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Protein

Calpain-6

Gene

CAPN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.971

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-6
Alternative name(s):
Calpain-like protease X-linked
Calpamodulin
Short name:
CalpM
Gene namesi
Name:CAPN6
Synonyms:CALPM, CANPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000077274.8
HGNCiHGNC:1483 CAPN6
MIMi300146 gene
neXtProtiNX_Q9Y6Q1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi827
OpenTargetsiENSG00000077274
PharmGKBiPA26063

Polymorphism and mutation databases

BioMutaiCAPN6
DMDMi13959315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077171 – 641Calpain-6Add BLAST641

Proteomic databases

EPDiQ9Y6Q1
PaxDbiQ9Y6Q1
PeptideAtlasiQ9Y6Q1
PRIDEiQ9Y6Q1
ProteomicsDBi86759

PTM databases

iPTMnetiQ9Y6Q1
PhosphoSitePlusiQ9Y6Q1

Expressioni

Tissue specificityi

Expressed only in placenta.

Gene expression databases

BgeeiENSG00000077274
CleanExiHS_CAPN6
GenevisibleiQ9Y6Q1 HS

Organism-specific databases

HPAiHPA040383

Interactioni

Subunit structurei

Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107277, 12 interactors
IntActiQ9Y6Q1, 2 interactors
MINTiQ9Y6Q1
STRINGi9606.ENSP00000317214

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Q1
SMRiQ9Y6Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticPROSITE-ProRule annotationAdd BLAST318
Domaini518 – 620C2Add BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 495Domain IIIAdd BLAST152

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232036
HOVERGENiHBG001095
InParanoidiQ9Y6Q1
KOiK08575
OMAiEQEWDPR
OrthoDBiEOG091G030A
PhylomeDBiQ9Y6Q1
TreeFamiTF314748

Family and domain databases

CDDicd04046 C2_Calpain, 1 hit
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884 C2_Calpain
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029540 CAPN6
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF381 PTHR10183:SF381, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPLKLFKN QKYQELKQEC IKDSRLFCDP TFLPENDSLF YNRLLPGKVV
60 70 80 90 100
WKRPQDICDD PHLIVGNISN HQLTQGRLGH KPMVSAFSCL AVQESHWTKT
110 120 130 140 150
IPNHKEQEWD PQKTEKYAGI FHFRFWHFGE WTEVVIDDLL PTINGDLVFS
160 170 180 190 200
FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIVDFT GTLAETVDMQ
210 220 230 240 250
KGRYTELVEE KYKLFGELYK TFTKGGLICC SIESPNQEEQ EVETDWGLLK
260 270 280 290 300
GHTYTMTDIR KIRLGERLVE VFSAEKVYMV RLRNPLGRQE WSGPWSEISE
310 320 330 340 350
EWQQLTASDR KNLGLVMSDD GEFWMSLEDF CRNFHKLNVC RNVNNPIFGR
360 370 380 390 400
KELESVLGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM
410 420 430 440 450
SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRKFRLHHLY IQERAGTSTY
460 470 480 490 500
IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD
510 520 530 540 550
MPKMSCWNLA RGYPKVVTQI TVHSAEDLEK KYANETVNPY LVIKCGKEEV
560 570 580 590 600
RSPVQKNTVH AIFDTQAIFY RRTTDIPIIV QVWNSRKFCD QFLGQVTLDA
610 620 630 640
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L
Length:641
Mass (Da):74,576
Last modified:May 4, 2001 - v2
Checksum:iA48E5291169B1028
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42N → F in CAA04051 (Ref. 3) Curated1
Sequence conflicti415 – 416RP → KT in AAB86605 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021084277V → L1 PublicationCorresponds to variant dbSNP:rs12013711Ensembl.1
Natural variantiVAR_036048358G → R in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051515518T → I. Corresponds to variant dbSNP:rs12851517Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029232 mRNA Translation: AAB86605.1
AJ000388 mRNA Translation: CAA04051.1
AY800242 Genomic DNA Translation: AAV41896.1
AL031117 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02650.1
CH471120 Genomic DNA Translation: EAX02651.1
BC000730 mRNA Translation: AAH00730.1
CCDSiCCDS14555.1
RefSeqiNP_055104.2, NM_014289.3
UniGeneiHs.496593

Genome annotation databases

EnsembliENST00000324068; ENSP00000317214; ENSG00000077274
GeneIDi827
KEGGihsa:827
UCSCiuc004epc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAN6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Q1
Secondary accession number(s): D3DUY7, Q9UEQ1, Q9UJA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: June 20, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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