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Protein

Sulfide:quinone oxidoreductase, mitochondrial

Gene

SQOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).1 Publication

Catalytic activityi

Hydrogen sulfide + sulfite + ubiquinone-10 + 2 H+ = thiosulfate + ubiquinol-10.1 Publication

Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei201Cysteine persulfide intermediate1 Publication1
Active sitei379Cysteine persulfide intermediate1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 54FADBy similarity5

GO - Molecular functioni

  • quinone binding Source: UniProtKB-KW
  • sulfide:quinone oxidoreductase activity Source: UniProtKB

GO - Biological processi

  • hydrogen sulfide metabolic process Source: UniProtKB
  • sulfide oxidation, using sulfide:quinone oxidoreductase Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:HS06393-MONOMER
BRENDAi1.8.5.4 2681
ReactomeiR-HSA-1614517 Sulfide oxidation to sulfate

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide:quinone oxidoreductase, mitochondrialCurated (EC:1.8.5.-1 Publication)
Short name:
SQORImported
Alternative name(s):
Sulfide dehydrogenase-like
Sulfide quinone oxidoreductaseImported
Gene namesi
Name:SQORImported
Synonyms:SQRDLImported
ORF Names:CGI-44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137767.13
HGNCiHGNC:20390 SQOR
MIMi617658 gene
neXtProtiNX_Q9Y6N5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi58472
OpenTargetsiENSG00000137767
PharmGKBiPA134894920

Polymorphism and mutation databases

DMDMi27151704

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000022408? – 450Sulfide:quinone oxidoreductase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173N6-acetyllysineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, Quinone

Proteomic databases

EPDiQ9Y6N5
MaxQBiQ9Y6N5
PaxDbiQ9Y6N5
PeptideAtlasiQ9Y6N5
PRIDEiQ9Y6N5
ProteomicsDBi86742

PTM databases

iPTMnetiQ9Y6N5
PhosphoSitePlusiQ9Y6N5
SwissPalmiQ9Y6N5

Expressioni

Gene expression databases

BgeeiENSG00000137767
CleanExiHS_SQRDL
ExpressionAtlasiQ9Y6N5 baseline and differential
GenevisibleiQ9Y6N5 HS

Organism-specific databases

HPAiHPA017079
HPA041589

Interactioni

Protein-protein interaction databases

BioGridi121806, 31 interactors
IntActiQ9Y6N5, 53 interactors
MINTiQ9Y6N5
STRINGi9606.ENSP00000260324

Structurei

3D structure databases

ProteinModelPortaliQ9Y6N5
SMRiQ9Y6N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3851 Eukaryota
COG0446 LUCA
GeneTreeiENSGT00390000019406
HOGENOMiHOG000249874
HOVERGENiHBG029110
InParanoidiQ9Y6N5
KOiK22470
OMAiYQPMFTL
OrthoDBiEOG091G08RU
PhylomeDBiQ9Y6N5
TreeFamiTF314384

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR015904 Sulphide_quinone_reductase
PANTHERiPTHR10632 PTHR10632, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPLVAVVSG PRAQLFACLL RLGTQQVGPL QLHTGASHAA RNHYEVLVLG
60 70 80 90 100
GGSGGITMAA RMKRKVGAEN VAIVEPSERH FYQPIWTLVG AGAKQLSSSG
110 120 130 140 150
RPTASVIPSG VEWIKARVTE LNPDKNCIHT DDDEKISYRY LIIALGIQLD
160 170 180 190 200
YEKIKGLPEG FAHPKIGSNY SVKTVEKTWK ALQDFKEGNA IFTFPNTPVK
210 220 230 240 250
CAGAPQKIMY LSEAYFRKTG KRSKANIIFN TSLGAIFGVK KYADALQEII
260 270 280 290 300
QERNLTVNYK KNLIEVRADK QEAVFENLDK PGETQVISYE MLHVTPPMSP
310 320 330 340 350
PDVLKTSPVA DAAGWVDVDK ETLQHRRYPN VFGIGDCTNL PTSKTAAAVA
360 370 380 390 400
AQSGILDRTI SVIMKNQTPT KKYDGYTSCP LVTGYNRVIL AEFDYKAEPL
410 420 430 440 450
ETFPFDQSKE RLSMYLMKAD LMPFLYWNMM LRGYWGGPAF LRKLFHLGMS
Length:450
Mass (Da):49,961
Last modified:November 1, 1999 - v1
Checksum:i943ABD4049E3634D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014959264I → T1 PublicationCorresponds to variant dbSNP:rs1044032Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042284 mRNA Translation: AAD41160.1
AF151802 mRNA Translation: AAD34039.1
BC016836 mRNA Translation: AAH16836.1
CCDSiCCDS10127.1
RefSeqiNP_001258142.1, NM_001271213.1
NP_067022.1, NM_021199.3
UniGeneiHs.511251
Hs.743355

Genome annotation databases

EnsembliENST00000260324; ENSP00000260324; ENSG00000137767
ENST00000568606; ENSP00000456019; ENSG00000137767
GeneIDi58472
KEGGihsa:58472
UCSCiuc001zvv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSQOR_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6N5
Secondary accession number(s): Q9UQM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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