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Entry version 207 (08 May 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Nuclear receptor coactivator 3

Gene

NCOA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Miscellaneous

NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-9018519 Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9Y6Q9

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y6Q9

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q9Y6Q9 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 3 (EC:2.3.1.48)
Short name:
NCoA-3
Alternative name(s):
ACTR
Amplified in breast cancer 1 protein
Short name:
AIB-1
CBP-interacting protein
Short name:
pCIP
Class E basic helix-loop-helix protein 42
Short name:
bHLHe42
Receptor-associated coactivator 3
Short name:
RAC-3
Steroid receptor coactivator protein 3
Short name:
SRC-3
Thyroid hormone receptor activator molecule 1
Short name:
TRAM-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA3
Synonyms:AIB1, BHLHE42, RAC3, TRAM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7670 NCOA3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601937 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6Q9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi616K → Q: Strongly reduces acetylation by CREBBP. 1 Publication1
Mutagenesisi619 – 620KK → QQ: Abolishes acetylation by CREBBP. 1 Publication2
Mutagenesisi647K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi681K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi687K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi700K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi708K → Q: Does not affect acetylation by CREBBP. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8202

Open Targets

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OpenTargetsi
ENSG00000124151

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31472

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1615382

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NCOA3

Domain mapping of disease mutations (DMDM)

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DMDMi
23396777

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944062 – 1424Nuclear receptor coactivator 3Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei569PhosphoserineBy similarity1
Modified residuei601Phosphoserine; by CK11 Publication1
Modified residuei616N6-acetyllysine; by CREBBP1 Publication1
Modified residuei619N6-acetyllysine; by CREBBP1 Publication1
Modified residuei620N6-acetyllysine; by CREBBP1 Publication1
Modified residuei687N6-acetyllysineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei728PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei860PhosphoserineBy similarity1
Modified residuei867PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1171Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1188Asymmetric dimethylarginineCombined sources1
Modified residuei1330PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.1 Publication
Methylated by CARM1.By similarity
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y6Q9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y6Q9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y6Q9

PeptideAtlas

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PeptideAtlasi
Q9Y6Q9

PRoteomics IDEntifications database

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PRIDEi
Q9Y6Q9

ProteomicsDB human proteome resource

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ProteomicsDBi
86766
86767 [Q9Y6Q9-2]
86768 [Q9Y6Q9-3]
86769 [Q9Y6Q9-4]
86770 [Q9Y6Q9-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y6Q9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y6Q9

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9Y6Q9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000124151 Expressed in 240 organ(s), highest expression level in endometrium epithelium

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y6Q9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009800
HPA024210

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5. Interacts with PSMB9. Interacts with NPAS2. Interacts with NR4A3 (By similarity). Interacts with ESRRB; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency (By similarity).By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113841, 117 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y6Q9

Database of interacting proteins

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DIPi
DIP-30876N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9Y6Q9

Protein interaction database and analysis system

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IntActi
Q9Y6Q9, 54 interactors

Molecular INTeraction database

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MINTi
Q9Y6Q9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000361066

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9Y6Q9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KBHNMR-A1045-1091[»]
3L3XX-ray1.55B618-629[»]
3L3ZX-ray2.00B735-746[»]
6ES7NMR-A1045-1086[»]

Database of protein disorder

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DisProti
DP00343

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y6Q9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y6Q9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 82bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini110 – 180PASPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1023 – 1093Interaction with CREBBP1 PublicationAdd BLAST71
Regioni1097 – 1304AcetyltransferaseAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi685 – 689LXXLL motif 15
Motifi738 – 742LXXLL motif 25
Motifi1057 – 1061LXXLL motif 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi505 – 671Ser-richAdd BLAST167
Compositional biasi976 – 980Poly-Gln5
Compositional biasi1248 – 1278Poly-GlnAdd BLAST31
Compositional biasi1392 – 1417Met-richAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQ5R Eukaryota
ENOG410ZDZC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183021

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y6Q9

KEGG Orthology (KO)

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KOi
K11256

Identification of Orthologs from Complete Genome Data

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OMAi
SCKDSSI

Database of Orthologous Groups

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OrthoDBi
59971at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y6Q9

TreeFam database of animal gene trees

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TreeFami
TF332652

Family and domain databases

Conserved Domains Database

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CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.287.1070, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL

The PANTHER Classification System

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PANTHERi
PTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038181 Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9Y6Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGLGENLDP LASDSRKRKL PCDTPGQGLT CSGEKRRREQ ESKYIEELAE
60 70 80 90 100
LISANLSDID NFNVKPDKCA ILKETVRQIR QIKEQGKTIS NDDDVQKADV
110 120 130 140 150
SSTGQGVIDK DSLGPLLLQA LDGFLFVVNR DGNIVFVSEN VTQYLQYKQE
160 170 180 190 200
DLVNTSVYNI LHEEDRKDFL KNLPKSTVNG VSWTNETQRQ KSHTFNCRML
210 220 230 240 250
MKTPHDILED INASPEMRQR YETMQCFALS QPRAMMEEGE DLQSCMICVA
260 270 280 290 300
RRITTGERTF PSNPESFITR HDLSGKVVNI DTNSLRSSMR PGFEDIIRRC
310 320 330 340 350
IQRFFSLNDG QSWSQKRHYQ EAYLNGHAET PVYRFSLADG TIVTAQTKSK
360 370 380 390 400
LFRNPVTNDR HGFVSTHFLQ REQNGYRPNP NPVGQGIRPP MAGCNSSVGG
410 420 430 440 450
MSMSPNQGLQ MPSSRAYGLA DPSTTGQMSG ARYGGSSNIA SLTPGPGMQS
460 470 480 490 500
PSSYQNNNYG LNMSSPPHGS PGLAPNQQNI MISPRNRGSP KIASHQFSPV
510 520 530 540 550
AGVHSPMASS GNTGNHSFSS SSLSALQAIS EGVGTSLLST LSSPGPKLDN
560 570 580 590 600
SPNMNITQPS KVSNQDSKSP LGFYCDQNPV ESSMCQSNSR DHLSDKESKE
610 620 630 640 650
SSVEGAENQR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSSCKESS
660 670 680 690 700
VSVTSPSGVS SSTSGGVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK
710 720 730 740 750
ITAEATGKDT SSITSCGDGN VVKQEQLSPK KKENNALLRY LLDRDDPSDA
760 770 780 790 800
LSKELQPQVE GVDNKMSQCT SSTIPSSSQE KDPKIKTETS EEGSGDLDNL
810 820 830 840 850
DAILGDLTSS DFYNNSISSN GSHLGTKQQV FQGTNSLGLK SSQSVQSIRP
860 870 880 890 900
PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR MMDSQENYGS
910 920 930 940 950
SMGGPNRNVT VTQTPSSGDW GLPNSKAGRM EPMNSNSMGR PGGDYNTSLP
960 970 980 990 1000
RPALGGSIPT LPLRSNSIPG ARPVLQQQQQ MLQMRPGEIP MGMGANPYGQ
1010 1020 1030 1040 1050
AAASNQLGSW PDGMLSMEQV SHGTQNRPLL RNSLDDLVGP PSNLEGQSDE
1060 1070 1080 1090 1100
RALLDQLHTL LSNTDATGLE EIDRALGIPE LVNQGQALEP KQDAFQGQEA
1110 1120 1130 1140 1150
AVMMDQKAGL YGQTYPAQGP PMQGGFHLQG QSPSFNSMMN QMNQQGNFPL
1160 1170 1180 1190 1200
QGMHPRANIM RPRTNTPKQL RMQLQQRLQG QQFLNQSRQA LELKMENPTA
1210 1220 1230 1240 1250
GGAAVMRPMM QPQVSSQQGF LNAQMVAQRS RELLSHHFRQ QRVAMMMQQQ
1260 1270 1280 1290 1300
QQQQQQQQQQ QQQQQQQQQQ QQQQQQTQAF SPPPNVTASP SMDGLLAGPT
1310 1320 1330 1340 1350
MPQAPPQQFP YQPNYGMGQQ PDPAFGRVSS PPNAMMSSRM GPSQNPMMQH
1360 1370 1380 1390 1400
PQAASIYQSS EMKGWPSGNL ARNSSFSQQQ FAHQGNPAVY SMVHMNGSSG
1410 1420
HMGQMNMNPM PMSGMPMGPD QKYC
Length:1,424
Mass (Da):155,293
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i732CDF0423161679
GO
Isoform 2 (identifier: Q9Y6Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     903-917: Missing.

Show »
Length:1,409
Mass (Da):153,797
Checksum:i04B4DF09150BD916
GO
Isoform 3 (identifier: Q9Y6Q9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: E → EVTSDGIFSPT
     903-917: Missing.
     1214-1217: Missing.

Show »
Length:1,415
Mass (Da):154,400
Checksum:i4A162AB05BA34062
GO
Isoform 4 (identifier: Q9Y6Q9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: E → EVTSDGIFSPT
     837-901: Missing.
     903-917: Missing.
     1214-1217: Missing.

Show »
Length:1,350
Mass (Da):147,499
Checksum:iF75584B329A892C4
GO
Isoform 5 (identifier: Q9Y6Q9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1217: Missing.

Show »
Length:1,420
Mass (Da):154,892
Checksum:i654343CEA0855C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131 – 132DG → EA in AAC51663 (PubMed:9238002).Curated2

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The length of the poly-Gln region is polymorphic in the normal population.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053527218R → C1 PublicationCorresponds to variant dbSNP:rs6094752Ensembl.1
Natural variantiVAR_060695220R → I1 PublicationCorresponds to variant dbSNP:rs72645252Ensembl.1
Natural variantiVAR_053528369L → F. Corresponds to variant dbSNP:rs6094756Ensembl.1
Natural variantiVAR_013831460G → R. Corresponds to variant dbSNP:rs1052765Ensembl.1
Natural variantiVAR_060696556I → V1 PublicationCorresponds to variant dbSNP:rs72645272Ensembl.1
Natural variantiVAR_013832559P → S1 PublicationCorresponds to variant dbSNP:rs2230781Ensembl.1
Natural variantiVAR_013833586Q → H1 PublicationCorresponds to variant dbSNP:rs2230782Ensembl.1
Natural variantiVAR_053529777S → A1 PublicationCorresponds to variant dbSNP:rs2230783Ensembl.1
Natural variantiVAR_0606971247M → K1 PublicationCorresponds to variant dbSNP:rs72645299Ensembl.1
Natural variantiVAR_0606981247M → L1 PublicationCorresponds to variant dbSNP:rs72645298Ensembl.1
Natural variantiVAR_0138341248 – 1250Missing 2 Publications3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003405321E → EVTSDGIFSPT in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_003406837 – 901Missing in isoform 4. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_003407903 – 917Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0034081214 – 1217Missing in isoform 3, isoform 4 and isoform 5. 4 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF016031 mRNA Translation: AAC51849.1
AF036892 mRNA Translation: AAB92368.1
AF012108 mRNA Translation: AAC51677.1
AF010227 mRNA Translation: AAC51663.1
EF488684 Genomic DNA Translation: ABO43042.1
AL034418 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75698.1
CH471077 Genomic DNA Translation: EAW75702.1
BC119001 mRNA Translation: AAI19002.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13406.1 [Q9Y6Q9-5]
CCDS13407.1 [Q9Y6Q9-1]
CCDS54472.1 [Q9Y6Q9-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T03851

NCBI Reference Sequences

More...
RefSeqi
NP_001167559.1, NM_001174088.1 [Q9Y6Q9-3]
NP_006525.2, NM_006534.3 [Q9Y6Q9-5]
NP_858045.1, NM_181659.2 [Q9Y6Q9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371997; ENSP00000361065; ENSG00000124151 [Q9Y6Q9-3]
ENST00000371998; ENSP00000361066; ENSG00000124151 [Q9Y6Q9-1]
ENST00000372004; ENSP00000361073; ENSG00000124151 [Q9Y6Q9-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8202

