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UniProtKB - Q9Y6R7 (FCGBP_HUMAN)

Protein

IgGFc-binding protein

Gene

FCGBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.1 Publication

Protein family/group databases

MEROPSiI08.954

Names & Taxonomyi

Protein namesi
Recommended name:
IgGFc-binding protein
Alternative name(s):
Fcgamma-binding protein antigen
Short name:
FcgammaBP
Gene namesi
Name:FCGBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13572 FCGBP
MIMi617553 gene
neXtProtiNX_Q9Y6R7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8857
PharmGKBiPA28059

Polymorphism and mutation databases

BioMutaiFCGBP
DMDMi224471888

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000025669824 – 5405IgGFc-binding proteinAdd BLAST5382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi494 ↔ 502PROSITE-ProRule annotation
Disulfide bondi886 ↔ 894PROSITE-ProRule annotation
Disulfide bondi1274 ↔ 1282PROSITE-ProRule annotation
Glycosylationi1317N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi1695 ↔ 1704PROSITE-ProRule annotation
Glycosylationi1743N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2094 ↔ 2102PROSITE-ProRule annotation
Glycosylationi2138N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2475 ↔ 2483PROSITE-ProRule annotation
Glycosylationi2518N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi2896 ↔ 2905PROSITE-ProRule annotation
Disulfide bondi3295 ↔ 3303PROSITE-ProRule annotation
Disulfide bondi3676 ↔ 3684PROSITE-ProRule annotation
Glycosylationi3719N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi4097 ↔ 4106PROSITE-ProRule annotation
Glycosylationi4145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4496 ↔ 4504PROSITE-ProRule annotation
Glycosylationi4540N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4878 ↔ 4886PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y6R7
MaxQBiQ9Y6R7
PaxDbiQ9Y6R7
PeptideAtlasiQ9Y6R7
PRIDEiQ9Y6R7
ProteomicsDBi86780

PTM databases

GlyConnecti1386
iPTMnetiQ9Y6R7
PhosphoSitePlusiQ9Y6R7

Expressioni

Tissue specificityi

Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).3 Publications

Gene expression databases

BgeeiENSG00000281123 Expressed in 10 organ(s), highest expression level in colon
CleanExiHS_FCGBP

Organism-specific databases

HPAiHPA003517
HPA003564

Interactioni

Subunit structurei

Interacts with the Fc portion of IgG and with MUC2.2 Publications

Protein-protein interaction databases

BioGridi114381, 2 interactors
IntActiQ9Y6R7, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R7
SMRiQ9Y6R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 690VWFD 1PROSITE-ProRule annotationAdd BLAST220
Domaini745 – 799TIL 1Add BLAST55
Domaini863 – 1081VWFD 2PROSITE-ProRule annotationAdd BLAST219
Domaini1136 – 1189TIL 2Add BLAST54
Domaini1251 – 1477VWFD 3PROSITE-ProRule annotationAdd BLAST227
Domaini1532 – 1585TIL 3Add BLAST54
Domaini1672 – 1895VWFD 4PROSITE-ProRule annotationAdd BLAST224
Domaini1950 – 2007TIL 4Add BLAST58
Domaini2071 – 2282VWFD 5PROSITE-ProRule annotationAdd BLAST212
Domaini2337 – 2390TIL 5Add BLAST54
Domaini2452 – 2678VWFD 6PROSITE-ProRule annotationAdd BLAST227
Domaini2733 – 2786TIL 6Add BLAST54
Domaini2873 – 3096VWFD 7PROSITE-ProRule annotationAdd BLAST224
Domaini3151 – 3208TIL 7Add BLAST58
Domaini3272 – 3483VWFD 8PROSITE-ProRule annotationAdd BLAST212
Domaini3538 – 3591TIL 8Add BLAST54
Domaini3653 – 3879VWFD 9PROSITE-ProRule annotationAdd BLAST227
Domaini3934 – 3987TIL 9Add BLAST54
Domaini4074 – 4297VWFD 10PROSITE-ProRule annotationAdd BLAST224
Domaini4352 – 4409TIL 10Add BLAST58
Domaini4473 – 4684VWFD 11PROSITE-ProRule annotationAdd BLAST212
Domaini4739 – 4792TIL 11Add BLAST54
Domaini4855 – 5066VWFD 12PROSITE-ProRule annotationAdd BLAST212
Domaini5121 – 5174TIL 12Add BLAST54
Domaini5234 – 5405VWFD 13PROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 450IgGFc-bindingAdd BLAST427

