Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 157 (16 Oct 2019)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Electrogenic sodium bicarbonate cotransporter 1

Gene

SLC4A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.8 Publications
Isoform 2: May have a higher activity than isoform 1.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by stilbene derivatives and regulated by cyclic AMP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425381 Bicarbonate transporters
R-HSA-5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.2.12 the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electrogenic sodium bicarbonate cotransporter 1
Short name:
Sodium bicarbonate cotransporter
Alternative name(s):
Na(+)/HCO3(-) cotransporter
Solute carrier family 4 member 4
kNBC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A4
Synonyms:NBC, NBC1, NBCE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11030 SLC4A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603345 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6R1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 466Cytoplasmic1 Publication1 PublicationAdd BLAST466
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei467 – 491Helical; Name=12 PublicationsAdd BLAST25
Topological domaini492 – 501Extracellular2 Publications10
Transmembranei502 – 520Helical; Name=22 PublicationsAdd BLAST19
Topological domaini521Cytoplasmic2 Publications1
Transmembranei522 – 542Discontinuously helical; Name=31 PublicationAdd BLAST21
Topological domaini543 – 550Extracellular1 Publication1 Publication8
Transmembranei551 – 571Helical; Name=42 PublicationsAdd BLAST21
Topological domaini572 – 585Cytoplasmic2 PublicationsAdd BLAST14
Transmembranei586 – 609Helical; Name=51 PublicationAdd BLAST24
Topological domaini610 – 692Extracellular1 Publication1 PublicationAdd BLAST83
Transmembranei693 – 710Helical; Name=62 PublicationsAdd BLAST18
Topological domaini711 – 725Cytoplasmic2 PublicationsAdd BLAST15
Transmembranei726 – 745Helical; Name=72 PublicationsAdd BLAST20
Topological domaini746 – 779Extracellular2 PublicationsAdd BLAST34
Transmembranei780 – 807Helical; Name=82 PublicationsAdd BLAST28
Topological domaini808 – 819Cytoplasmic2 PublicationsAdd BLAST12
Transmembranei820 – 836Helical; Name=92 PublicationsAdd BLAST17
Topological domaini837Extracellular2 Publications1
Transmembranei838 – 855Discontinuously helical; Name=101 PublicationAdd BLAST18
Topological domaini856 – 877Cytoplasmic1 Publication1 PublicationAdd BLAST22
Transmembranei878 – 894Helical; Name=112 PublicationsAdd BLAST17
Topological domaini895 – 901Extracellular2 Publications7
Transmembranei902 – 918Helical; Name=121 PublicationAdd BLAST17
Topological domaini919 – 960Cytoplasmic1 Publication1 PublicationAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei961 – 986Discontinuously helical1 PublicationAdd BLAST26
Topological domaini987 – 1079Cytoplasmic1 Publication1 PublicationAdd BLAST93

