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Entry version 170 (05 Jun 2019)
Sequence version 3 (05 Oct 2010)
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Protein

Laminin subunit gamma-3

Gene

LAMC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-8874081 MET activates PTK2 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-3
Alternative name(s):
Laminin-12 subunit gamma
Laminin-14 subunit gamma
Laminin-15 subunit gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6494 LAMC3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604349 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6N6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cortical malformations occipital (OCCM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066404350G → R in OCCM. 1 PublicationCorresponds to variant dbSNP:rs571785750Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10319

MalaCards human disease database

More...
MalaCardsi
LAMC3
MIMi614115 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000050555

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
280640 Occipital pachygyria and polymicrogyria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30282

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAMC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153586

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707920 – 1575Laminin subunit gamma-3Add BLAST1556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi271 ↔ 280PROSITE-ProRule annotation
Disulfide bondi273 ↔ 290PROSITE-ProRule annotation
Disulfide bondi292 ↔ 301PROSITE-ProRule annotation
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 324PROSITE-ProRule annotation
Disulfide bondi327 ↔ 336PROSITE-ProRule annotation
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 352PROSITE-ProRule annotation
Disulfide bondi355 ↔ 364PROSITE-ProRule annotation
Disulfide bondi367 ↔ 380PROSITE-ProRule annotation
Disulfide bondi383 ↔ 395PROSITE-ProRule annotation
Disulfide bondi385 ↔ 401PROSITE-ProRule annotation
Disulfide bondi403 ↔ 412PROSITE-ProRule annotation
Disulfide bondi415 ↔ 427PROSITE-ProRule annotation
Disulfide bondi430 ↔ 441PROSITE-ProRule annotation
Disulfide bondi432 ↔ 448PROSITE-ProRule annotation
Disulfide bondi450 ↔ 459PROSITE-ProRule annotation
Disulfide bondi462 ↔ 477PROSITE-ProRule annotation
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi707 ↔ 715PROSITE-ProRule annotation
Disulfide bondi709 ↔ 722PROSITE-ProRule annotation
Disulfide bondi724 ↔ 733PROSITE-ProRule annotation
Disulfide bondi736 ↔ 752PROSITE-ProRule annotation
Disulfide bondi755 ↔ 763PROSITE-ProRule annotation
Disulfide bondi757 ↔ 774PROSITE-ProRule annotation
Disulfide bondi777 ↔ 786PROSITE-ProRule annotation
Disulfide bondi789 ↔ 807PROSITE-ProRule annotation
Disulfide bondi810 ↔ 824PROSITE-ProRule annotation
Disulfide bondi812 ↔ 831PROSITE-ProRule annotation
Disulfide bondi834 ↔ 843PROSITE-ProRule annotation
Glycosylationi837N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi846 ↔ 863PROSITE-ProRule annotation
Disulfide bondi866 ↔ 880PROSITE-ProRule annotation
Disulfide bondi868 ↔ 887PROSITE-ProRule annotation
Disulfide bondi889 ↔ 898PROSITE-ProRule annotation
Disulfide bondi901 ↔ 914PROSITE-ProRule annotation
Disulfide bondi917 ↔ 929PROSITE-ProRule annotation
Disulfide bondi919 ↔ 936PROSITE-ProRule annotation
Disulfide bondi938 ↔ 947PROSITE-ProRule annotation
Disulfide bondi950 ↔ 962PROSITE-ProRule annotation
Disulfide bondi965 ↔ 977PROSITE-ProRule annotation
Disulfide bondi967 ↔ 983PROSITE-ProRule annotation
Glycosylationi980N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi985 ↔ 994PROSITE-ProRule annotation
Disulfide bondi997 ↔ 1010PROSITE-ProRule annotation
Glycosylationi1185N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y6N6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y6N6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y6N6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6N6

PeptideAtlas

More...
PeptideAtlasi
Q9Y6N6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6N6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86743

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y6N6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6N6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed in: skin, heart, lung, and the reproductive tracts.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000050555 Expressed in 123 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y6N6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y6N6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-3 is a subunit of laminin-12 (laminin-213), laminin-14 (laminin-423) and laminin-15 (laminin-523).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115603, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1781 Laminin-213 complex
CPX-1782 Laminin-423 complex
CPX-1784 Laminin-523 complex

Protein interaction database and analysis system

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IntActi
Q9Y6N6, 30 interactors

Molecular INTeraction database

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MINTi
Q9Y6N6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354360

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y6N6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 270Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini271 – 326Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini327 – 382Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini383 – 429Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini430 – 479Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini480 – 489Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini499 – 672Laminin IV type APROSITE-ProRule annotationAdd BLAST174
Domaini673 – 706Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST34
Domaini707 – 754Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini755 – 809Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST55
Domaini810 – 865Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST56
Domaini866 – 916Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST51
Domaini917 – 964Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48
Domaini965 – 1013Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1014 – 1575Domain II and IAdd BLAST562

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1073 – 1134Sequence analysisAdd BLAST62
Coiled coili1201 – 1228Sequence analysisAdd BLAST28
Coiled coili1410 – 1492Sequence analysisAdd BLAST83
Coiled coili1523 – 1567Sequence analysisAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1059 – 1061Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IP68 Eukaryota
ENOG4111F9V LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161559

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000019301

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y6N6

KEGG Orthology (KO)

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KOi
K06247

Identification of Orthologs from Complete Genome Data

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OMAi
TCIQLAD

Database of Orthologous Groups

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OrthoDBi
156553at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y6N6

TreeFam database of animal gene trees

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TreeFami
TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 11 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 11 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 10 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y6N6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAALLLGL ALLAPRAAGA GMGACYDGAG RPQRCLPVFE NAAFGRLAQA
60 70 80 90 100
SHTCGSPPED FCPHVGAAGA GAHCQRCDAA DPQRHHNASY LTDFHSQDES
110 120 130 140 150
TWWQSPSMAF GVQYPTSVNI TLRLGKAYEI TYVRLKFHTS RPESFAIYKR
160 170 180 190 200
SRADGPWEPY QFYSASCQKT YGRPEGQYLR PGEDERVAFC TSEFSDISPL
210 220 230 240 250
SGGNVAFSTL EGRPSAYNFE ESPGLQEWVT STELLISLDR LNTFGDDIFK
260 270 280 290 300
DPKVLQSYYY AVSDFSVGGR CKCNGHASEC GPDVAGQLAC RCQHNTTGTD
310 320 330 340 350
CERCLPFFQD RPWARGTAEA AHECLPCNCS GRSEECTFDR ELFRSTGHGG
360 370 380 390 400
RCHHCRDHTA GPHCERCQEN FYHWDPRMPC QPCDCQSAGS LHLQCDDTGT
410 420 430 440 450
CACKPTVTGW KCDRCLPGFH SLSEGGCRPC TCNPAGSLDT CDPRSGRCPC
460 470 480 490 500
KENVEGNLCD RCRPGTFNLQ PHNPAGCSSC FCYGHSKVCA STAQFQVHHI
510 520 530 540 550
LSDFHQGAEG WWARSVGGSE HPPQWSPNGV LLSPEDEEEL TAPEKFLGDQ
560 570 580 590 600
RFSYGQPLIL TFRVPPGDSP LPVQLRLEGT GLALSLRHSS LSGPQDAGHP
610 620 630 640 650
REVELRFHLQ ETSEDVAPPL PPFHFQRLLA NLTSLRLRVS PGPSPAGPVF
660 670 680 690 700
LTEVRLTSAR PGLSPPASWV EICSCPTGYT GQFCESCAPG YKREMPQGGP
710 720 730 740 750
YASCVPCTCN QHGTCDPNTG ICVCSHHTEG PSCERCLPGF YGNPFAGQAD
760 770 780 790 800
DCQPCPCPGQ SACTTIPESR EVVCTHCPPG QRGRRCEVCD DGFFGDPLGL
810 820 830 840 850
FGHPQPCHQC QCSGNVDPNA VGNCDPLSGH CLRCLHNTTG DHCEHCQEGF
860 870 880 890 900
YGSALAPRPA DKCMPCSCHP QGSVSEQMPC DPVTGQCSCL PHVTARDCSR
910 920 930 940 950
CYPGFFDLQP GRGCRSCKCH PLGSQEDQCH PKTGQCTCRP GVTGQACDRC
960 970 980 990 1000
QLGFFGFSIK GCRACRCSPL GAASAQCHEN GTCVCRPGFE GYKCDRCHDN
1010 1020 1030 1040 1050
FFLTADGTHC QQCPSCYALV KEEAAKLKAR LTLTEGWLQG SDCGSPWGPL
1060 1070 1080 1090 1100
DILLGEAPRG DVYQGHHLLP GAREAFLEQM MSLEGAVKAA REQLQRLNKG
1110 1120 1130 1140 1150
ARCAQAGSQK TCTQLADLEA VLESSEEEIL HAAAILASLE IPQEGPSQPT
1160 1170 1180 1190 1200
KWSHLATEAR ALARSHRDTA TKIAATAWRA LLASNTSYAL LWNLLEGRVA
1210 1220 1230 1240 1250
LETQRDLEDR YQEVQAAQKA LRTAVAEVLP EAESVLATVQ QVGADTAPYL
1260 1270 1280 1290 1300
ALLASPGALP QKSRAEDLGL KAKALEKTVA SWQHMATEAA RTLQTAAQAT
1310 1320 1330 1340 1350
LRQTEPLTKL HQEARAALTQ ASSSVQAATV TVMGARTLLA DLEGMKLQFP
1360 1370 1380 1390 1400
RPKDQAALQR KADSVSDRLL ADTRKKTKQA ERMLGNAAPL SSSAKKKGRE
1410 1420 1430 1440 1450
AEVLAKDSAK LAKALLRERK QAHRRASRLT SQTQATLQQA SQQVLASEAR
1460 1470 1480 1490 1500
RQELEEAERV GAGLSEMEQQ IRESRISLEK DIETLSELLA RLGSLDTHQA
1510 1520 1530 1540 1550
PAQALNETQW ALERLRLQLG SPGSLQRKLS LLEQESQQQE LQIQGFESDL
1560 1570
AEIRADKQNL EAILHSLPEN CASWQ
Length:1,575
Mass (Da):171,227
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD09DAFB3A900E1BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY04H7BY04_HUMAN
Laminin subunit gamma-3
LAMC3
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD36991 differs from that shown. Reason: Frameshift at positions 598 and 609.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti957F → S in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti979E → Y in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti999D → Y in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti1024A → T in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti1157T → I in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti1309K → MARSRLTATFASQ in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti1313E → G in AAD36991 (PubMed:10225960).Curated1
Sequence conflicti1433T → M in BAD92124 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066404350G → R in OCCM. 1 PublicationCorresponds to variant dbSNP:rs571785750Ensembl.1
Natural variantiVAR_056145522P → S1 PublicationCorresponds to variant dbSNP:rs869457EnsemblClinVar.1
Natural variantiVAR_056146544E → G2 PublicationsCorresponds to variant dbSNP:rs10901333EnsemblClinVar.1
Natural variantiVAR_056147770R → G2 PublicationsCorresponds to variant dbSNP:rs3739510EnsemblClinVar.1
Natural variantiVAR_0561481082S → G2 PublicationsCorresponds to variant dbSNP:rs2275140EnsemblClinVar.1
Natural variantiVAR_0561491264R → W. Corresponds to variant dbSNP:rs11244275EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF041835 mRNA Translation: AAD36991.1 Frameshift.
AL355872 Genomic DNA No translation available.
AL583807 Genomic DNA No translation available.
AB208887 mRNA Translation: BAD92124.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6938.1

