Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitogen-activated protein kinase kinase kinase 4

Gene

MAP3K4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1372ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1463Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1349 – 1357ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.12.2 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y6R4

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y6R4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 4 (EC:2.7.11.25)
Alternative name(s):
MAP three kinase 1
MAPK/ERK kinase kinase 4
Short name:
MEK kinase 4
Short name:
MEKK 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K4
Synonyms:KIAA0213, MAPKKK4, MEKK4, MTK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000085511.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6856 MAP3K4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602425 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6R4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1372K → R: Loss of activity. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4216

Open Targets

More...
OpenTargetsi
ENSG00000085511

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30600

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4853

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP3K4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000862471 – 1608Mitogen-activated protein kinase kinase kinase 4Add BLAST1608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84PhosphoserineBy similarity1
Modified residuei431PhosphoserineCombined sources1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei458PhosphothreonineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei1252PhosphoserineCombined sources1
Modified residuei1274PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6R4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6R4

PeptideAtlas

More...
PeptideAtlasi
Q9Y6R4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6R4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86777
86778 [Q9Y6R4-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9Y6R4

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085511 Expressed in 227 organ(s), highest expression level in endocervix

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAP3K4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6R4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6R4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007625

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (PubMed:12052864). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (PubMed:20221403). Interacts with CDC42 (By similarity).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110380, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y6R4

Protein interaction database and analysis system

More...
IntActi
Q9Y6R4, 15 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6R4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375986

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y6R4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y6R4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6R4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1343 – 1601Protein kinasePROSITE-ProRule annotationAdd BLAST259

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 7Poly-Ala4
Compositional biasi25 – 38Poly-ProAdd BLAST14
Compositional biasi1190 – 1202Poly-AlaAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4645 Eukaryota
ENOG410XQZE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00880000138034

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006304

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6R4

KEGG Orthology (KO)

More...
KOi
K04428

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPFVKVC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00SM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6R4

TreeFam database of animal gene trees

More...
TreeFami
TF105114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6R4-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA
60 70 80 90 100
RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
110 120 130 140 150
RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL
160 170 180 190 200
RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV
210 220 230 240 250
SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE
260 270 280 290 300
NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT
310 320 330 340 350
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS
360 370 380 390 400
FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT
410 420 430 440 450
KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE
460 470 480 490 500
LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE
510 520 530 540 550
DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM
560 570 580 590 600
DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS
610 620 630 640 650
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ
660 670 680 690 700
LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV
710 720 730 740 750
YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL
760 770 780 790 800
FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA
810 820 830 840 850
LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY
860 870 880 890 900
VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY
910 920 930 940 950
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM
960 970 980 990 1000
QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR
1010 1020 1030 1040 1050
ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV
1060 1070 1080 1090 1100
VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ
1110 1120 1130 1140 1150
AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTGL YLAIHRNSPR
1160 1170 1180 1190 1200
PMKVPRCHSD PPNPHLIIPT PEGFSTRSMP SDARSHGSPA AAAAAAAAAV
1210 1220 1230 1240 1250
AASRPSPSGG DSVLPKSISS AHDTRGSSVP ENDRLASIAA ELQFRSLSRH
1260 1270 1280 1290 1300
SSPTEERDEP AYPRGDSSGS TRRSWELRTL ISQSKDTASK LGPIEAIQKS
1310 1320 1330 1340 1350
VRLFEEKRYR EMRRKNIIGQ VCDTPKSYDN VMHVGLRKVT FKWQRGNKIG
1360 1370 1380 1390 1400
EGQYGKVYTC ISVDTGELMA MKEIRFQPND HKTIKETADE LKIFEGIKHP
1410 1420 1430 1440 1450
NLVRYFGVEL HREEMYIFME YCDEGTLEEV SRLGLQEHVI RLYSKQITIA
1460 1470 1480 1490 1500
INVLHEHGIV HRDIKGANIF LTSSGLIKLG DFGCSVKLKN NAQTMPGEVN
1510 1520 1530 1540 1550
STLGTAAYMA PEVITRAKGE GHGRAADIWS LGCVVIEMVT GKRPWHEYEH
1560 1570 1580 1590 1600
NFQIMYKVGM GHKPPIPERL SPEGKDFLSH CLESDPKMRW TASQLLDHSF

VKVCTDEE
Length:1,608
Mass (Da):181,685
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC22294914945EA91
GO
Isoform 2 (identifier: Q9Y6R4-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1175-1224: Missing.

