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Entry version 138 (18 Sep 2019)
Sequence version 3 (03 Mar 2009)
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Protein

IgGFc-binding protein

Gene

FCGBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.1 Publication

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.954

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IgGFc-binding protein
Alternative name(s):
Fcgamma-binding protein antigen
Short name:
FcgammaBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCGBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13572 FCGBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617553 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6R7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8857

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28059

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6R7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FCGBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
224471888

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025669824 – 5405IgGFc-binding proteinAdd BLAST5382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi494 ↔ 502PROSITE-ProRule annotation
Disulfide bondi886 ↔ 894PROSITE-ProRule annotation
Disulfide bondi1274 ↔ 1282PROSITE-ProRule annotation
Glycosylationi1317N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi1695 ↔ 1704PROSITE-ProRule annotation
Glycosylationi1743N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2094 ↔ 2102PROSITE-ProRule annotation
Glycosylationi2138N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2475 ↔ 2483PROSITE-ProRule annotation
Glycosylationi2518N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi2896 ↔ 2905PROSITE-ProRule annotation
Disulfide bondi3295 ↔ 3303PROSITE-ProRule annotation
Disulfide bondi3676 ↔ 3684PROSITE-ProRule annotation
Glycosylationi3719N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi4097 ↔ 4106PROSITE-ProRule annotation
Glycosylationi4145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4496 ↔ 4504PROSITE-ProRule annotation
Glycosylationi4540N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4878 ↔ 4886PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-1133

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y6R7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6R7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y6R7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y6R7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6R7

PeptideAtlas

More...
PeptideAtlasi
Q9Y6R7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6R7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86780

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1386

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6R7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6R7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000281123 Expressed in 10 organ(s), highest expression level in colon

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003517
HPA003564

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the Fc portion of IgG and with MUC2.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114381, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y6R7, 5 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6R7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini471 – 690VWFD 1PROSITE-ProRule annotationAdd BLAST220
Domaini745 – 799TIL 1Add BLAST55
Domaini863 – 1081VWFD 2PROSITE-ProRule annotationAdd BLAST219
Domaini1136 – 1189TIL 2Add BLAST54
Domaini1251 – 1477VWFD 3PROSITE-ProRule annotationAdd BLAST227
Domaini1532 – 1585TIL 3Add BLAST54
Domaini1672 – 1895VWFD 4PROSITE-ProRule annotationAdd BLAST224
Domaini1950 – 2007TIL 4Add BLAST58
Domaini2071 – 2282VWFD 5PROSITE-ProRule annotationAdd BLAST212
Domaini2337 – 2390TIL 5Add BLAST54
Domaini2452 – 2678VWFD 6PROSITE-ProRule annotationAdd BLAST227
Domaini2733 – 2786TIL 6Add BLAST54
Domaini2873 – 3096VWFD 7PROSITE-ProRule annotationAdd BLAST224
Domaini3151 – 3208TIL 7Add BLAST58
Domaini3272 – 3483VWFD 8PROSITE-ProRule annotationAdd BLAST212
Domaini3538 – 3591TIL 8Add BLAST54
Domaini3653 – 3879VWFD 9PROSITE-ProRule annotationAdd BLAST227
Domaini3934 – 3987TIL 9Add BLAST54
Domaini4074 – 4297VWFD 10PROSITE-ProRule annotationAdd BLAST224
Domaini4352 – 4409TIL 10Add BLAST58
Domaini4473 – 4684VWFD 11PROSITE-ProRule annotationAdd BLAST212
Domaini4739 – 4792TIL 11Add BLAST54
Domaini4855 – 5066VWFD 12PROSITE-ProRule annotationAdd BLAST212
Domaini5121 – 5174TIL 12Add BLAST54
Domaini5234 – 5405VWFD 13PROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 450IgGFc-bindingAdd BLAST427

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi741 – 847Cys-richAdd BLAST107
Compositional biasi1132 – 1235Cys-richAdd BLAST104
Compositional biasi1528 – 1656Cys-richAdd BLAST129
Compositional biasi2333 – 2436Cys-richAdd BLAST104
Compositional biasi2729 – 2857Cys-richAdd BLAST129
Compositional biasi3534 – 3637Cys-richAdd BLAST104
Compositional biasi3930 – 4058Cys-richAdd BLAST129
Compositional biasi5117 – 5219Cys-richAdd BLAST103

