UniProtKB - Q9Y6R9 (CCD61_HUMAN)
Protein
Coiled-coil domain-containing protein 61
Gene
CCDC61
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 61 |
Gene namesi | Name:CCDC61 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33629 CCDC61 |
neXtProti | NX_Q9Y6R9 |
Subcellular locationi
Cytoskeleton
- centrosome Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000104983 |
Miscellaneous databases
Pharosi | Q9Y6R9 |
Polymorphism and mutation databases
BioMutai | CCDC61 |
DMDMi | 160380583 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311255 | 1 – 512 | Coiled-coil domain-containing protein 61Add BLAST | 512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 285 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 334 | PhosphoserineCombined sources | 1 | |
Modified residuei | 336 | PhosphoserineCombined sources | 1 | |
Modified residuei | 373 | PhosphoserineCombined sources | 1 | |
Modified residuei | 376 | PhosphoserineCombined sources | 1 | |
Modified residuei | 447 | PhosphoserineCombined sources | 1 | |
Modified residuei | 473 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y6R9 |
jPOSTi | Q9Y6R9 |
MassIVEi | Q9Y6R9 |
PeptideAtlasi | Q9Y6R9 |
PRIDEi | Q9Y6R9 |
ProteomicsDBi | 86781 [Q9Y6R9-1] |
PTM databases
iPTMneti | Q9Y6R9 |
PhosphoSitePlusi | Q9Y6R9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104983 Expressed in 127 organ(s), highest expression level in right uterine tube |
ExpressionAtlasi | Q9Y6R9 baseline and differential |
Genevisiblei | Q9Y6R9 HS |
Organism-specific databases
HPAi | HPA040325 HPA061548 |
Interactioni
Protein-protein interaction databases
BioGridi | 609841, 32 interactors |
IntActi | Q9Y6R9, 30 interactors |
STRINGi | 9606.ENSP00000471454 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 175 – 277 | Sequence analysisAdd BLAST | 103 |
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00940000154133 |
HOGENOMi | HOG000111425 |
InParanoidi | Q9Y6R9 |
KOi | K16755 |
OMAi | QTYNGPN |
OrthoDBi | 1433381at2759 |
TreeFami | TF329415 |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y6R9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDQPAGLQVD YVFRGVEHAV RVMVSGQVLE LEVEDRMTAD QWRGEFDAGF
60 70 80 90 100
IEDLTHKTGN FKQFNIFCHM LESALTQSSE SVTLDLLTYT DLESLRNRKM
110 120 130 140 150
GGRPGSLAPR SAQLNSKRYL ILIYSVEFDR IHYPLPLPYQ GKPDPVVLQG
160 170 180 190 200
IIRSLKEELG RLQGLDGQNT RDTRENEIWH LREQVSRLAS EKRELEAQLG
210 220 230 240 250
RSREEALAGR AARQEAEALR GLVRGLELEL RQERGLGHRV AGRRGQDCRR
260 270 280 290 300
LAKELEEAKA SERSLRARLK TLTSELALYK RGRRTPPVQP PPTREDRASS
310 320 330 340 350
SRERSASRGR GAARSSSRES GRGSRGRGRP ARPSPSPTGG RALRFDPTAF
360 370 380 390 400
VKAKERKQRE IQMKQQQRNR LGSGGSGDGP SVSWSRQTQP PAALTGRGDA
410 420 430 440 450
PNRSRNRSSS VDSFRSRCSS ASSCSDLEDF SESLSRGGHR RRGKPPSPTP
460 470 480 490 500
WSGSNMKSPP VERSHHQKSL ANSGGWVPIK EYSSEHQAAD MAEIDARLKA
510
LQEYMNRLDM RS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYL5 | M0QYL5_HUMAN | Coiled-coil domain-containing prote... | CCDC61 | 77 | Annotation score: | ||
M0QY15 | M0QY15_HUMAN | Coiled-coil domain-containing prote... | CCDC61 | 49 | Annotation score: |
Sequence cautioni
The sequence AAD38244 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAD38244 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF98366 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 389 | Q → R in ACT79331 (Ref. 1) Curated | 1 | |
Sequence conflicti | 459 | P → L in ACT79331 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053741 | 185 – 364 | Missing in isoform 2. 1 PublicationAdd BLAST | 180 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ375050 mRNA Translation: ACT79331.1 AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems. AC011545 Genomic DNA Translation: AAF98366.1 Different initiation. |
CCDSi | CCDS46120.2 [Q9Y6R9-1] |
RefSeqi | NP_001254652.1, NM_001267723.1 [Q9Y6R9-1] XP_005259249.1, XM_005259192.4 [Q9Y6R9-1] XP_011525559.1, XM_011527257.2 [Q9Y6R9-1] |
Genome annotation databases
Ensembli | ENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2] ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2] ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1] |
GeneIDi | 729440 |
KEGGi | hsa:729440 |
UCSCi | uc021uwd.3 human [Q9Y6R9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ375050 mRNA Translation: ACT79331.1 AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems. AC011545 Genomic DNA Translation: AAF98366.1 Different initiation. |
CCDSi | CCDS46120.2 [Q9Y6R9-1] |
RefSeqi | NP_001254652.1, NM_001267723.1 [Q9Y6R9-1] XP_005259249.1, XM_005259192.4 [Q9Y6R9-1] XP_011525559.1, XM_011527257.2 [Q9Y6R9-1] |
3D structure databases
SMRi | Q9Y6R9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 609841, 32 interactors |
IntActi | Q9Y6R9, 30 interactors |
STRINGi | 9606.ENSP00000471454 |
PTM databases
iPTMneti | Q9Y6R9 |
PhosphoSitePlusi | Q9Y6R9 |
Polymorphism and mutation databases
BioMutai | CCDC61 |
DMDMi | 160380583 |
Proteomic databases
EPDi | Q9Y6R9 |
jPOSTi | Q9Y6R9 |
MassIVEi | Q9Y6R9 |
PeptideAtlasi | Q9Y6R9 |
PRIDEi | Q9Y6R9 |
ProteomicsDBi | 86781 [Q9Y6R9-1] |
Genome annotation databases
Ensembli | ENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2] ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2] ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1] |
GeneIDi | 729440 |
KEGGi | hsa:729440 |
UCSCi | uc021uwd.3 human [Q9Y6R9-1] |
Organism-specific databases
CTDi | 729440 |
GeneCardsi | CCDC61 |
HGNCi | HGNC:33629 CCDC61 |
HPAi | HPA040325 HPA061548 |
neXtProti | NX_Q9Y6R9 |
OpenTargetsi | ENSG00000104983 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154133 |
HOGENOMi | HOG000111425 |
InParanoidi | Q9Y6R9 |
KOi | K16755 |
OMAi | QTYNGPN |
OrthoDBi | 1433381at2759 |
TreeFami | TF329415 |
Miscellaneous databases
ChiTaRSi | CCDC61 human |
GenomeRNAii | 729440 |
Pharosi | Q9Y6R9 |
PROi | PR:Q9Y6R9 |
Gene expression databases
Bgeei | ENSG00000104983 Expressed in 127 organ(s), highest expression level in right uterine tube |
ExpressionAtlasi | Q9Y6R9 baseline and differential |
Genevisiblei | Q9Y6R9 HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD61_HUMAN | |
Accessioni | Q9Y6R9Primary (citable) accession number: Q9Y6R9 Secondary accession number(s): C8CAP4, Q9HDB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | March 19, 2014 | |
Last modified: | October 16, 2019 | |
This is version 109 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM