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UniProtKB - Q9Y6R9 (CCD61_HUMAN)

Entry version 116 (02 Dec 2020)
Sequence version 3 (19 Mar 2014)
Previous versions | rss
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Protein

Centrosomal protein CCDC61

Gene

CCDC61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023).3 Publications

Miscellaneous

The N-terminal 3D structure (head domain) resembles that of NHEJ1/XLF, PAXX, SASS6 and XRCC4.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y6R9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein CCDC611 Publication
Alternative name(s):
Coiled-coil domain-containing protein 61
VFL3 homolog2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC61Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000104983.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:33629, CCDC61

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y6R9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi128 – 129FD → EA: Loss of dimerization. 1 Publication2
Mutagenesisi259K → E: Loss of microtubule-binding; when associated with E-263, E-266, E-268 and E-270. 1 Publication1
Mutagenesisi263R → E: Loss of microtubule-binding; when associated with E-259, E-266, E-268 and E-270. 1 Publication1
Mutagenesisi266R → E: Loss of microtubule-binding; when associated with E-259, E-263, E-268 and E-270. 1 Publication1
Mutagenesisi268R → E: Loss of microtubule-binding; when associated with E-259, E-263, E-266 and E-270. 1 Publication1
Mutagenesisi270K → E: Loss of microtubule-binding; when associated with E-259, E-263, E-266 and E-268. 1 Publication1

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000104983

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y6R9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC61

Domain mapping of disease mutations (DMDM)

More...DMDMi		160380583

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112551 – 512Centrosomal protein CCDC61Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei285PhosphothreonineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y6R9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y6R9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y6R9

PeptideAtlas

More...PeptideAtlasi		Q9Y6R9

PRoteomics IDEntifications database

More...PRIDEi		Q9Y6R9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86781 [Q9Y6R9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y6R9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y6R9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104983, Expressed in right uterine tube and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y6R9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y6R9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104983, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers (via head domain) (PubMed:32375023).

Interacts with CEP170 (PubMed:30354798, PubMed:31789463).

Interacts with PCM1 and CEP131 (PubMed:31789463). Binds tubulin (PubMed:31789463).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		609841, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y6R9, 30 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000471454

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y6R9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y6R9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 143Head domain1 PublicationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili178 – 205Sequence analysisAdd BLAST28
Coiled coili248 – 275Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domains are involved in microtubule-binding.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC61 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRAS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154133

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038746_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y6R9

Identification of Orthologs from Complete Genome Data

More...OMAi		THRIKDK

Database of Orthologous Groups

More...OrthoDBi		1433381at2759

TreeFam database of animal gene trees

More...TreeFami		TF329415

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6R9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQPAGLQVD YVFRGVEHAV RVMVSGQVLE LEVEDRMTAD QWRGEFDAGF 
        60         70         80         90        100
IEDLTHKTGN FKQFNIFCHM LESALTQSSE SVTLDLLTYT DLESLRNRKM 
       110        120        130        140        150
GGRPGSLAPR SAQLNSKRYL ILIYSVEFDR IHYPLPLPYQ GKPDPVVLQG 
       160        170        180        190        200
IIRSLKEELG RLQGLDGQNT RDTRENEIWH LREQVSRLAS EKRELEAQLG 
       210        220        230        240        250
RSREEALAGR AARQEAEALR GLVRGLELEL RQERGLGHRV AGRRGQDCRR 
       260        270        280        290        300
LAKELEEAKA SERSLRARLK TLTSELALYK RGRRTPPVQP PPTREDRASS 
       310        320        330        340        350
SRERSASRGR GAARSSSRES GRGSRGRGRP ARPSPSPTGG RALRFDPTAF 
       360        370        380        390        400
VKAKERKQRE IQMKQQQRNR LGSGGSGDGP SVSWSRQTQP PAALTGRGDA 
       410        420        430        440        450
PNRSRNRSSS VDSFRSRCSS ASSCSDLEDF SESLSRGGHR RRGKPPSPTP 
       460        470        480        490        500
WSGSNMKSPP VERSHHQKSL ANSGGWVPIK EYSSEHQAAD MAEIDARLKA 
       510 
LQEYMNRLDM RS
Length:512
Mass (Da):57,368
Last modified:March 19, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DCB8BAFAF5B532E
GO
Isoform 2 (identifier: Q9Y6R9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-364: Missing.