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi741 – 847Cys-richAdd BLAST107
Compositional biasi1132 – 1235Cys-richAdd BLAST104
Compositional biasi1528 – 1656Cys-richAdd BLAST129
Compositional biasi2333 – 2436Cys-richAdd BLAST104
Compositional biasi2729 – 2857Cys-richAdd BLAST129
Compositional biasi3534 – 3637Cys-richAdd BLAST104
Compositional biasi3930 – 4058Cys-richAdd BLAST129
Compositional biasi5117 – 5219Cys-richAdd BLAST103

Domaini

The N-terminal IgGFc-binding region is primate-specific.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR8B Eukaryota
ENOG410XSFB LUCA
HOGENOMiHOG000112559
InParanoidiQ9Y6R7
OrthoDBiEOG091G002A
PhylomeDBiQ9Y6R7
TreeFamiTF316399

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR003645 Fol_N
IPR035234 IgGFc-bd_N
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF08742 C8, 12 hits
PF17517 IgGFc_binding, 1 hit
PF01826 TIL, 12 hits
PF12714 TILa, 12 hits
PF00094 VWD, 13 hits
SMARTiView protein in SMART
SM00832 C8, 12 hits
SM00181 EGF, 7 hits
SM00274 FOLN, 9 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 11 hits
SM00216 VWD, 13 hits
SUPFAMiSSF57567 SSF57567, 12 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y6R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK 
        60         70         80         90        100
AYPRLLISSL SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG 
       110        120        130        140        150
SKIFQHAVVI HSDYAISVQA LNAKPDTAEL TLLRPIQALG TEYFVLTPPG 
       160        170        180        190        200
TSARNVKEFA VVAGAAGASV SVTLKGSVTF NGKFYPAGDV LRVTLQPYNV 
       210        220        230        240        250
AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE QLLPTSAWGT 
       260        270        280        290        300
HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR 
       310        320        330        340        350
PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS 
       360        370        380        390        400
VPGCEGVALV VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT 
       410        420        430        440        450
ADMIHTAEAT TNLGLLTFGL AKAIGYATAA DCGRTVLSPV EPSCEGMQCA 
       460        470        480        490        500
AGQRCQVVGG KAGCVAESTA VCRAQGDPHY TTFDGRRYDM MGTCSYTMVE 
       510        520        530        540        550
LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV SLTRGEVGFV 
       560        570        580        590        600
LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP 
       610        620        630        640        650
ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE 
       660        670        680        690        700
DGCQNNCPAC TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC 
       710        720        730        740        750
VYDLCVVGGE RLSLCRGLSA YAQACLELGI SVGDWRSPAN CPLSCPANSR 
       760        770        780        790        800
YELCGPACPT SCNGAAAPSN CSGRPCVEGC VCLPGFVASG GACVPASSCG 
       810        820        830        840        850
CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS CPAGERCSVQ 
       860        870        880        890        900
NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL 
       910        920        930        940        950
PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY 
       960        970        980        990       1000
LPFQAADGQV QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC 
      1010       1020       1030       1040       1050
GLCGNFNGDP ADDLALRGGG QAANALAFGN SWQEETRPGC GATEPGDCPK 
      1060       1070       1080       1090       1100
LDSLVAQQLQ SKNECGILAD PKGPFRECHS KLDPQGAVRD CVYDRCLLPG 
      1110       1120       1130       1140       1150
QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS HYEACSYGCP 
      1160       1170       1180       1190       1200
LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP 
      1210       1220       1230       1240       1250
GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS 
      1260       1270       1280       1290       1300
TCQASGDPHY TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW 
      1310       1320       1330       1340       1350
GNGRVSVTRV ITVQVANFTL RLEQRQWKVT VNGVDMKLPV VLANGQIRAS 
      1360       1370       1380       1390       1400
QHGSDVVIET DFGLRVAYDL VYYVRVTVPG NYYQQMCGLC GNYNGDPKDD 
      1410       1420       1430       1440       1450
FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED CIPSHKCPPE 
      1460       1470       1480       1490       1500
LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI 
      1510       1520       1530       1540       1550
LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS 
      1560       1570       1580       1590       1600
ALSAPPQCQD GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV 
      1610       1620       1630       1640       1650
LIDNCRQQCT CHAGKGMVCQ EHSCKPGQVC QPSGGILSCV TKDPCHGVTC 
      1660       1670       1680       1690       1700
RPQETCKEQG GQGVCLPNYE ATCWLWGDPH YHSFDGRKFD FQGTCNYVLA 
      1710       1720       1730       1740       1750
TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL GTNISIHKDE 
      1760       1770       1780       1790       1800
IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD 
      1810       1820       1830       1840       1850
VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD 
      1860       1870       1880       1890       1900
PLCWDECRGS CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES 
      1910       1920       1930       1940       1950
FFKGCVLDVC MGGGDRDILC KALASYVAAC QAAGVVIEDW RAQVGCEITC 
      1960       1970       1980       1990       2000
PENSHYEVCG SPCPASCPSP APLTTPAVCE GPCVEGCQCD AGFVLSADRC 
      2010       2020       2030       2040       2050
VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS LVCTPASCGL 
      2060       2070       2080       2090       2100
GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA 
      2110       2120       2130       2140       2150
PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK 
      2160       2170       2180       2190       2200
LQVDGVFVTL PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP 
      2210       2220       2230       2240       2250
AAYAGSLCGL CGNYNQDPAD DLKAVGGKPA GWQVGGAQGC GECVSKPCPS 
      2260       2270       2280       2290       2300
PCTPEQQESF GGPDACGVIS ATDGPLAPCH GLVPPAQYFQ GCLLDACQVQ 
      2310       2320       2330       2340       2350
GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH SHYELCGDSC 
      2360       2370       2380       2390       2400
PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP 
      2410       2420       2430       2440       2450
LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS 
      2460       2470       2480       2490       2500
TTCQASGDPH YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA 
      2510       2520       2530       2540       2550
WGNGRVSVTR VITVQVANFT LRLEQRQWKV TVNGVDMKLP VVLANGQIRA 
      2560       2570       2580       2590       2600
SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP GNYYQLMCGL CGNYNGDPKD 
      2610       2620       2630       2640       2650
DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE GCIPSEECPP 
      2660       2670       2680       2690       2700
ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS 
      2710       2720       2730       2740       2750
ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC 
      2760       2770       2780       2790       2800
SALSAPLQCP DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT 
      2810       2820       2830       2840       2850
VLIDNCRQQC TCHVGKVVVC QEHSCKPGQV CQPSGGILSC VNKDPCHGVT 
      2860       2870       2880       2890       2900
CRPQETCKEQ GGQGVCLPNY EATCWLWGDP HYHSFDGRKF DFQGTCNYVL 
      2910       2920       2930       2940       2950
ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA LGTNISIHKD 
      2960       2970       2980       2990       3000
EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV 
      3010       3020       3030       3040       3050
DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW 
      3060       3070       3080       3090       3100
DPLCWDECRG SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE 
      3110       3120       3130       3140       3150
SFFKGCVLDV CMGGGDRDIL CKALASYVAA CQAAGVVIED WRAQVGCEIT 
      3160       3170       3180       3190       3200
CPENSHYEVC GPPCPASCPS PAPLTTPAVC EGPCVEGCQC DAGFVLSADR 
      3210       3220       3230       3240       3250
CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG SLVCTPASCG 
      3260       3270       3280       3290       3300
LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS 
      3310       3320       3330       3340       3350
APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR 
      3360       3370       3380       3390       3400
KLQVDGVFVT LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV 
      3410       3420       3430       3440       3450
PAAYAGSLCG LCGNYNQDPA DDLKAVGGKP AGWQVGGAQG CGECVSKPCP 
      3460       3470       3480       3490       3500
SPCTPEQQES FGGPDACGVI SATDGPLAPC HGLVPPAQYF QGCLLDACQV 
      3510       3520       3530       3540       3550
QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA HSHYELCGDS 
      3560       3570       3580       3590       3600
CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY 
      3610       3620       3630       3640       3650
PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG 
      3660       3670       3680       3690       3700
STTCQASGDP HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV 
      3710       3720       3730       3740       3750
AWGNGRVSVT RVITVQVANF TLRLEQRQWK VTVNGVDMKL PVVLANGQIR 
      3760       3770       3780       3790       3800
ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV PGNYYQLMCG LCGNYNGDPK 
      3810       3820       3830       3840       3850
DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS AGCIPSDKCP 
      3860       3870       3880       3890       3900
PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL 
      3910       3920       3930       3940       3950
SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG 
      3960       3970       3980       3990       4000
CSALSAPLQC PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ 
      4010       4020       4030       4040       4050
TVLIDNCRQQ CTCHVGKVVV CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV 
      4060       4070       4080       4090       4100
TCRPQETCKE QGGQGVCLPN YEATCWLWGD PHYHSFDGRK FDFQGTCNYV 
      4110       4120       4130       4140       4150
LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA ALGTNISIHK 
      4160       4170       4180       4190       4200
DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR 
      4210       4220       4230       4240       4250
VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG 
      4260       4270       4280       4290       4300
WDPLCWDECR GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP 
      4310       4320       4330       4340       4350
ESFFKGCVLD VCMGGGDRDI LCKALASYVA ACQAAGVVIE DWRAQVGCEI 
      4360       4370       4380       4390       4400
TCPENSHYEV CGPPCPASCP SPAPLTTPAV CEGPCVEGCQ CDAGFVLSAD 
      4410       4420       4430       4440       4450
RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG GSLVCTPASC 
      4460       4470       4480       4490       4500
GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL 
      4510       4520       4530       4540       4550
SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP 
      4560       4570       4580       4590       4600
RKLQVDGVFV ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR 
      4610       4620       4630       4640       4650
VPAAYAASLC GLCGNYNQDP ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC 
      4660       4670       4680       4690       4700
PSPCTPEQQE SFGGPDACGV ISATDGPLAP CHGLVPPAQY FQGCLLDACQ 
      4710       4720       4730       4740       4750
VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP AHSHYELCGD 
      4760       4770       4780       4790       4800
SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY 
      4810       4820       4830       4840       4850
YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA 
      4860       4870       4880       4890       4900
TGCGRCLANG GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE 
      4910       4920       4930       4940       4950
KNAAGDLQRL LVTVAGQVVS LAQGQQVTVD GEAVALPVAV GRVRVTAEGR 
      4960       4970       4980       4990       5000
NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG RLCGLCGNFN GNWSDDFVLP 
      5010       5020       5030       5040       5050
NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE TAPYESNEAC 
      5060       5070       5080       5090       5100
GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA 
      5110       5120       5130       5140       5150
CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR 
      5160       5170       5180       5190       5200
CFEGCECDDR FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC 
      5210       5220       5230       5240       5250
SSSSGLTCQA AGCPPGRVCE VKAEARNCWA TRGLCVLSVG ANLTTFDGAR 
      5260       5270       5280       5290       5300
GATTSPGVYE LSSRCPGLQN TIPWYRVVAE VQICHGKTEA VGQVHIFFQD 
      5310       5320       5330       5340       5350
GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV RQKAGVQVWL 
      5360       5370       5380       5390       5400
GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF 

SPCYG
Length:5,405
Mass (Da):572,017
Last modified:March 3, 2009 - v3
Checksum:i6E502F782261355F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YF91A0A286YF91_HUMAN
IgGFc-binding protein
FCGBP
1,132Annotation score:
A0A087WUZ2A0A087WUZ2_HUMAN
IgGFc-binding protein
FCGBP
1,642Annotation score:
A0A087WXI2A0A087WXI2_HUMAN
IgGFc-binding protein
FCGBP
3,072Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1961S → P in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti2719Q → H in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti2842N → T in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti2976T → A in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3117R → H in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3668H → R in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3841A → E in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3847 – 3848DK → EE in BAA19526 (PubMed:9182547).Curated2
Sequence conflicti4043T → N in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti4284S → A in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti4318R → H in BAA19526 (PubMed:9182547).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054490732V → A. Corresponds to variant dbSNP:rs34181317Ensembl.1
Natural variantiVAR_054491770N → S. Corresponds to variant dbSNP:rs34939346Ensembl.1
Natural variantiVAR_054492929G → R. Corresponds to variant dbSNP:rs35338934Ensembl.1
Natural variantiVAR_054493971V → M. Corresponds to variant dbSNP:rs35922811Ensembl.1
Natural variantiVAR_0544941019G → R. Corresponds to variant dbSNP:rs34254649Ensembl.1
Natural variantiVAR_0289031340V → L. Corresponds to variant dbSNP:rs11083543Ensembl.1
Natural variantiVAR_0544951436P → L. Corresponds to variant dbSNP:rs36106401Ensembl.1
Natural variantiVAR_0544961445H → D. Corresponds to variant dbSNP:rs2909229Ensembl.1
Natural variantiVAR_0544971524T → N. Corresponds to variant dbSNP:rs34938990Ensembl.1
Natural variantiVAR_0289041616G → V. Corresponds to variant dbSNP:rs7248839Ensembl.1
Natural variantiVAR_0289051617M → V. Corresponds to variant dbSNP:rs7249743Ensembl.1
Natural variantiVAR_0289062089N → D. Corresponds to variant dbSNP:rs885723Ensembl.1
Natural variantiVAR_0289072646E → D. Corresponds to variant dbSNP:rs140171218Ensembl.1
Natural variantiVAR_0289082647E → K. Corresponds to variant dbSNP:rs2542319Ensembl.1
Natural variantiVAR_0289092793A → V. Corresponds to variant dbSNP:rs2542316Ensembl.1
Natural variantiVAR_0289102814V → A1 PublicationCorresponds to variant dbSNP:rs3746009Ensembl.1
Natural variantiVAR_0289113264G → S. Corresponds to variant dbSNP:rs6508919Ensembl.1
Natural variantiVAR_0289123920H → Q. Corresponds to variant dbSNP:rs2542318Ensembl.1
Natural variantiVAR_0289134015V → A. Corresponds to variant dbSNP:rs3746009Ensembl.1
Natural variantiVAR_0289144095G → D. Corresponds to variant dbSNP:rs1975181Ensembl.1
Natural variantiVAR_0289154465G → S1 PublicationCorresponds to variant dbSNP:rs6508919Ensembl.1
Natural variantiVAR_0289164906D → H1 PublicationCorresponds to variant dbSNP:rs3746013Ensembl.1
Natural variantiVAR_0544985017A → V1 PublicationCorresponds to variant dbSNP:rs741143Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84239 mRNA Translation: BAA19526.1
AC006950 Genomic DNA Translation: AAD15624.1
AC007842 Genomic DNA Translation: AAD39266.1
AC011536 Genomic DNA No translation available.
RefSeqiNP_003881.2, NM_003890.2
UniGeneiHs.111732

