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UniProtKB - Q9Y6T7 (DGKB_HUMAN)

Entry version 192 (25 May 2022)
Sequence version 2 (11 Jan 2001)
Previous versions | rss
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Protein

Diacylglycerol kinase beta

Gene

DGKB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity).

Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).

By similarityCurated1 Publication

Does not associate with membranes but has a diacylglycerol kinase activity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by calcium.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi162Calcium 1PROSITE-ProRule annotation1
Metal bindingi164Calcium 1PROSITE-ProRule annotation1
Metal bindingi166Calcium 1PROSITE-ProRule annotation1
Metal bindingi173Calcium 1PROSITE-ProRule annotation1
Metal bindingi207Calcium 2PROSITE-ProRule annotation1
Metal bindingi209Calcium 2PROSITE-ProRule annotation1
Metal bindingi211Calcium 2PROSITE-ProRule annotation1
Metal bindingi213Calcium 2PROSITE-ProRule annotation1
Metal bindingi218Calcium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri244 – 294Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri309 – 358Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.107, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y6T7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114508, Effects of PIP2 hydrolysis

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9Y6T7

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00230

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000915 [Q9Y6T7-1]
SLP:000000916 [Q9Y6T7-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase beta (EC:2.7.1.1071 Publication)
Short name:
DAG kinase beta
Alternative name(s):
90 kDa diacylglycerol kinase
Diglyceride kinase beta
Short name:
DGK-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKB
Synonyms:DAGK2, KIAA0718
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2850, DGKB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604070, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y6T7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136267

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1607

Open Targets

More...OpenTargetsi		ENSG00000136267

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27311

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y6T7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105755

Drug and drug target database

More...DrugBanki		DB14001, alpha-Tocopherol succinate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DGKB

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002184571 – 804Diacylglycerol kinase betaAdd BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei117PhosphothreonineBy similarity1
Modified residuei420PhosphoserineBy similarity1
Modified residuei793PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y6T7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y6T7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y6T7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y6T7

PeptideAtlas

More...PeptideAtlasi		Q9Y6T7

PRoteomics IDEntifications database

More...PRIDEi		Q9Y6T7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86787 [Q9Y6T7-1]
86788 [Q9Y6T7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y6T7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y6T7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in brain but also detected in uterus (PubMed:11719522). In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522).1 Publication
More ubiquitously expressed but at lower level compared to isoform 1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136267, Expressed in caudate nucleus and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y6T7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y6T7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136267, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107977, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385780

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y6T7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y6T7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y6T7

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 184EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini194 – 229EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini434 – 568DAGKcPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni385 – 406DisorderedSequence analysisAdd BLAST22
Regioni673 – 694DisorderedSequence analysisAdd BLAST22
Regioni771 – 804Required for association with membranes and function in neurite spine formation1 PublicationAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 294Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri309 – 358Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1169, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159770

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y6T7

Database of Orthologous Groups

More...OrthoDBi		633642at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y6T7

TreeFam database of animal gene trees

More...TreeFami		TF313104

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.238.110, 2 hits
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR046349, C1-like_sf
IPR029477, DAG_kinase_typeI_N
IPR037607, DGK
IPR038199, DGK_typeI_N_sf
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd

The PANTHER Classification System

More...PANTHERi		PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 2 hits
PF14513, DAG_kinase_N, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF13499, EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111331, SSF111331, 1 hit
SSF47473, SSF47473, 2 hits
SSF57889, SSF57889, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50146, DAGK, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6T7-1) [UniParc]FASTAAdd to basket
Also known as: STD1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTNQEKWAHL SPSEFSQLQK YAEYSTKKLK DVLEEFHGNG VLAKYNPEGK 
        60         70         80         90        100
QDILNQTIDF EGFKLFMKTF LEAELPDDFT AHLFMSFSNK FPHSSPMVKS 
       110        120        130        140        150
KPALLSGGLR MNKGAITPPR TTSPANTCSP EVIHLKDIVC YLSLLERGRP 
       160        170        180        190        200
EDKLEFMFRL YDTDGNGFLD SSELENIISQ MMHVAEYLEW DVTELNPILH 
       210        220        230        240        250
EMMEEIDYDH DGTVSLEEWI QGGMTTIPLL VLLGLENNVK DDGQHVWRLK 
       260        270        280        290        300
HFNKPAYCNL CLNMLIGVGK QGLCCSFCKY TVHERCVARA PPSCIKTYVK 
       310        320        330        340        350
SKRNTDVMHH YWVEGNCPTK CDKCHKTVKC YQGLTGLHCV WCQITLHNKC 
       360        370        380        390        400
ASHLKPECDC GPLKDHILPP TTICPVVLQT LPTSGVSVPE ERQSTVKKEK 
       410        420        430        440        450
SGSQQPNKVI DKNKMQRANS VTVDGQGLQV TPVPGTHPLL VFVNPKSGGK 
       460        470        480        490        500
QGERIYRKFQ YLLNPRQVYS LSGNGPMPGL NFFRDVPDFR VLACGGDGTV 
       510        520        530        540        550
GWVLDCIEKA NVGKHPPVAI LPLGTGNDLA RCLRWGGGYE GENLMKILKD 
       560        570        580        590        600
IENSTEIMLD RWKFEVIPND KDEKGDPVPY SIINNYFSIG VDASIAHRFH 
       610        620        630        640        650
IMREKHPEKF NSRMKNKFWY FEFGTSETFS ATCKKLHESV EIECDGVQID 
       660        670        680        690        700
LINISLEGIA ILNIPSMHGG SNLWGESKKR RSHRRIEKKG SDKRTTVTDA 
       710        720        730        740        750
KELKFASQDL SDQLLEVVGL EGAMEMGQIY TGLKSAGRRL AQCSCVVIRT 
       760        770        780        790        800
SKSLPMQIDG EPWMQTPCTI KITHKNQAPM LMGPPPKTGL FCSLVKRTRN 

RSKE
Length:804
Mass (Da):90,595
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBCABD2339BFE176
GO
Isoform 2 (identifier: Q9Y6T7-2) [UniParc]FASTAAdd to basket
Also known as: SV3'1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     770-773: IKIT → VSTE
     774-804: Missing.

Show »
Length:773
Mass (Da):87,051
Checksum:i9AF7118E642F8EB8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MBY2B5MBY2_HUMAN
Diacylglycerol kinase
DGKB
803Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCD5B5MCD5_HUMAN
Diacylglycerol kinase
DGKB
796Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA18C9JA18_HUMAN
Diacylglycerol kinase beta
DGKB
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS07533 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048858789G → S. Corresponds to variant dbSNP:rs34616903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021898770 – 773IKIT → VSTE in isoform 2. 1 Publication4
Alternative sequenceiVSP_021899774 – 804Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AX032742 mRNA Translation: CAC09945.1
AC005039 Genomic DNA Translation: AAS07495.1
AC005248 Genomic DNA Translation: AAC25525.1
AC006150 Genomic DNA No translation available.
AC011229 Genomic DNA Translation: AAP21868.1
AC073258 Genomic DNA Translation: AAS07533.1 Sequence problems.
AC105459 Genomic DNA Translation: AAP22362.1
CH236948 Genomic DNA Translation: EAL24292.1
CH236948 Genomic DNA Translation: EAL24293.1
CH471073 Genomic DNA Translation: EAW93663.1
CH471073 Genomic DNA Translation: EAW93664.1
BC105005 mRNA Translation: AAI05006.1
AB018261 mRNA Translation: BAA34438.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47547.1 [Q9Y6T7-1]
CCDS47548.1 [Q9Y6T7-2]

NCBI Reference Sequences

More...RefSeqi		NP_004071.1, NM_004080.2
NP_663733.1, NM_145695.2 [Q9Y6T7-2]
XP_005249685.1, XM_005249628.2
XP_011513455.1, XM_011515153.2
XP_011513456.1, XM_011515154.2 [Q9Y6T7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399322.7; ENSP00000382260.3; ENSG00000136267.14
ENST00000403951.6; ENSP00000385780.2; ENSG00000136267.14
ENST00000406247.7; ENSP00000386066.3; ENSG00000136267.14 [Q9Y6T7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1607