Show »
Length:332
Mass (Da):37,302
Checksum:i4D76D3436565996E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYL5M0QYL5_HUMAN
Coiled-coil domain-containing prote...
CCDC61
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY15M0QY15_HUMAN
Coiled-coil domain-containing prote...
CCDC61
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD38244 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAD38244 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF98366 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389Q → R in ACT79331 (Ref. 1) Curated1
Sequence conflicti459P → L in ACT79331 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053741185 – 364Missing in isoform 2. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GQ375050 mRNA Translation: ACT79331.1
AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems.
AC011545 Genomic DNA Translation: AAF98366.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46120.2 [Q9Y6R9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001254652.1, NM_001267723.1 [Q9Y6R9-1]
XP_005259249.1, XM_005259192.4 [Q9Y6R9-1]
XP_011525559.1, XM_011527257.2 [Q9Y6R9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2]
ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2]
ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		729440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:729440

UCSC genome browser

More...UCSCi		uc021uwd.3, human [Q9Y6R9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ375050 mRNA Translation: ACT79331.1
AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems.
AC011545 Genomic DNA Translation: AAF98366.1 Different initiation.
CCDSiCCDS46120.2 [Q9Y6R9-1]
RefSeqiNP_001254652.1, NM_001267723.1 [Q9Y6R9-1]
XP_005259249.1, XM_005259192.4 [Q9Y6R9-1]
XP_011525559.1, XM_011527257.2 [Q9Y6R9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HXTX-ray2.55A/B/C1-143[»]
SMRiQ9Y6R9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi609841, 34 interactors
IntActiQ9Y6R9, 30 interactors
STRINGi9606.ENSP00000471454

PTM databases

iPTMnetiQ9Y6R9
PhosphoSitePlusiQ9Y6R9

Polymorphism and mutation databases

BioMutaiCCDC61
DMDMi160380583

Proteomic databases

EPDiQ9Y6R9
jPOSTiQ9Y6R9
MassIVEiQ9Y6R9
PeptideAtlasiQ9Y6R9
PRIDEiQ9Y6R9
ProteomicsDBi86781 [Q9Y6R9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49264, 120 antibodies

Genome annotation databases

EnsembliENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2]
ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2]
ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1]
GeneIDi729440
KEGGihsa:729440
UCSCiuc021uwd.3, human [Q9Y6R9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		729440
EuPathDBiHostDB:ENSG00000104983.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC61
HGNCiHGNC:33629, CCDC61
HPAiENSG00000104983, Low tissue specificity
neXtProtiNX_Q9Y6R9
OpenTargetsiENSG00000104983

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRAS, Eukaryota
GeneTreeiENSGT00940000154133
HOGENOMiCLU_038746_1_0_1
InParanoidiQ9Y6R9
OMAiTHRIKDK
OrthoDBi1433381at2759
TreeFamiTF329415

Enzyme and pathway databases

PathwayCommonsiQ9Y6R9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		729440, 8 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC61, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		729440
PharosiQ9Y6R9, Tdark

Protein Ontology

More...PROi		PR:Q9Y6R9
RNActiQ9Y6R9, protein

Gene expression databases

BgeeiENSG00000104983, Expressed in right uterine tube and 142 other tissues
ExpressionAtlasiQ9Y6R9, baseline and differential
GenevisibleiQ9Y6R9, HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD61_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6R9
Secondary accession number(s): C8CAP4, Q9HDB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 19, 2014
Last modified: December 2, 2020
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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