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Protein

Numb-like protein

Gene

NUMBL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.2 Publications

GO - Biological processi

  • adherens junction organization Source: Ensembl
  • axonogenesis Source: Ensembl
  • cytokine-mediated signaling pathway Source: UniProtKB
  • lateral ventricle development Source: UniProtKB
  • nervous system development Source: ProtInc
  • neuroblast division in subventricular zone Source: UniProtKB
  • positive regulation of neurogenesis Source: UniProtKB
  • protein metabolic process Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9Y6R0

Names & Taxonomyi

Protein namesi
Recommended name:
Numb-like protein
Alternative name(s):
Numb-related protein
Short name:
Numb-R
Gene namesi
Name:NUMBL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105245.9
HGNCiHGNC:8061 NUMBL
MIMi604018 gene
neXtProtiNX_Q9Y6R0

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9253
OpenTargetsiENSG00000105245
PharmGKBiPA31846

Polymorphism and mutation databases

BioMutaiNUMBL
DMDMi14194976

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579991 – 609Numb-like proteinAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei279PhosphothreonineCombined sources1
Modified residuei411PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6R0
MaxQBiQ9Y6R0
PaxDbiQ9Y6R0
PeptideAtlasiQ9Y6R0
PRIDEiQ9Y6R0
ProteomicsDBi86771

PTM databases

iPTMnetiQ9Y6R0
PhosphoSitePlusiQ9Y6R0

Expressioni

Gene expression databases

BgeeiENSG00000105245
CleanExiHS_NUMBL
ExpressionAtlasiQ9Y6R0 baseline and differential
GenevisibleiQ9Y6R0 HS

Organism-specific databases

HPAiHPA058251
HPA058380

Interactioni

Subunit structurei

Interacts (via PTB domain) with MAP3K7IP2 (via C-terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBFOX1Q9NWB12EBI-945925,EBI-945906

Protein-protein interaction databases

BioGridi114677, 35 interactors
ELMiQ9Y6R0
IntActiQ9Y6R0, 28 interactors
MINTiQ9Y6R0
STRINGi9606.ENSP00000252891

Structurei

Secondary structure

1609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni64 – 66Combined sources3
Helixi67 – 74Combined sources8
Beta strandi78 – 91Combined sources14
Helixi96 – 107Combined sources12
Beta strandi114 – 120Combined sources7
Beta strandi122 – 129Combined sources8
Turni130 – 132Combined sources3
Beta strandi135 – 140Combined sources6
Helixi141 – 143Combined sources3
Beta strandi144 – 149Combined sources6
Beta strandi156 – 163Combined sources8
Turni164 – 167Combined sources4
Beta strandi168 – 179Combined sources12
Helixi181 – 201Combined sources21

3D structure databases

ProteinModelPortaliQ9Y6R0
SMRiQ9Y6R0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6R0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 223PIDPROSITE-ProRule annotationAdd BLAST150

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi427 – 446Poly-GlnAdd BLAST20

Domaini

The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.

Phylogenomic databases

eggNOGiKOG3537 Eukaryota
ENOG410XT15 LUCA
GeneTreeiENSGT00530000062937
HOGENOMiHOG000220819
HOVERGENiHBG006672
InParanoidiQ9Y6R0
KOiK06057
OMAiPEQHLPP
OrthoDBiEOG091G0FJH
PhylomeDBiQ9Y6R0
TreeFamiTF314159

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016698 Numb/numb-like
IPR010449 Numb_domain
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF06311 NumbF, 1 hit
PF00640 PID, 1 hit
PIRSFiPIRSF017607 Numb/numb-like, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSAAASGG PRRPERHLPP APCGAPGPPE TCRTEPDGAG TMNKLRQSLR
60 70 80 90 100
RRKPAYVPEA SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE
110 120 130 140 150
DAVKKLKAMG RKSVKSVLWV SADGLRVVDD KTKDLLVDQT IEKVSFCAPD
160 170 180 190 200
RNLDKAFSYI CRDGTTRRWI CHCFLALKDS GERLSHAVGC AFAACLERKQ
210 220 230 240 250
RREKECGVTA AFDASRTSFA REGSFRLSGG GRPAEREAPD KKKAEAAAAP
260 270 280 290 300
TVAPGPAQPG HVSPTPATTS PGEKGEAGTP VAAGTTAAAI PRRHAPLEQL
310 320 330 340 350
VRQGSFRGFP ALSQKNSPFK RQLSLRLNEL PSTLQRRTDF QVKGTVPEME
360 370 380 390 400
PPGAGDSDSI NALCTQISSS FASAGAPAPG PPPATTGTSA WGEPSVPPAA
410 420 430 440 450
AFQPGHKRTP SEAERWLEEV SQVAKAQQQQ QQQQQQQQQQ QQQQQQAASV
460 470 480 490 500
APVPTMPPAL QPFPAPVGPF DAAPAQVAVF LPPPHMQPPF VPAYPGLGYP
510 520 530 540 550
PMPRVPVVGI TPSQMVANAF CSAAQLQPQP ATLLGKAGAF PPPAIPSAPG
560 570 580 590 600
SQARPRPNGA PWPPEPAPAP APELDPFEAQ WAALEGKATV EKPSNPFSGD

LQKTFEIEL
Length:609
Mass (Da):64,891
Last modified:November 1, 1999 - v1
Checksum:i69458D161B60F4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015041 mRNA Translation: AAD01549.1
BC001794 mRNA No translation available.
BT009807 mRNA Translation: AAP88809.1
CCDSiCCDS12561.1
RefSeqiNP_001276908.1, NM_001289979.1
NP_001276909.1, NM_001289980.2
NP_004747.1, NM_004756.4
UniGeneiHs.326953

Genome annotation databases

EnsembliENST00000252891; ENSP00000252891; ENSG00000105245
GeneIDi9253
KEGGihsa:9253
UCSCiuc002oon.5 human

Similar proteinsi

Entry informationi

Entry nameiNUMBL_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R0
Secondary accession number(s): Q7Z4J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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