Show »
Length:1,558
Mass (Da):177,014
Checksum:i4F94E9CF82E88354
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNB8J3KNB8_HUMAN
Mitogen-activated protein kinase ki...
MAP3K4
1,554Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H538F5H538_HUMAN
Mitogen-activated protein kinase ki...
MAP3K4
1,604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4R1F5H4R1_HUMAN
Mitogen-activated protein kinase ki...
MAP3K4
1,442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1X6F5H1X6_HUMAN
Mitogen-activated protein kinase ki...
MAP3K4
636Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2S6F5H2S6_HUMAN
Mitogen-activated protein kinase ki...
MAP3K4
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H534F5H534_HUMAN
Mitogen-activated protein kinase ki...
MAP3K4
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13204 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35P → PP in AAI36277 (PubMed:15489334).Curated1
Sequence conflicti500E → D in AAI46771 (PubMed:15489334).Curated1
Sequence conflicti791R → I in AAB68804 (PubMed:9305639).Curated1
Sequence conflicti1190Missing in EAW47587 (Ref. 5) Curated1
Sequence conflicti1190Missing in AAI43736 (PubMed:15489334).Curated1
Sequence conflicti1190Missing in AAI36277 (PubMed:15489334).Curated1
Sequence conflicti1199Missing in AAB68804 (PubMed:9305639).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059767157R → H1 PublicationCorresponds to variant dbSNP:rs4559074Ensembl.1
Natural variantiVAR_040686294I → T1 PublicationCorresponds to variant dbSNP:rs35842248Ensembl.1
Natural variantiVAR_040687335V → I1 PublicationCorresponds to variant dbSNP:rs35730939Ensembl.1
Natural variantiVAR_040688566R → H1 PublicationCorresponds to variant dbSNP:rs55765351Ensembl.1
Natural variantiVAR_040689584Q → H1 PublicationCorresponds to variant dbSNP:rs34018542Ensembl.1
Natural variantiVAR_040690906H → P1 PublicationCorresponds to variant dbSNP:rs35533223Ensembl.1
Natural variantiVAR_0406911413E → Q in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0406921492A → V1 PublicationCorresponds to variant dbSNP:rs41267837Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0048841175 – 1224Missing in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF002715 mRNA Translation: AAB68804.1
D86968 mRNA Translation: BAA13204.2 Different initiation.
AL109942 Genomic DNA No translation available.
AL139393 Genomic DNA No translation available.
AL591045 Genomic DNA No translation available.
AL596452 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47587.1
BC136276 mRNA Translation: AAI36277.1
BC143735 mRNA Translation: AAI43736.1
BC146770 mRNA Translation: AAI46771.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34565.1 [Q9Y6R4-1]
CCDS34566.1 [Q9Y6R4-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T03022

NCBI Reference Sequences

More...
RefSeqi
NP_001278887.1, NM_001291958.1
NP_001288001.1, NM_001301072.1
NP_005913.2, NM_005922.3
NP_006715.2, NM_006724.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.390428

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366919; ENSP00000355886; ENSG00000085511 [Q9Y6R4-2]
ENST00000392142; ENSP00000375986; ENSG00000085511 [Q9Y6R4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4216

UCSC genome browser

More...
UCSCi
uc003qtn.4 human [Q9Y6R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002715 mRNA Translation: AAB68804.1
D86968 mRNA Translation: BAA13204.2 Different initiation.
AL109942 Genomic DNA No translation available.
AL139393 Genomic DNA No translation available.
AL591045 Genomic DNA No translation available.
AL596452 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47587.1
BC136276 mRNA Translation: AAI36277.1
BC143735 mRNA Translation: AAI43736.1
BC146770 mRNA Translation: AAI46771.1
CCDSiCCDS34565.1 [Q9Y6R4-1]
CCDS34566.1 [Q9Y6R4-2]
PIRiT03022
RefSeqiNP_001278887.1, NM_001291958.1
NP_001288001.1, NM_001301072.1
NP_005913.2, NM_005922.3
NP_006715.2, NM_006724.3
UniGeneiHs.390428

3D structure databases

ProteinModelPortaliQ9Y6R4
SMRiQ9Y6R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110380, 53 interactors
CORUMiQ9Y6R4
IntActiQ9Y6R4, 15 interactors
MINTiQ9Y6R4
STRINGi9606.ENSP00000375986

Chemistry databases

BindingDBiQ9Y6R4
ChEMBLiCHEMBL4853

PTM databases

CarbonylDBiQ9Y6R4
iPTMnetiQ9Y6R4
PhosphoSitePlusiQ9Y6R4

Polymorphism and mutation databases

BioMutaiMAP3K4
DMDMi296434576

Proteomic databases

EPDiQ9Y6R4
PaxDbiQ9Y6R4
PeptideAtlasiQ9Y6R4
PRIDEiQ9Y6R4
ProteomicsDBi86777
86778 [Q9Y6R4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366919; ENSP00000355886; ENSG00000085511 [Q9Y6R4-2]
ENST00000392142; ENSP00000375986; ENSG00000085511 [Q9Y6R4-1]
GeneIDi4216
KEGGihsa:4216
UCSCiuc003qtn.4 human [Q9Y6R4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4216
DisGeNETi4216
EuPathDBiHostDB:ENSG00000085511.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAP3K4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0151295
HGNCiHGNC:6856 MAP3K4
HPAiHPA007625
MIMi602425 gene
neXtProtiNX_Q9Y6R4
OpenTargetsiENSG00000085511
PharmGKBiPA30600

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4645 Eukaryota
ENOG410XQZE LUCA
GeneTreeiENSGT00880000138034
HOVERGENiHBG006304
InParanoidiQ9Y6R4
KOiK04428
OMAiHPFVKVC
OrthoDBiEOG091G00SM
PhylomeDBiQ9Y6R4
TreeFamiTF105114

Enzyme and pathway databases

BRENDAi2.7.12.2 2681
SignaLinkiQ9Y6R4
SIGNORiQ9Y6R4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAP3K4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAP3K4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4216

Protein Ontology

More...
PROi
PR:Q9Y6R4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000085511 Expressed in 227 organ(s), highest expression level in endocervix
CleanExiHS_MAP3K4
ExpressionAtlasiQ9Y6R4 baseline and differential
GenevisibleiQ9Y6R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6R4
Secondary accession number(s): A6H8W0
, B7ZLD3, B9EG75, Q5VTT8, Q5VTT9, Q92612, Q9H408
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again