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn extremely rare autosomal recessive syndrome characterized by short stature, profound proximal renal tubular acidosis, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. pRTA is due to a failure of the proximal tubular cells to reabsorb filtered bicarbonate from the urine, leading to urinary bicarbonate wasting and subsequent acidemia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024751342R → S in pRTA-OA; decreased localization to the basolateral membrane; mistargeting to the apical membrane probably explains the loss of the cotransporter activity. 1 Publication3 PublicationsCorresponds to variant dbSNP:rs121908856EnsemblClinVar.1
Natural variantiVAR_024752471S → L in pRTA-OA; mistargeting to the apical membrane and altered function. 2 Publications1
Natural variantiVAR_024753529T → S in pRTA-OA; decreased cotransporter activity. 1 Publication1 Publication1
Natural variantiVAR_071661530G → R in pRTA-OA; decreased cotransporter activity; no effect on localization to the basolateral membrane. 1 Publication1
Natural variantiVAR_024754554R → H in pRTA-OA; mistargeting and altered function. 3 PublicationsCorresponds to variant dbSNP:rs121908857EnsemblClinVar.1
Natural variantiVAR_071662566L → P in pRTA-OA; loss of localization to the plasma membrane; the retention in the cytoplasm probably explains the loss of the cotransporter activity. 1 Publication1 Publication1
Natural variantiVAR_024755843A → V in pRTA-OA; altered function. 1 Publication1
Natural variantiVAR_024756925R → C in pRTA-OA; altered function. 1 PublicationCorresponds to variant dbSNP:rs1203164637Ensembl.1
Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49T → A: Loss of conductance regulation by cAMP; isoform 1. 1 Publication1
Mutagenesisi49T → D: Loss of conductance regulation by cAMP; isoform 1. 1 Publication1
Mutagenesisi135E → R: Mistargeting and altered function. 1 Publication1
Mutagenesisi477Y → F: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi493D → N: Prevents membrane targeting. 1 Publication1
Mutagenesisi494A → K: Prevents membrane targeting. 1 Publication1
Mutagenesisi503E → Q: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi504S → L: Prevents membrane targeting. 1 Publication1
Mutagenesisi527 – 529SST → GFS: Confers anion exchange activity; when associated with E-798; S-842; T-844 and R-847. 1 Publication3
Mutagenesisi527S → C: Severely reduces transporter activity. 1 Publication1
Mutagenesisi536E → Q: Prevents membrane targeting. 1 Publication1
Mutagenesisi552E → N: Prevents membrane targeting. 1 Publication1
Mutagenesisi554R → D: Prevents membrane targeting. 1 Publication1
Mutagenesisi582R → N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi582R → Q: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi586E → Q: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi599D → N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi600A → T: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi602K → Q: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi603K → Q: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi691D → R: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi700F → M: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi711K → E, N or Q: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi711K → R: No effect on the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi712K → N: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi714K → Q: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi715T → N: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi721T → G: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi724R → E: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi725K → N: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi728S → G: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi729D → N or R: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi743D → K or N: Prevents membrane targeting. 1 Publication1
Mutagenesisi749D → N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi752K → Q: Prevents membrane targeting. 1 Publication1
Mutagenesisi766R → Q: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi767G → T: Alters interaction with CA4. 1 Publication1
Mutagenesisi775E → N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi798D → C: Abolishes transporter activity. 1 Publication1
Mutagenesisi798D → E: Severely reduces transporter activity. Confers anion exchange activity; when associated with SST-527--529-GFS; S-842; T-844 and R-847. 1 Publication1
Mutagenesisi798D → N or R: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi802T → C: Abolishes transporter activity. 1 Publication1
Mutagenesisi808 – 809RK → NN: Strong reduction of the sodium-dependent ion transport activity. 1 Publication2
Mutagenesisi814 – 815KK → NN: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication2
Mutagenesisi820H → D, N, S or R: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi822D → N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi842V → S: Confers anion exchange activity; when associated with SST-527--529-GFS; D-798; T-844 and R-847. 1 Publication1
Mutagenesisi844A → T: Confers anion exchange activity; when associated with SST-527--529-GFS; D-798; S-842 and R-847. 1 Publication1
Mutagenesisi845T → C: Strongly reduces transporter activity. 1 Publication1
Mutagenesisi847I → R: Abolishes transporter activity. Confers anion exchange activity; when associated with SST-527--529-GFS; D-798; S-842 and T-844. 1 Publication1
Mutagenesisi851H → N: Prevents membrane targeting. 1 Publication1
Mutagenesisi853D → N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi858 – 860ETE → MSK: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication3
Mutagenesisi875 – 877EQR → QQQ: Prevents membrane targeting. 1 Publication3
Mutagenesisi875E → Q: Strong reduction of the sodium-dependent ion transport activity. 1
Mutagenesisi898K → E: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi925 – 927RLK → NLN: Prevents membrane targeting. 1 Publication3
Mutagenesisi948R → E: Strong reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi949R → E: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi951H → D: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi951H → N or R: Prevents membrane targeting. 1 Publication1
Mutagenesisi968K → Q: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi987R → E or N: Moderate reduction of the sodium-dependent ion transport activity. 1 Publication1
Mutagenesisi1002L → N: Partial loss of interaction with CA2. 1 Publication1
Mutagenesisi1003D → N: Abolishes interaction with CA2. 1 Publication1
Mutagenesisi1004D → N: Partial loss of interaction with CA2. 1 Publication1
Mutagenesisi1026S → A: Prevents phosphorylation by PKA. Loss of regulation by cAMP of the transporter stoichiometry. 2 Publications1
Mutagenesisi1026S → D: Loss of regulation by cAMP of the transporter stoichiometry. Shifts transporter stoichiometry from 3:1 to 2:1. 2 Publications1
Mutagenesisi1030 – 1033DNDD → NNNN: Abolishes interaction with CA2. 1 Publication4
Mutagenesisi1030D → N: Loss of regulation by cAMP of the transporter stoichiometry. Abolishes interaction with CA2. 1 Publication1
Mutagenesisi1032D → N: Loss of regulation by cAMP of the transporter stoichiometry. Partial loss of interaction with CA2. 1 Publication1
Mutagenesisi1033D → N: No effect on regulation by cAMP of the transporter stoichiometry. Partial loss of interaction with CA2. 1 Publication1
Mutagenesisi1057F → A: Targeting to apical membrane. 1 Publication1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
8671