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal IgGFc-binding region is primate-specific.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR8B Eukaryota
ENOG410XSFB LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112559

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6R7

Database of Orthologous Groups

More...
OrthoDBi
22053at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y6R7

TreeFam database of animal gene trees

More...
TreeFami
TF316399

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR003645 Fol_N
IPR035234 IgGFc-bd_N
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 12 hits
PF17517 IgGFc_binding, 1 hit
PF01826 TIL, 12 hits
PF12714 TILa, 11 hits
PF00094 VWD, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 12 hits
SM00181 EGF, 7 hits
SM00274 FOLN, 9 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 11 hits
SM00216 VWD, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51233 VWFD, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y6R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK
60 70 80 90 100
AYPRLLISSL SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG
110 120 130 140 150
SKIFQHAVVI HSDYAISVQA LNAKPDTAEL TLLRPIQALG TEYFVLTPPG
160 170 180 190 200
TSARNVKEFA VVAGAAGASV SVTLKGSVTF NGKFYPAGDV LRVTLQPYNV
210 220 230 240 250
AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE QLLPTSAWGT
260 270 280 290 300
HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR
310 320 330 340 350
PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS
360 370 380 390 400
VPGCEGVALV VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT
410 420 430 440 450
ADMIHTAEAT TNLGLLTFGL AKAIGYATAA DCGRTVLSPV EPSCEGMQCA
460 470 480 490 500
AGQRCQVVGG KAGCVAESTA VCRAQGDPHY TTFDGRRYDM MGTCSYTMVE
510 520 530 540 550
LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV SLTRGEVGFV
560 570 580 590 600
LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP
610 620 630 640 650
ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE
660 670 680 690 700
DGCQNNCPAC TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC
710 720 730 740 750
VYDLCVVGGE RLSLCRGLSA YAQACLELGI SVGDWRSPAN CPLSCPANSR
760 770 780 790 800
YELCGPACPT SCNGAAAPSN CSGRPCVEGC VCLPGFVASG GACVPASSCG
810 820 830 840 850
CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS CPAGERCSVQ
860 870 880 890 900
NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL
910 920 930 940 950
PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY
960 970 980 990 1000
LPFQAADGQV QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC
1010 1020 1030 1040 1050
GLCGNFNGDP ADDLALRGGG QAANALAFGN SWQEETRPGC GATEPGDCPK
1060 1070 1080 1090 1100
LDSLVAQQLQ SKNECGILAD PKGPFRECHS KLDPQGAVRD CVYDRCLLPG
1110 1120 1130 1140 1150
QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS HYEACSYGCP
1160 1170 1180 1190 1200
LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP
1210 1220 1230 1240 1250
GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS
1260 1270 1280 1290 1300
TCQASGDPHY TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW
1310 1320 1330 1340 1350
GNGRVSVTRV ITVQVANFTL RLEQRQWKVT VNGVDMKLPV VLANGQIRAS
1360 1370 1380 1390 1400
QHGSDVVIET DFGLRVAYDL VYYVRVTVPG NYYQQMCGLC GNYNGDPKDD
1410 1420 1430 1440 1450
FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED CIPSHKCPPE
1460 1470 1480 1490 1500
LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI
1510 1520 1530 1540 1550
LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS
1560 1570 1580 1590 1600
ALSAPPQCQD GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV
1610 1620 1630 1640 1650
LIDNCRQQCT CHAGKGMVCQ EHSCKPGQVC QPSGGILSCV TKDPCHGVTC
1660 1670 1680 1690 1700
RPQETCKEQG GQGVCLPNYE ATCWLWGDPH YHSFDGRKFD FQGTCNYVLA
1710 1720 1730 1740 1750
TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL GTNISIHKDE
1760 1770 1780 1790 1800
IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD
1810 1820 1830 1840 1850
VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD
1860 1870 1880 1890 1900
PLCWDECRGS CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES
1910 1920 1930 1940 1950
FFKGCVLDVC MGGGDRDILC KALASYVAAC QAAGVVIEDW RAQVGCEITC
1960 1970 1980 1990 2000
PENSHYEVCG SPCPASCPSP APLTTPAVCE GPCVEGCQCD AGFVLSADRC
2010 2020 2030 2040 2050
VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS LVCTPASCGL
2060 2070 2080 2090 2100
GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA
2110 2120 2130 2140 2150
PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK
2160 2170 2180 2190 2200
LQVDGVFVTL PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP
2210 2220 2230 2240 2250
AAYAGSLCGL CGNYNQDPAD DLKAVGGKPA GWQVGGAQGC GECVSKPCPS
2260 2270 2280 2290 2300
PCTPEQQESF GGPDACGVIS ATDGPLAPCH GLVPPAQYFQ GCLLDACQVQ
2310 2320 2330 2340 2350
GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH SHYELCGDSC
2360 2370 2380 2390 2400
PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP
2410 2420 2430 2440 2450
LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS
2460 2470 2480 2490 2500
