation: BAC11416.1
AK290363 mRNA Translation: BAF83052.1
AB067492 mRNA Translation: BAB67798.1 Different initiation.
AC005281 Genomic DNA Translation: AAD15423.1
CH471073 Genomic DNA Translation: EAW93647.1
BC021090 mRNA Translation: AAH21090.1
BU193785 mRNA No translation available.
CCDSiCCDS47545.1 [Q9Y6U3-1]
CCDS47546.1 [Q9Y6U3-3]
RefSeqiNP_001106177.1, NM_001112706.2 [Q9Y6U3-1]
NP_149119.1, NM_033128.3 [Q9Y6U3-3]
UniGeneiHs.633359
Hs.655515

Genome annotation databases

EnsembliENST00000297029; ENSP00000297029; ENSG00000006747 [Q9Y6U3-1]
ENST00000341757; ENSP00000341375; ENSG00000006747 [Q9Y6U3-2]
ENST00000519209; ENSP00000430997; ENSG00000006747 [Q9Y6U3-3]
GeneIDi85477
KEGGihsa:85477
UCSCiuc003ssn.5 human [Q9Y6U3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276507 mRNA Translation: AAK60494.1
AK027778 mRNA Translation: BAB55361.1
AK075123 mRNA Translation: BAC11416.1
AK290363 mRNA Translation: BAF83052.1
AB067492 mRNA Translation: BAB67798.1 Different initiation.
AC005281 Genomic DNA Translation: AAD15423.1
CH471073 Genomic DNA Translation: EAW93647.1
BC021090 mRNA Translation: AAH21090.1
BU193785 mRNA No translation available.
CCDSiCCDS47545.1 [Q9Y6U3-1]
CCDS47546.1 [Q9Y6U3-3]
RefSeqiNP_001106177.1, NM_001112706.2 [Q9Y6U3-1]
NP_149119.1, NM_033128.3 [Q9Y6U3-3]
UniGeneiHs.633359
Hs.655515

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FG6X-ray3.00A/B/C/D/E/F/G/H345-715[»]
5A1KX-ray2.90A/B6-349[»]
5A1MX-ray1.81A247-350[»]
ProteinModelPortaliQ9Y6U3
SMRiQ9Y6U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124552, 13 interactors
IntActiQ9Y6U3, 2 interactors
STRINGi9606.ENSP00000297029

PTM databases

CarbonylDBiQ9Y6U3
iPTMnetiQ9Y6U3
PhosphoSitePlusiQ9Y6U3

Polymorphism and mutation databases

BioMutaiSCIN
DMDMi57015325

Proteomic databases

EPDiQ9Y6U3
PaxDbiQ9Y6U3
PeptideAtlasiQ9Y6U3
PRIDEiQ9Y6U3
ProteomicsDBi86789
86790 [Q9Y6U3-2]
86791 [Q9Y6U3-3]

Protocols and materials databases

DNASUi85477
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297029; ENSP00000297029; ENSG00000006747 [Q9Y6U3-1]
ENST00000341757; ENSP00000341375; ENSG00000006747 [Q9Y6U3-2]
ENST00000519209; ENSP00000430997; ENSG00000006747 [Q9Y6U3-3]
GeneIDi85477
KEGGihsa:85477
UCSCiuc003ssn.5 human [Q9Y6U3-1]

Organism-specific databases

CTDi85477
DisGeNETi85477
EuPathDBiHostDB:ENSG00000006747.14
GeneCardsiSCIN
HGNCiHGNC:21695 SCIN
HPAiHPA020518
HPA024264
MIMi613416 gene
neXtProtiNX_Q9Y6U3
OpenTargetsiENSG00000006747
PharmGKBiPA134981389
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000233630
HOVERGENiHBG004183
InParanoidiQ9Y6U3
KOiK05768
OMAiLGKECTQ
OrthoDBiEOG091G05SC
PhylomeDBiQ9Y6U3
TreeFamiTF313468

Miscellaneous databases

ChiTaRSiSCIN human
EvolutionaryTraceiQ9Y6U3
GeneWikiiSCIN
GenomeRNAii85477
PROiPR:Q9Y6U3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006747 Expressed in 173 organ(s), highest expression level in tibia
CleanExiHS_SCIN
ExpressionAtlasiQ9Y6U3 baseline and differential
GenevisibleiQ9Y6U3 HS

Family and domain databases

Gene3Di3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR030012 Adseverin
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF78 PTHR11977:SF78, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 6 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits
SUPFAMiSSF82754 SSF82754, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADSV_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6U3
Secondary accession number(s): A8K2U8
, Q8NBZ6, Q8WU97, Q96JC7, Q96PY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 164 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again