NCBI Reference Sequences

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RefSeqi
NP_006050.3, NM_006059.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361069; ENSP00000354360; ENSG00000050555

Database of genes from NCBI RefSeq genomes

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GeneIDi
10319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10319

UCSC genome browser

More...
UCSCi
uc004caa.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041835 mRNA Translation: AAD36991.1 Frameshift.
AL355872 Genomic DNA No translation available.
AL583807 Genomic DNA No translation available.
AB208887 mRNA Translation: BAD92124.1
CCDSiCCDS6938.1
RefSeqiNP_006050.3, NM_006059.3

3D structure databases

SMRiQ9Y6N6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115603, 20 interactors
ComplexPortaliCPX-1781 Laminin-213 complex
CPX-1782 Laminin-423 complex
CPX-1784 Laminin-523 complex
IntActiQ9Y6N6, 30 interactors
MINTiQ9Y6N6
STRINGi9606.ENSP00000354360

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

iPTMnetiQ9Y6N6
PhosphoSitePlusiQ9Y6N6

Polymorphism and mutation databases

BioMutaiLAMC3
DMDMi308153586

Proteomic databases

EPDiQ9Y6N6
jPOSTiQ9Y6N6
MaxQBiQ9Y6N6
PaxDbiQ9Y6N6
PeptideAtlasiQ9Y6N6
PRIDEiQ9Y6N6
ProteomicsDBi86743

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10319
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361069; ENSP00000354360; ENSG00000050555
GeneIDi10319
KEGGihsa:10319
UCSCiuc004caa.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10319
DisGeNETi10319

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAMC3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008477
HGNCiHGNC:6494 LAMC3
HPAiHPA022814
MalaCardsiLAMC3
MIMi604349 gene
614115 phenotype
neXtProtiNX_Q9Y6N6
OpenTargetsiENSG00000050555
Orphaneti280640 Occipital pachygyria and polymicrogyria
PharmGKBiPA30282

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IP68 Eukaryota
ENOG4111F9V LUCA
GeneTreeiENSGT00940000161559
HOGENOMiHOG000019301
InParanoidiQ9Y6N6
KOiK06247
OMAiTCIQLAD
OrthoDBi156553at2759
PhylomeDBiQ9Y6N6
TreeFamiTF352481

Enzyme and pathway databases

ReactomeiR-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-8874081 MET activates PTK2 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMC3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LAMC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10319

Protein Ontology

More...
PROi
PR:Q9Y6N6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000050555 Expressed in 123 organ(s), highest expression level in placenta
ExpressionAtlasiQ9Y6N6 baseline and differential
GenevisibleiQ9Y6N6 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 11 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 11 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 10 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6N6
Secondary accession number(s): B1APX9, B1APY0, Q59H72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 5, 2010
Last modified: June 5, 2019
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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