UCSC genome browser

More...
UCSCi
uc002xtk.4 human [Q9Y6Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016031 mRNA Translation: AAC51849.1
AF036892 mRNA Translation: AAB92368.1
AF012108 mRNA Translation: AAC51677.1
AF010227 mRNA Translation: AAC51663.1
EF488684 Genomic DNA Translation: ABO43042.1
AL034418 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75698.1
CH471077 Genomic DNA Translation: EAW75702.1
BC119001 mRNA Translation: AAI19002.1
CCDSiCCDS13406.1 [Q9Y6Q9-5]
CCDS13407.1 [Q9Y6Q9-1]
CCDS54472.1 [Q9Y6Q9-3]
PIRiT03851
RefSeqiNP_001167559.1, NM_001174088.1 [Q9Y6Q9-3]
NP_006525.2, NM_006534.3 [Q9Y6Q9-5]
NP_858045.1, NM_181659.2 [Q9Y6Q9-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KBHNMR-A1045-1091[»]
3L3XX-ray1.55B618-629[»]
3L3ZX-ray2.00B735-746[»]
6ES7NMR-A1045-1086[»]
DisProtiDP00343
SMRiQ9Y6Q9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113841, 117 interactors
CORUMiQ9Y6Q9
DIPiDIP-30876N
ELMiQ9Y6Q9
IntActiQ9Y6Q9, 54 interactors
MINTiQ9Y6Q9
STRINGi9606.ENSP00000361066

Chemistry databases

BindingDBiQ9Y6Q9
ChEMBLiCHEMBL1615382

Protein family/group databases

MoonDBiQ9Y6Q9 Predicted

PTM databases

iPTMnetiQ9Y6Q9
PhosphoSitePlusiQ9Y6Q9
SwissPalmiQ9Y6Q9

Polymorphism and mutation databases

BioMutaiNCOA3
DMDMi23396777

Proteomic databases

EPDiQ9Y6Q9
jPOSTiQ9Y6Q9
PaxDbiQ9Y6Q9
PeptideAtlasiQ9Y6Q9
PRIDEiQ9Y6Q9
ProteomicsDBi86766
86767 [Q9Y6Q9-2]
86768 [Q9Y6Q9-3]
86769 [Q9Y6Q9-4]
86770 [Q9Y6Q9-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371997; ENSP00000361065; ENSG00000124151 [Q9Y6Q9-3]
ENST00000371998; ENSP00000361066; ENSG00000124151 [Q9Y6Q9-1]
ENST00000372004; ENSP00000361073; ENSG00000124151 [Q9Y6Q9-5]
GeneIDi8202
KEGGihsa:8202
UCSCiuc002xtk.4 human [Q9Y6Q9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8202
DisGeNETi8202

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCOA3
HGNCiHGNC:7670 NCOA3
HPAiCAB009800
HPA024210
MIMi601937 gene
neXtProtiNX_Q9Y6Q9
OpenTargetsiENSG00000124151
PharmGKBiPA31472

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ5R Eukaryota
ENOG410ZDZC LUCA
GeneTreeiENSGT00950000183021
InParanoidiQ9Y6Q9
KOiK11256
OMAiSCKDSSI
OrthoDBi59971at2759
PhylomeDBiQ9Y6Q9
TreeFamiTF332652

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiQ9Y6Q9
SIGNORiQ9Y6Q9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCOA3 human
EvolutionaryTraceiQ9Y6Q9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Nuclear_receptor_coactivator_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8202

Protein Ontology

More...
PROi
PR:Q9Y6Q9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124151 Expressed in 240 organ(s), highest expression level in endometrium epithelium
GenevisibleiQ9Y6Q9 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6Q9
Secondary accession number(s): A4LAZ5
, Q0VF45, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: May 8, 2019
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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