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Entry version 159 (07 Apr 2021)
Sequence version 2 (15 Aug 2003)
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Protein

Stonin-1

Gene

STON1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the endocytic machinery.By similarity

Miscellaneous

In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby does not interact with EPS15, EPS15R and ITSN1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin adaptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9Y6Q2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y6Q2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stonin-1
Alternative name(s):
Stoned B-like factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STON1
Synonyms:SALF, SBLF, STN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17003, STON1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605357, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6Q2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000068781.21
HostDB:ENSG00000243244.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11037
286749

Open Targets

More...
OpenTargetsi
ENSG00000068781
ENSG00000243244

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485623
PA162390383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6Q2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STON1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33860221

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857361 – 735Stonin-1Add BLAST735

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6Q2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y6Q2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6Q2

PeptideAtlas

More...
PeptideAtlasi
Q9Y6Q2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6Q2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2326
6042
86760 [Q9Y6Q2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6Q2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000243244, Expressed in myometrium and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6Q2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6Q2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000243244, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116226, 7 interactors
130414, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9Y6Q2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384615

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y6Q2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini275 – 408SHDPROSITE-ProRule annotationAdd BLAST134
Domaini412 – 715MHDPROSITE-ProRule annotationAdd BLAST304

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Stoned B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2677, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158817

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016541_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y6Q2

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVMLDTC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6Q2

TreeFam database of animal gene trees

More...
TreeFami
TF318623

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR028565, MHD
IPR012320, SHD_dom
IPR031232, Ston1
IPR017110, Stonin

The PANTHER Classification System

More...
PANTHERi
PTHR10529:SF339, PTHR10529:SF339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00928, Adap_comp_sub, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037099, Stonin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447, SSF49447, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51072, MHD, 1 hit
PS51070, SHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCSTNPGKWV TFDDDPAVQS SQKSKNFPLE NQGVCRPNGL KLNLPGLREF
60 70 80 90 100
PSGSSSTSST PLSSPIVDFY FSPGPPSNSP LSTPTKDFPG FPGIPKAGTH
110 120 130 140 150
VLYPIPESSS DSPLAISGGE SSLLPTRPTC LSHALLPSDH SCTHPTPKVG
160 170 180 190 200
LPDEVNPQQA ESLGFQSDDL PQFQYFREDC AFSSPFWKDE GSDSHFTLDP
210 220 230 240 250
PGSKKMFSSR NKEMPIDQKS LNKCSLNYIC EKLEHLQSAE NQDSLRSLSM
260 270 280 290 300
HCLCAEENAS SFVPHTLFRS QPKSGWSFML RIPEKKNMMS SRQWGPIFLK
310 320 330 340 350
VLPGGILQMY YEQGLEKPFK EIQLDPYCRL SEPKVENFSV AGKIHTVKIE
360 370 380 390 400
HVSYTEKRKY HSKTEVVHEP DIEQMLKLGS TSYHDFLDFL TTVEEELMKL
410 420 430 440 450
PAVSKPKKNY EEQEISLEIV DNFWGKVTKE GKFVESAVIT QIYCLCFVNG
460 470 480 490 500
NLECFLTLND LELPKRDESY YEKDSEKKGI DILDYHFHKC VNVQEFEQSR
510 520 530 540 550
IIKFVPLDAC RFELMRFKTL YNGDNLPFSL KSVVVVQGAY VELQAFVNMA
560 570 580 590 600
SLAQRSSYAG SLRSCDNIRI HFPVPSQWIK ALWTMNLQRQ KSLKAKMNRR
610 620 630 640 650
ACLGSLQELE SEPVIQVTVG SAKYESAYQA VVWKIDRLPD KNSSLDHPHC
660 670 680 690 700
LSYKLELGSD QEIPSDWYPF ATVQFSVPDT CASRTEVRSL GVESDVQPQK
710 720 730
HVQQRACYNI QVEIEKKWIK IDGEDPDKIG DCITQ
Length:735
Mass (Da):83,141
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DD70005CC88EF3D
GO
Isoform 2 (identifier: Q9Y6Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-735: VEIEKKWIKIDGEDPDKIGDCITQ → PKLYRSVIED...GDTRVRHGQQ

Show »
Length:1,158
Mass (Da):129,227
Checksum:i4824BDFD694CF57C
GO
Isoform 3 (identifier: Q9Y6Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-735: VEIEKKWIKIDGEDPDKIGDCITQ → PKLYRSVIED...FAKAIGDAEW