TTCQASGDPH YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA
2510 2520 2530 2540 2550
WGNGRVSVTR VITVQVANFT LRLEQRQWKV TVNGVDMKLP VVLANGQIRA
2560 2570 2580 2590 2600
SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP GNYYQLMCGL CGNYNGDPKD
2610 2620 2630 2640 2650
DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE GCIPSEECPP
2660 2670 2680 2690 2700
ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS
2710 2720 2730 2740 2750
ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC
2760 2770 2780 2790 2800
SALSAPLQCP DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT
2810 2820 2830 2840 2850
VLIDNCRQQC TCHVGKVVVC QEHSCKPGQV CQPSGGILSC VNKDPCHGVT
2860 2870 2880 2890 2900
CRPQETCKEQ GGQGVCLPNY EATCWLWGDP HYHSFDGRKF DFQGTCNYVL
2910 2920 2930 2940 2950
ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA LGTNISIHKD
2960 2970 2980 2990 3000
EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV
3010 3020 3030 3040 3050
DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW
3060 3070 3080 3090 3100
DPLCWDECRG SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE
3110 3120 3130 3140 3150
SFFKGCVLDV CMGGGDRDIL CKALASYVAA CQAAGVVIED WRAQVGCEIT
3160 3170 3180 3190 3200
CPENSHYEVC GPPCPASCPS PAPLTTPAVC EGPCVEGCQC DAGFVLSADR
3210 3220 3230 3240 3250
CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG SLVCTPASCG
3260 3270 3280 3290 3300
LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS
3310 3320 3330 3340 3350
APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR
3360 3370 3380 3390 3400
KLQVDGVFVT LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV
3410 3420 3430 3440 3450
PAAYAGSLCG LCGNYNQDPA DDLKAVGGKP AGWQVGGAQG CGECVSKPCP
3460 3470 3480 3490 3500
SPCTPEQQES FGGPDACGVI SATDGPLAPC HGLVPPAQYF QGCLLDACQV
3510 3520 3530 3540 3550
QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA HSHYELCGDS
3560 3570 3580 3590 3600
CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY
3610 3620 3630 3640 3650
PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG
3660 3670 3680 3690 3700
STTCQASGDP HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV
3710 3720 3730 3740 3750
AWGNGRVSVT RVITVQVANF TLRLEQRQWK VTVNGVDMKL PVVLANGQIR
3760 3770 3780 3790 3800
ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV PGNYYQLMCG LCGNYNGDPK
3810 3820 3830 3840 3850
DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS AGCIPSDKCP
3860 3870 3880 3890 3900
PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL
3910 3920 3930 3940 3950
SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG
3960 3970 3980 3990 4000
CSALSAPLQC PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ
4010 4020 4030 4040 4050
TVLIDNCRQQ CTCHVGKVVV CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV
4060 4070 4080 4090 4100
TCRPQETCKE QGGQGVCLPN YEATCWLWGD PHYHSFDGRK FDFQGTCNYV
4110 4120 4130 4140 4150
LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA ALGTNISIHK
4160 4170 4180 4190 4200
DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR
4210 4220 4230 4240 4250
VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG
4260 4270 4280 4290 4300
WDPLCWDECR GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP
4310 4320 4330 4340 4350
ESFFKGCVLD VCMGGGDRDI LCKALASYVA ACQAAGVVIE DWRAQVGCEI
4360 4370 4380 4390 4400
TCPENSHYEV CGPPCPASCP SPAPLTTPAV CEGPCVEGCQ CDAGFVLSAD
4410 4420 4430 4440 4450
RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG GSLVCTPASC
4460 4470 4480 4490 4500
GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL
4510 4520 4530 4540 4550
SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP
4560 4570 4580 4590 4600
RKLQVDGVFV ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR
4610 4620 4630 4640 4650
VPAAYAASLC GLCGNYNQDP ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC
4660 4670 4680 4690 4700
PSPCTPEQQE SFGGPDACGV ISATDGPLAP CHGLVPPAQY FQGCLLDACQ
4710 4720 4730 4740 4750
VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP AHSHYELCGD
4760 4770 4780 4790 4800
SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY
4810 4820 4830 4840 4850
YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA
4860 4870 4880 4890 4900
TGCGRCLANG GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE
4910 4920 4930 4940 4950
KNAAGDLQRL LVTVAGQVVS LAQGQQVTVD GEAVALPVAV GRVRVTAEGR
4960 4970 4980 4990 5000
NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG RLCGLCGNFN GNWSDDFVLP
5010 5020 5030 5040 5050
NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE TAPYESNEAC
5060 5070 5080 5090 5100
GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA
5110 5120 5130 5140 5150
CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR
5160 5170 5180 5190 5200
CFEGCECDDR FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC
5210 5220 5230 5240 5250
SSSSGLTCQA AGCPPGRVCE VKAEARNCWA TRGLCVLSVG ANLTTFDGAR
5260 5270 5280 5290 5300
GATTSPGVYE LSSRCPGLQN TIPWYRVVAE VQICHGKTEA VGQVHIFFQD
5310 5320 5330 5340 5350
GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV RQKAGVQVWL
5360 5370 5380 5390 5400
GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF

SPCYG
Length:5,405
Mass (Da):572,017
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E502F782261355F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUZ2A0A087WUZ2_HUMAN
IgGFc-binding protein
FCGBP
1,642Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXI2A0A087WXI2_HUMAN
IgGFc-binding protein
FCGBP
4,204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1961S → P in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti2719Q → H in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti2842N → T in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti2976T → A in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3117R → H in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3668H → R in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3841A → E in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti3847 – 3848DK → EE in BAA19526 (PubMed:9182547).Curated2
Sequence conflicti4043T → N in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti4284S → A in BAA19526 (PubMed:9182547).Curated1
Sequence conflicti4318R → H in BAA19526 (PubMed:9182547).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054490732V → A. Corresponds to variant dbSNP:rs34181317Ensembl.1
Natural variantiVAR_054491770N → S. Corresponds to variant dbSNP:rs34939346Ensembl.1
Natural variantiVAR_054492929G → R. Corresponds to variant dbSNP:rs35338934Ensembl.1
Natural variantiVAR_054493971V → M. Corresponds to variant dbSNP:rs35922811Ensembl.1
Natural variantiVAR_0544941019G → R. Corresponds to variant dbSNP:rs34254649Ensembl.1
Natural variantiVAR_0289031340V → L. Corresponds to variant dbSNP:rs11083543Ensembl.1
Natural variantiVAR_0544951436P → L. Corresponds to variant dbSNP:rs36106401Ensembl.1
Natural variantiVAR_0544961445H → D. Corresponds to variant dbSNP:rs2909229Ensembl.1
Natural variantiVAR_0544971524T → N. Corresponds to variant dbSNP:rs34938990Ensembl.1
Natural variantiVAR_0289041616G → V. Corresponds to variant dbSNP:rs7248839Ensembl.1
Natural variantiVAR_0289051617M → V. Corresponds to variant dbSNP:rs7249743Ensembl.1
Natural variantiVAR_0289062089N → D. Corresponds to variant dbSNP:rs885723Ensembl.1
Natural variantiVAR_0289072646E → D. Corresponds to variant dbSNP:rs140171218Ensembl.1
Natural variantiVAR_0289082647E → K. Corresponds to variant dbSNP:rs1176978283Ensembl.1
Natural variantiVAR_0289092793A → V. Corresponds to variant dbSNP:rs2542316Ensembl.1
Natural variantiVAR_0289102814V → A1 PublicationCorresponds to variant dbSNP:rs3746009Ensembl.1
Natural variantiVAR_0289113264G → S. Corresponds to variant dbSNP:rs1290971390Ensembl.1
Natural variantiVAR_0289123920H → Q. Corresponds to variant dbSNP:rs2542318Ensembl.1
Natural variantiVAR_0289134015V → A. Corresponds to variant dbSNP:rs3746009Ensembl.1
Natural variantiVAR_0289144095G → D. Corresponds to variant dbSNP:rs1975181Ensembl.1
Natural variantiVAR_0289154465G → S1 PublicationCorresponds to variant dbSNP:rs6508919Ensembl.1
Natural variantiVAR_0289164906D → H1 PublicationCorresponds to variant dbSNP:rs3746013Ensembl.1
Natural variantiVAR_0544985017A → V1 PublicationCorresponds to variant dbSNP:rs741143Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D84239 mRNA Translation: BAA19526.1
AC006950 Genomic DNA Translation: AAD15624.1
AC007842 Genomic DNA Translation: AAD39266.1
AC011536 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_003881.2, NM_003890.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000628705; ENSP00000487490; ENSG00000281123
ENST00000639918; ENSP00000491148; ENSG00000281123

