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Protein

Coiled-coil domain-containing protein 61

Gene

CCDC61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 61
Gene namesi
Name:CCDC61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104983.8
HGNCiHGNC:33629 CCDC61
neXtProtiNX_Q9Y6R9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104983

Polymorphism and mutation databases

DMDMi160380583

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112551 – 512Coiled-coil domain-containing protein 61Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei285PhosphothreonineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6R9
PeptideAtlasiQ9Y6R9
PRIDEiQ9Y6R9
ProteomicsDBi86781

PTM databases

iPTMnetiQ9Y6R9
PhosphoSitePlusiQ9Y6R9

Expressioni

Gene expression databases

BgeeiENSG00000104983 Expressed in 127 organ(s), highest expression level in right uterine tube
CleanExiHS_CCDC61
ExpressionAtlasiQ9Y6R9 baseline and differential
GenevisibleiQ9Y6R9 HS

Organism-specific databases

HPAiHPA040325
HPA061548

Interactioni

Protein-protein interaction databases

BioGridi609841, 32 interactors
IntActiQ9Y6R9, 30 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R9
SMRiQ9Y6R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 277Sequence analysisAdd BLAST103

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000013311
HOGENOMiHOG000111425
HOVERGENiHBG079567
InParanoidiQ9Y6R9
KOiK16755
OMAiLYKRGRR
OrthoDBiEOG091G0OH0
TreeFamiTF329415

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6R9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQPAGLQVD YVFRGVEHAV RVMVSGQVLE LEVEDRMTAD QWRGEFDAGF
60 70 80 90 100
IEDLTHKTGN FKQFNIFCHM LESALTQSSE SVTLDLLTYT DLESLRNRKM
110 120 130 140 150
GGRPGSLAPR SAQLNSKRYL ILIYSVEFDR IHYPLPLPYQ GKPDPVVLQG
160 170 180 190 200
IIRSLKEELG RLQGLDGQNT RDTRENEIWH LREQVSRLAS EKRELEAQLG
210 220 230 240 250
RSREEALAGR AARQEAEALR GLVRGLELEL RQERGLGHRV AGRRGQDCRR
260 270 280 290 300
LAKELEEAKA SERSLRARLK TLTSELALYK RGRRTPPVQP PPTREDRASS
310 320 330 340 350
SRERSASRGR GAARSSSRES GRGSRGRGRP ARPSPSPTGG RALRFDPTAF
360 370 380 390 400
VKAKERKQRE IQMKQQQRNR LGSGGSGDGP SVSWSRQTQP PAALTGRGDA
410 420 430 440 450
PNRSRNRSSS VDSFRSRCSS ASSCSDLEDF SESLSRGGHR RRGKPPSPTP
460 470 480 490 500
WSGSNMKSPP VERSHHQKSL ANSGGWVPIK EYSSEHQAAD MAEIDARLKA
510
LQEYMNRLDM RS
Length:512
Mass (Da):57,368
Last modified:March 19, 2014 - v3
Checksum:i2DCB8BAFAF5B532E
GO
Isoform 2 (identifier: Q9Y6R9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-364: Missing.

Show »
Length:332
Mass (Da):37,302
Checksum:i4D76D3436565996E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYL5M0QYL5_HUMAN
Coiled-coil domain-containing prote...
CCDC61
77Annotation score:
M0QY15M0QY15_HUMAN
Coiled-coil domain-containing prote...
CCDC61
49Annotation score:

Sequence cautioni

The sequence AAD38244 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAD38244 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF98366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti389Q → R in ACT79331 (Ref. 1) Curated1
Sequence conflicti459P → L in ACT79331 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053741185 – 364Missing in isoform 2. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ375050 mRNA Translation: ACT79331.1
AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems.
AC011545 Genomic DNA Translation: AAF98366.1 Different initiation.
CCDSiCCDS46120.2 [Q9Y6R9-1]
RefSeqiNP_001254652.1, NM_001267723.1 [Q9Y6R9-1]
XP_005259249.1, XM_005259192.4 [Q9Y6R9-1]
XP_011525559.1, XM_011527257.2 [Q9Y6R9-1]
UniGeneiHs.515479

Genome annotation databases

EnsembliENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2]
ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2]
ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1]
GeneIDi729440
KEGGihsa:729440
UCSCiuc021uwd.3 human [Q9Y6R9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ375050 mRNA Translation: ACT79331.1
AC007785 Genomic DNA Translation: AAD38244.1 Sequence problems.
AC011545 Genomic DNA Translation: AAF98366.1 Different initiation.
CCDSiCCDS46120.2 [Q9Y6R9-1]
RefSeqiNP_001254652.1, NM_001267723.1 [Q9Y6R9-1]
XP_005259249.1, XM_005259192.4 [Q9Y6R9-1]
XP_011525559.1, XM_011527257.2 [Q9Y6R9-1]
UniGeneiHs.515479

3D structure databases

ProteinModelPortaliQ9Y6R9
SMRiQ9Y6R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609841, 32 interactors
IntActiQ9Y6R9, 30 interactors

PTM databases

iPTMnetiQ9Y6R9
PhosphoSitePlusiQ9Y6R9

Polymorphism and mutation databases

DMDMi160380583

Proteomic databases

EPDiQ9Y6R9
PeptideAtlasiQ9Y6R9
PRIDEiQ9Y6R9
ProteomicsDBi86781

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536603; ENSP00000444279; ENSG00000104983 [Q9Y6R9-2]
ENST00000594087; ENSP00000469466; ENSG00000104983 [Q9Y6R9-2]
ENST00000595358; ENSP00000471454; ENSG00000104983 [Q9Y6R9-1]
GeneIDi729440
KEGGihsa:729440
UCSCiuc021uwd.3 human [Q9Y6R9-1]

Organism-specific databases

CTDi729440
EuPathDBiHostDB:ENSG00000104983.8
GeneCardsiCCDC61
HGNCiHGNC:33629 CCDC61
HPAiHPA040325
HPA061548
neXtProtiNX_Q9Y6R9
OpenTargetsiENSG00000104983
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000013311
HOGENOMiHOG000111425
HOVERGENiHBG079567
InParanoidiQ9Y6R9
KOiK16755
OMAiLYKRGRR
OrthoDBiEOG091G0OH0
TreeFamiTF329415

Miscellaneous databases

ChiTaRSiCCDC61 human
GenomeRNAii729440
PROiPR:Q9Y6R9

Gene expression databases

BgeeiENSG00000104983 Expressed in 127 organ(s), highest expression level in right uterine tube
CleanExiHS_CCDC61
ExpressionAtlasiQ9Y6R9 baseline and differential
GenevisibleiQ9Y6R9 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD61_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R9
Secondary accession number(s): C8CAP4, Q9HDB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 19, 2014
Last modified: November 7, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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