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1607

UCSC genome browser

More...UCSCi		uc003ssz.3, human [Q9Y6T7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AX032742 mRNA Translation: CAC09945.1
AC005039 Genomic DNA Translation: AAS07495.1
AC005248 Genomic DNA Translation: AAC25525.1
AC006150 Genomic DNA No translation available.
AC011229 Genomic DNA Translation: AAP21868.1
AC073258 Genomic DNA Translation: AAS07533.1 Sequence problems.
AC105459 Genomic DNA Translation: AAP22362.1
CH236948 Genomic DNA Translation: EAL24292.1
CH236948 Genomic DNA Translation: EAL24293.1
CH471073 Genomic DNA Translation: EAW93663.1
CH471073 Genomic DNA Translation: EAW93664.1
BC105005 mRNA Translation: AAI05006.1
AB018261 mRNA Translation: BAA34438.1
CCDSiCCDS47547.1 [Q9Y6T7-1]
CCDS47548.1 [Q9Y6T7-2]
RefSeqiNP_004071.1, NM_004080.2
NP_663733.1, NM_145695.2 [Q9Y6T7-2]
XP_005249685.1, XM_005249628.2
XP_011513455.1, XM_011515153.2
XP_011513456.1, XM_011515154.2 [Q9Y6T7-1]

3D structure databases

AlphaFoldDBiQ9Y6T7
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi107977, 3 interactors
STRINGi9606.ENSP00000385780

Chemistry databases

BindingDBiQ9Y6T7
ChEMBLiCHEMBL4105755
DrugBankiDB14001, alpha-Tocopherol succinate
SwissLipidsiSLP:000000915 [Q9Y6T7-1]
SLP:000000916 [Q9Y6T7-2]

PTM databases

iPTMnetiQ9Y6T7
PhosphoSitePlusiQ9Y6T7

Genetic variation databases

BioMutaiDGKB
DMDMi12643960

Proteomic databases

jPOSTiQ9Y6T7
MassIVEiQ9Y6T7
MaxQBiQ9Y6T7
PaxDbiQ9Y6T7
PeptideAtlasiQ9Y6T7
PRIDEiQ9Y6T7
ProteomicsDBi86787 [Q9Y6T7-1]
86788 [Q9Y6T7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25192, 220 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		1607

Genome annotation databases

EnsembliENST00000399322.7; ENSP00000382260.3; ENSG00000136267.14
ENST00000403951.6; ENSP00000385780.2; ENSG00000136267.14
ENST00000406247.7; ENSP00000386066.3; ENSG00000136267.14 [Q9Y6T7-2]
GeneIDi1607
KEGGihsa:1607
UCSCiuc003ssz.3, human [Q9Y6T7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1607
DisGeNETi1607

GeneCards: human genes, protein and diseases

More...GeneCardsi		DGKB
HGNCiHGNC:2850, DGKB
HPAiENSG00000136267, Tissue enriched (brain)
MIMi604070, gene
neXtProtiNX_Q9Y6T7
OpenTargetsiENSG00000136267
PharmGKBiPA27311
VEuPathDBiHostDB:ENSG00000136267

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1169, Eukaryota
GeneTreeiENSGT00940000159770
InParanoidiQ9Y6T7
OrthoDBi633642at2759
PhylomeDBiQ9Y6T7
TreeFamiTF313104

Enzyme and pathway databases

UniPathwayiUPA00230
BRENDAi2.7.1.107, 2681
PathwayCommonsiQ9Y6T7
ReactomeiR-HSA-114508, Effects of PIP2 hydrolysis
SABIO-RKiQ9Y6T7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1607, 5 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DGKB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DGKB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1607
PharosiQ9Y6T7, Tbio

Protein Ontology

More...PROi		PR:Q9Y6T7
RNActiQ9Y6T7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136267, Expressed in caudate nucleus and 141 other tissues
ExpressionAtlasiQ9Y6T7, baseline and differential
GenevisibleiQ9Y6T7, HS

Family and domain databases

CDDicd00029, C1, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.238.110, 2 hits
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR046349, C1-like_sf
IPR029477, DAG_kinase_typeI_N
IPR037607, DGK
IPR038199, DGK_typeI_N_sf
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 2 hits
PF14513, DAG_kinase_N, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF13499, EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00054, EFh, 2 hits
SUPFAMiSSF111331, SSF111331, 1 hit
SSF47473, SSF47473, 2 hits
SSF57889, SSF57889, 2 hits
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6T7
Secondary accession number(s): A4D116
, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: May 25, 2022
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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