UniProtKB - Q9Y6N7 (ROBO1_HUMAN)
Roundabout homolog 1
ROBO1
Functioni
Miscellaneous
GO - Molecular functioni
- axon guidance receptor activity Source: ProtInc
- identical protein binding Source: UniProtKB
- LRR domain binding Source: UniProtKB
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- aorta development Source: BHF-UCL
- aortic valve morphogenesis Source: BHF-UCL
- axon guidance Source: Reactome
- axon midline choice point recognition Source: UniProtKB
- cell adhesion Source: ProtInc
- cell migration involved in sprouting angiogenesis Source: BHF-UCL
- chemorepulsion involved in postnatal olfactory bulb interneuron migration Source: UniProtKB
- endocardial cushion formation Source: BHF-UCL
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of chemokine-mediated signaling pathway Source: BHF-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of mammary gland epithelial cell proliferation Source: BHF-UCL
- negative regulation of negative chemotaxis Source: UniProtKB
- nervous system development Source: ProtInc
- outflow tract septum morphogenesis Source: BHF-UCL
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of Notch signaling pathway involved in heart induction Source: BHF-UCL
- positive regulation of Rho protein signal transduction Source: UniProtKB
- positive regulation of vascular endothelial growth factor signaling pathway Source: BHF-UCL
- pulmonary valve morphogenesis Source: BHF-UCL
- Roundabout signaling pathway Source: UniProtKB
- ventricular septum morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Chemotaxis, Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6N7 |
Reactomei | R-HSA-373752, Netrin-1 signaling R-HSA-376176, Signaling by ROBO receptors R-HSA-428540, Activation of RAC1 R-HSA-428542, Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428543, Inactivation of CDC42 and RAC1 R-HSA-428890, Role of ABL in ROBO-SLIT signaling R-HSA-8985586, SLIT2:ROBO1 increases RHOA activity R-HSA-8985801, Regulation of cortical dendrite branching R-HSA-9010553, Regulation of expression of SLITs and ROBOs |
SIGNORi | Q9Y6N7 |
Names & Taxonomyi
Protein namesi | Recommended name: Roundabout homolog 1Alternative name(s): Deleted in U twenty twenty H-Robo-1 |
Gene namesi | Name:ROBO1 Synonyms:DUTT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169855.19 |
HGNCi | HGNC:10249, ROBO1 |
MIMi | 602430, gene |
neXtProti | NX_Q9Y6N7 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Other locations
- axon By similarity
- Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass membrane protein By similarity
Note: Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity).By similarity
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: HPA
Other locations
- axon Source: UniProtKB-SubCell
- cell surface Source: UniProtKB
- cytoplasm Source: UniProtKB
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 897 | ExtracellularSequence analysisAdd BLAST | 872 | |
Transmembranei | 898 – 918 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 919 – 1651 | CytoplasmicSequence analysisAdd BLAST | 733 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6091 |
MalaCardsi | ROBO1 |
OpenTargetsi | ENSG00000169855 |
Orphaneti | 95496, Pituitary stalk interruption syndrome |
PharmGKBi | PA34620 |
Miscellaneous databases
Pharosi | Q9Y6N7, Tbio |
Polymorphism and mutation databases
BioMutai | ROBO1 |
DMDMi | 49036500 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000031033 | 26 – 1651 | Roundabout homolog 1Add BLAST | 1626 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 89 ↔ 147 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 191 ↔ 240 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 283 ↔ 330 | PROSITE-ProRule annotation | ||
Disulfide bondi | 372 ↔ 428 | PROSITE-ProRule annotation | ||
Glycosylationi | 463 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 476 ↔ 525 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 790 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 820 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 827 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 940 | PhosphoserineCombined sources | 1 | |
Modified residuei | 948 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1038 | Phosphotyrosine; by ABL; in vitro1 Publication | 1 | |
Modified residuei | 1055 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1073 | Phosphotyrosine; by ABL; in vitro1 Publication | 1 | |
Modified residuei | 1114 | Phosphotyrosine; by ABL; in vitro1 Publication | 1 | |
Modified residuei | 1240 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1297 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y6N7 |
jPOSTi | Q9Y6N7 |
MassIVEi | Q9Y6N7 |
PaxDbi | Q9Y6N7 |
PeptideAtlasi | Q9Y6N7 |
PRIDEi | Q9Y6N7 |
ProteomicsDBi | 19585 86744 [Q9Y6N7-1] 86745 [Q9Y6N7-2] 86746 [Q9Y6N7-3] 86747 [Q9Y6N7-4] 86748 [Q9Y6N7-5] |
PTM databases
GlyGeni | Q9Y6N7, 6 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y6N7 |
PhosphoSitePlusi | Q9Y6N7 |
SwissPalmi | Q9Y6N7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000169855, Expressed in forebrain and 235 other tissues |
ExpressionAtlasi | Q9Y6N7, baseline and differential |
Genevisiblei | Q9Y6N7, HS |
Organism-specific databases
HPAi | ENSG00000169855, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Dimerization is mediated by the extracellular domain and is independent of SLIT liganding (PubMed:24673457).
Interacts with SLIT1 (By similarity).
Interacts with SLIT2 (PubMed:10102268, PubMed:11404413, PubMed:17848514).
Interacts with FLRT3 (PubMed:24560577).
Interacts with MYO9B (via Rho-GAP domain) (PubMed:26529257).
By similarity6 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- identical protein binding Source: UniProtKB
- LRR domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112018, 22 interactors |
DIPi | DIP-33034N |
ELMi | Q9Y6N7 |
IntActi | Q9Y6N7, 17 interactors |
MINTi | Q9Y6N7 |
STRINGi | 9606.ENSP00000420321 |
Miscellaneous databases
RNActi | Q9Y6N7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y6N7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y6N7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 164 | Ig-like C2-type 1Add BLAST | 97 | |
Domaini | 170 – 257 | Ig-like C2-type 2Add BLAST | 88 | |
Domaini | 262 – 346 | Ig-like C2-type 3Add BLAST | 85 | |
Domaini | 351 – 446 | Ig-like C2-type 4Add BLAST | 96 | |
Domaini | 455 – 541 | Ig-like C2-type 5Add BLAST | 87 | |
Domaini | 563 – 657 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 676 – 773 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 778 – 874 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 97 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4222, Eukaryota |
GeneTreei | ENSGT00940000154477 |
HOGENOMi | CLU_003227_3_0_1 |
InParanoidi | Q9Y6N7 |
OMAi | SHNDCSI |
OrthoDBi | 45439at2759 |
PhylomeDBi | Q9Y6N7 |
TreeFami | TF351053 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR032986, Robo1 |
PANTHERi | PTHR12231:SF243, PTHR12231:SF243, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 2 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKWKHVPFLV MISLLSLSPN HLFLAQLIPD PEDVERGNDH GTPIPTSDND
60 70 80 90 100
DNSLGYTGSR LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE
110 120 130 140 150
WYKGGERVET DKDDPRSHRM LLPSGSLFFL RIVHGRKSRP DEGVYVCVAR
160 170 180 190 200
NYLGEAVSHN ASLEVAILRD DFRQNPSDVM VAVGEPAVME CQPPRGHPEP
210 220 230 240 250
TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC VGTNMVGERE
260 270 280 290 300
SEVAELTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTVRWRKDDG
310 320 330 340 350
ELPKSRYEIR DDHTLKIRKV TAGDMGSYTC VAENMVGKAE ASATLTVQEP
360 370 380 390 400
PHFVVKPRDQ VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ
410 420 430 440 450
SSSRFSVSQT GDLTITNVQR SDVGYYICQT LNVAGSIITK AYLEVTDVIA
460 470 480 490 500
DRPPPVIRQG PVNQTVAVDG TFVLSCVATG SPVPTILWRK DGVLVSTQDS
510 520 530 540 550
RIKQLENGVL QIRYAKLGDT GRYTCIASTP SGEATWSAYI EVQEFGVPVQ
560 570 580 590 600
PPRPTDPNLI PSAPSKPEVT DVSRNTVTLS WQPNLNSGAT PTSYIIEAFS
610 620 630 640 650
HASGSSWQTV AENVKTETSA IKGLKPNAIY LFLVRAANAY GISDPSQISD
660 670 680 690 700
PVKTQDVLPT SQGVDHKQVQ RELGNAVLHL HNPTVLSSSS IEVHWTVDQQ
710 720 730 740 750
SQYIQGYKIL YRPSGANHGE SDWLVFEVRT PAKNSVVIPD LRKGVNYEIK
760 770 780 790 800
ARPFFNEFQG ADSEIKFAKT LEEAPSAPPQ GVTVSKNDGN GTAILVSWQP
810 820 830 840 850
PPEDTQNGMV QEYKVWCLGN ETRYHINKTV DGSTFSVVIP FLVPGIRYSV
860 870 880 890 900
EVAASTGAGS GVKSEPQFIQ LDAHGNPVSP EDQVSLAQQI SDVVKQPAFI
910 920 930 940 950
AGIGAACWII LMVFSIWLYR HRKKRNGLTS TYAGIRKVPS FTFTPTVTYQ
960 970 980 990 1000
RGGEAVSSGG RPGLLNISEP AAQPWLADTW PNTGNNHNDC SISCCTAGNG
1010 1020 1030 1040 1050
NSDSNLTTYS RPADCIANYN NQLDNKQTNL MLPESTVYGD VDLSNKINEM
1060 1070 1080 1090 1100
KTFNSPNLKD GRFVNPSGQP TPYATTQLIQ SNLSNNMNNG SGDSGEKHWK
1110 1120 1130 1140 1150
PLGQQKQEVA PVQYNIVEQN KLNKDYRAND TVPPTIPYNQ SYDQNTGGSY
1160 1170 1180 1190 1200
NSSDRGSSTS GSQGHKKGAR TPKVPKQGGM NWADLLPPPP AHPPPHSNSE
1210 1220 1230 1240 1250
EYNISVDESY DQEMPCPVPP ARMYLQQDEL EEEEDERGPT PPVRGAASSP
1260 1270 1280 1290 1300
AAVSYSHQST ATLTPSPQEE LQPMLQDCPE ETGHMQHQPD RRRQPVSPPP
1310 1320 1330 1340 1350
PPRPISPPHT YGYISGPLVS DMDTDAPEEE EDEADMEVAK MQTRRLLLRG
1360 1370 1380 1390 1400
LEQTPASSVG DLESSVTGSM INGWGSASEE DNISSGRSSV SSSDGSFFTD
1410 1420 1430 1440 1450
ADFAQAVAAA AEYAGLKVAR RQMQDAAGRR HFHASQCPRP TSPVSTDSNM
1460 1470 1480 1490 1500
SAAVMQKTRP AKKLKHQPGH LRRETYTDDL PPPPVPPPAI KSPTAQSKTQ
1510 1520 1530 1540 1550
LEVRPVVVPK LPSMDARTDR SSDRKGSSYK GREVLDGRQV VDMRTNPGDP
1560 1570 1580 1590 1600
REAQEQQNDG KGRGNKAAKR DLPPAKTHLI QEDILPYCRP TFPTSNNPRD
1610 1620 1630 1640 1650
PSSSSSMSSR GSGSRQREQA NVGRRNIAEM QVLGGYERGE DNNEELEETE
S
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZ85 | A0A087WZ85_HUMAN | Roundabout homolog 1 | ROBO1 | 1,525 | Annotation score: | ||
A0A087WTM1 | A0A087WTM1_HUMAN | Roundabout homolog 1 | ROBO1 | 1,606 | Annotation score: | ||
A0A0A0MSX4 | A0A0A0MSX4_HUMAN | Roundabout homolog 1 | ROBO1 | 1,531 | Annotation score: | ||
H7C545 | H7C545_HUMAN | Roundabout homolog 1 | ROBO1 | 190 | Annotation score: | ||
H7C4Y7 | H7C4Y7_HUMAN | Roundabout homolog 1 | ROBO1 | 192 | Annotation score: | ||
F8WEV8 | F8WEV8_HUMAN | Roundabout homolog 1 | ROBO1 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 182 | A → V in AAI15023 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 835 | F → L in AAI15023 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1095 | G → S in CAD98093 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1223 | M → T in Z95705 (PubMed:16641997).Curated | 1 | |
Sequence conflicti | 1443 | P → L in CAD98093 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1536 | D → G in Z95705 (PubMed:16641997).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053640 | 336 | V → A. Corresponds to variant dbSNP:rs9647397Ensembl. | 1 | |
Natural variantiVAR_019071 | 1055 | S → N in a breast cancer sample. 1 PublicationCorresponds to variant dbSNP:rs919603543Ensembl. | 1 | |
Natural variantiVAR_053641 | 1091 | S → N. Corresponds to variant dbSNP:rs35456279Ensembl. | 1 | |
Natural variantiVAR_019072 | 1533 | E → D in a breast cancer sample. 1 PublicationCorresponds to variant dbSNP:rs36055689EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043881 | 1 – 57 | MKWKH…SLGYT → MIAEPAHFYLFGLICLCS in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_010643 | 1 – 39 | Missing in isoform 3 and isoform 4. CuratedAdd BLAST | 39 | |
Alternative sequenceiVSP_010644 | 40 – 57 | HGTPI…SLGYT → MIAEPAHFYLFGLICLCS in isoform 3 and isoform 4. CuratedAdd BLAST | 18 | |
Alternative sequenceiVSP_010645 | 348 | Q → QVGS in isoform 3, isoform 5 and isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_010646 | 543 | Q → QGKVN in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_043882 | 938 – 946 | Missing in isoform 5 and isoform 6. 1 Publication | 9 | |