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8857

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84239 mRNA Translation: BAA19526.1
AC006950 Genomic DNA Translation: AAD15624.1
AC007842 Genomic DNA Translation: AAD39266.1
AC011536 Genomic DNA No translation available.
RefSeqiNP_003881.2, NM_003890.2

3D structure databases

SMRiQ9Y6R7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114381, 2 interactors
IntActiQ9Y6R7, 5 interactors

Protein family/group databases

MEROPSiI08.954

PTM databases

GlyConnecti1386
iPTMnetiQ9Y6R7
PhosphoSitePlusiQ9Y6R7

Polymorphism and mutation databases

BioMutaiFCGBP
DMDMi224471888

Proteomic databases

CPTACinon-CPTAC-1133
EPDiQ9Y6R7
jPOSTiQ9Y6R7
MassIVEiQ9Y6R7
MaxQBiQ9Y6R7
PaxDbiQ9Y6R7
PeptideAtlasiQ9Y6R7
PRIDEiQ9Y6R7
ProteomicsDBi86780

Genome annotation databases

EnsembliENST00000628705; ENSP00000487490; ENSG00000281123
ENST00000639918; ENSP00000491148; ENSG00000281123
GeneIDi8857
KEGGihsa:8857

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8857
DisGeNETi8857

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FCGBP
HGNCiHGNC:13572 FCGBP
HPAiHPA003517
HPA003564
MIMi617553 gene
neXtProtiNX_Q9Y6R7
PharmGKBiPA28059

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR8B Eukaryota
ENOG410XSFB LUCA
HOGENOMiHOG000112559
InParanoidiQ9Y6R7
OrthoDBi22053at2759
PhylomeDBiQ9Y6R7
TreeFamiTF316399

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FCGBP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FCGBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8857
PharosiQ9Y6R7

Protein Ontology

More...
PROi
PR:Q9Y6R7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000281123 Expressed in 10 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR003645 Fol_N
IPR035234 IgGFc-bd_N
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF08742 C8, 12 hits
PF17517 IgGFc_binding, 1 hit
PF01826 TIL, 12 hits
PF12714 TILa, 11 hits
PF00094 VWD, 13 hits
SMARTiView protein in SMART
SM00832 C8, 12 hits
SM00181 EGF, 7 hits
SM00274 FOLN, 9 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 11 hits
SM00216 VWD, 13 hits
SUPFAMiSSF57567 SSF57567, 12 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCGBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6R7
Secondary accession number(s): O95784
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 3, 2009
Last modified: September 18, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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