UniProtKB - Q9Y6R9 (CCD61_HUMAN)

BLAST

>sp|Q9Y6R9|CCD61_HUMAN Coiled-coil domain-containing protein 61 OS=Homo sapiens OX=9606 GN=CCDC61 PE=1 SV=3
MDQPAGLQVDYVFRGVEHAVRVMVSGQVLELEVEDRMTADQWRGEFDAGFIEDLTHKTGN
FKQFNIFCHMLESALTQSSESVTLDLLTYTDLESLRNRKMGGRPGSLAPRSAQLNSKRYL
ILIYSVEFDRIHYPLPLPYQGKPDPVVLQGIIRSLKEELGRLQGLDGQNTRDTRENEIWH
LREQVSRLASEKRELEAQLGRSREEALAGRAARQEAEALRGLVRGLELELRQERGLGHRV
AGRRGQDCRRLAKELEEAKASERSLRARLKTLTSELALYKRGRRTPPVQPPPTREDRASS
SRERSASRGRGAARSSSRESGRGSRGRGRPARPSPSPTGGRALRFDPTAFVKAKERKQRE
IQMKQQQRNRLGSGGSGDGPSVSWSRQTQPPAALTGRGDAPNRSRNRSSSVDSFRSRCSS
ASSCSDLEDFSESLSRGGHRRRGKPPSPTPWSGSNMKSPPVERSHHQKSLANSGGWVPIK
EYSSEHQAADMAEIDARLKALQEYMNRLDMRS

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History
Entry version 101 (07 Nov 2018)
Sequence version 3 (19 Mar 2014)
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Protein

Coiled-coil domain-containing protein 61

Gene

CCDC61

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coiled-coil domain-containing protein 61
Gene namesⁱ	Name:CCDC61
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104983.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33629 CCDC61
neXtProtⁱ	NX_Q9Y6R9

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000104983

OpenTargetsⁱ

ENSG00000104983

Polymorphism and mutation databases

DMDMⁱ	160380583

DMDMⁱ

160380583

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000311255	1 – 512	Coiled-coil domain-containing protein 61Add BLAST		512

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	285	PhosphothreonineCombined sources	1
Modified residueⁱ	334	PhosphoserineCombined sources	1
Modified residueⁱ	336	PhosphoserineCombined sources	1
Modified residueⁱ	373	PhosphoserineCombined sources	1
Modified residueⁱ	376	PhosphoserineCombined sources	1
Modified residueⁱ	447	PhosphoserineCombined sources	1
Modified residueⁱ	473	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y6R9
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6R9
PRIDEⁱ	Q9Y6R9
ProteomicsDBⁱ	86781

PTM databases

iPTMnetⁱ	Q9Y6R9
PhosphoSitePlusⁱ	Q9Y6R9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104983 Expressed in 127 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_CCDC61
ExpressionAtlasⁱ	Q9Y6R9 baseline and differential
Genevisibleⁱ	Q9Y6R9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040325 HPA061548

HPAⁱ

HPA040325
HPA061548

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	609841, 32 interactors
IntActⁱ	Q9Y6R9, 30 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y6R9
SMRⁱ	Q9Y6R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	175 – 277	Sequence analysisAdd BLAST		103

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013311
HOGENOMⁱ	HOG000111425
HOVERGENⁱ	HBG079567
InParanoidⁱ	Q9Y6R9
KEGG Orthology (KO) More...KOⁱ	K16755
OMAⁱ	LYKRGRR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OH0
TreeFamⁱ	TF329415