Alternative sequenceiVSP_046084 | 1013 – 1067 | Missing in isoform 6. 1 PublicationAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF040990 mRNA Translation: AAC39575.1 Z95705 Genomic DNA No translation available. AC016946 Genomic DNA No translation available. AC055731 Genomic DNA No translation available. AC106718 Genomic DNA No translation available. AC106720 Genomic DNA No translation available. AC108719 Genomic DNA No translation available. AC117461 Genomic DNA No translation available. AC117479 Genomic DNA No translation available. AC119035 Genomic DNA No translation available. AC123565 Genomic DNA No translation available. AC125624 Genomic DNA No translation available. AC125766 Genomic DNA No translation available. AC125815 Genomic DNA No translation available. AC131008 Genomic DNA No translation available. CH471110 Genomic DNA Translation: EAW68884.1 CH471110 Genomic DNA Translation: EAW68885.1 BC001969 mRNA Translation: AAH01969.1 BC115022 mRNA Translation: AAI15023.1 BC157861 mRNA Translation: AAI57862.1 BC171855 mRNA Translation: AAI71855.1 BX538319 mRNA Translation: CAD98093.1 |
CCDSi | CCDS46872.2 [Q9Y6N7-5] CCDS54610.1 [Q9Y6N7-6] CCDS54611.1 [Q9Y6N7-1] |
RefSeqi | NP_001139317.1, NM_001145845.1 [Q9Y6N7-6] NP_002932.1, NM_002941.3 [Q9Y6N7-1] NP_598334.2, NM_133631.3 [Q9Y6N7-5] XP_006713340.1, XM_006713277.2 [Q9Y6N7-3] XP_016862472.1, XM_017006983.1 [Q9Y6N7-4] |
Genome annotation databases
Ensembli | ENST00000464233; ENSP00000420321; ENSG00000169855 [Q9Y6N7-1] ENST00000467549; ENSP00000417992; ENSG00000169855 [Q9Y6N7-6] ENST00000495273; ENSP00000420637; ENSG00000169855 [Q9Y6N7-5] |
GeneIDi | 6091 |
KEGGi | hsa:6091 |
UCSCi | uc003dqc.3, human [Q9Y6N7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF040990 mRNA Translation: AAC39575.1 Z95705 Genomic DNA No translation available. AC016946 Genomic DNA No translation available. AC055731 Genomic DNA No translation available. AC106718 Genomic DNA No translation available. AC106720 Genomic DNA No translation available. AC108719 Genomic DNA No translation available. AC117461 Genomic DNA No translation available. AC117479 Genomic DNA No translation available. AC119035 Genomic DNA No translation available. AC123565 Genomic DNA No translation available. AC125624 Genomic DNA No translation available. AC125766 Genomic DNA No translation available. AC125815 Genomic DNA No translation available. AC131008 Genomic DNA No translation available. CH471110 Genomic DNA Translation: EAW68884.1 CH471110 Genomic DNA Translation: EAW68885.1 BC001969 mRNA Translation: AAH01969.1 BC115022 mRNA Translation: AAI15023.1 BC157861 mRNA Translation: AAI57862.1 BC171855 mRNA Translation: AAI71855.1 BX538319 mRNA Translation: CAD98093.1 |
CCDSi | CCDS46872.2 [Q9Y6N7-5] CCDS54610.1 [Q9Y6N7-6] CCDS54611.1 [Q9Y6N7-1] |
RefSeqi | NP_001139317.1, NM_001145845.1 [Q9Y6N7-6] NP_002932.1, NM_002941.3 [Q9Y6N7-1] NP_598334.2, NM_133631.3 [Q9Y6N7-5] XP_006713340.1, XM_006713277.2 [Q9Y6N7-3] XP_016862472.1, XM_017006983.1 [Q9Y6N7-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EO9 | NMR | - | A | 454-564 | [»] | |
2V9Q | X-ray | 2.50 | A | 61-266 | [»] | |
2V9R | X-ray | 2.00 | A | 61-266 | [»] | |
2V9T | X-ray | 1.70 | A | 61-166 | [»] | |
3WIH | X-ray | 1.70 | A/B | 777-873 | [»] | |
4HLJ | X-ray | 1.80 | A | 660-897 | [»] | |
5O5G | X-ray | 3.03 | A | 63-446 | [»] | |