Show »
Length:1,135
Mass (Da):127,325
Checksum:iC7898A0618F044C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1E2H7C1E2_HUMAN
Stonin-1
STON1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD39617 differs from that shown. Chimeric cDNA. The in vivo relevance of this transcript of the STON1 and GTF2A1L (AC Q9UNN4) genes creating a chimeric protein of 1182 residues is uncertain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44L → P in AAD39617 (PubMed:11159353).Curated1
Sequence conflicti44L → P in AAK11719 (PubMed:11159353).Curated1
Sequence conflicti167S → I in AAI43521 (PubMed:15489334).Curated1
Sequence conflicti187W → R in AAD39617 (PubMed:11159353).Curated1
Sequence conflicti187W → R in AAK11719 (PubMed:11159353).Curated1
Isoform 2 (identifier: Q9Y6Q2-2)
Sequence conflicti963N → D in AK309740 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0521568K → N. Corresponds to variant dbSNP:rs17039250Ensembl.1
Natural variantiVAR_020183127R → T. Corresponds to variant dbSNP:rs940389Ensembl.1
Natural variantiVAR_020184544Q → H. Corresponds to variant dbSNP:rs3828341Ensembl.1
Natural variantiVAR_020185607Q → H1 PublicationCorresponds to variant dbSNP:rs3792234Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045845712 – 735VEIEK…DCITQ → PKLYRSVIEDVIEGVRNLFA EEGIEEQVLKDLKQLWETKV LQSKATEDFFRNSIQSPLFT LQLPHSLHQTLQSSTASLVI PAGRTLPSFTTAELGTSNSS ANFTFPGYPIHVPAGVTLQT VSGHLYKVNVPIMVTETSGR AGILQHPIQQVFQQLGQPSV IQTSVPQLNPWSLQATTEKS QRIETVLQQPAILPSGPVDR KHLENATSDILVSPGNEHKI VPEALLCHQESSHYISLPGV VFSPQVSQTNSNVESVLSGS ASMAQNLHDESLSTSPHGAL HQHVTDIQLHILKNRMYGCD SVKQPRNIEEPSNIPVSEKD SNSQVDLSIRVTDDDIGEII QVDGSGDTSSNEEIGSTRDA DENEFLGNIDGGDLKVPEEE ADSISNEDSATNSSDNEDPQ VNIVEEDPLNSGDDVSEQDV PDLFDTDNVIVCQYDKQGDT RVRHGQQ in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_045846712 – 735VEIEK…DCITQ → PKLYRSVIEDVIEGVRNLFA EEGIEEQVLKDLKQLWETKV LQSKATEDFFRNSIQSPLFT LQLPHSLHQTLQSSTGHLYK VNVPIMVTETSGRAGILQHP IQQVFQQLGQPSVIQTSVPQ LNPWSLQATTEKSQRIETVL QQPAILPSGPVDRKHLENAT SDILVSPGNEHKIVPEALLC HQESSHYISLPGVVFSPQVS QTNSNVESVLSGSASMAQNL HDESLSTSPHGALHQHVTDI QLHILKNRMYGCDSVKQPRN IEEPSNIPVSEKDSNSQVDL SIRVTDDDIGEIIQVDGSGD TSSNEEIGSTRDADENEFLG NIDGGDLKVPEEEADSISNE DSATNSSDNEDPQVNIVEED PLNSGDDVSEQDVPDLFDTD NVIVCQYDKIHRSKNKWKFY LKDGVMCFGGRDYVFAKAIG DAEW in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF026169 mRNA Translation: AAD39617.1 Sequence problems.
AY026319 mRNA Translation: AAK11719.1
AF255310 mRNA Translation: AAK57559.1
AK309740 mRNA No translation available.
AC073082 Genomic DNA No translation available.
AC087816 Genomic DNA No translation available.
AC091788 Genomic DNA No translation available.
KF456667 Genomic DNA No translation available.
BC143520 mRNA Translation: AAI43521.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1841.1 [Q9Y6Q2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001185522.1, NM_001198593.1 [Q9Y6Q2-2]
NP_001185523.1, NM_001198594.1 [Q9Y6Q2-3]
NP_001185524.1, NM_001198595.1 [Q9Y6Q2-1]
NP_006864.2, NM_006873.3 [Q9Y6Q2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000404752; ENSP00000385273; ENSG00000243244 [Q9Y6Q2-1]
ENST00000406226; ENSP00000384615; ENSG00000243244 [Q9Y6Q2-1]
ENST00000649748; ENSP00000497745; ENSG00000243244 [Q9Y6Q2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11037
286749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11037
hsa:286749

UCSC genome browser

More...
UCSCi
uc002rwo.5, human [Q9Y6Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026169 mRNA Translation: AAD39617.1 Sequence problems.
AY026319 mRNA Translation: AAK11719.1
AF255310 mRNA Translation: AAK57559.1
AK309740 mRNA No translation available.
AC073082 Genomic DNA No translation available.
AC087816 Genomic DNA No translation available.
AC091788 Genomic DNA No translation available.
KF456667 Genomic DNA No translation available.
BC143520 mRNA Translation: AAI43521.1
CCDSiCCDS1841.1 [Q9Y6Q2-1]
RefSeqiNP_001185522.1, NM_001198593.1 [Q9Y6Q2-2]
NP_001185523.1, NM_001198594.1 [Q9Y6Q2-3]
NP_001185524.1, NM_001198595.1 [Q9Y6Q2-1]
NP_006864.2, NM_006873.3 [Q9Y6Q2-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116226, 7 interactors
130414, 1 interactor
IntActiQ9Y6Q2, 4 interactors
STRINGi9606.ENSP00000384615

PTM databases

iPTMnetiQ9Y6Q2
PhosphoSitePlusiQ9Y6Q2

Genetic variation databases

BioMutaiSTON1
DMDMi33860221

Proteomic databases

jPOSTiQ9Y6Q2
MassIVEiQ9Y6Q2
PaxDbiQ9Y6Q2
PeptideAtlasiQ9Y6Q2
PRIDEiQ9Y6Q2
ProteomicsDBi2326
6042
86760 [Q9Y6Q2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
35033, 93 antibodies

The DNASU plasmid repository

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DNASUi
11037

Genome annotation databases

EnsembliENST00000404752; ENSP00000385273; ENSG00000243244 [Q9Y6Q2-1]
ENST00000406226; ENSP00000384615; ENSG00000243244 [Q9Y6Q2-1]
ENST00000649748; ENSP00000497745; ENSG00000243244 [Q9Y6Q2-1]
GeneIDi11037
286749
KEGGihsa:11037
hsa:286749
UCSCiuc002rwo.5, human [Q9Y6Q2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11037
286749
DisGeNETi11037
286749

GeneCards: human genes, protein and diseases

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GeneCardsi
STON1
HGNCiHGNC:17003, STON1
HPAiENSG00000243244, Low tissue specificity
MIMi605357, gene
neXtProtiNX_Q9Y6Q2
OpenTargetsiENSG00000068781
ENSG00000243244
PharmGKBiPA143485623
PA162390383
VEuPathDBiHostDB:ENSG00000068781.21
HostDB:ENSG00000243244.5

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2677, Eukaryota
GeneTreeiENSGT00940000158817
HOGENOMiCLU_016541_0_0_1
InParanoidiQ9Y6Q2
OMAiFVMLDTC
PhylomeDBiQ9Y6Q2
TreeFamiTF318623

Enzyme and pathway databases

PathwayCommonsiQ9Y6Q2
ReactomeiR-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SignaLinkiQ9Y6Q2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11037, 6 hits in 946 CRISPR screens
286749, 235 hits in 910 CRISPR screens
PharosiQ9Y6Q2, Tbio

Protein Ontology

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PROi
PR:Q9Y6Q2
RNActiQ9Y6Q2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000243244, Expressed in myometrium and 209 other tissues
ExpressionAtlasiQ9Y6Q2, baseline and differential
GenevisibleiQ9Y6Q2, HS

Family and domain databases

InterProiView protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR028565, MHD
IPR012320, SHD_dom
IPR031232, Ston1
IPR017110, Stonin
PANTHERiPTHR10529:SF339, PTHR10529:SF339, 1 hit
PfamiView protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PIRSFiPIRSF037099, Stonin, 1 hit
SUPFAMiSSF49447, SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS51072, MHD, 1 hit
PS51070, SHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTON1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6Q2
Secondary accession number(s): A0A0A6YYH4
, A8MXJ1, B5MCF5, B7ZL16, Q96JE3, Q9BYX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 15, 2003
Last modified: April 7, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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