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y6R9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQPAGLQVD YVFRGVEHAV RVMVSGQVLE LEVEDRMTAD QWRGEFDAGF 
        60         70         80         90        100
IEDLTHKTGN FKQFNIFCHM LESALTQSSE SVTLDLLTYT DLESLRNRKM 
       110        120        130        140        150
GGRPGSLAPR SAQLNSKRYL ILIYSVEFDR IHYPLPLPYQ GKPDPVVLQG 
       160        170        180        190        200
IIRSLKEELG RLQGLDGQNT RDTRENEIWH LREQVSRLAS EKRELEAQLG 
       210        220        230        240        250
RSREEALAGR AARQEAEALR GLVRGLELEL RQERGLGHRV AGRRGQDCRR 
       260        270        280        290        300
LAKELEEAKA SERSLRARLK TLTSELALYK RGRRTPPVQP PPTREDRASS 
       310        320        330        340        350
SRERSASRGR GAARSSSRES GRGSRGRGRP ARPSPSPTGG RALRFDPTAF 
       360        370        380        390        400
VKAKERKQRE IQMKQQQRNR LGSGGSGDGP SVSWSRQTQP PAALTGRGDA 
       410        420        430        440        450
PNRSRNRSSS VDSFRSRCSS ASSCSDLEDF SESLSRGGHR RRGKPPSPTP 
       460        470        480        490        500
WSGSNMKSPP VERSHHQKSL ANSGGWVPIK EYSSEHQAAD MAEIDARLKA 
       510 
LQEYMNRLDM RS

Length:512

Mass (Da):57,368

Last modified:March 19, 2014 - v3

Checksum:ⁱ2DCB8BAFAF5B532E

Isoform 2 (identifier: Q9Y6R9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
185-364: Missing.

« Hide

        10         20         30         40         50
MDQPAGLQVD YVFRGVEHAV RVMVSGQVLE LEVEDRMTAD QWRGEFDAGF 
        60         70         80         90        100
IEDLTHKTGN FKQFNIFCHM LESALTQSSE SVTLDLLTYT DLESLRNRKM 
       110        120        130        140        150
GGRPGSLAPR SAQLNSKRYL ILIYSVEFDR IHYPLPLPYQ GKPDPVVLQG 
       160        170        180        190        200
IIRSLKEELG RLQGLDGQNT RDTRENEIWH LREQQQQRNR LGSGGSGDGP 
       210        220        230        240        250
SVSWSRQTQP PAALTGRGDA PNRSRNRSSS VDSFRSRCSS ASSCSDLEDF 
       260        270        280        290        300
SESLSRGGHR RRGKPPSPTP WSGSNMKSPP VERSHHQKSL ANSGGWVPIK 
       310        320        330 
EYSSEHQAAD MAEIDARLKA LQEYMNRLDM RS

Show »

Length:332

Mass (Da):37,302

Checksum:ⁱ4D76D3436565996E

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QYL5	M0QYL5_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 61	CCDC61	77	Annotation score:
M0QY15	M0QY15_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 61	CCDC61	49	Annotation score:

Sequence cautionⁱ

The sequence AAD38244 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAD38244 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAF98366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	389	Q → R in ACT79331 (Ref. 1) Curated		1
Sequence conflictⁱ	459	P → L in ACT79331 (Ref. 1) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053741	185 – 364	Missing in isoform 2. 1 PublicationAdd BLAST		180

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ375050 mRNA Translation: ACT79331.1 AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems. AC011545 Genomic DNA Translation: AAF98366.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46120.2 [Q9Y6R9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001254652.1, NM_001267723.1 [Q9Y6R9-1] XP_005259249.1, XM_005259192.4 [Q9Y6R9-1] XP_011525559.1, XM_011527257.2 [Q9Y6R9-1]
UniGeneⁱ	Hs.515479