Genome annotation databases

EnsembliENST00000628705; ENSP00000487490; ENSG00000281123
ENST00000639918; ENSP00000491148; ENSG00000281123
GeneIDi8857
KEGGihsa:8857

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84239 mRNA Translation: BAA19526.1
AC006950 Genomic DNA Translation: AAD15624.1
AC007842 Genomic DNA Translation: AAD39266.1
AC011536 Genomic DNA No translation available.
RefSeqiNP_003881.2, NM_003890.2
UniGeneiHs.111732

3D structure databases

ProteinModelPortaliQ9Y6R7
SMRiQ9Y6R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114381, 2 interactors
IntActiQ9Y6R7, 4 interactors

Protein family/group databases

MEROPSiI08.954

PTM databases

GlyConnecti1386
iPTMnetiQ9Y6R7
PhosphoSitePlusiQ9Y6R7

Polymorphism and mutation databases

BioMutaiFCGBP
DMDMi224471888

Proteomic databases

EPDiQ9Y6R7
MaxQBiQ9Y6R7
PaxDbiQ9Y6R7
PeptideAtlasiQ9Y6R7
PRIDEiQ9Y6R7
ProteomicsDBi86780

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000628705; ENSP00000487490; ENSG00000281123
ENST00000639918; ENSP00000491148; ENSG00000281123
GeneIDi8857
KEGGihsa:8857

Organism-specific databases

CTDi8857
DisGeNETi8857
GeneCardsiFCGBP
H-InvDBiHIX0040147
HGNCiHGNC:13572 FCGBP
HPAiHPA003517
HPA003564
MIMi617553 gene
neXtProtiNX_Q9Y6R7
PharmGKBiPA28059
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8B Eukaryota
ENOG410XSFB LUCA
HOGENOMiHOG000112559
InParanoidiQ9Y6R7
OrthoDBiEOG091G002A
PhylomeDBiQ9Y6R7
TreeFamiTF316399

Miscellaneous databases

ChiTaRSiFCGBP human
GeneWikiiFCGBP
GenomeRNAii8857
PROiPR:Q9Y6R7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000281123 Expressed in 10 organ(s), highest expression level in colon
CleanExiHS_FCGBP

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR003645 Fol_N
IPR035234 IgGFc-bd_N
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF08742 C8, 12 hits
PF17517 IgGFc_binding, 1 hit
PF01826 TIL, 12 hits
PF12714 TILa, 12 hits
PF00094 VWD, 13 hits
SMARTiView protein in SMART
SM00832 C8, 12 hits
SM00181 EGF, 7 hits
SM00274 FOLN, 9 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 11 hits
SM00216 VWD, 13 hits
SUPFAMiSSF57567 SSF57567, 12 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCGBP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R7
Secondary accession number(s): O95784
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 3, 2009
Last modified: October 10, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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