MalaCards human disease database

More...
MalaCardsi
SLC4A4
MIMi604278 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000080493

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93607 Autosomal recessive proximal renal tubular acidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35898

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6R1

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01390 Sodium bicarbonate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC4A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74721543

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792271 – 1079Electrogenic sodium bicarbonate cotransporter 1Add BLAST1079

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphotyrosineBy similarity1
Modified residuei49Phosphothreonine; by PKA1 Publication1
Modified residuei61PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei223PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei249PhosphothreonineBy similarity1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei256PhosphoserineBy similarity1
Modified residuei257PhosphoserineCombined sources1
Modified residuei262PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi627 ↔ 6291 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi641N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi661N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi674 ↔ 6861 Publication
Modified residuei1026Phosphoserine; by PKA1 Publication1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1034PhosphoserineCombined sources1
Modified residuei1044PhosphoserineBy similarity1
Modified residuei1069PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na+:HCO3- stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity.By similarity2 Publications
N-glycosylation is not necessary for the transporter basic functions.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6R1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y6R1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6R1

PeptideAtlas

More...
PeptideAtlasi
Q9Y6R1

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6R1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86772 [Q9Y6R1-1]
86773 [Q9Y6R1-2]
86774 [Q9Y6R1-3]
86775 [Q9Y6R1-4]
86776 [Q9Y6R1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6R1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6R1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y6R1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.7 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000080493 Expressed in 200 organ(s), highest expression level in duodenum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6R1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6R1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022493
HPA035628
HPA035629

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:29500354).

Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity (PubMed:12411514, PubMed:14567693, PubMed:15218065, PubMed:15563508). Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890).

Interacts with AHCYL2 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CA4P482832EBI-6859278,EBI-6859264From Oryctolagus cuniculus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114219, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-59373N

Protein interaction database and analysis system

More...
IntActi
Q9Y6R1, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6R1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393557

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6R1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62Required for interaction with AHCYL11 PublicationAdd BLAST62
Regioni748 – 779Interaction with CA4Add BLAST32
Regioni1002 – 1004CA2-binding3
Regioni1030 – 1033CA2-binding4
Regioni1057 – 1059Required for basolateral targeting3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1009 – 1024Lys-richAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156290

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6R1

KEGG Orthology (KO)

More...
KOi
K13575

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMIVDNQ

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6R1

TreeFam database of animal gene trees

More...
TreeFami
TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453 PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834 ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6R1-1) [UniParc]FASTAAdd to basket
Also known as: hcNBC, hhNBC, hNBC1, pNBC, pNCB1, pNBC-1, NBC1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKTG
60 70 80 90 100
HKEKKEKERI SENYSDKSDI ENADESSSSI LKPLISPAAE RIRFILGEED
110 120 130 140 150
DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV
160 170 180 190 200
ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIVDHQ IETGLLKPEL
210 220 230 240 250
KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFTN PDNGSPAMTH
260 270 280 290 300
RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI
310 320 330 340 350
AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD
360 370 380 390 400
EVFHDIAYKA KDRHDLIAGI DEFLDEVIVL PPGEWDPAIR IEPPKSLPSS
410 420 430 440 450
DKRKNMYSGG ENVQMNGDTP HDGGHGGGGH GDCEELQRTG RFCGGLIKDI
460 470 480 490 500
KRKAPFFASD FYDALNIQAL SAILFIYLAT VTNAITFGGL LGDATDNMQG
510 520 530 540 550
VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF NFSKDNNFDY
560 570 580 590 600
LEFRLWIGLW SAFLCLILVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA
610 620 630 640 650
FKKMIKLADY YPINSNFKVG YNTLFSCTCV PPDPANISIS NDTTLAPEYL
660 670 680 690 700
PTMSSTDMYH NTTFDWAFLS KKECSKYGGN LVGNNCNFVP DITLMSFILF
710 720 730 740 750
LGTYTSSMAL KKFKTSPYFP TTARKLISDF AIILSILIFC VIDALVGVDT
760 770 780 790 800
PKLIVPSEFK PTSPNRGWFV PPFGENPWWV CLAAAIPALL VTILIFMDQQ
810 820 830 840 850
ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VICSLMALPW YVAATVISIA
860 870 880 890 900
HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI
910 920 930 940 950
PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV
960 970 980 990 1000
HLFTFLQVLC LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS
1010 1020 1030 1040 1050
FLDDVIPEKD KKKKEDEKKK KKKKGSLDSD NDDSDCPYSE KVPSIKIPMD
1060 1070
IMEQQPFLSD SKPSDRERSP TFLERHTSC
Length:1,079
Mass (Da):121,461
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14B981A94DD64293
GO
Isoform 2 (identifier: Q9Y6R1-2) [UniParc]FASTAAdd to basket
Also known as: hkNBC, hkNBCe1, kNBC, kNBC1, kNBC-1, NBC1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     45-85: HKRKTGHKEK...SSSSILKPLI → MSTENVEGKP...FNHSIFTSAV

Show »
Length:1,035
Mass (Da):116,040
Checksum:i122096381B33D776
GO
Isoform 3 (identifier: Q9Y6R1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     45-85: HKRKTGHKEK...SSSSILKPLI → MSTENVEGKP...FNHSIFTSAV
     635-690: ANISISNDTT...LVGNNCNFVP → GEGITLCVYA...EFDVSLPEVF
     691-1079: Missing.

Show »
Length:646
Mass (Da):72,049
Checksum:i285D5E23C540A516
GO
Isoform 4 (identifier: Q9Y6R1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     813-896: Missing.

Show »
Length:995
Mass (Da):112,272
Checksum:i38B4A37EA047E9AC
GO
Isoform 5 (identifier: Q9Y6R1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1079: SDCPYSEKVP...PTFLERHTSC → EKDHQHSLNA...WRSKGTETTL

Show »
Length:1,094
Mass (Da):123,181
Checksum:iB02FF2193A5F95C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PNW8A0A1W2PNW8_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A4
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRU6A0A1W2PRU6_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A4
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6V → A in AAG47773 (PubMed:12907161).Curated1
Sequence conflicti49T → A in BAH58226 (Ref. 6) Curated1
Sequence conflicti78S → G in AAF21718 (PubMed:10069984).Curated1
Sequence conflicti256S → F in AAD42020 (PubMed:10069984).Curated1
Sequence conflicti263D → E in AAF21718 (PubMed:10069984).Curated1
Sequence conflicti298P → H in BAH58226 (Ref. 6) Curated1
Sequence conflicti364H → R in AAF21719 (PubMed:10069984).Curated1
Sequence conflicti605I → V in AAF21718 (PubMed:10069984).Curated1
Sequence conflicti654S → P in AAF21718 (PubMed:10069984).Curated1
Sequence conflicti749D → G in AAF21719 (PubMed:10069984).Curated1
Sequence conflicti799Q → R in AAG47773 (PubMed:12907161).Curated1
Sequence conflicti856K → R in AAG47773 (PubMed:12907161).Curated1
Sequence conflicti912M → R in AAF21718 (PubMed:10069984).Curated1
Sequence conflicti913G → R in AAF21719 (PubMed:10069984).Curated1
Sequence conflicti940I → V in AAF21718 (PubMed:10069984).Curated1
Sequence conflicti1007P → S in AAF21719 (PubMed:10069984).Curated1
Sequence conflicti1069S → P in AAF21719 (PubMed:10069984).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024751342R → S in pRTA-OA; decreased localization to the basolateral membrane; mistargeting to the apical membrane probably explains the loss of the cotransporter activity. 1 Publication3 PublicationsCorresponds to variant dbSNP:rs121908856EnsemblClinVar.1
Natural variantiVAR_024752471S → L in pRTA-OA; mistargeting to the apical membrane and altered function. 2 Publications1
Natural variantiVAR_024753529T → S in pRTA-OA; decreased cotransporter activity. 1 Publication1 Publication1
Natural variantiVAR_071661530G → R in pRTA-OA; decreased cotransporter activity; no effect on localization to the basolateral membrane. 1 Publication1
Natural variantiVAR_024754554R → H in pRTA-OA; mistargeting and altered function. 3 PublicationsCorresponds to variant dbSNP:rs121908857EnsemblClinVar.1
Natural variantiVAR_071662566L → P in pRTA-OA; loss of localization to the plasma membrane; the retention in the cytoplasm probably explains the loss of the cotransporter activity. 1 Publication1 Publication1
Natural variantiVAR_024755843A → V in pRTA-OA; altered function. 1 Publication1
Natural variantiVAR_024756925R → C in pRTA-OA; altered function. 1 PublicationCorresponds to variant dbSNP:rs1203164637Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0167041 – 44Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_01670545 – 85HKRKT…LKPLI → MSTENVEGKPSNLGERGRAR SSTFLRVVQPMFNHSIFTSA V in isoform 2 and isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_016706635 – 690ANISI…CNFVP → GEGITLCVYARFVFGGRCRL HACKFSTCCHGPQELVLFFS LKNSATEFDVSLPEVF in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_016707691 – 1079Missing in isoform 3. 1 PublicationAdd BLAST389
Alternative sequenceiVSP_016708813 – 896Missing in isoform 4. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_0410031034 – 1079SDCPY…RHTSC → EKDHQHSLNATHHADKIPFL QSLGMPSPPRTPVKVVPQIR IELEPEDNDYFWRSKGTETT L in isoform 5. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007216 mRNA Translation: AAC51645.1
AF011390 mRNA Translation: AAC39840.1
AF053753 mRNA Translation: AAF21718.1
AF053754 mRNA Translation: AAF21719.1
AF069510 mRNA Translation: AAD42020.1
AF310248 mRNA Translation: AAG47773.1
AF157492 mRNA Translation: AAF80343.1
AB470072 mRNA Translation: BAH58226.1
AC019089 Genomic DNA No translation available.
AC079230 Genomic DNA No translation available.
AC096713 Genomic DNA No translation available.
AC110783 Genomic DNA No translation available.
AC112226 Genomic DNA No translation available.
BC030977 mRNA Translation: AAH30977.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3549.1 [Q9Y6R1-2]
CCDS43236.1 [Q9Y6R1-1]
CCDS47071.1 [Q9Y6R1-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001091954.1, NM_001098484.2 [Q9Y6R1-1]
NP_003750.1, NM_003759.3 [Q9Y6R1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264485; ENSP00000264485; ENSG00000080493 [Q9Y6R1-1]
ENST00000340595; ENSP00000344272; ENSG00000080493 [Q9Y6R1-2]
ENST00000351898; ENSP00000307349; ENSG00000080493 [Q9Y6R1-4]
ENST00000425175; ENSP00000393557; ENSG00000080493 [Q9Y6R1-5]
ENST00000512686; ENSP00000422400; ENSG00000080493 [Q9Y6R1-3]
ENST00000649996; ENSP00000497468; ENSG00000080493 [Q9Y6R1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8671

UCSC genome browser

More...
UCSCi
uc003hfy.4 human [Q9Y6R1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007216 mRNA Translation: AAC51645.1
AF011390 mRNA Translation: AAC39840.1
AF053753 mRNA Translation: AAF21718.1
AF053754 mRNA Translation: AAF21719.1
AF069510 mRNA Translation: AAD42020.1
AF310248 mRNA Translation: AAG47773.1
AF157492 mRNA Translation: AAF80343.1
AB470072 mRNA Translation: BAH58226.1
AC019089 Genomic DNA No translation available.
AC079230 Genomic DNA No translation available.
AC096713 Genomic DNA No translation available.
AC110783 Genomic DNA No translation available.
AC112226 Genomic DNA No translation available.
BC030977 mRNA Translation: AAH30977.1
CCDSiCCDS3549.1 [Q9Y6R1-2]
CCDS43236.1 [Q9Y6R1-1]
CCDS47071.1 [Q9Y6R1-5]
RefSeqiNP_001091954.1, NM_001098484.2 [Q9Y6R1-1]
NP_003750.1, NM_003759.3 [Q9Y6R1-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CAAelectron microscopy3.90A/B77-1079[»]
SMRiQ9Y6R1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114219, 2 interactors
DIPiDIP-59373N
IntActiQ9Y6R1, 8 interactors
MINTiQ9Y6R1
STRINGi9606.ENSP00000393557

Chemistry databases

DrugBankiDB01390 Sodium bicarbonate

Protein family/group databases

TCDBi2.A.31.2.12 the anion exchanger (ae) family

PTM databases

iPTMnetiQ9Y6R1
PhosphoSitePlusiQ9Y6R1
SwissPalmiQ9Y6R1

Polymorphism and mutation databases

BioMutaiSLC4A4
DMDMi74721543

Proteomic databases

jPOSTiQ9Y6R1
MassIVEiQ9Y6R1
PaxDbiQ9Y6R1
PeptideAtlasiQ9Y6R1
PRIDEiQ9Y6R1
ProteomicsDBi86772 [Q9Y6R1-1]
86773 [Q9Y6R1-2]
86774 [Q9Y6R1-3]
86775 [Q9Y6R1-4]
86776 [Q9Y6R1-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8671

Genome annotation databases

EnsembliENST00000264485; ENSP00000264485; ENSG00000080493 [Q9Y6R1-1]
ENST00000340595; ENSP00000344272; ENSG00000080493 [Q9Y6R1-2]
ENST00000351898; ENSP00000307349; ENSG00000080493 [Q9Y6R1-4]
ENST00000425175; ENSP00000393557; ENSG00000080493 [Q9Y6R1-5]
ENST00000512686; ENSP00000422400; ENSG00000080493 [Q9Y6R1-3]
ENST00000649996; ENSP00000497468; ENSG00000080493 [Q9Y6R1-1]
GeneIDi8671
KEGGihsa:8671
UCSCiuc003hfy.4 human [Q9Y6R1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8671
DisGeNETi8671

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC4A4
HGNCiHGNC:11030 SLC4A4
HPAiCAB022493
HPA035628
HPA035629
MalaCardsiSLC4A4
MIMi603345 gene
604278 phenotype
neXtProtiNX_Q9Y6R1
OpenTargetsiENSG00000080493
Orphaneti93607 Autosomal recessive proximal renal tubular acidosis
PharmGKBiPA35898

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000156290
InParanoidiQ9Y6R1
KOiK13575
OMAiEMIVDNQ
OrthoDBi265068at2759
PhylomeDBiQ9Y6R1
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-HSA-425381 Bicarbonate transporters
R-HSA-5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC4A4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC4A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8671
PharosiQ9Y6R1

Protein Ontology

More...
PROi
PR:Q9Y6R1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000080493 Expressed in 200 organ(s), highest expression level in duodenum
ExpressionAtlasiQ9Y6R1 baseline and differential
GenevisibleiQ9Y6R1 HS

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6R1
Secondary accession number(s): C4B714
, O15153, Q8NEJ2, Q9H262, Q9NRZ1, Q9UIC0, Q9UIC1, Q9UP50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1999
Last modified: October 16, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again