Genome annotation databases

Ensemblⁱ	ENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2] ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2] ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1]
GeneIDⁱ	729440
KEGGⁱ	hsa:729440
UCSC genome browser More...UCSCⁱ	uc021uwd.3 human [Q9Y6R9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6R9	Coiled-coil domain containing 61		SAIBB		544	UniRef90_Q9Y6R9
Uncharacterized protein		PAPAN		520
Uncharacterized protein		MACFA		519
Coiled-coil domain-containing protein 61		CALJA		514
CCDC61 isoform 2		PANTR		514
+37
Q9Y6R9-2	Coiled-coil domain-containing protein 61-like protein		CAMFR		335	UniRef90_Q9Y6R9-2
Coiled-coil domain containing 61		CALJA		334
LOW QUALITY PROTEIN: coiled-coil domain-containing protein 61		TARSY		333
CCDC61 isoform 1		PANTR		332
Uncharacterized protein		PANPA		332
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6R9	Coiled-coil domain-containing protein 61		RAT		512	UniRef50_Q9Y6R9
Coiled-coil domain-containing protein 61		MOUSE		511
Coiled-coil domain containing 61		SAIBB		544
Uncharacterized protein		PAPAN		520
Uncharacterized protein		MACFA		519
+183
Q9Y6R9-2	Coiled-coil domain-containing protein 61-like protein		CAMFR		335	UniRef50_Q9Y6R9-2
Coiled-coil domain containing 61		CALJA		334
LOW QUALITY PROTEIN: coiled-coil domain-containing protein 61		TARSY		333
Uncharacterized protein		NOMLE		332
Uncharacterized protein		CERAT		332
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ375050 mRNA Translation: ACT79331.1 AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems. AC011545 Genomic DNA Translation: AAF98366.1 Different initiation.
CCDSⁱ	CCDS46120.2 [Q9Y6R9-1]
RefSeqⁱ	NP_001254652.1, NM_001267723.1 [Q9Y6R9-1] XP_005259249.1, XM_005259192.4 [Q9Y6R9-1] XP_011525559.1, XM_011527257.2 [Q9Y6R9-1]
UniGeneⁱ	Hs.515479

3D structure databases

ProteinModelPortalⁱ	Q9Y6R9
SMRⁱ	Q9Y6R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	609841, 32 interactors
IntActⁱ	Q9Y6R9, 30 interactors

PTM databases

iPTMnetⁱ	Q9Y6R9
PhosphoSitePlusⁱ	Q9Y6R9

Polymorphism and mutation databases

DMDMⁱ	160380583

DMDMⁱ

160380583

Proteomic databases

EPDⁱ	Q9Y6R9
PeptideAtlasⁱ	Q9Y6R9
PRIDEⁱ	Q9Y6R9
ProteomicsDBⁱ	86781

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2] ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2] ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1]
GeneIDⁱ	729440
KEGGⁱ	hsa:729440
UCSCⁱ	uc021uwd.3 human [Q9Y6R9-1]

Organism-specific databases

CTDⁱ	729440
EuPathDBⁱ	HostDB:ENSG00000104983.8
GeneCardsⁱ	CCDC61
HGNCⁱ	HGNC:33629 CCDC61
HPAⁱ	HPA040325 HPA061548
neXtProtⁱ	NX_Q9Y6R9
OpenTargetsⁱ	ENSG00000104983
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000013311
HOGENOMⁱ	HOG000111425
HOVERGENⁱ	HBG079567
InParanoidⁱ	Q9Y6R9
KOⁱ	K16755
OMAⁱ	LYKRGRR
OrthoDBⁱ	EOG091G0OH0
TreeFamⁱ	TF329415

Miscellaneous databases

ChiTaRSⁱ	CCDC61 human
GenomeRNAiⁱ	729440
Protein Ontology More...PROⁱ	PR:Q9Y6R9

Gene expression databases

Bgeeⁱ	ENSG00000104983 Expressed in 127 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_CCDC61
ExpressionAtlasⁱ	Q9Y6R9 baseline and differential
Genevisibleⁱ	Q9Y6R9 HS

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	CCD61_HUMAN
Accessionⁱ	Q9Y6R9Primary (citable) accession number: Q9Y6R9 Secondary accession number(s): C8CAP4, Q9HDB6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	March 19, 2014
	Last modified:	November 7, 2018
	This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y6R9 (CCD61_HUMAN)

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Coiled-coil domain-containing protein 61

CCDC61

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Keywords - Domaini

Phylogenomic databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