5O5I | X-ray | 3.01 | A | 454-543 | [»] | |
5OPE | X-ray | 2.54 | A | 63-447 | [»] | |
6A77 | X-ray | 2.00 | A | 455-543 | [»] | |
6A78 | X-ray | 2.10 | A/B | 455-543 | [»] | |
6A79 | X-ray | 2.31 | A/B | 455-543 | [»] | |
SMRi | Q9Y6N7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112018, 22 interactors |
DIPi | DIP-33034N |
ELMi | Q9Y6N7 |
IntActi | Q9Y6N7, 17 interactors |
MINTi | Q9Y6N7 |
STRINGi | 9606.ENSP00000420321 |
PTM databases
GlyGeni | Q9Y6N7, 6 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y6N7 |
PhosphoSitePlusi | Q9Y6N7 |
SwissPalmi | Q9Y6N7 |
Polymorphism and mutation databases
BioMutai | ROBO1 |
DMDMi | 49036500 |
Proteomic databases
EPDi | Q9Y6N7 |
jPOSTi | Q9Y6N7 |
MassIVEi | Q9Y6N7 |
PaxDbi | Q9Y6N7 |
PeptideAtlasi | Q9Y6N7 |
PRIDEi | Q9Y6N7 |
ProteomicsDBi | 19585 86744 [Q9Y6N7-1] 86745 [Q9Y6N7-2] 86746 [Q9Y6N7-3] 86747 [Q9Y6N7-4] 86748 [Q9Y6N7-5] |
Protocols and materials databases
ABCDi | Q9Y6N7, 1 sequenced antibody |
Antibodypediai | 4617, 347 antibodies |
Genome annotation databases
Ensembli | ENST00000464233; ENSP00000420321; ENSG00000169855 [Q9Y6N7-1] ENST00000467549; ENSP00000417992; ENSG00000169855 [Q9Y6N7-6] ENST00000495273; ENSP00000420637; ENSG00000169855 [Q9Y6N7-5] |
GeneIDi | 6091 |
KEGGi | hsa:6091 |
UCSCi | uc003dqc.3, human [Q9Y6N7-1] |
Organism-specific databases
CTDi | 6091 |
DisGeNETi | 6091 |
EuPathDBi | HostDB:ENSG00000169855.19 |
GeneCardsi | ROBO1 |
HGNCi | HGNC:10249, ROBO1 |
HPAi | ENSG00000169855, Low tissue specificity |
MalaCardsi | ROBO1 |
MIMi | 602430, gene |
neXtProti | NX_Q9Y6N7 |
OpenTargetsi | ENSG00000169855 |
Orphaneti | 95496, Pituitary stalk interruption syndrome |
PharmGKBi | PA34620 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4222, Eukaryota |
GeneTreei | ENSGT00940000154477 |
HOGENOMi | CLU_003227_3_0_1 |
InParanoidi | Q9Y6N7 |
OMAi | SHNDCSI |
OrthoDBi | 45439at2759 |
PhylomeDBi | Q9Y6N7 |
TreeFami | TF351053 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6N7 |
Reactomei | R-HSA-373752, Netrin-1 signaling R-HSA-376176, Signaling by ROBO receptors R-HSA-428540, Activation of RAC1 R-HSA-428542, Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428543, Inactivation of CDC42 and RAC1 R-HSA-428890, Role of ABL in ROBO-SLIT signaling R-HSA-8985586, SLIT2:ROBO1 increases RHOA activity R-HSA-8985801, Regulation of cortical dendrite branching R-HSA-9010553, Regulation of expression of SLITs and ROBOs |
SIGNORi | Q9Y6N7 |
Miscellaneous databases
BioGRID-ORCSi | 6091, 7 hits in 847 CRISPR screens |
ChiTaRSi | ROBO1, human |
EvolutionaryTracei | Q9Y6N7 |
GeneWikii | ROBO1 |
GenomeRNAii | 6091 |
Pharosi | Q9Y6N7, Tbio |
PROi | PR:Q9Y6N7 |
RNActi | Q9Y6N7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169855, Expressed in forebrain and 235 other tissues |
ExpressionAtlasi | Q9Y6N7, baseline and differential |
Genevisiblei | Q9Y6N7, HS |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR032986, Robo1 |
PANTHERi | PTHR12231:SF243, PTHR12231:SF243, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 2 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROBO1_HUMAN | |
Accessioni | Q9Y6N7Primary (citable) accession number: Q9Y6N7 Secondary accession number(s): B2RXI1 Q9BUS7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations