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Protein

Cadherin-10

Gene

CDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-10
Alternative name(s):
T2-cadherin
Gene namesi
Name:CDH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000040731.10
HGNCiHGNC:1749 CDH10
MIMi604555 gene
neXtProtiNX_Q9Y6N8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini55 – 613ExtracellularSequence analysisAdd BLAST559
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Topological domaini635 – 788CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1008
OpenTargetsiENSG00000040731
PharmGKBiPA26283

Polymorphism and mutation databases

BioMutaiCDH10
DMDMi116241276

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000378123 – 54Sequence analysisAdd BLAST32
ChainiPRO_000000378255 – 788Cadherin-10Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei784PhosphoserineCombined sources1
Modified residuei788PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y6N8
PeptideAtlasiQ9Y6N8
PRIDEiQ9Y6N8
ProteomicsDBi86749

PTM databases

iPTMnetiQ9Y6N8
PhosphoSitePlusiQ9Y6N8

Expressioni

Tissue specificityi

Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.1 Publication

Gene expression databases

BgeeiENSG00000040731 Expressed in 119 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_CDH10
ExpressionAtlasiQ9Y6N8 baseline and differential
GenevisibleiQ9Y6N8 HS

Organism-specific databases

HPAiHPA010651

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107443, 6 interactors
IntActiQ9Y6N8, 4 interactors
STRINGi9606.ENSP00000264463

Structurei

3D structure databases

ProteinModelPortaliQ9Y6N8
SMRiQ9Y6N8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 160Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini161 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini270 – 384Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini385 – 487Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini488 – 606Cadherin 5PROSITE-ProRule annotationAdd BLAST119

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ9Y6N8
KOiK06802
OMAiLWVCLPH
OrthoDBiEOG091G0298
PhylomeDBiQ9Y6N8
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y6N8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH
60 70 80 90 100
RQKRGWMWNQ FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT
110 120 130 140 150
LFIIDEKTGD IHATRRIDRE EKAFYTLRAQ AINRRTLRPV EPESEFVIKI
160 170 180 190 200
HDINDNEPTF PEEIYTASVP EMSVVGTSVV QVTATDADDP SYGNSARVIY
210 220 230 240 250
SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK DMGGQMGGLS
260 270 280 290 300
GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK
310 320 330 340 350
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA
360 370 380 390 400
ENTHVDPRFY YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG
410 420 430 440 450
TIIGTVMARD PDSISSPIRF SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE
460 470 480 490 500
LSQWHNLTVI AAEINNPKET TRVAVFVRIL DVNDNAPQFA VFYDTFVCEN
510 520 530 540 550
ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN EDNTARILTR
560 570 580 590 600
KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA
610 620 630 640 650
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI
660 670 680 690 700
RDNIVSYNDE GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR
710 720 730 740 750
TPTAPDNTDV RDFINERLKE HDLDPTAPPY DSLATYAYEG NDSIAESLSS
760 770 780
LESGTTEGDQ NYDYLREWGP RFNKLAEMYG GGESDKDS
Length:788
Mass (Da):88,451
Last modified:October 17, 2006 - v2
Checksum:iE92908F9C19270B2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJG0D6RJG0_HUMAN
Cadherin-10
CDH10
436Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → R in AAD44017 (PubMed:10386616).Curated1
Sequence conflicti482V → A in AAD44017 (PubMed:10386616).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036102371V → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028751413S → F. Corresponds to variant dbSNP:rs1395027Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039747 mRNA Translation: AAD44017.1
AB035303 mRNA Translation: BAA87417.1
CCDSiCCDS3892.1
RefSeqiNP_006718.2, NM_006727.4
XP_011512225.1, XM_011513923.2
UniGeneiHs.92489

Genome annotation databases

EnsembliENST00000264463; ENSP00000264463; ENSG00000040731
GeneIDi1008
KEGGihsa:1008

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039747 mRNA Translation: AAD44017.1
AB035303 mRNA Translation: BAA87417.1
CCDSiCCDS3892.1
RefSeqiNP_006718.2, NM_006727.4
XP_011512225.1, XM_011513923.2
UniGeneiHs.92489

3D structure databases

ProteinModelPortaliQ9Y6N8
SMRiQ9Y6N8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107443, 6 interactors
IntActiQ9Y6N8, 4 interactors
STRINGi9606.ENSP00000264463

PTM databases

iPTMnetiQ9Y6N8
PhosphoSitePlusiQ9Y6N8

Polymorphism and mutation databases

BioMutaiCDH10
DMDMi116241276

Proteomic databases

PaxDbiQ9Y6N8
PeptideAtlasiQ9Y6N8
PRIDEiQ9Y6N8
ProteomicsDBi86749

Protocols and materials databases

DNASUi1008
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264463; ENSP00000264463; ENSG00000040731
GeneIDi1008
KEGGihsa:1008

Organism-specific databases

CTDi1008
DisGeNETi1008
EuPathDBiHostDB:ENSG00000040731.10
GeneCardsiCDH10
HGNCiHGNC:1749 CDH10
HPAiHPA010651
MIMi604555 gene
neXtProtiNX_Q9Y6N8
OpenTargetsiENSG00000040731
PharmGKBiPA26283
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ9Y6N8
KOiK06802
OMAiLWVCLPH
OrthoDBiEOG091G0298
PhylomeDBiQ9Y6N8
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Miscellaneous databases

ChiTaRSiCDH10 human
GeneWikiiCDH10
GenomeRNAii1008
PROiPR:Q9Y6N8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000040731 Expressed in 119 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_CDH10
ExpressionAtlasiQ9Y6N8 baseline and differential
GenevisibleiQ9Y6N8 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6N8
Secondary accession number(s): Q9ULB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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